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| 1 | Hagen-Poiseuille's law:The link between cirrhosis,liver stiffness,portal hypertension and hepatic decompensation显示文摘The onset of hepatic decompensation in cirrhosis heralds an accelerated downhill course with poor outcome. The sole predictor of this decompensationin cirrhosis is increased hepatic vein to portal vein gradient hepatic venous pressure gradient(HVPG). Surrogate markers of liver function or hepatic reserve appear to be less relevant. The hepatic sinusoids become less elastic and more rigid as liver fibrosis and cirrhosis progress. We propose that the HagenPoiseuille's law,which applies to rigid,but not elastic vessels,determines the pressure-flow characteristics in the sinusoids. In the rigid cirrhotic liver,HVPG rises dramatically with any change in net surface area or radius,r4 of the vasculature that follows surgical resection. This review relates liver stiffness to the risk of decompensation in patients with cirrhosis. The liver has a unique dual blood supply comprising a low pressure portal vein and high pressure hepatic artery. We compare the complexity of autoregulation in the normal elastic liver with that in the rigid cirrhotic liver. Therapeutic modalities to reduce portal pressure may reduce the risk of hepatic decompensation and improve outcomes in cirrhosis. | Gerond Lake-Bakaar Muneeb Ahmed Amy Evenson Alan Bonder Salomao Faintuch Vinay Sundaram | 2015 | World Journal of Hepatology2015，7，1： | 2 |
| 2 | Utility of liver biopsy in predicting clinical outcomes after percutaneous angioplasty for hepatic venous obstruction in liver transplant patients显示文摘AIM: To determine utility of transplant liver biopsy in evaluating efficacy of percutaneous transluminal angioplasty(PTA) for hepatic venous obstruction(HVOO). METHODS: Adult liver transplant patients treated with PTA for HVOO(2003-2013) at a single institution were reviewed for pre/post-PTA imaging findings, manometry(gradient with right atrium), presence of HVOO on prePTA and post-PTA early and late biopsy(EB and LB, < or > 60 d after PTA), and clinical outcome, defined as good(no clinical issues, non-HVOO-related death) or poor(surgical correction, recurrent HVOO, or HVOOrelated death). RESULTS: Fifteen patients meeting inclusion criteria underwent 21 PTA, 658 ± 1293 d after transplant.In procedures with pre-PTA biopsy(n = 19), no difference was seen between pre-PTA gradient in 13/19 procedures with HVOO on biopsy and 6/19 procedures without HVOO(8 ± 2.4 mm Hg vs 6.8 ± 4.3 mm Hg; P = 0.35). Post-PTA, 10/21 livers had EB(29 ± 21 d) and 9/21 livers had LB(153 ± 81 d). On clinical follow-up(392 ± 773 d), HVOO on LB resulted in poor outcomes and absence of HVOO on LB resulted good outcomes. Patients with HVOO on EB(3/7 good, 4/7 poor) and no HVOO on EB(2/3 good, 1/3 poor) had mixed outcomes. CONCLUSION: Negative liver biopsy greater than 60 d after PTA accurately identifies patients with good clinical outcomes. | Ammar Sarwar Edward Ahn Ian Brennan Olga R Brook Salomao Faintuch Raza Malik Khalid Khwaja Muneeb Ahmed | 2015 | World Journal of Hepatology2015，7，14： | 2 |
| 3 | Effects of continuous versus bolus infusion of enteral nutrition in critical patients显示文摘 | Serpa LF Kimura M Faintuch J | 2003 | Rev Hosp Clin Fac Med Sao Paulo2003，58，1： | 1 |
| 4 | Pro- and Anti-inflammatory Cytokines in Steatosis and Steatohepatitis显示文摘 | Fabiola Rabelo Claudia P. M. S. Oliveira Joel Faintuch Daniel F. C. Mazo Vicencia M. R. Lima Jose Tadeu Stefano Hermes V. Barbeiro Francisco G. Soriano Venancio A. Ferreira Alves Flair J. Carrilho | 2010 | Obesity Surgery2010，，7： | 1 |
| 5 | Lipid peroxidation in bariatric candidates with nonalcoholic fatty liver disease (NAFLD)-preliminary findings显示文摘 | Oliveira CP Faintuch J Rascovski A | 2005 | Obes Surg2005，15，4： | 1 |
| 6 | Effects of contin- uous versus bolus infusion of enteral nutrition in critical pa- tients 显示文摘 | Serpa L F Kimura M Faintuch J | 2003 | Rev Hosp Clin Fac Med Sao Paulo2003，58，1： | 1 |
| 7 | Determination of splenomegaly by CT:is there a place for a single measurement?显示文摘 | D'Ippolito G Faintuch S | 2005 | Am J Roentgenol2005，184，5： | 1 |
| 8 | Retrievable versus permanent caval filter procedures:when are they cost-effective for interventional radiology?显示文摘 | Janne d′Othée B Faintuch S Reedy AW | 2008 | J Vasc Interv Radiol2008，19，3： | 1 |
| 9 | Determination of splenomegaly by CT:is there a place for a single measurement显示文摘 | Bezerra AS D'Ippolito G Faintuch S | 2005 | AJR Am J Roentgenol2005，184，： | 1 |
| 10 | Continuous infusion 5-fluorouracil, etoposide and eisdiamminedichloroplatinum in pa- tients with metastatic carcinoma of unknown primary origin显示文摘 | Rabcr MN Faintuch J Abbruzzese JL | 1991 | Ann Oncol1991，2，： | 1 |
| 11 | B-1 cells temper endotoxemic inflammatory responses 显示文摘 | Barbeiro DF Barbeiro HV Faintuch J | 2011 | Immunobiology2011，216，3： | 1 |
| 12 | Pro- and anti-inflammatory cytokines in steatosis and steatohepatitis 显示文摘 | Rabelo F Oliveira CP Faintuch J Mazo DF Lima VM Stefano JT Barbeiro HV Soriano FG Alves VA Carrilho FJ | 2010 | Obes Surg2010，20，7： | 1 |
| 13 | Beneficial effect of tetracycline prophylaxis in a sepsis model mimicking portal and systemic bacterial translocation routes?显示文摘 | Faintuch S Schraibman V Silva RM | 2002 | Transplantation Proceedings2002，34，3： | 1 |
| 14 | Sexual hormones and erectile function more than 6 years after hariatric sur- gery显示文摘 | Rosenblatt A Faintuch J Cecconello I | 2013 | Surg Obes Relat Dis2013，9，5： | 1 |
| 15 | Supplemen- tation of vitamin E, vitamin C, and zinc attenuates oxidative stress in burned children: a randomized, double-blind, placebo-controlled pilot study显示文摘 | Barbosa E Faintuch J Machado Moreira EA | 2009 | J Burn Care Res2009，30，5： | 1 |
| 16 | Supplementation of vitamin E, vitamin C, and zinc attenuatesoxidative stress in burned children a randomized,double-blind placebo-controlled pilot study显示文摘 | BARBOSA E FAINTUCH J MACHADO MOREIRA E A | 2009 | J Burn CareRes2009，30，5： | 1 |
| 17 | Refractory and new-onset diabetes more than 5?years after gastric bypass for morbid obesity显示文摘 | Camila Yamaguchi Joel Faintuch Silvia Hayashi Jacob Faintuch Ivan Cecconello | 2012 | Surgical Endoscopy2012，，10： | 1 |
| 18 | Hematoligic aspects of the national team athletes显示文摘 | FAINTUCH J J LEITE J J MUNHOS M A | 1997 | Rev Hosp Clin Fao Med Sao Paulo1997，52，11： | 1 |
| 19 | Lipid per- oxidation in bariatrie candidates with nonaleoholie fatty liver disease ( NAFLD ) -preliminary findings 显示文摘 | OLIVEIRA C P FAINTUCH J RASCOVSKI A | 2005 | Obes Surg2005，15，4： | 1 |
| 20 | Radiolabeled NGR phage display peptide sequence for tumor targeting显示文摘 | Faintuch BL Oliveira EA Targino RC | 2014 | Appl Radiat Isot2014，86，： | 1 |
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