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| 1 | Pulmonary fibrosis and emphysema: Is the emphysema type associated with the pattern of fibrosis?显示文摘AIM: To investigate whether the predominant emphysema type is associated with the high resolution computed tomography(HRCT) pattern of fibrosis in combined pulmonary fibrosis and emphysema(CPFE).METHODS: Fifty-three smokers with upper lobe emphysema and lower lobe pulmonary fibrosis on- HRCT-were retrospectively evaluated. Patients were stratified into 3 groups according to the predominant type of emphysema: Centrilobular(CLE), paraseptal(PSE), CLE = PSE. Patients were also stratified into 3 other groups according to the predominant type of fibrosis on HRCT: Typical usual interstitial pneumonia(UIP), probable UIP and nonspecific interstitial pneumonia(NSIP). HRCTs were scored at 5 predetermined levels for the coarseness of fibrosis(Coarseness), extent of emphysema(emphysema), extent of interstitial lung disease(Tot Ext ILD), extent of reticular pattern not otherwise specified(Ret NOS), extent of ground glass opacity with traction bronchiectasis(extG GOBx), extent of pure ground glass opacity and extent of honeycombing. HRCT mean scores, pulmonary function tests, diffusion capacity(DLCO) and systolic pulmonary arterial pressure were compared among the groups.RESULTS: The predominant type of emphysema was strongly correlated with the predominant type of fibrosis. The centrilobular emphysema group exhibited a significantly higher extent of emphysema(P < 0.001) and a lower extent of interstitial lung disease(P < 0.002), reticular pattern not otherwise specified(P < 0.023), extent of ground glass opacity with traction bronchiectasis(P < 0.002), extent of honeycombing(P < 0.001) and coarseness of fibrosis(P < 0.001) than the paraseptal group. The NSIP group exhibited a significantly higher extent of emphysema(P < 0.05), total lung capacity(P < 0.01) and diffusion capacity(DLCO)(P < 0.05) than the typical UIP group. The typical UIP group exhibited a significantly higher extent of interstitial lung disease, extent of reticular pattern not otherwise specified, extent of ground glass opacity with traction bronchiectasis, extent of honeycombing and coarseness of fibrosis(0.039 > P > 0.000). Although the pulmonary arterial pressure was higher in typical UIP group relative to the NSIP group, the difference was not statistically significant.CONCLUSION: In CPFE patients, paraseptal emphysema is associated more with UIP-HRCT pattern and higher extent of fibrosis than centrilobular emphysema. | Anastasia Oikonomou Paraskevi Mintzopoulou Argyris Tzouvelekis Petros Zezos George Zacharis Anastasios Koutsopoulos Demosthenes Bouros Panos Prassopoulos | 2015 | World Journal of Radiology2015，7，9： | 2 |
| 2 | Rare case of failure by an automated system to detect extended-spectrum β-lactamases in a cephalosporin-resistant Klebsiella pneumoniae isolate显示文摘 | Tzouvelekis LS Vatopoulos AC Katsanis G | 1999 | J Clin Microbiol1999，37，： | 1 |
| 3 | Effect and safety of my-cophenolate mofetil or sodium in systemic sclerosis-associated interstitial lung disease:a meta-analysis 显示文摘 | Tzouvelekis A Galanopoulos N Bouros E | 2012 | Pulm Med2012，2012，14： | 1 |
| 4 | Interventional strategies and current clinical experience with carbapenemase- producing Gram- negative bacteria显示文摘 | Akova M Daikos GL Tzouvelekis L | 2012 | Clin Microbiol Infect2012，18，5： | 1 |
| 5 | Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions 显示文摘 | Tzouvelekis LS Markogiannakis A Psichogiou M | 2012 | Clin Microbiol Rev2012，25，4： | 1 |
| 6 | Emergence of Escherichia coli sequence type 410 (ST410) with KPC-2 β-lactamase显示文摘 | Angeliki Mavroidi Vivi Miriagou Ergina Malli Angelos Stefos George N. Dalekos Leonidas S. Tzouvelekis Efthymia Petinaki | 2011 | International Journal of Antimicrobial Agents2011，，3： | 1 |
| 7 | Imipenem resistance in a Salmonella clinical strain due to plasmid-mediated class A carbapenemase KPC-2 显示文摘 | Miriagou V Tzouvelekis LS Rossiter S | 2003 | Antimicrob Agents Chemother2003，47，4： | 1 |
| 8 | Diversity of β-lactamases among Klebsiella pneumoniae strains isolated in a university hospital in Greece显示文摘 | TZOUVELEKIS L S DOUBOYAS J | 1997 | European Journal of Epidemiology1997，，13： | 1 |
| 9 | Comparative expression profiling in pulmonary fibrosis suggests a role of hypoxia-inducible factor-lalpha in disease pathogenesis显示文摘 | Tzouvelekis A Harokopos V Paparountas T | 2007 | Am J Respir Crit Care Med2007，176，11： | 1 |
| 10 | Different angiogenie activity in pulmonary sarcoidosis and idiopathic pulmonary fibrosis显示文摘 | Antoniou KM Tzouvelekis A Alexandrakis MG | 2006 | Chest2006，130，： | 1 |
| 11 | Serum biomarkers in interstitial lung diseases显示文摘 | Tzouvelekis A Kouliatsis G Anevlavis S | 2005 | Respir Res2005，6，： | 1 |
| 12 | Rare case of failure by an automated system to detect extend-spectrum beta-lactamases in a cephalosporin-resistant Klebsiella pneumoniae isolate显示文摘 | Tzouvelekis L S Vatopoulos A C Katsanis G | 1999 | J Clin Microbiol1999，37，： | 1 |
| 13 | Discrepancies and interpretation problems in susceptibility testing of VIM-1-pro ducing Klebsiella pneumoniae isolates显示文摘 | Giakkoupi P Tzouvelekis LS Daikos GL | 2005 | J Clin Microbiol2005，43，： | 1 |
| 14 | Angiogenesis in interstitial lung diseases: a pathogenetic hallmark or a bystander?显示文摘 | Tzouvelekis A Anevlavis S Bouros D | 2006 | Respir Res2006，7，： | 1 |
| 15 | A prospective,non-randomized,no placebo-controlled,phase Ib clinical trial to study the safety of the adipose derived stromal cells-stromal vascular fraction in idiopathic pulmonary fibrosis显示文摘 | Tzouvelekis A Paspaliaris V Koliakos G | 2013 | J Transl Med2013，11，： | 1 |
| 16 | Relative strength of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter显示文摘 | Papagiannitsis CC Tzouvelekis LS Miriagou V | | 0，，： | 1 |
| 17 | Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions 显示文摘 | TZOUVELEKIS L S MARKOGIANNAKIS A PSICHOG- IOV M | 2012 | Clin Microbiol Rev2012，25，4： | 1 |
| 18 | VIM-12,a novel plasmid-mediated metallo-β-lactamase from Klebsiella pneumoniae that resembles aVIM-1/VIM-2 hybrid显示文摘 | POURNARAS S IKONOMIDIS A TZOUVELEKIS L S | | 0，，12： | 1 |
| 19 | Identification of a novel plasmid-mediated beta-lactamase with chromosomal cephalosporinase characteristics from Klebsiella pneumoniae 显示文摘 | Tzouvelekis LS Tzelepi E Mentis AF | 1993 | J Antimicrob Chemother1993，31，： | 1 |
| 20 | A prospective, non- randomized, no placebo-controlled, phase Ib clinical trial to study the safety of the adipose derived stromal cells-stromal vascular frac- tion in idiopathic pulmonary fibrosis 显示文摘 | Tzouvelekis A Paspaliaris V Koliakos G | 2013 | J Transl Med2013，11，： | 1 |
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