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| 1 | Management of oligometastatic non-small cell lung cancer patients:Current controversies and future directions显示文摘Oligometastatic non-small cell lung cancer(NSCLC)describes an intermediate stage of NSCLC between localized and widely-disseminated disease.This stage of NSCLC is characterized by a limited number of metastases and a more indolent tumor biology.Currently,the management of oligometastatic NSCLC involves radical treatment(radiotherapy or surgery)that targets the metastatic lesions and the primary tumor to achieve disease control.This approach offers the potential to achieve prolonged survival in patients who,in the past,would have only received palliative measures.The optimal therapeutic strategies for the different scenarios of oligometastatic disease(intracranial vs extracranial disease,synchronous vs metachronous)remain undefined.Given the lack of head-to-head studies comparing radiotherapy to surgery in these patients,the decision to apply surgery or radiotherapy(with or without systemic treatment)must be based on prognostic factors that allow us to classify patients.This classification will allow us to select the most appropriate therapeutic strategy on an individualized basis.In the future,the molecular or microRNA profiles will likely improve the treatment selection process.The objective of the present article is to review the most relevant scientific evidence on the management of patients with oligometastatic NSCLC,focusing on the role of radiotherapy and surgery.We also discuss areas of controversy and future directions. | Felipe Counago Javier Luna Luis Leonardo Guerrero Blanca Vaquero María Cecilia Guillén-Sacoto Teresa González-Merino Begona Taboada Verónica Díaz Belén Rubio-Viqueira Ana Aurora Díaz-Gavela Francisco JoséMarcos Elia del Cerro | 2019 | World Journal of Clinical Oncology2019，10，10： | 5 |
| 2 | jModelTest 2: more models,new heuristics and parallel computing显示文摘 | Darriba D Taboada G L Doallo R | 2012 | Nat Methods2012，9，8： | 1 |
| 3 | Experiences in reusing knowledge sources using Protégé and PROMPT显示文摘 | Martínez D Mira J | 2005 | International Journal of Human-Computer Studies2005，62，5： | 1 |
| 4 | Design of optical wide-band log-periodic nanoantennas using surface integral equation techniques 显示文摘 | SOL TABOADA J M ARA~O G | 2013 | Optics Communications2013，，8： | 1 |
| 5 | jModelTest 2: more models, new heuristics and parallel computing 显示文摘 | Darriba D Taboada GL Doallo R | 2012 | Nat Methods2012，9，8： | 1 |
| 6 | Tomographic study ofthe inflection points of the Pressure-volume curve in acute lung injury显示文摘 | Albaiceta GM Taboada F Parra D | 2004 | Am J Respir Crit Care Med2004，170，： | 1 |
| 7 | Coping strategies and quality of life among liver transplantation candidates显示文摘 | Jurado R Isabel M Taboada D | 2011 | Psicothema2011，23，1： | 1 |
| 8 | MOMS-GA: A multi-objective multi-state genetic algorithm for system reliability optimization design problems显示文摘 | Taboada H A Espiritu J F Colt D W | 2008 | IEEE Trans on Reliability2008，57，1： | 1 |
| 9 | A new multiple objective evolutionary algorithm for reliability optimization of series-parallel systems显示文摘 | Taboada H A Coit D W | 2012 | Int J of Applied Evolutionary Computation2012，3，2： | 1 |
| 10 | Design allocation of multi-state series-parallel systems for power systems planning:a multiple objective evolutionary approach显示文摘 | Taboada H A Espiritu J F Coit D W | 2008 | Journal of Risk and Reliability2008，222，3： | 1 |
| 11 | Preparation, character- ization and catalytic properties of carbon nanofiber-supperted Pt, Pd, Ru monometallic particles in aqueous-phase reactions 显示文摘 | Taboada C D Batista J Pintar A | 2009 | Applied Catalysis B : Environmental2009，89，34： | 1 |
| 12 | Coping strategies and quality of life among liver transplantation candidates 显示文摘 | Jurado R Morales I Taboada D | 2011 | Psicothema2011，23，1： | 1 |
| 13 | Experiences in reusing knowledge sources using Protégé and PROMPT显示文摘 | Taboada M Martinez D Mira J | 2005 | Int J Human-Computer Studies2005，62，： | 1 |
| 14 | Solubility, Density, Viscosity, Electrical Conductivity, and Refractive Index of Saturated Solutions of Lithium Hydroxide in Water +Ethanol显示文摘 | M E Taboada D M Ve1iz H R Galleguillos | 2005 | Journal of Chemical and Engineering Data2005，50，1： | 1 |
| 15 | A multi-objective multi-state genetic algorithm for system reliability optimization design problems 显示文摘 | TABOADA H ESPIRITU J COIT D | 2008 | IEEE Transactions on Reliability2008，57，1： | 1 |
| 16 | MOMS-GA:a multi-objective multi-state genetic algorithm for system reliability optimization design problems显示文摘 | Taboada H A Espiritu J F Coit D W | 2008 | IEEE Transactions on Reliability2008，57，1： | 1 |
| 17 | jModelTest 2: more models,new heuristics and parallel eomputing显示文摘 | Darriba D Taboada G L Doallo R | 2012 | Nature Methods2012，9，8： | 1 |
| 18 | Comparison of compaction induced by conventional and zerotillage in two soils of the RollingPampa of Argentina显示文摘 | Taboada M A Micucci F G Cosentino D J | 1998 | Soil and Tillage Research1998，49，： | 1 |
| 19 | Update in spontaneous cerebral hemorrhage显示文摘 | Escudero Augusto D Marques Alvarez L Taboada Costa F | 2008 | Med Intensive2008，32，6： | 1 |
| 20 | Experiences in lie using knowledge sources tusing Prot6g and PROMPT显示文摘 | Taboada M Martinez D Mira J | 2005 | International Journal of Human--Computer Studies2005，62，5： | 1 |
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