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| 1 | Post‐liver transplantation sarcopenia in cirrhosis: A prospective evaluation显示文摘 | Cynthia Tsien Ari Garber Arvind Narayanan Shetal N Shah David Barnes Bijan Eghtesad John Fung Arthur J McCullough Srinivasan Dasarathy | 2014 | J Gastroenterol Hepatol2014，，6： | 2 |
| 2 | Towards Transgenic Primates:What can we learn from mouse genetics?显示文摘Considering the great physiological and behavioral similarities with humans,monkeys represent the ideal models not only for the study of complex cognitive behavior but also for the preclinical research and development of novel therapeutics for treating human diseases.Various powerful genetic tech-nologies initially developed for making mouse models are being explored for generating transgenic primate models.We review the latest genetic engineering technologies and discuss the potentials and limitations for systematic production of transgenic primates. | WANG Phillip L. TSIEN Joe Z. | 2009 | Science China(Life Sciences)2009，52，6： | 2 |
| 3 | Ca^2+ binding kinetics of fura-2 and azo-1 from temperature-jump relaxation measurements 显示文摘 | Kao J P Tsien R Y | 1988 | Biophys J1988，53，4： | 1 |
| 4 | Measuring and manipulating cytosolic Ca2+ with trapped indicators 显示文摘 | | 1984 | Kroc Found Ser1984，17，4： | 1 |
| 5 | Emptying of intracel lular Ca^2+ stores releases a novel small messenger that stimulates Ca^2+ influx显示文摘 | Randriamampita C Tsien R Y | 1993 | Nature1993，364，6440： | 1 |
| 6 | Constructing and exploiting the fluorescent protein paintbox (Nobel Lecture)显示文摘 | Tsien R Y | 2009 | Angewandte Chemie Interna tional Edition in English2009，48，31： | 1 |
| 7 | Wavelength muta- tions and posttranslational autoxidation of green fluorescent protein显示文摘 | HEIM R PRASHER D C TSIEN R Y | 1994 | Proc Natl Acad Sci1994，91，12： | 1 |
| 8 | Wavelength mutations and posttranslational autoxidation of green fluorescent protein显示文摘 | Heim R Prasher D Tsien R | 1994 | Proc Natl Acad Sci USA1994，91，12： | 1 |
| 9 | Improved green fluorescence显示文摘 | Heim R Cubitt AB Tsien RY | 1995 | Nature1995，373，： | 1 |
| 10 | Calcium homeostasis in intact lymphocytes:cytoplasmic free calcium monitored with a newintracellularly trapped fluorescent indicator显示文摘 | Tsien R Y Pozzan T Rink T J | 1982 | Journal of Cell Biology1982，94，： | 1 |
| 11 | On brain activity mapping: Insights and lessons from Brain Decoding Project to map memory patterns in the hippocampus显示文摘The BRAIN project recently announced by the president Obama is the reflection of unrelenting human quest for cracking the brain code, the patterns of neuronal activity that define who we are and what we are. While the Brain Activity Mapping proposal has rightly emphasized on the need to develop new technologies for measuring every spike from every neuron, it might be helpful to consider both the theoretical and experimental aspects that would accelerate our search for the organizing principles of the brain code. Here we share several insights and lessons from the similar proposal, namely, Brain Decoding Project that we initiated since 2007. We provide a specific example in our initial mapping of real-time memory traces from one part of the memory circuit, namely, the CA1 region of the mouse hippocampus. We show how innovative behavioral tasks and appropriate mathematical analyses of large datasets can play equally, if not more, important roles in uncovering the specific-to-general feature-coding cell assembly mechanism by which episodic memory, semantic knowledge, and imagination are generated and organized. Our own experiences suggest that the bottleneck of the Brain Project is not only at merely developing additional new technologies, but also the lack of efficient avenues to disseminate cutting edge platforms and decoding expertise to neuroscience community. Therefore, we propose that in order to harness unique insights and extensive knowledge from various investigators working in diverse neuroscience subfields, ranging from perception and emotion to memory and social behaviors, the BRAIN project should create a set of International and National Brain Decoding Centers at which cutting-edge recording technologies and expertise on analyzing large datasets analyses can be made readily available to the entire community of neuroscientists who can apply and schedule to perform cutting-edge research. | TSIEN Joe Z. LI Meng OSAN Remus CHEN GuiFen LIN LongNian WANG Phillip Lei FREY Sabine FREY Julietta ZHU DaJiang LIU TianMing ZHAO Fang KUANG Hui | 2013 | Science China(Life Sciences)2013，56，9： | 1 |
| 12 | Organizing principles of real- time memory encoding: neural clique assemblies and universal neural codes显示文摘 | Lin Long-nion Osan R Tsien JZ | 2006 | Trends Neurosci2006，29，1： | 1 |
| 13 | Active involvement of Ca^2+ in mitotic progression of Swiss 3T3 fibroblasts 显示文摘 | Kao J P Alderton JM Tsien R Y | 1990 | J Biol Chem1990，111，1： | 1 |
| 14 | Improved green fluorescence 显示文摘 | HEIM R CUBITT A B AND TSIEN R Y | 1995 | Nature1995，0373，6516： | 1 |
| 15 | Comparison of apparent diffusion coefficients and distributed diffusion coefficients in high-grade gliomas显示文摘 | Kwee TC Galba CJ Tsien C | 2010 | J Magn Reson Imaging2010，31，3： | 1 |
| 16 | Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores 显示文摘 | AMinta A Kao J P Tsien R Y | 1989 | J Biol Cbem1989，264，14： | 1 |
| 17 | Engineering green fluorescent protein for improved brightness,longer wavelengths and fluorescence resonance energy transfer显示文摘 | Heim R Tsien RY | 1996 | Curr Biol1996，6，： | 1 |
| 18 | A New Generation of Ca2+ Indicators with Greatly Improved Fluorescence Properties显示文摘 | Grynkiewicz G Poenie M Tsien RY | 1985 | J Bio Chamistry1985，260，： | 1 |
| 19 | A new generation of Ca2+indicators with greatly improved fluorescence properties显示文摘 | Grynkiewiez G Poenie M Tsien R Y | 1985 | Journal of Biological Chemistry1985，260，： | 1 |
| 20 | The green fluorescent protein显示文摘 | Tsien RY | 1998 | Annu Rev Biochem1998，67，： | 1 |
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