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154篇 您的检索式:作者名="TYRRELL J"
    题名 作者 年代 出处 被引量
1年龄相关性线粒体功能障碍加速动脉粥样硬化形成显示文摘老化是动脉粥样硬化的最强危险因素之一。然而,老化是否独立于慢性高血脂症而增加动脉粥样硬化的风险尚不清楚。该研究旨在确定高血脂症诱导前的血管老化是否会加速动脉粥样硬化的形成。研究者分析了幼年和老年正常血脂野生型(wild type,WT)、无疾病小鼠的主动脉,发现老化导致白细胞介素(interleukin,IL)6水平升高和线粒体功能障碍,并与线粒体自噬增加和其相关蛋白Parkin增加相关。在主动脉组织培养中,研究者发现随着老化的出现,线粒体功能障碍与IL-6存在正反馈关系。研究者通过诱导低密度脂蛋白受体的肝脏特异性降解,再结合10周的西方食物喂养,在老年和幼年小鼠中诱发急性高血脂症,发现老年WT小鼠的动脉粥样硬化增强。高血脂症进一步降低了老年小鼠的线粒体功能,增加了主动脉中Parkin的水平,但幼鼠则没有。刘青(译) 叶鹏(摘、审校) Tyrrell DJ Blin M Song J Wood S Zhang M Beard DA Goldstein D 2020中华高血压杂志2020,28,2:2
2A framework for assessing direct economic impacts of tourist events: distinguishing ori- gins,destinations, and causes of expenditures显示文摘TYRRELL T J JOHNSTON R J 2001J Travel Res2001,40,:1
3Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm 显示文摘Longley B J Tyrrell L Lu SZ 1996Nat Genet1996,12,3:1
4A methodology for estimating the at- tendance and economic impact of an open-gate festival显示文摘TYRRELL B ISMAIL J 2005E- vent Manage2005,9,:1
5The subtle effects of sea water acidification on the amphipod Gammarus locusta显示文摘Hauton C Tyrrell T Williams J E 2009Biogeosciences2009,,6:1
6Home nocturnal hemodialysis in children显示文摘Geary DF Piva E Tyrrell J 2005J Pediatr2005,147,3:1
7Importance of light for the formation of algal blooms by Emiliania huxleyi显示文摘Nanninga H J Tyrrell T 1996Marine Ecology Progress Series1996,136,:1
8In vitro evaluation of nebulization properties, antimicrobial activity, and regional airway surface liquid concentration of liposomal polymyxin B sulfate显示文摘Desai T R Tyrrell G J Ng T 2003Pharm Res2003,20,3:1
9High homocysteine levels are independently related systolic hypertention in older adults 显示文摘Sutton - Tyrrell K Bostom A Sellub J 1997Circulation1997,96,:1
10IFITM1is a tight junction protein that inhibits hepatitis C virus entry显示文摘Wilkins C Woodward J Lau D T Barnes A Joyce M McFarlane N McKeating J A Tyrrell D L Gale M Jr 2013Hepatology2013,58,1:1
11Images of nanobubbles on hydrophobic surfaces and their interactions 显示文摘Tyrrell J W G Attard P 2001Phys Rev Lett2001,87,17:1
12Inflammation in acute ischemic stroke and its relevance to stroke critical care显示文摘Emsley HC Smith C J Tyrrell PJ 2008Neurocrit Care2008,9,:1
13NaN, a nov- el voltage-gated Na channel, is expressed preferentially in pe- ripheral sensory neurons and down-regulated after axotomy显示文摘DIB-HAJJ S D TYRRELL L BLACK J A 1998Proceedings of the National Academy of Sciences of the Unit- ed States of America1998,95,15:1
14Effect of restrictions on television food advertising to children on exposure to advertisements for 'less healthy' foods : Repeat cross-sectional study显示文摘Adams J Tyrrell R Adamson A J 2012PloS one2012,7,31:1
15Effects of diet forage-to-concentrate ratio and intake on energy metabolism in growing beef heifers: net nutrient metabolism by visceral tissues显示文摘Reynolds C K Tyrrell H F Reynolds P J 1991Journal of Nutrition1991,121,:1
16Integrated system for the purchase, distribution, and use of drugs in hospital 显示文摘Tyrrell P J Lidgate RA Davies DM 1970Lancet1970,1,7643:1
17Older patient s undergoing dialysistreatment:cognitive functioning,depressive mood and health 2 relatedquality of life显示文摘Tyrrell J Paturel L Cadec B 2005A ging Ment Health2005,9,4:1
18Interleukin-1 and neuronal injury显示文摘Allan S M Tyrrell P J Rothwell N J 0,,08:1
19Effect of restrictions on television food advertising to children on exposure to advertisements for 'less healthy' foods : Repeat cress-sectional study 显示文摘ADAMS J TYRRELL R ADAMSON A J 2012PloS one2012,7,31:1
20Successful treatment of a large macroprolactinoma with cabergoline during pregnancy显示文摘Liu C Tyrrell J B 2001Pituitary2001,4,3:1
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