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| 1 | Changed clinical aspects of primary liver cancer in China during the past 30 years显示文摘BACKGROUND: Primary liver cancer (PLC) is one of the most frequently seen tumors in China. Thirty years ago, patients with PLC were often detected at relatively late stage, with a palpable mass or marked clinical symptoms and poor prognosis. In the past 30 years, the diagnosis and treatment of PLC have been greatly improved with better prognosis. METHODS: In order to study the changes of PLC during the 30 years, the clinical data of 3250 patients with PLC from 10 medical institutions of China were collected, ana- lyzed , and compared with those of 3254 PLC patients be- fore the 30 years. RESULTS: In the 3250 patients aged 1-80 years, with an average age of 49.1 years, the male to female ratio (2.3:1) was lower than that before the 30 years. 73.5% of the 3250 patients sought medical advice within 3 months after the onset of the disease in contrast to 63.8% before the 30 years. Compared with those patients before the 30 years the symptoms and signs were alleviated generally. The HBsAg positive rate was 81.0%, but the HCV-Ab positive rate was 13.2%. The AFP level in 75% of patients was elevated, but in the remaining 25% was normal. 1912 patients (58.8%) were confirmed pathologically. Among them 1755 patients (91.8%) had hepatocellular carcinoma. The overall resec- tion rate was 46.3%. Those who had early, middle, late stage carcinoma accounted for 29.9%, 51.5%, and 18.6%respectively in contrast to 0.4%, 47.0%, and 52.6% repor- ted before the 30 years. The 1-, 3-, 5-year survival rates of the patients were 66.1%, 39.7%, and 32.5% respectively, whereas 93.5%, 70.1%, and 59.1% for the early stage pa- tients, and 65.3%, 30.5%, and 23.5% for the middle stage patients. The half and 1-year survival rates of the late stage patients were 52.5%, and 14.7%, respectively. CONCLUSION: Comparison with the clinical data before and after the 30 years show that PLC can be diagnosed ear- ly. More PLC patients tend to undergo resection while re- ceiving a better conservative treatment, which ensures a prognosis. | Bing-Hui Yang, Jing-Lin Xia, Li-Wen Huang, Zhao-You Tang, Ming-Shan Chen, Jin-Qing Li, An-Min Liang, Qin-Guo Mo, Hui-Shan Lu, Chao-Liu Dai, Lu-Nan Yan, Zhi-Jian Yu, Rong-Sheng Rao, Le-Qun Li, Zhi-Xiong Su, Zhuang-Wei Fang Shanghai, China Liver Cancer Institute & Zhongshan Hospital, Fudan University, Shanghai 200032, China Tumor Hospital, Zhongshan University, Guangzhou 510000, China Tumor Hospital, Guangxi Medical Universi- ty, Nanning 530000, China Xiehe Hospital, Fujian Medical University, Fuzhou 350000, China Second Hos- pital, Chinese Medical University, Shenyang 110000, China Huaxi Hospital, Sichuan University, Chengdu 610041, China Hospital Affiliated to Nantong Medical University, Nantong 226000 , China Second Hospital, Jiangxi Medical University, Nanchang 330000 , China First Hospital Affiliated to Guangxi Medical University, Nanning 530000 , China People’s Hospital of Hainan Province, Haikou 570000, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 20 |
| 2 | Correlation of glycosyltransferases mRNA expression in extrahepatic bile duct carcinoma with clinical pathological characteristics显示文摘BACKGROUND: The incidence of extrahepatic bile duct carcinoma (EBDC) has been increasing, especially in aged people, but the glycobiology of the tumor is not elucida- ted. In this study we investigated the expressions of three glycosyltransferases in 35 patients with EBDC and 35 pa- tients with benign biliary duct disease (BBDD) as well as their clinicopathological significance. METHOD: The patients were divided into several sub- groups by tumor differentiation, TNM stage, and invasion by the standards recommended by UICC. Tumor samples were immediately frozen in liquid nitrogen after resection, followed by mRNA determination of enzymes in the tissue using a mRNA selective reverse trancriptase-polymerase chain reaction kit. The mRNA levels of different groups were semi-quantitatively compared. RESULTS: The mRNA levels of N-acetylglucosaminyltrans- ferase V (GnT-V) and a subtype of α2,3 sialyltransferases for N-glycans, ST3Gal- were elevated 7.75 and 5.39 times in EBDC as compared with BBDD, respectively, and they were correlated to several clinicopathological factors including tumor advancement, differentiation, metastasis, and invasiveness. The mRNA expression of another sialyl- transferase, ST6Gal- , was also 0.63-fold higher in EBDC than in BBDD, but not involved in the clinicopathological characteristics. CONCLUSION: The elevated expression of these three gly- cosyltransferases can be considered as an important molecu- lar event in the occurrence and progression of EBDC. | Xiao-Ling Jin, Shu-Sen Zheng, Bing-Sheng Wang and Hui-Li Chen Nanjing, China Department of General Surgery, Nanjing First Hospi- tal Affiliated to Nanjing Medical University, Nanjing 210006, China Department of Hepatobiliary Surgery, First Affiliated Hospital, Zhe- jiang University School of Medicine, Hangzhou 310003, China Department of General Surgery, Zhongshan Hospital, Fudan Universi- ty, Shanghai 200032 , China and Key Laboratory of Glycocon- jugate Research, Ministry of Health, Department of Biochemistry, Fudan University School of Medicine, Shanghai 200032, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 6 |
| 3 | The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein.显示文摘 | Chen TY Liu PH Ruan CT Chiu L Kung FL | 2006 | 中国生物学文摘2006，20，9： | 4 |
| 4 | Dynamic Buckling of Laminated Composite Bars Subjected to Axial Impact显示文摘The impact buckling of a laminated composite bar is investigated in case of one of its endsmoving due to axial impact compression.The governing equations considering the first-order sheardeformation effect are derived by the Hamilton principle and solved by the finite difference method.Thecritical axial shortness is determined by the B-R cirterion.The given example is used to highlight the in-fluences of initial imperfection,impact velocity,stress wave and coupled stiffness.It is found that theunsymmetrically laminated bar has a quite different dynamic buckling behaviour from that of thesymmetrically laminated bar. | Wang, DY Chen, TY Xin, GN | 1998 | China Ocean Engineering1998，13，2： | 3 |
| 5 | Intravitreal bevacizumab ( Avastin) for neovascular age-related macular degeneration: a shortterm study 显示文摘 | Chen CY Wong TY Heriot WJ | 2007 | Am J Ophthalmol2007，143，3： | 1 |
| 6 | Rebleeding of aneurysmal subarachnoid hemorrhage in computed tomography angiography: risk factor, rebleeding pattern, and outcome analysis显示文摘 | Wu TC Tsui YK Chen TY | 2012 | J Comput Assist Tomogr2012，36，1： | 1 |
| 7 | Increased apoptosis of peripheral blood lymphocytes and its association with interleukin-1 8 in patients with active untreated adult-onset Still's disease 显示文摘 | Chen DY Hsieh TY Hsieh CW | 2007 | Arthritis Rheum2007，57，8： | 1 |
| 8 | Metabolic function and regeneration of cirrhoticand non-cirrhotic liver after hepatic lobectomy in man显示文摘 | Lin TY Chen CC | 1965 | Ann Surg1965，162，6： | 1 |
| 9 | Clinical manifestations, disease course, and complications of adult-onset Still's disease in Taiwan显示文摘 | CHEN DY LAN JL HSIEH TY el al | 2004 | Journal of the Formosan Medical Association2004，103，11： | 1 |
| 10 | The comparison of distress, stress, and coping strategies on infertile couples 显示文摘 | Lee TY Chang SP Chen CC | 1997 | Nursing Reasearch (Taiwan)1997，5，5： | 1 |
| 11 | Characterization of Aspergillus spores by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry显示文摘 | Li TY Liu BH Chen YC | 2000 | Rapid Communications in Mass Spectrometry2000，14，24： | 1 |
| 12 | Langerhans cell histiocytosis in a newborn显示文摘 | Yang TY Chen SJ Yang LY et a1 | 2009 | J Chin MedAssoc2009，72，11： | 1 |
| 13 | Outcomes of hepatectomy for hepatolithiasis显示文摘 | Lee TY Chen YL Chang HC | 2007 | World J Surg2007，31，3： | 1 |
| 14 | Optimum design of headstocks of precision lathes显示文摘 | TY Chen WJ Wei | 1999 | International[J]Journal of Machine Tools & Manufacture1999，12，39： | 1 |
| 15 | Directed evolution to produce an alkalophilic variant from a Neocallimastix patriciarum xylanase显示文摘 | Chen YL Tang TY Cheng KJ | 2001 | Can J Microbiol2001，47，12： | 1 |
| 16 | Genetic analysis of enterovirus 71 iso- lated from fatal and non-fatal cases of hand, foot and mouth disease during an epidemic in Taiwan, 1998 显示文摘 | Shih SR Ho MS Lin KH Wu SL Chen YT Wu CN Lin TY Chang LY Tsao KC Ning HC Chang PY Jung SM Hsueh C Chang KS | 2000 | Virus Res2000，68，2： | 1 |
| 17 | Gne-environment interaction between angiotensinogen and chronic exposure to occupational noise contribute to hypertension显示文摘 | Hwang BF Chang TY Chen KY | | 0，，： | 1 |
| 18 | Effects of reactive oxygen species from activated leucocytes on human sperm motility, viability and morphology 显示文摘 | Shi TY Chen G Huang X | 2012 | Andrologia2012，44，： | 1 |
| 19 | Estimation of benchmark dose for pancreatic damage in cadmium-exposed smelters 显示文摘 | Lei LJ Chen L Jin TY | 2007 | Toxicological Sciences2007，97，1： | 1 |
| 20 | GL331, a topoisomerase II inhibitor, induces radiosensitization of human glioma cells 显示文摘 | CHEN Y LIN TY CHEN JC | 2006 | Anticaneer Res2006，26，3： | 1 |
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