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| 1 | Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression显示文摘Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial for treatment. Galectin-1(Gal-1) belongs to a family of glycan-binding proteins, or lectins, with the ability to cross-link specific glycoconjugates. A variety of biological activities have been attributed to Gal-1 at different steps of tumor progression. Herein, we summarize the current literature regarding the roles of Gal-1 in gastrointestinal malignancies. Accumulating evidence shows that Gal-1 is drastically up-regulated in human gastric cancer, hepatocellular carcinoma, colorectal cancer and pancreatic ductal adenocarcinoma tissues, both in tumor epithelial and tumor-associated stromal cells. Moreover, Gal-1 makes a crucial contribution to the pathogenesis of gastrointestinal malignancies, favoring tumor development, aggressiveness, metastasis, immunosuppression and angiogenesis. We also highlight that alterations in Gal-1-specific glycoepitopes may be relevant for gastrointestinal cancer progression. Despite the findings obtained so far, further functional studies are still required. Elucidating the precise molecular mechanisms modulated by Gal-1 underlying gastrointestinal tumor progression, might lead to the development of novel Gal-1-based diagnostic methods and/or therapies. | maría l bacigalupo pablo carabias maría f troncoso | 2017 | World Journal of Gastroenterology2017，23，29： | 11 |
| 2 | MicroRNAs contribute to ATP-binding cassette transporter-and autophagy-mediated chemoresistance in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) has an elevated mortality rate, largely because of high recurrence and metastasis. Additionally, the main obstacle during treatment of HCC is that patients usually develop resistance to chemotherapy.Cancer drug resistance involves many different mechanisms, including alterations in drug metabolism and processing, impairment of the apoptotic machine, activation of cell survival signaling, decreased drug sensitivity and autophagy, among others. Nowadays, miRNAs are emerging as master regulators of normal physiology-and tumor-related gene expression. In HCC,aberrant expression of many miRNAs leads to chemoresistance. Herein, we particularly analyzed miRNA impact on HCC resistance to drug therapy. Certain miRNAs target ABC(ATP-binding cassette) transporter genes. As most of these miRNAs are downregulated in HCC, transporter levels increase and intracellular drug accumulation decrease, turning cells less sensitive to death. Others miRNAs target autophagy-related gene expression, inhibiting autophagy and acting as tumor suppressors. Nevertheless, due to its downregulation in HCC, these miRNAs do not inhibit autophagy or tumor growth and, resistance is favored.Concluding, modulation of ABC transporter and/or autophagy-related gene expression or function by miRNAs could be determinant for HCC cell survival under chemotherapeutic drug treatment. Undoubtedly, more insights on the biological processes, signaling pathways and/or molecular mechanisms regulated by miRNAs are needed. Anyway, miRNA-based therapy together with conventional chemotherapeutic drugs has a great future in cancer therapy. | María V Espelt María L Bacigalupo Pablo Carabias María F Troncoso | 2019 | World Journal of Hepatology2019，11，4： | 3 |
| 3 | Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)represents a global health problem.Infections with hepatitis B or C virus,non-alcoholic steatohepatitis disease,alcohol abuse,or dietary exposure to aflatoxin are the major risk factors to the development of this tumor.Regardless of the carcinogenic insult,HCC usually develops in a context of cirrhosis due to chronic inflammation and advanced fibrosis.Galectins are a family of evolutionarily-conserved proteins defined by at least one carbohydrate recognition domain with affinity forβ-galactosides and conserved sequence motifs.Here,we summarize the current literature implicating galectins in the pathogenesis of HCC.Expression of'proto-type'galectin-1,'chimera-type'galectin-3 and'tandem repeat-type'galectin-4 is up-regulated in HCC cells compared to their normal counterparts.On the other hand,the'tandemrepeat-type'lectins galectin-8 and galectin-9 are downregulated in tumor hepatocytes.The abnormal expression of these galectins correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,postoperative recurrence and poor prognosis.Moreover,these galectins have important roles in other pathological conditions of the liver,where chronic inflammation and/or fibrosis take place.Galectin-based therapies have been proposed to attenuate liver pathologies.Further functional studies are required to delineate the precise molecular mechanisms through which galectins contribute to HCC. | María L Bacigalupo Malena Manzi Gabriel A Rabinovich María F Troncoso | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 4 | A case report of pulmonary coinfection of Strongyloides stercoralis and Pneumocystis jiroveci显示文摘A case of pulmonary coinfection by Strongyloides stercoralis and Pneumocystis jiroveci has been detected in an AIDS patient treated in the Respiratory Intensive Care Unit of the Muniz Hospital.At diagnosis,the patient presented cough with mucopurulent expectoration,dyspnea,fever,bilateral pulmonary infiltrates on the chest X-ray,negative bacilloscopy for acid fast bacteria and a CD4^+ T lymphocytes count of 52 cells/μ L.The microbiological diagnosis was achieved by microscopic observation of the respiratory secretions obtained by bronchoalveolar lavage,while the wet mount examination revealed rhabditiform and filariform larvae of the nematode and foamy exudates,pathognomonic of the pulmonary pneumocystosis.It was the unique case of this association among about 3 000 samples performed in our laboratory in the last 10 years and diagnosed by microscopy.Other complementary stains(a rapid modification of Grocott,Kinyoun and Giemsa) were applied to the smears after the diagnosis of mycotic and parasitary infections achieved by fresh microscopy.Both physicians and microbiologists should take into account the possible coexistence of respiratory pathogens in immunocompromised patients,such as those with AIDS. | Bava AJ Romero MM Prieto R Troncoso A | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 2 |
| 5 | Evaluation of Salt Tolerance of in Vitro-grown Grapevine Rootstock Varieties显示文摘 | Matte C Cantos M | 1999 | Vitis1999，38，2： | 1 |
| 6 | Comparison of antioxidant activity of wine phenolic compounds and metabolites in vitro显示文摘 | VILLANO D PACHON M S F TRONCOSO A M | 2005 | Anal Chim Acta2005，538，12： | 1 |
| 7 | ()ptimi- zation of prostate biopsy strategy using computer based analysis显示文摘 | Chen M E Troncoso P Johnston D A | 1997 | J Urol1997，158，6： | 1 |
| 8 | Ion-exclusion chromatographic determination of organic acids in vinegars显示文摘 | Lourdes Morales M Gustavo Gonzalez A Ana M Troncoso | 1998 | Journal of Chromatography A1998，822，： | 1 |
| 9 | lndentification of Cryptosporidium parvum occyst/ sporozite antigens recognized by infected and hyperimmue lambs显示文摘 | Ortega L M Troncoso J M Rojo F A | 1994 | Vet Para1994，53，： | 1 |
| 10 | Evaluation of salt tolerance of in vitro-grown grapevine rootstock varieties显示文摘 | TRONCOSO A MATTE C CANTOS M | 1999 | Vi- tis1999，38，2： | 1 |
| 11 | Molecular markers of outcome after radiotherapy in patients with prostate carcinoma: Ki-67, bcl-2,bax, and bcl-x显示文摘 | Pollack A Cowen D Troncoso P | 2003 | Cancer2003，97，7： | 1 |
| 12 | Accelerated aging of wine vinegars with oak chips : evaluation of wood flavour compounds 显示文摘 | Morales M L Benitez B Troncoso A M | 2004 | Food Chemistry2004，88，： | 1 |
| 13 | Density and refractive index in mixtures of ionic liquids and organic solvents:Correlations and predictions显示文摘 | IGLESIAS-OTERO M A TRONCOSO J CARBALLO E | | 0，，06： | 1 |
| 14 | Density and refractive index in mixtures of ionic liquids and organic solvents: Correlations and predictions 显示文摘 | Iglesias-Otero M A Troncoso J Carballo E | 2008 | J Chem Thermodyn2008，40，6： | 1 |
| 15 | Evaluation ofsalt tolerance of in vitro-grown grapevine rootstock varieties显示文摘 | Troncoso A Matte C Cantos M | 1999 | Vitis1999，38，2： | 1 |
| 16 | Determination of amino acids in grape-derived products: a review 显示文摘 | Callejon R M Troncoso A M Morales M L | 2010 | Talanta2010，，81： | 1 |
| 17 | Optimization of prostate biopsy strategy using computer based analysis显示文摘 | CHEN M E TRONCOSO P JOHNSTON D A | 1997 | J Urol1997，158，6： | 1 |
| 18 | Analysis of the isothiocyanates present in cabbage leaves ex tract and their potential application to control Alternaria rot in bell peppers显示文摘 | Troncoso R Espinoza C Sanchez-Estrada A | 2005 | Food Res Int2005，38，： | 1 |
| 19 | Salinity and germination of annual Melilotus from the Guadalquivir delta (SW Spain)显示文摘 | MARANON T GARCIA L V TRONCOSO A | 1989 | Plant and Soil1989，119，： | 1 |
| 20 | Molecular mark-ers of outcome after radiotherapy in patients with prostate carcino-ma:Ki-67,bcl-2,bax,and bcl-x显示文摘 | POLLACK A COWEN D TRONCOSO P | 2003 | Cancer2003，97，7： | 1 |
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