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| 1 | Combined resection and multi-agent adjuvant chemotherapy for desmoplastic small round cell tumor arising in the abdominal cavity:Report of a case显示文摘促结缔织增生的小圆房间肿瘤(DSRCT ) 是有特殊组织学的特征的稀罕、高度好攻击的恶意:在稠密的促结缔织增生基质以内的细胞的生长的一个嵌套的模式,与男优势发生在年轻人口。吝啬的幸存时期仅仅关于 1.5-2.5 年。肿瘤共同表示上皮,在免疫的肌肉,和神经标记组织化学的研究。这个工作报导与吐血和长期的便秘介绍的一个 27 岁的人。包括内视镜检查法,上面的胃肠的系列,腹的计算断层摄影术和钡灌肠的连续研究学习内脏的机关的显示出的传播参与。病人经历了好攻击的外科并且收到了由 5 氟尿嘧啶,出租机动三轮车磷酰胺, etoposide, doxorubicin,和 cisplatin 组成的手术后的辅助化疗。没有任何疾病,他在外科以后为 20 瞬间幸存。没有标准疗法协议被建立了。与手术后的多代理人助手化疗相结合的好攻击的外科被认为正当不仅减轻症状而且试着在这个先进 DSRCT 年轻病人改进结果。 | Chang-Cheng Chang Jun-Te Hsu Jeng-Hwei Tseng Tsann-Long Hwang Han-Ming Chen Yi-Yin Jan | 2006 | World Journal of Gastroenterology2006，12，5： | 104 |
| 2 | 黄精药理作用研究进展显示文摘黄精为我国常用传统中药,在长江以南大部分地区广泛分布,具有补益肝肾、延年益寿等作用,是自古以来的道家养生圣药。因其含有多糖、皂苷、黄酮、木脂素、氨基酸、醌类化合物、维生素、生物碱及多种微量元素等成分,从而具有较高的药用价值和营养价值,国内各研究机构对其进行了较深入的研究,国外对其仍处于初步研究阶段。目前实验研究主要集中在黄精多糖、黄精醇、黄精皂苷提取物或黄精水提物上,以动物实验或单方和复方制剂的临床研究为主。其多种黄精制剂已广泛应用于临床,如黄精口服液、黄精茶、苁蓉精颗粒、黄精赞育胶囊、黄精精油眼罩等,发挥着不同的效用。查阅有关黄精的研究文献,对其药理作用进行全面的综合分析,多角度总结其效用价值,为黄精的深入开发与应用提供参考。 | 赵文莉 赵晔 Yiider Tseng | 2018 | 中草药2018，49，18： | 144 |
| 3 | Increased numbers of Foxp3-positive regulatory T cells in gastritis, peptic ulcer and gastric adenocarcinoma显示文摘AIM: To determine the number of regulatory T cells (Tregs) in gastric mucosa of patients with gastritis, peptic ulcers and gastric cancer. METHODS: This study was a retrospective analysis of gastric antrum biopsy specimens from healthy controls (n = 22) and patients with gastritis (n = 30), peptic ulcer (n = 83), or gastric cancer (n = 32). Expression of CD4, CD25 and Foxp3 was determined by immunohistochemistry in three consecutive sections per sample.RESULTS: Compared with healthy controls, there was an increased number of CD25+ and Foxp3+ cells in patients with gastritis (P = 0.004 and P = 0.008), peptic ulcer (P < 0.001 and P < 0.001), and gastric cancer (P < 0.001 and P < 0.001). The ratio of CD25+/CD4+ or Foxp3+/CD4+ cells was also significantly higher in all disease groups (P < 0.001, respectively). The number of CD4+, CD25+, and Foxp3+ cells, and the ratio of CD25+/CD4+ and Foxp3+/CD4+ cells, were associated with the histological grade of the specimens, including acute inflammation, chronic inflammation, lymphoid follicle number, and Helicobacter pylori infection. The number of CD4+, CD25+ and Foxp3+ cells, and the ratio of CD25+/CD4+ and Foxp3+/CD4+ cells, were negatively associated with intestinal metaplasia among gastritis (P < 0.001, P < 0.001, P < 0.001, P = 0.002 and P = 0.002) and peptic ulcer groups (P = 0.013, P = 0.004, P < 0.001, P = 0.040 and P = 0.003). | Hsin-Hung Cheng Guan-Ying Tseng Hsiao-Bai Yang Hung-Jung Wang Hwai-Jeng Lin Wen-Ching Wang | 2012 | World Journal of Gastroenterology2012，18，1： | 56 |
| 4 | SHRIMP U-Pb geochronology of the zircons from the Precambrian basement of the Qilian Block and its geological significances显示文摘Origin and tectonic evolution of the Qilian Precambrian basement on NW China were investigated using zircon U-Pb ages with collaborating stratigraphic and paleontological evidence. Zircon grains were separated from two schists, two granitic gneisses and one mylonized gneiss and dated with SHRIMP. Seventy percent of sixty-one detrital zircon ages from two schists ranges from 0.88 Ga to 3.09 Ga, mostly within 1.0 Ga to 1.8 Ga with a peak at 1.6 Ga to 1.8 Ga, and twenty percent varies from 2.0 Ga to 2.5 Ga. A few falls in the Archean and Neoproterozoic periods. The two granitic gneisses were dated 930±8 Ma and 918±14 Ma, whereas the mylonized granitic gneiss was dated 790±12 Ma. These ages represent two periods of magmatisms, which can be correlated with the early and late stages of magmatisms associated with the Jinningian movement on the Yangtze Blocks. The results from this and previous studies indicate that the ages of the Precambrian detrital zircons from the Qilian Block are widely distributed in the Proterozoic era, distinct from the North China Block which was stable in the Neo-Mesoproterozoic era. By contrast, the age histograms of the detrital zircons from the Qilian Block is similar to those from Precambrian basement of the Yangtze Craton. Therefore, it is suggested that the Qilian Block had a strong affinity toward the Yangtze Craton and might belong to the supercontinent Gondwana in the Neoproterozoic time. This inference is supported by Nd model age (TDM), stratigraphic, and paleontological evidence. It is further considered that the Qilian Block was rifted from the supercontinent Gondwana during late Sinian to form an isolated continent in the Proto-Tethyan Ocean, moving towards the Alaxa Block in the North China Craton. The part of Proto-Tethyan Ocean between the Qilian and Alaxa Blocks should correspond to the so-called Paleo-Qilian Ocean. Following the closure of the Paleo-Qilian Ocean in the early Paleozoic, the Qilian Block collided with the Alaxa Block to form the North Qilian Orogenic Belt. Based on this tectonic explanation, the North Qilian ophiolites should represent parts of lithosphere from the Proto-Tethyan Ocean. Lithological and geochronological evidence also indicates that the Qilian Block underwent continental reactivation possibly induced by the deep northward subduction of the North Qaidam Block in early Paleozoic time. | Kuoan TUNG Huai-Jen YANG Houng-Yi YANG LIU DunYi ZHANG JianXin WAN YuSheng Chien-Yuan TSENG | 2007 | Chinese Science Bulletin2007，52，19： | 42 |
| 5 | The Dongcaohe ophiolite from the North Qilian Moun-tains: A fossil oceanic crust of the Paleo-Qilian ocean显示文摘The Dongcaohe ophiolite, located at the south of the North Qilian subduction complexes, is a tectonic block with an exposed area of about 3 km×6 km. It consists of an intrusive section overlain by an ex- trusive section. The lower part of the intrusive section consists of cyclic layers of cumulate dunites, troctolites, anorthosites, anorthositic gabbros, and gabbros with small discordant dunite and troctolite bodies. This layered sequence grades upward to isotropic gabbros and gabbronorites, which are overlain by the extrusive sequence of diabasic sheeted dikes and basaltic lavas. The overall mineral crystallization sequence was olivine±Cr-spinel, plagioclase, clinopyroxene, orthopyroxene, and Fe-Ti oxides. The Cr-spinel (Mg#: 42-66, Cr#: 41-57) in these layered cumulates and present-day abyssal peridotites have similar compositions. Also, the compositional variations of the plagioclase and cli- nopyroxene in the intrusive section reflect crystallization from melts compositionally similar to the present-day ocean basalts. Moreover, the rare earth element (REE) and multi-element distribution pat- terns of the intrusive and extrusive lithologies in the Dongcaohe ophiolite are consistent with crystal- lization of mid-ocean ridge basalts. The zircon grains separated from the gabbronorite have an SHRIMP average 206Pb/238U weighted age of 497 ± 7 Ma, which is considered as the tectonic emplacement age of the Dongcaohe ophiolite. The field occurrence, mineral and whole-rock compositions indicate that the Dongcaohe ophiolite represents a well-persevered oceanic crustal fragment composed of a complete oceanic crustal section of layered cumulates at bottom upgrading through isotropic cumulates to sheeted dikes and lava flows. | Chien-Yuan TSENG Huai-Jen YANG Houng-Yi YANG LIU DunYi Ching-Lang TSAI WU HanQuan ZUO GuoChao | 2007 | Chinese Science Bulletin2007，52，17： | 38 |
| 6 | Finding of Neoproterozoic (~775 Ma) magmatism recorded in metamorphic complexes from the North Qilian orogen: Evidence from SHRIMP zircon U-Pb dating显示文摘标明日期的虾 U-Pb 从 Niuxinshan 片麻岩的花岗石和 Leigongshan 在锆石上被执行在北方 Qilian orogen 的片麻岩的吨子盐, NW 中国。结果分别地产出 776+-10 妈和 774 +-23 妈的加权的平均 ~(206 )Pb/~(238 ) U 年龄。Igneousmorphology,摆动的 zonings,和为这些锆石的相对高的 Th/U 比率建议 magmaticorigin。这些年龄作为岩浆炮兵阵地预定并且因此代表 aNeoproterozoic (约 775 妈) 被解释在北方 Qilian 区域的 magmatic 事件。thismagmatism 可能与超级大陆 Rodinia 的决裂有关,这被建议。这发现,和 750 ~ 800 妈的类似的年龄为南方中央的 Qilian 和北方 Qaidam 的附近的岩层报导了,具有到在韦斯特中国的 Rodinia 进化的理解的意义。 | Chien-Yuan Tseng Houng-Yi Yang WAN Yusheng LIU Dunyi Da-Jen Wen Tzung-Chi Lin Kuo-An Tung | 2006 | Chinese Science Bulletin2006，51，8： | 26 |
| 7 | Limited water infusion decreases pain during minimally sedated colonoscopy显示文摘AIM:To investigate a limited water infusion method in colonoscopy.METHODS:Consecutive patients undergoing minimally sedated colonoscopy were randomized to receive air insufflation(n = 89) or water infusion limited to the rectum,sigmoid colon and descending colon(n = 90).Completion rates,cecal intubation times,procedure times,need for abdominal compression,turning of patients and levels of discomfort were evaluated.RESULTS:Completion rates,total procedure times,need for abdominal compression,and turning of patients were similar between groups.Less pain was experienced in the water group than in the air group(2.5 ± 2.5 vs 3.4 ± 2.8,mean ± SD,P = 0.021).The cecal intubation time was significantly longer in the water group than in the air group(6.4 ± 3.1 min vs 4.5 ± 2.4 min,P < 0.001).More water was infused in the water group(322 ± 80.9 mL vs 26.2 ± 39.4 mL,P < 0.001).CONCLUSION:Limited airless water infusion in the distal colon reduces patients' pain during colonoscopy. | Yu-Hsi Hsieh Hwai-Jeng Lin Kuo-Chih Tseng | 2011 | World Journal of Gastroenterology2011，17，17： | 26 |
| 8 | Isolation of Fucoxanthin from the Rhizoid of Laminariajaponica Aresch显示文摘Fucoxanthin was extracted from the intact rhizoid of Laminariajaponica Aresch with dimethylsulfoxide (DMSO), and then recovered from the DMSO extract by partitioning into ethyl acetate and subse-quent evaporation. Some isolation conditions such as solvent volume and extraction time were screened.The quantity and quality of the extracted fucoxanthin were determined by spectral analysis (absorptionspectra and fluorescence emission spectra). The results indicated that: (1) the average total content offucoxanthin was 122.1 μg in 1 g of fresh L. japonica rhizoid; (2) in comparison with the widely used organicsolvent, acetone, DMSO was much more effective for the extraction of fucoxanthin; (3) both DMSO volumeand extraction time influenced extraction efficiency such as the recovery rate and purity of fucoxanthin (1 gpurity 0.63); (4) when (NH4)2SO4 concentration was in the range of 0.5-1.0 mol/L, the pigments rapidly andentirely moved from DMSO into the ethyl acetate phase; (5) the ethyl acetate and DMSO were recycledusing a rotary evaporator. | Wen-Jun WANG Guang-Ce WANG Ming ZHANG C. K. TSENG | 2005 | Journal of Integrative Plant Biology2005，47，8： | 24 |
| 9 | SHRIMP U-Pb geochronology of the detrital zircons from the Longshoushan Group and its tectonic significance显示文摘Sixty-two geologically meaningful U-Pb dates were obtained by using SHRIMP technique for the detrital zircons in three metasedimentary rocks from stratigraphically uppermost parts of the Longshoushan Group in the present study. Eighty percents of these dates range from 1.7 Ga to 2.2 Ga with a peak at 1.8-2.0 Ga and twenty percents from 2.3 Ga to 2.7 Ga. The youngest detrital zircon is dated at 1724±19 Ma which is interpreted as the maximum depositional age of the metasedimentary rocks. Therefore, the age for the diagenesis and lithification of the original sedimentary rocks of the Longshoushan Group before the metamorphism must be younger than 1724±19 Ma. Comparison of the age histograms of these detrital zircons with the ages of the igneous rocks on the surrounding older massifs suggests that the sediments of the Longshoushan Group were most likely derived from the Alaxa Block and Tarim Craton. This implies that the affinity between Alaxa Block and Tarim Craton was strong and that they might have been a unified craton during middle-early Proterozoic time. | KuoAn TUNG HoungYi YANG LIU DunYi ZHANG JianXin ChienYuan TSENG WAN YuSheng | 2007 | Chinese Science Bulletin2007，52，10： | 24 |
| 10 | Clinicopathological study of solid and pseudopapillary tumor of pancreas: Emphasis on magnetic resonance imaging findings显示文摘AIM: To report the clinicopathological features and magnetic resonance imaging (MRI) findings of solid and pseudopapillary tumor (SPT) of pancreas.METHODS: From 1981 to 2005, 26 surgically treated cases of SPT were retrospectively reviewed. MRI findings of the latest 11 consecutive SPT cases were investigated.RESULTS: There were 25 women and one man having SPT (median age: 23 year) with a median tumor size of 7.5 cm. Among them, nine patients developed solid pseudopapillary carcinoma. During the median follow-up period of 66 mo, the 5-year survival rate of the 26 SPT patients was 96.2%. Three MRI features were proposed including Type 1 image, displaying SPT with completely solid part. All SPT patients with type 1 image were detected incidentally. Type 2 image displays of SPT with solid mass hemorrhage and type 3 image with massive hemorrhage. All the eight SPT patients with type 2 and 3 images suffered abdominal pain due to hemorrhage from SPT.CONCLUSION: SPT had a favorable survival rate irrespective of surgical procedures, malignancy, and MRI findings, however, MRI could reliably correlate with its clinicopathological features. | Chi-Chang Yu Jeng-Hwei Tseng Chun-Nan Yeh Tsann-Long Hwang Yi-Yin Jan | 2007 | World Journal of Gastroenterology2007，13，12： | 21 |
| 11 | Liver metastasis from hepatoid adenocarcinoma of the stomach mimicking hepatocellular carcinoma: Dynamic computed tomography findings显示文摘AIM: To evaluate the dynamic computed tomography(CT) findings of liver metastasis from hepatoid adenocarcinoma of the stomach(HAS) and compared them with hepatocellular carcinoma(HCC).METHODS: Between January 2000 and January 2015, 8 patients with pathologically proven HAS and liver metastases were enrolled. Basic tumor status was evaluated for the primary tumor location and metastatic sites. The CT findings of the liver metastases were analyzed for tumor number and size, presence of tumor necrosis, hemorrhage, venous tumor thrombosis, and dynamic enhancing pattern.RESULTS: The body and antrum were the most common site for primary HAS(n = 7), and observed metastatic sites included the liver(n = 8), lymph nodes(n = 7), peritoneum(n = 4), and lung(n = 2). Most of the liver metastases exhibited tumor necrosis regardless of tumor size. By contrast, tumor hemorrhage was observed only in liver lesions larger than 5 cm(n = 4). Three patterns of venous tumor thrombosis were identified: direct venous invasion by the primary HAS(n = 1), direct venous invasion by the liver metastases(n = 7), and isolated portal vein tumor thrombosis(n = 2). Dynamic CT revealed arterial hyperattenuation and late phase washout in all the liver metastases.CONCLUSION: On dynamic CT, liver metastasis from HAS shared many imaging similarities with HCC. For liver nodules, the presence of isolated portal vein tumor thrombosis and a tendency for tumor necrosis are imaging clues that suggest the diagnosis of HAS. | Yang-Yu Lin Chien-Ming Chen Yu-Hsiu Huang Cheng-Yu Lin Sung-Yu Chu Ming-Yi Hsu Kuang-Tse Pan Jeng-Hwei Tseng | 2015 | World Journal of Gastroenterology2015，21，48： | 17 |
| 12 | Current status in the treatment options for esophageal achalasia显示文摘Recent advances in the treatment of achalasia include the use of high-resolution manometry to predict the outcome of patients and the introduction of peroral endoscopic myotomy(POEM).The first multicenter randomized,controlled,2-year follow-up study conducted by the European Achalasia Trial group indicated that laparoscopic Heller myotomy(LHM)was not superior to pneumatic dilations(PD).Publications on the long-term success of laparoscopic surgery continue to emerge.In addition,laparoscopic single-site surgery is applicable to advanced laparoscopic operations such as LHM and anterior fundoplication.The optimal treatment option is an ongoing matter of debate.In this review,we provide an update of the current progress in the treatment of esophageal achalasia.Unless new conclusive data prove otherwise,LHM is considered the most durable treatment for achalasia at the expense of increased reflux-associated complications.However,PD is the first choice for non-surgical treatment and is more costeffective.Repeated PD according to an'on-demand'strategy based on symptom recurrence can achieve long-term remission.Decision making should be based on clinical evidence that identifies a subcategory of patients who would benefit from specific treatment options.POEM has shown promise but its long-term efficacy and safety need to be assessed further. | Seng-Kee Chuah Chien-Hua Chiu Wei-Chen Tai Jyong-Hong Lee Hung-I Lu Chi-Sin Changchien Ping-Huei Tseng Keng-Liang Wu | 2013 | World Journal of Gastroenterology2013，19，33： | 15 |
| 13 | Expression of hepatitis B surface antigen gene (HBsAg) in Laminaria japonica (Laminariales,Phaeophyta)显示文摘A transformation model for Laminaria japonica was established from 1993 to 1998, on the basis of which the transgenic kelp with heterologous gene encoding hepatitis B surface antigen (HBsAg) was obtained by using the micro-particle bombardment transformation method. Results of quantitative ELISA showed that HBsAg in transgenic kelp was 0.529μg/mg soluble proteins on average and the highest value was 2.497μg/mg, implying that recombinant HBsAg had natural epitope. Further support for the integration of HBsAg gene into kelp genome was obtained by PCR-Southern and total DNA hybridization. Prospect of kelp bio-reactor producing high value materials such as edible HBY vaccine was discussed as well. | JIANG Peng QIN Song TSENG Chengkui | 2002 | Chinese Science Bulletin2002，47，17： | 14 |
| 14 | Helicobacter pylori infection concomitant with metabolic syndrome further increase risk of colorectal adenomas显示文摘AIM: To investigate the association of colorectal adenomas with both Helicobacter pylori (H. pylori) infection and metabolic syndrome. METHODS: Using a cross-sectional hospital-based study, we analyzed physical examination data from 9311 healthy subjects with overnight physical examinations performed between January 2004 and December 2006. Examined data included gender, age, life style, anthropometric measurements, blood pressure, biochemical and hematological studies, H. pylori infection detected by esophagogastroduodenoscopy and biopsy urease tests, and colorectal adenomas detected with a complete total colonoscopy. RESULTS: The prevalence values for H. pylori infection, metabolic syndrome, and colorectal adenoma were39.2%, 18.7%, and 20.7%, respectively. Colorectal adenoma risk factors included male gender [odd ratio (OR): 2.005, 95% conf idence interval (CI): 1.740-2.310, P < 0.001], advanced age (OR: 1.046, 95% CI: 1.040-1.052, P < 0.001), smoking (OR: 1.377, 95% CI: 1.146-1.654, P = 0.001), increased body fat (OR: 1.016, 95% CI: 1.007-1.026, P = 0.001), higher white blood cell count (OR: 1.038, 95% CI: 1.005-1.073, P = 0.025), H. pylori infection (OR: 1.366, 95% CI: 1.230-1.517, P < 0.001), and metabolic syndrome (OR: 1.408, 95% CI: 1.231-1.610, P < 0.001). In addition, concomitant H. pylori infection with metabolic syndrome further increased the probability of colorectal adenomas. CONCLUSION: Our study revealed H. pylori infection with concomitant metabolic syndrome might further increase the risk of colorectal adenomas. | Ying-Lung Lin Jui-Kun Chiang Shih-Min Lin Chih-En Tseng | 2010 | World Journal of Gastroenterology2010，16，30： | 13 |
| 15 | Sequential versus triple therapy for the first-line treatment of Helicobacter pylori : a multicentre, open-label, randomised trial显示文摘 | Jyh-Ming Liou Chieh-Chang Chen Mei-Jyh Chen Chien-Chuan Chen Chi-Yang Chang Yu-Jen Fang Ji–Yuh Lee Shih-Jer Hsu Jiing-Chyuan Luo Wen-Hsiung Chang Yao-Chun Hsu Cheng-Hao Tseng Ping-Huei Tseng Hsiu-Po Wang Ueng-Cheng Yang Chia-Tung Shun Jaw-Town Lin Yi-Chia | 2012 | The Lancet2012，，： | 13 |
| 16 | Diabetes and gastric cancer: The potential links显示文摘This article reviews the epidemiological evidence linking diabetes and gastric cancer and discusses some of the potential mechanisms,confounders and biases in the evaluation of such an association.Findings from four meta-analyses published from 2011 to 2013 suggest a positive link,which may be more remarkable in females and in the Asian populations.Putative mechanisms may involve shared risk factors,hyperglycemia,Helicobacter pylori(H.pylori)infection,high salt intake,medications and comorbidities.Diabetes may increase the risk of gastric cancer through shared risk factors including obesity,insulin resistance,hyperinsulinemia and smoking.Hyperglycemia,even before the clinical diagnosis of diabetes,may predict gastric cancer in some epidemiological studies,which is supported by in vitro,and in vivo studies.Patients with diabetes may also have a higher risk of gastric cancer through the higher infection rate,lower eradication rate and higher reinfection rate of H.pylori.High salt intake can act synergistically with H.pylori infection in the induction of gastric cancer.Whether a higher risk of gastric cancer in patients with diabetes may be ascribed to a higher intake of salt due to the loss of taste sensation awaits further investigation.The use of medications such as insulin,metformin,sulfonylureas,aspirin,statins and antibiotics may also influence the risk of gastric cancer,but most of them have not been extensively studied.Comorbidities may affect the development of gastric cancer through the use of medications and changes in lifestyle,dietary intake,and the metabolism of drugs.Finally,a potential detection bias related to gastrointestinal symptoms more commonly seen in patients with diabetes and with multiple comorbidities should be pointed out.Taking into account the inconsistent findings and the potential confounders and detection bias in previous epidemiological studies,it is expected that there are still more to be explored for the clarification of the association between diabetes and gastric cancer. | Chin-Hsiao Tseng Farn-Hsuan Tseng | 2014 | World Journal of Gastroenterology2014，20，7： | 13 |
| 17 | Lagrangian-based investigation of multiphase flows by finite-timeLyapunov exponents显示文摘Multiphase flows are ubiquitous in our daily lifeand engineering applications.It is important to investigatethe flow structures to predict their dynamical behaviors effectively.Lagrangian coherent structures(LCS) defined bythe ridges of the finite-time Lyapunov exponent(FTLE) isutilized in this study to elucidate the multiphase interactionsin gaseous jets injected into water and time-dependent turbulent cavitation under the framework of Navier-Stokes flowcomputations.For the gaseous jets injected into water,the highlightedphenomena of the jet transportation can be observed by theLCS method,including expansion,bulge,necking/breaking,and back-attack.Besides,the observation of the LCS revealsthat the back-attack phenomenon arises from the fact that theinjected gas has difficulties to move toward downstream region after the necking/breaking.For the turbulent cavitatingflow,the ridge of the FTLE field can form a LCS to capturethe front and boundary of the re-entraint jet when the adverse pressure gradient is strong enough.It represents a barrier between particles trapped inside the circulation regionand those moving downstream.The results indicate that theFTLE field has the potential to identify the structures of multiphase flows,and the LCS can capture the interface/barrieror the vortex/circulation region. | Jia-Ning Tang Chien-Chou Tseng Ning-FeiWang | 2012 | Acta Mechanica Sinica2012，28，3： | 12 |
| 18 | Potential prognostic,diagnostic and therapeutic markers for human gastric cancer显示文摘The high incidence of gastric cancer(GC) and its consequent mortality rate severely threaten human health. GC is frequently not diagnosed until a relatively advanced stage. Surgery is the only potentially curative treatment. Thus,early screening and diagnosis are critical for improving prognoses in patients with GC. Gastroscopy with biopsy is an appropriate method capable of aiding the diagnosis of specific early GC tumor types;however,the stress caused by this method together with it being excessively expensive makes it difficult to use it as a routine method for screening for GC on a population basis. The currently used tumor marker assays for detecting GC are simple and rapid,but their use is limited by their low sensitivity and specificity. In recent years,several markers have been identified and tested for their clinical relevance in the management of GC.Here,we review the serum-based tumor markers for GC and their clinical significance,focusing on discoveries from microarray/proteomics research.We also review tissue-based GC tumor markers and their clinical application,focusing on discoveries from immunohistochemical research.This review provides a brief description of various tumor markers for the purposes of diagnosis,prognosis and therapeutics,and we include markers already in clinical practice and various forthcoming biomarkers. | Ming-Ming Tsai Chia-Siu Wang Chung-Ying Tsai Hsiang-Cheng Chi Yi-Hsin Tseng Kwang-Huei Lin | 2014 | World Journal of Gastroenterology2014，20，38： | 12 |
| 19 | A light-weight high-entropy alloy Al_(20)Be_(20)Fe_(10)Si_(15)Ti_(35)显示文摘A light-weight high-entropy alloy(LWHEA) Al_(20)Be_(20)Fe_(10)Si_(15)Ti_(35) has been developed to have unique mechanical properties and oxidation resistance. One major and two minor phases are observed in the as-cast microstructure. The density of the alloy is3.91 g cm^(-3), and its hardness is HV 911, which is higher than quartz. The hardness and hardness to density ratio are the highest of all light-weight alloys reported before. In addition, it has excellent oxidation resistance at 700℃ and 900℃, which far exceeds that of Ti-6 A1-4 V. Thus, the combination of properties is promising for high-temperature applications, which require light weight,wear-resistant and oxidation-resistant components. | tseng kokai yang yachu juan chienchang chin tsungshune tsai chewei yeh jienwei | 2018 | Science China(Technological Sciences)2018，61，2： | 12 |
| 20 | Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus显示文摘 | Naru Zhang Rudragouda Channappanavar Cuiqing Ma Lili Wang Jian Tang Tania Garron Xinrong Tao Sumaiya Tasneem Lu Lu Chien-Te K Tseng Yusen Zhou Stanley Perlman Shibo Jiang Lanying Du | 2016 | Cellular & Molecular Immunology2016，13，2： | 12 |
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