|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The role of Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC) is closely associated with Epstein-Barr virus(EBV) infection. EBV episomes are detected in almost all NPC cells. The role of EBV in NPC pathogenesis has long been postulated but remains enigmatic. In contrast to infection of B lymphocytes, EBV infection does not directly transform nasopharyngeal epithelial cells into proliferative clones with malignant potential. EBV infection of normal pharyngeal epithelial cells is predominantly lytic in nature. Genetic alterations in premalignant nasopharyngeal epithelium, in combination with inflammatory stimulation in the nasopharyngeal mucosa, presumably play essential roles in the establishment of a latent EBV infection in infected nasopharyngeal epithelial cells during the early development of NPC. Establishment of latent EBV infection in premalignant nasopharyngeal epithelial cells and expression of latent viral genes, including the BART transcripts and BART-encoded micro RNAs, are crucial features of NPC. Expression of EBV genes may drive further malignant transformation of premalignant nasopharyngeal epithelial cells into cancer cells. The difficulties involved in the establishment of NPC cell lines and the progressive loss of EBV epsiomes in NPC cells propagated in culture strongly implicate the contribution of host stromal components to the growth of NPC cells in vivo and maintenance of EBV in infected NPC cells. Defining the growth advantages of EBV-infected NPC cells in vivo will lead to a better understanding of the contribution of EBV infection in NPC pathogenesis, and may lead to the identification of novel therapeutic targets for NPC treatment. | Chi Man Tsang Sai Wah Tsao | 2015 | Virologica Sinica2015，30，2： | 26 |
| 2 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 3 | Induction of Functional Recovery by Co-transplantation of Neural Stem Cells and Schwann Cells in a Rat Spinal Cord Contusion Injury Model显示文摘Objective To study the transplantation efficacy of neural stem cells (NSCs) and Schwann cells (SC) in a rat model of spinal cord contusion injury. Methods Multipotent neural stem cells (NSCs) and Schwann cells were harvested from the spinal cords of embryonic rats at 16 days post coitus and sciatic nerves of newborn rats, respectively. The differential characteristics of NSCs in vitro induced by either serum-based culture or co-culture with SC were analyzed by immunofluorescence. NSCs and SCs were co-transplanted into adult rats having undergone spinal cord contusion at T9 level. The animals were weekly monitored using the Basso-Beattie-Bresnahan locomotor rating system to evaluate functional recovery from contusion-induced spinal cord injury. Migration and differentiation of transplanted NSCs were studied in tissue sections using immunohistochemical staining. Results Embryonic spinal cord-derived NSCs differentiated into a large number of oligodendrocytes in serum-based culture upon the withdrawal of mitogens. In cocultures with SCs, NSCs differentiated into neuron more readily. Rats with spinal cord contusion injury which had undergone transplantation of NSCs and SCs into the intraspinal cavity demonstrated a moderate improvement in motor functions. Conclusions SC may contribute to neuronal differentiation of NSCs in vitro and in vivo. Transplantation of NSCs and SCs into the affected area may be a feasible approach to promoting motor recovery in patients after spinal cord injury. | JIN LI CHONG-RAN SUNN HAN ZHANG KAM-SZE TSANG JUN-HUA LI SHAO-DONG ZHANG YI-HuA AN | 2007 | Biomedical and Environmental Sciences2007，20，3： | 22 |
| 4 | Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma显示文摘We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma.Human bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral RLR ligand poly(I:C)/LyoVec or infection-related cytokine TNF-αto induce expression of cytokines/chemokines/adhesion molecules.House dust mite(HDM)-induced allergic asthma and humanized allergic asthma NOD/SCID murine models were established to assess anti-inflammatory mechanisms in vivo.IL-38 significantly inhibited induced proinflammatory IL-6,IL-1β,CCL5,and CXCL10 production,and antiviral interferon-βand intercellular adhesion molecule-1 expression in the coculture system.Mass cytometry and RNA-sequencing analysis revealed that IL-38 could antagonize the activation of the intracellular STAT1,STAT3,p38 MAPK,ERK1/2,and NF-κB pathways,and upregulate the expression of the host defense-related gene POU2AF1 and anti-allergic response gene RGS13.Intraperitoneal injection of IL-38 into HDM-induced allergic asthma mice could ameliorate airway hyperreactivity by decreasing the accumulation of eosinophils in the lungs and inhibiting the expression of the Th2-related cytokines IL-4,IL-5,and IL-13 in the bronchoalveolar lavage fluid(BALF)and lung homogenates.Histological examination indicated lung inflammation was alleviated by reductions in cell infiltration and goblet cell hyperplasia,together with reduced Th2,Th17,and innate lymphoid type 2 cell numbers but increased proportions of regulatory T cells in the lungs,spleen,and lymph nodes.IL-38 administration suppressed airway hyperreactivity and asthma-related IL-4 and IL-5 expression in humanized mice,together with significantly decreased CCR3^(+) eosinophil numbers in the BALF and lungs,and a reduced percentage of human CD4^(+)CRTH2^(+)Th2 cells in the lungs and mediastinal lymph nodes.Together,our results demonstrated the anti-inflammatory mechanisms of IL-38 and provided a basis for the development of a regulatory cytokine-based treatment for allergic asthma. | Xiaoyu Sun Tianheng Hou Edwin Cheung Tiffany Nga-Teng Iu Victor Wai-Hou Tam Ida Miu-Ting Chu Miranda Sin-Man Tsang Paul Kay-Sheung Chan Christopher Wai-Kei Lam Chun-Kwok Wong | 2020 | Cellular & Molecular Immunology2020，17，6： | 22 |
| 5 | 非均质介质中地下水流动与溶质运移模拟——问题与挑战显示文摘对大空间尺度和长时间跨度的地下水流动及污染物质运移进行预测的需求 ,使水文地质研究面临异乎寻常的挑战 .这些需求来自于对核废料地质储放方法的安全性评价、地下水污染状况评价及其治理方案的选择 .流动系统的非均质性是地下水流动及物质运移模拟中最主要的困难之一 ,这种困难来自对非均质系统进行特征描述 (通过原位观测实现 )、概念化及模拟 .评述了非均质介质中流动运移模拟的一些重要问题与挑战 ,讨论了解决的途径 .讨论的主题包括 :动力流动的沟道化 ,示踪剂穿透曲线 ,裂隙岩石中流体流动的多尺度 ,观测的不同尺度 ,模拟、预测与非均质性以及系统特征描述和预测性模拟的分析 . | Chin-Fu Tsang 胥思勤 | 2000 | 地球科学(中国地质大学学报)2000，25，5： | 17 |
| 6 | B-cell-targeted therapies in systemic lupus erythematosus显示文摘Autoreactive B 房间是在全身的豺狼座 erythematosus (SLE ) 的致病被含有的关键有免疫力的房间之一。除了有害自身抗体(auto-Abs ) 的生产, B 房间作为介绍抗原的房间告知 autoreactive T 房间并且分泌大量支持 inflammatory cytokines 有 autocrine 和 paracrine 效果。调制 B 房间的代理人可能因此具有潜在的治疗学的价值。当前的策略包括指向 B 房间表面抗原, cytokines 支持 B 房间生长和功能,和 B 房间和 T 房间相互作用。在这篇文章,我们在动物和人的研究在 SLE 考察 B 细胞的角色,并且我们检验为这个条件的处理作为有希望的策略支持 B 房间调整的以前的报告。另外,我们在场评估了在人的 SLE 反对 CD20, CD22 和 B 淋巴细胞激发器(BLyS ) 的代理人的治疗学的功效和安全的临床的试用上的更改。当这些研究的许多的结果仍然保持不确定时, belimumab,对 BLyS 的人的 monoclonal 抗体,显示出诺言并且最近被 US 食物药品管理局为病人作为显示的治疗同意了与对中等 SLE 温和。无疑,在 B 房间免疫学的进展将继续带我们到 SLE 致病的更好的理解和指向 B 房间的新奇特定的治疗的发展。 | Vera Sau-Fong Chan Helen Hoi-Lun Tsang Rachel Chun-Yee Tam Liwei Lu Chak-Sing Lau | 2013 | Cellular & Molecular Immunology2013，10，2： | 12 |
| 7 | In-situ fabrication of PtSe2/GaN heterojunction for self-powered deep ultraviolet photodetector with ultrahigh current on/off ratio and detectivity显示文摘The research of ultraviolet photodetectors(UV PDs)have been attracting extensive attention,due to their important applications in many areas.In this study,PtSe2/GaN heterojunction is in-situ fabricated by synthesis of large-area vertically standing two-dimensional(2D)PtSe2 film on n-GaN substrate.The PtSe2/GaN heterojunction device demonstrates excellent photoresponse properties under illumination by deep UV light of 265 nm at zero bias voltage.Further analysis reveals that a high responsivity of 193 mA·W^-1,an ultrahigh specific detectivity of 3.8 × 10^14 Jones,linear dynamic range of 155d B and current on/off ratio of^10^8,as well as fast response speeds of 45/102μs were obtained at zero bias voltage.Moreover,this device response quickly to the pulse laser of 266 nm with a rise time of 172 ns.Such high-performanee PtSe2/GaN heteroj u nction UV PD demonstrated in this work is far superior to previously reported results,suggesting that it has great potential for deep UV detection. | Ranran Zhuo Longhui Zeng Huiyu Yuan Di Wu Yuange Wang Zhifeng Shi Tingting Xu Yongtao Tian Xinjian Li Yuen Hong Tsang | 2019 | Nano Research2019，12，1： | 11 |
| 8 | 经皮椎板间隙入路L_5S_1椎间盘切除术显示文摘目的探讨经皮椎板间隙入路内窥镜激光辅助椎间盘切除术治疗L5S1椎间盘突出症的疗效。方法回顾性研究2002年5月至2003年12月收治的L5S1椎间盘突出症病例168例,全部采用局麻下经皮椎板间隙入路内窥镜激光辅助椎间盘切除术,男92例,女76例;年龄18~73岁,平均42.8岁。依据Yeung分型,中央型22例、旁正中型120例、椎间孔型23例、椎间孔外侧型3例。其中钙化突出椎间盘8例,游离椎间盘19例。骶髂间距平均38.6mm。结果随访5~19个月,平均8.3个月。手术时间30￣90min,平均45min;平均住院时间1.3d。临床结果以MacNab标准评定,优73例(43.5%),良79例(47.0%),可8例(4.8%),差8例(4.8%);优良率90.5%。1例发生术中显微髓核钳断裂,8例术后MRI显示病变椎间盘减压不彻底、症状体征未改善,1例发生椎间盘炎,26例出现术后一过性感觉麻木。无一例发生死亡、硬脊膜破裂及脑脊液漏、血管损伤。结论L5S1的椎间盘突出可以采用经皮椎板间隙入椎管途径的内窥镜激光辅助椎间盘切除术,特别适用于髂嵴较高的患者。 | 杨波 刘尚礼 LEE Sangho TSANG Yisheng 李斯明 | 2005 | 中华骨科杂志2005，25，5： | 10 |
| 9 | Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels显示文摘 | Fu H Li W Lao Y Luo J Lee NT Kan KK Tsang HW Tsim KW Pang Y Li Z Chang DC Li M Han Y | 2006 | 中国生物学文摘2006，20，10： | 10 |
| 10 | 水文地质研究的关键科学问题及其创新资助策略显示文摘水文地质学在解决人类面临的众多资源-环境问题中发挥着关键作用,近40年得到快速发展。水文地质研究中带共性的关键科学问题包括:地下水系统中的物理-化学过程、场地评价方法和耦合模拟方法。为加快水文地质研究的创新进程,应当建立三种类型的研究项目平衡资助机制:小型的单个研究者主持的研究项目,多学科项目和多机构项目。 | Tsang ChinFu 王焰新 | 2003 | 中国科学基金2003，17，6： | 9 |
| 11 | 基于有限元模型分析伸直型桡骨远端骨折的生物力学特点显示文摘背景:老年人跌倒所致桡骨远端骨折临床发生率较高,从生物力学上分析受伤机制、预防骨折发生的研究非常重要但相对不足。目的:探讨伸直型桡骨远端骨折的生物力学特性。方法:选取29岁健康男性志愿者1名,对其前臂、腕关节、手进行CT扫描。将扫描获得的CT图像导入三维成像软件Mimics10.01建立腕关节背伸损伤的有限元模型,约束模型的手掌面,给予模型一个大小为2m/s、方向垂直向下的速度载荷,观测载荷作用后腕关节软组织、骨骼的应力分布。结果与结论:建立了真实有效的腕关节背伸位有限元模型,载荷作用后软组织应力主要集中于手掌小鱼际以及腕背侧,骨骼应力背侧主要集中于尺桡骨下端,桡骨下端的应力最大、最集中,掌侧应力主要集中于尺桡骨中下段交界偏下处以及腕中部,尺桡骨的应力分布不对称。研究结果可用于伸直型桡骨远端骨折损伤机制的解释,可为腕关节背伸跌倒损伤的预防提供一定的生物力学依据。 | 张朝驹 何川 陈洪卫 庞启雄 万安 刘道东 Tsang WWN 李孝林 | 2019 | 中国组织工程研究2019，23，12： | 9 |
| 12 | Pancreaticoduodenectomy with vascular reconstruction for adenocarcinoma of the pancreas with borderline resectability显示文摘AIM:To analyze whether pancreaticoduodenectomy with simultaneous resection of tumor-involved vessels is a safe approach with acceptable patient survival.METHODS:Between January 2001 and March 2012,136 patients received pancreaticoduodenectomy for adenocarcinoma at our hospital.Seventy-eight patients diagnosed with pancreatic head carcinoma were included in this study.Among them,46 patients received standard pancreaticoduodenectomy(group 1)and32 patients received pancreaticoduodenectomy with simultaneous resection of the portal vein or the superior mesenteric vein or artery(group 2)followed by reconstruction.The immediate surgical outcomes and survivals were compared between the groups.Fifty-five patients with unresectable adenocarcinoma of the pancreas without liver metastasis who received only bypassoperations(group 3)were selected for additional survival comparison.RESULTS:The median ages of patients were 67 years(range:37-82 years)in group 1,and 63 years(range:35-86 years)in group 2.All group 2 patients had resection of the portal vein or the superior mesenteric vein and three patients had resection of the superior mesenteric artery.The pancreatic fistula formation rate was21.7%(10/46)in group 1 and 15.6%(5/32)in group2(P=0.662).Two hospital deaths(4.3%)occurred in group 1 and one hospital death(3.1%)occurred in group 2(P=0.641).The one-year,three-year and five-year overall survival rates in group 1 were 71.1%,23.6%and 13.5%,respectively.The corresponding rates in group 2 were 70.6%,33.3%and 22.2%(P=0.815).The one-year survival rate in group 3 was13.8%.Pancreaticoduodenectomy with simultaneous vascular resection was safe for pancreatic head adenocarcinoma.CONCLUSION:The short-term and survival outcomes with simultaneous resection were not compromised when compared with that of standard pancreaticoduodenectomy. | Tan To Cheung Ronnie TP Poon Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai See Ching Chan Sheung Tat Fan Chung Mau Lo | 2014 | World Journal of Gastroenterology2014，20，46： | 8 |
| 13 | Pass-through Effects of Global Commodity Prices on China's Inflation:An Empirical Investigation显示文摘现在的纸使用一条二拍子的圆舞途径在中国在国内消费者价格通货膨胀上在国际商品价格和 RMB 汇率估计变化的传递效果。我们首先在制片人价格上估计国际商品价格的传递效果然后在消费者价格通货膨胀上估计制片人价格通货膨胀的传递效果。我们发现国际商品价格的 10 百分比增加将导致中国以后到 1.2% 3 个月增加的制片人价格,它将接着在一样的时期上增加中国的国内通货膨胀 0.24% 。然而,对对美元的 RMB 汇率的 10 百分比欣赏将帮助在下列 3 个月在 4.4% 在制片人价格减少增加,它将接着导致一个 0.89 百分比在一样的时期上在消费者价格通货膨胀衰退。我们的调查结果建议对在升起的全球商品价格和弱美元的环境的 RMB 的欣赏能是一台有效仪器帮助在中国包含通货膨胀。 | Ligang Liu Andrew Tsang | 2008 | China & World Economy2008，16，6： | 8 |
| 14 | Epstein-Barr virus infection and persistence in nasopharyngeal epithelial cells显示文摘Epstein-Barr virus(EBV) infection is closely associated with undifferentiated nasopharyngeal carcinoma(NPC), strongly implicating a role for EBV in NPC pathogenesis; conversely, EBV infection is rarely detected in normal nasopharyngeal epithelial tissues. In general, EBV does not show a strong tropism for infecting human epithelial cells, and EBV infection in oropharyngeal epithelial cells is believed to be lytic in nature. To establish life-long infection in humans, EBV has evolved efficient strategies to infect B cells and hijack their cellular machinery for latent infection. Lytic EBV infection in oropharyngeal epithelial cells, though an infrequent event, is believed to be a major source of infectious EBV particles for salivary transmission. The biological events associated with nasopharyngeal epithelial cells are only beginning to be understood with the advancement of EBV infection methods and the availability of nasopharyngeal epithelial cell models for EBV infection studies. EBV infection in human epithelial cells is a highly inefficient process compared to that in B cells, which express the complement receptor type 2(CR2) to mediate EBV infection. Although receptor(s) on the epithelial cell surface for EBV infection remain(s) to be identified, EBV infection in epithelial cells could be achieved via the interaction of glycoproteins on the viral envelope with surface integrins on epithelial cells, which might trigger membrane fusion to internalize EBV in cells. Normal nasopharyngeal epithelial cells are not permissive for latent EBV infection, and EBV infection in normal nasopharyngeal epithelial cells usually results in growth arrest. However, genetic alterations in premalignant nasopharyngeal epithelial cells, including p16 deletion and cyclin D1 overexpression, could override the growth inhibitory effect of EBV infection to support stable and latent EBV infection in nasopharyngeal epithelial cells. The EBV episome in NPC is clonal in nature, suggesting that NPC develops from a single EBV-infected nasopharyngeal epithelial cell, and the establishment of persistent and latent EBV infection in premalignant nasopharyngeal epithelium may represent an early and critical event for NPC development. | Chi Man Tsang Wen Deng Yim Ling Yip Mu-Sheng Zeng Kwok Wai Lo Sai Wah Tsao | 2014 | Chinese Journal of Cancer2014，33，11： | 8 |
| 15 | Vertically standing PtSe_2 film: a saturable absorber for a passively mode-locked Nd:LuVO_4 laser显示文摘The novel vertically standing Pt Se2 film on transparent quartz was prepared by selenization of platinum film deposited by the magnetron sputtering method, and an Nd:Lu VO4 passively mode-locked solid-state laser was realized by using the fabricated Pt Se2 film as a saturable absorber. The X-ray diffraction pattern and Raman spectrum of the film indicate its good crystallinity with a layered structure. The thickness of Pt Se2 film is measured to be 24 nm according to the cross-section height profile of the atomic force microscope image. Highresolution transmission electron microscopy images clearly demonstrate its vertically standing structure with an interlayer distance of 0.54 nm along the c-axis direction. The modulation depth(ΔT) and saturation fluence(Φs)of Pt Se2 film are measured to be 12.6% and 17.1 μJ∕cm2, respectively. The obtained mode-locked laser spectrum has a central wavelength of 1066.573 nm, with a 3 d B bandwidth of 0.106 nm. The transform limited pulse width of the mode-locked laser was calculated to be 15.8 ps. A maximum average output power of 180 m W with a working repetition rate of 61.3 MHz is obtained. To the best of our knowledge, this is the first report of the generation of ultrafast mode-locked laser pulses by using layered Pt Se2 as a saturable absorber. | LILI TAO XIAOWEN HUANG JUNSHAN HE YAJUN LOU LONGHUI ZENG YONGHUI LI HUI LONG JINGBO LI LING ZHANG YUEN HONG TSANG | 2018 | Photonics Research2018，6，7： | 8 |
| 16 | 地下非均匀非饱和带中地下洞室的渗流问题数值模拟——介质参数的灵敏度分析显示文摘影响任何一个地下废物处置场所长期行为的一个重要因素是进入地下废物贮置洞室内的渗流量的大小.预测地下洞室中的渗流量是困难的,特别是当地下废物贮置洞室位于非均质非饱和带中.三维数值模型用于研究地下非均质中非饱和流动及流入地下洞室中的渗流量.讨论了非均质模型与均质模型的比较以及数值剖分尺度对计算结果的影响.进入洞室中的渗漏率随着引入系统中入渗量的增加而增大.选用4个参数来衡量渗流场的非均质程度:(1)介质的平均渗透率K0;(2)VanGenuchten参数α;(3)渗透率空间分布相关尺度;(4)渗透率空间分布变化的标准差σ.根据一个随机实现的渗透率分布,通过改变平均渗透率来研究其对流入洞室中渗透量的影响.对一个固定的入渗率而言,流入洞室中的渗漏率将随着VanGenuchten参数α的减小而减小.模拟结果表明流入洞室的渗漏率与介质的平均渗透率相关,即随平均渗透率的增大,流入洞室的渗漏率亦增大.流入洞室的渗漏率还高度依赖于非均质渗透率场的空间分布相关长度与标准差.一个大的相关长度或高的标准差均能导致流入洞室的渗漏率增大. | 李国敏 Chin Fu Tsang | 2003 | 地球科学(中国地质大学学报)2003，28，5： | 8 |
| 17 | NOD2 和 TLR2 ligands 由在遗传性过敏症的像皮炎的皮肤发炎与真皮的成纤维细胞交往触发 basophils 和嗜曙红血球的激活显示文摘有遗传性过敏症的皮炎(广告) 的病人的皮肤由葡萄球菌 aureus 为殖民有唯一的倾向(S。aureus ) ,它贡献发炎和广告的冷酷的预后。尽管位于 S 下面的机制。不清楚的、最近的研究在在 S 调整煽动性的回答为模式识别受体发现了一个枢轴的角色的广告遗体的导致 aureus 的恶化。aureus 感染。在现在的学习,我们使用了像广告的皮肤发炎的一个典型老鼠模型并且发现了那 S。联系 aureus 的核苷酸绑定 oligomerization 包含域的蛋白质 2 (NOD2 ) 并且像使用费的受体 2 (TLR2 ) ligands 加重了像广告的症状,它进一步被败坏由在里面 basophils 和嗜曙红血球的 vivo 扩大。随后的组织学的分析表明真皮的成纤维细胞在像广告的皮肤损害是弥漫的。有 basophils 和嗜曙红血球的人的真皮的成纤维细胞的合作文化在真皮的成纤维细胞上导致了对 NOD2/TLR2 ligands 和细胞间的粘附 molecule-1 的提高的表示的精力旺盛的 cytokine/chemokine 回答。Basophils 和嗜曙红血球为在合作文化的广告相关的 cytokine/chemokine 表示主要负责。直接细胞间的接触为在 basophils 和真皮的成纤维细胞之间的串音是必要的,当可溶的调停人是足够的调停时嗜曙红血球成纤维细胞相互作用。而且,细胞内部的 p38 激活 mitogen 的蛋白质 kinase,细胞外的调整信号的 kinase,和表明小径的原子 factor-kappa B 为在广告相关的发炎的 basophils,嗜曙红血球,和真皮的成纤维细胞的 NOD2/TLR2 调停 ligand 的激活是必要的。这研究通过天生的有免疫力的房间的激活提供广告的 NOD2/TLR2-mediated 恶化的证据因此使一条新奇机械学的小径由清楚些哪个 S。aureus 贡献广告的 pathophysiology。 | Delong Jiao Chun-Kwok Wong Huai-Na Qiu Jie Dong Zhe Cai Man Chu Kam-Lun Hon Miranda Sin-Man Tsang Christopher Wai-Kei Lam | 2016 | Cellular & Molecular Immunology2016，13，4： | 8 |
| 18 | Responses of Soil Microbial Community Structure and Activity to Incorporation of Straws and Straw Biochars and Their Effects on Soil Respiration and Soil Organic Carbon Turnover显示文摘Like straw, biochar incorporation can influence soil microorganisms and enzyme activities and soil carbon(C) responses;however,few studies have compared the various effects of straw and biochar and the underlying mechanisms. An experiment was performed to study the changes in soil respiration(SR) and soil organic C(SOC) fluxes in response to the incorporation of three kinds of straw(reed, smooth cordgrass, and rice) and their pyrolyzed products(biochars) at Chongming Island, China. In addition, the microbial activity and community structure of some amended soils were also analyzed to clarify the mechanisms of these responses. The results showed that all biochar incorporation(BC) induced lower SR than the corresponding unpyrolyzed straw incorporation(ST), and the average SR in the soils following BC and ST during the experimental periods was 21.69 and 65.32 μmol CO2 m^-2s^-1, respectively.Furthermore, the average SOC content was 16.97 g kg-1 following BC, which was higher than that(13.71 g kg-1) following ST,indicating that compared to ST, BC was a low-C strategy, even after accounting for the C loss during biochar production. Among the BC treatments, reed-BC induced the lowest SR(17.04 μmol CO2 m^-2s^-1), whereas smooth cordgrass-BC induced the highest SR(27.02 μmol CO2 m^-2s^-1). Furthermore, in contrast with ST, BC significantly increased the abundance of some bacteria with poorer mineralization or better humification ability, which led to lower SR. The lower easily oxidizable C(EOC) and higher total C contents of biochars induced lower SR and higher SOC in the soil following BC compared to that following ST. Among the BC treatments,the higher total nitrogen content of rice biochar led to significantly higher soil microbial biomass, and the lower EOC content of reed biochar led to lower soil microbial activity and SR. | TIAN Xiaoping WANG Lei HOU Yahong WANG Han TSANG Yiu Fai WU Jihua | 2019 | Pedosphere2019，29，4： | 7 |
| 19 | 褐脉少花龙葵毛状根的诱导、培养及其澳洲茄胺的产生显示文摘利用发根农杆菌的遗传转化和液体培养技术,研究了褐脉少花龙葵(Solanum nigrum L. var. pauciflorum)毛状根的诱导和离体培养及其澳洲茄胺的产生以及液体培养过程中培养基中N源和钙的消耗变化。结果表明,发根农杆菌ATCC15834感染褐脉少花龙葵叶片外植体5 d后产生毛状根,感染25d后,约90%的叶片外植体产生毛状根。毛状根能在无外源生长调节剂的MS固体和液体培养基上自主生长。PCR扩增结果显示发根农杆菌Ri质粒的rolB和rolC基因已在少花龙葵毛状根基因组中整合并得到表达。所产生的毛状根能产生药用次生物质澳洲茄胺,其含量约为非转化植株根的1.3倍,达到582.05μg/g干重。少花龙葵毛状根液体培养0-5 d内处于生长迟滞期、5-15 d为快速生长期、15d后进入生长平台期。培养基的硝态氮和铵态氮在毛状根液体培养过程中被逐渐吸收和消耗,至培养15 d时铵态氮被消耗殆尽,而硝态氮仍剩余44.7%;培养基中钙的浓度在培养过程中虽逐渐降低,但在培养25d时仍未被完全消耗,其浓度约为起始浓度的43.5%。该结果为今后设计合适的培养基来规模培养褐脉少花龙葵毛状根生产药用次生物质澳洲茄胺提供了可能性。 | 吴晓凤 施和平 TSANG Po Keung Eric | 2008 | 分子细胞生物学报2008，41，3： | 7 |
| 20 | Current and future molecular diagnostics in colorectal cancer and colorectal adenoma显示文摘Colorectal cancer(CRC)is one of the most prevalent cancers in developed countries.On the other hand,CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or sigmoidoscopy.Since CRC develops slowly from precancerous lesions,early detection can reduce both the incidence and mortality of the disease.Fecal occult blood test is a widely used non-invasive screening tool for CRC.Although fecal occult blood test is simple and cost-effective in screening CRC,there is room for improvement in terms of the accuracy of the test.Genetic dysregulations have been found to play an important role in CRC development.With better understanding of the molecular basis of CRC,there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for CRC.In this review,the molecular basis of CRC development,the characteristics and applications of different non-invasive molecular biomarkers,as well as the technologies available for the detection were discussed.This review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state,colorectal adenoma. | Andy Hin-Fung Tsang Ka-Ho Cheng Apple Siu-Ping Wong Simon Siu-Man Ng Brigette Buig-Yue Ma Charles Ming-Lok Chan Nancy Bo-Yin Tsui Lawrence Wing-Chi Chan Benjamin Yat-Ming Yung Sze-Chuen Cesar Wong | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
您所在的机构暂未开通此部分的功能，请联系管理员