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| 1 | Developmental Lead Exposure Alters the Distribution of Protein Kinase C Activity in the Rat Hippocampus显示文摘Chronic low-level lead (Pb) exposure in children is known to cause a deficit in learning and memory. In vitro studies have demonstrated that Pb altered protein kinase C (PKC) activityt Especially, hippocampal PKC has been correlated with performance in several learning tasks. The effects of Pb exposure on hippocampal PKC were investigated during development at various postnatal ages: postnatal day (PN) 7, 14, 28, and 56. Two-tenth % Pb acetate was administered to pregnant and lactating dams and then administered to weanling rats in drinking water. PKC activity was measured in both membrane and cytosolic fractions from the hippocampi of the controls and Pb-exposed animals. Pb-induced increase in PKC activity in the cytosolic fraction was obsereved in the PN56 rats. In contrast, PKC activity was decreased by Pb at PN7 in the membrane fraction. Furthermore, a significant decrease in the ratio of membrane to cytosolic PKC activity which is representative of PKC distribution was observed in the PN28 and PN56 Pb-exposed rats relative to the same-age controls. This study indicates that chronic Pb exposure during development influences hippocampal PKC activity and distribution. These changes may be involved in the subclinical neurotoxicity of chronic Pb exposure in young children. | HWEI-HSIEN CHEN TANGENG MA ARTHUR S. HUME AND ING K. HO(Deportment of Pharmacology and Toxicology, University ofMississippi Medical Center, 2500 North State Street,Jackson, MS 39216, USA) | 1998 | Biomedical and Environmental Sciences1998，11，1： | 7 |
| 2 | Angioplasty and Primary Stenting of High-grade, Long-segment Superficial Femoral Artery Disease: Is It Worthwhile?显示文摘 | Stephen W. K. Cheng MS FRCS FACS Albert C. W. Ting MBBS FRCS Pei Ho MBBS FRCS | 2003 | Annals of Vascular Surgery2003，，4： | 2 |
| 3 | Enterovirus 71 out-breaks, Tai- wan: occurrence and recognition 显示文摘 | Lin TY Twu SJ Ho MS | 2003 | Emerg hffect Dis2003，9，3： | 1 |
| 4 | Enterovirus 71 outbreaks, taiwan : occur- rence and recognition显示文摘 | Lin TY Twu S J Ho MS et d | 2003 | Emerg Infect Dis2003，9，3： | 1 |
| 5 | Chrysin induces G,phase cell cycle arrest in C6 glioma cells through inducing p21^Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase 显示文摘 | Weng MS Ho YS Lin JK | 2005 | Biochem PharmacoL2005，69，12： | 1 |
| 6 | Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21 Wall/Cipl expression : involvement of p38 mitogen - activated protein kinase 显示文摘 | Weng MS Ho YS Lin JK | 2005 | Biochem Pharmacol2005，69，12： | 1 |
| 7 | Serum alanine aminotransferase level in relation to hepatitis B and C virus infections among blood donors Liver显示文摘 | Tsai JF Jeng JE Ho MS | 1997 | 17 (1):241997，17，1： | 1 |
| 8 | Characterizing the neuroprotective effects of alkaline extractor Lycium barbarum on beta - amyloid peptide neuro- toxicity 显示文摘 | Ho YS Yu MS Lai CS | 2007 | Brain Res2007，7，16： | 1 |
| 9 | Genetic analysis of enterovirus 71 isolated from fatal and non-fatal cases of hand,foot and mouth disease during an epidemic in Taiwan, 1998显示文摘 | Shih SR Ho MS Lin K H | 2000 | Virus Res2000，68，： | 1 |
| 10 | Serum leptin and vascular risk factors in obstructive sleep apnea显示文摘 | Ip MS Lam KS Ho C | 2000 | Chest2000，118，： | 1 |
| 11 | Genetic analysis of enterovirus 71 iso- lated from fatal and non-fatal cases of hand, foot and mouth disease during an epidemic in Taiwan, 1998 显示文摘 | Shih SR Ho MS Lin KH Wu SL Chen YT Wu CN Lin TY Chang LY Tsao KC Ning HC Chang PY Jung SM Hsueh C Chang KS | 2000 | Virus Res2000，68，2： | 1 |
| 12 | Clinicopathological features and prognosis in reaectable synchronous and metachironous colorectal liver metastasis显示文摘 | Tsai MS Su YH Ho MC | 2007 | Ann Surg Oncol2007，14，2： | 1 |
| 13 | Primary humoral immuneresponses to formalin inactivated hemorrhagic fever with renalsyndrome vaccine(Hantavax):consideration of activeimmunization in South Korea显示文摘 | Sohn YM Rho HO Park MS | 2001 | Yonsei Med J2001，42，3： | 1 |
| 14 | STAT3 as a therapeutic target for Epstein-Barr virus (EBV)- associated nasopharyngeal carcinoma 显示文摘 | Ho Y Tsao SW Zeng MS | 2013 | Cancer Letters2013，330，2： | 1 |
| 15 | Clinic opathological features and prognosis in resectable synchronous and metachronous eolorec- tal liver metastases 显示文摘 | Tsai MS Su YH Ho MC | 2007 | Ann Surg Oncol2007，14，2： | 1 |
| 16 | Enterovirus 71 outbreaks, Taiwan : Occurrence and recognition 显示文摘 | Lin TY Twu SJ Ho MS | 2003 | Emerg Infect Dis2003，9，3： | 1 |
| 17 | Enterovirus 71 outbreaks, Taiwan: occurrence and recognition显示文摘 | Lin TY Twu SJ Ho MS | 2003 | Emerg Infect Dis2003，9，3： | 1 |
| 18 | Signalling pathway in the induction of neurite outgrowth in human mesenchymal stem cells 显示文摘 | Chu MS Chang CF Yang CC Bau YC Ho LL Hung SC | 2005 | Cell Signal2005，18，4： | 1 |
| 19 | Immunization with virus-like particles of en terevirus 71 elicits potent immune responses and protects mice against lethal challenge显示文摘 | Chung YC Ho MS Wu JC | 2008 | Vaccine2008，26，15： | 1 |
| 20 | Over-expression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in viro显示文摘 | LAWRENCE MS DY HO SUN GH | 1996 | J Neurosci1996，6，： | 1 |
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