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| 1 | Malignant peritoneal mesothelioma显示文摘Malignant mesothelioma is a highly aggressive neoplasm.The incidence of malignant mesothelioma is increasing worldwide.Diffuse malignant peritoneal mesothelioma(DMPM) represents one-fourth of all mesotheliomas.Association of asbestos exposure with DMPM has been observed,especially in males.The great majority of patients present with abdominal pain and distension,caused by accumulation of tumors and ascitic ? uid.In the past,DMPM was considered a pre-terminal condition;therefore attracted little attention.Patients invariably died from their disease within a year.Recently,several prospective trials have demonstrated a median survival of 40 to 90 mo and 5-year survival of 30% to 60% after combined treatment using cytoreductive surgery and perioperative intraperitoneal chemotherapy.This remarkable improvement in survival has prompted new search into the medical science related to DMPM,a disease previously ignored as uninteresting.This review article focuses on the key advances in the epidemiology,diagnosis,staging,treatments and prognosis of DMPM that have occurred in the past decade. | Stine Munkholm-Larsen Christopher Q Cao Tristan D Yan | 2009 | World Journal of Gastrointestinal Surgery2009，1，1： | 19 |
| 2 | A pharmacological review on intraperitoneal chemotherapy for peritoneal malignancy显示文摘Perioperative intraperitoneal chemotherapy in combination with cytoreductive surgery has been shown to be of benefit for treating selected patients with peritoneal surface malignancy.It has become a new standard of care in the management of diffuse malignant peritoneal mesothelioma and peritoneal dissemination of appendiceal malignancy.Numerous recent publications on carcinomatosis from colorectal cancer and gastric cancer identify groups of patients that would benef it from this local-regional approach for prevention and treatment of carcinomatosis.This review focuses on pharmacological information regarding intraperitoneal chemotherapeutic agents commonly used in gastrointestinal oncology. | Tristan D Yan Christopher Qian Cao Stine Munkholm-Larsen | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 14 |
| 3 | 油菜、蚕豆、鹰嘴豆和大豆对间作玉米籽粒Fe,Mn,Cu和Zn浓度及地上部累积量的影响显示文摘目前较多研究关注单作玉米的籽粒微量元素问题,间套作对玉米籽粒微量元素浓度和地上部吸收量的影响尚不清楚.田间试验用来研究白菜型油菜、蚕豆、鹰嘴豆和大豆对间作玉米籽粒铁(Fe)、锰(Mn)、铜(Cu)和锌(Zn)浓度及其相应地上部植株吸收量的影响.与单作玉米相比,与豆科作物间作玉米籽粒Fe,Mn,Cu和Zn的浓度及其相应的收获指数降低,而与白菜型油菜间作玉米则保持与单作玉米相同水平;但是间作促进了玉米植株地上部对Fe,Mn,Cu和Zn的吸收量.进一步研究表明,玉米籽粒产量与籽粒Fe和Cu的浓度呈显著负相关关系,而与Mn和Zn的浓度则未达到显著相关,但是所有这些籽粒微量元素浓度与相应的收获指数间均呈显著性正相关关系.因此,与蚕豆、鹰嘴豆和大豆间作玉米籽粒微量元素浓度的降低,主要是由Fe,Mn,Cu和Zn从营养器官向籽粒转移或再活化的比例降低所致,这可能与相应的玉米衰老进程减缓有关.白菜型油菜/玉米间作有利于维持玉米籽粒高产,同时未降低籽粒Fe,Mn,Cu和Zn的浓度,适合在本地区推广. | 夏海勇 赵建华 孙建好 薛艳芳 Tristan Eagling 包兴国 张福锁 李隆 | 2013 | 中国科学:生命科学2013，43，7： | 12 |
| 4 | Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis显示文摘Osteoarthritis(OA),long considered a primary disorder of articular cartilage,is commonly associated with subchondral bone sclerosis.However,the cellular mechanisms responsible for changes to subchondral bone in OA,and the extent to which these changes are drivers of or a secondary reaction to cartilage degeneration,remain unclear.In knee joints from human patients with end-stage OA,we found evidence of profound defects in osteocyte function.Suppression of osteocyte perilacunar/canalicular remodeling(PLR)was most severe in the medial compartment of OA subchondral bone,with lower protease expression,diminished canalicular networks,and disorganized and hypermineralized extracellular matrix.As a step toward evaluating the causality of PLR suppression in OA,we ablated the PLR enzyme MMP13 in osteocytes while leaving chondrocytic MMP13 intact,using Cre recombinase driven by the 9.6-kb DMP1 promoter.Not only did osteocytic MMP13 deficiency suppress PLR in cortical and subchondral bone,but it also compromised cartilage.Even in the absence of injury,osteocytic MMP13 deficiency was sufficient to reduce cartilage proteoglycan content,change chondrocyte production of collagen II,aggrecan,and MMP13,and increase the incidence of cartilage lesions,consistent with early OA.Thus,in humans and mice,defects in PLR coincide with cartilage defects.Osteocyte-derived MMP13 emerges as a critical regulator of cartilage homeostasis,likely via its effects on PLR.Together,these findings implicate osteocytes in bone-cartilage crosstalk in the joint and suggest a causal role for suppressed perilacunar/canalicular remodeling in osteoarthritis. | Courtney MMazur Jonathon JWoo Cristal SYee Aaron JFields Claire Acevedo Karsyn NBailey Serra Kaya Tristan WFowler Jeffrey CLotz Alexis Dang Alfred CKuo Thomas PVail Tamara Alliston | 2019 | Bone Research2019，7，4： | 10 |
| 5 | High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging显示文摘Progress in neuroscience relies on new techniques for investigating the complex dynamics of neuronal networks.An ongoing challenge is to achieve minimally invasive and high-resolution observations of neuronal activity in vivo inside deep brain areas.Recently introduced methods for holographic control of light propagation in complex media enable the use of a hair-thin multimode optical fibre as an ultranarrow imaging tool.Compared to endoscopes based on graded-index lenses or fibre bundles,this new approach offers a footprint reduction exceeding an order of magnitude,combined with a significant enhancement in resolution.We designed a compact and high-speed system for fluorescent imaging at the tip of a fibre,achieving a resolution of 1.18±0.04μm across a 50-μm field of view,yielding 7-kilopixel images at a rate of 3.5 frames/s.Furthermore,we demonstrate in vivo observations of cell bodies and processes of inhibitory neurons within deep layers of the visual cortex and hippocampus of anaesthetised mice.This study paves the way for modern microscopy to be applied deep inside tissues of living animal models while exerting a minimal impact on their structural and functional properties. | Sergey Turtaev Ivo T.Leite Tristan Altwegg-Boussac Janelle M.P.Pakan Nathalie L.Rochefort Tomáš Čižmár | 2018 | Light(Science & Applications)2018，7，1： | 8 |
| 6 | Maize grain concentrations and above-ground shoot acquisition of micronutrients as affected by intercropping with turnip, faba bean, chickpea, and soybean显示文摘Most research on micronutrients in maize has focused on maize grown as a monocrop. The aim of this study was to determine the effects of intercropping on the concentrations of micronutrients in maize grain and their acquisition via the shoot. We conducted field experiments to investigate the effects of intercropping with turnip (Brassica campestris L.), faba bean (Vicia faba L.), chickpea (Cicer arietinum L.), and soybean (Glycine max L.) on the iron (Fe), manganese (Mn), copper (Cu) and zinc (Zn) concentrations in the grain and their acquisition via the above-ground shoots of maize (Zea mays L.). Compared with monocropped maize grain, the grain of maize intercropped with legumes showed lower concentrations of Fe, Mn, Cu, and Zn and lower values of their corresponding harvest indexes. The micronutrient concentrations and harvest indexes in grain of maize intercropped with turnip were the same as those in monocropped maize grain. Intercropping stimulated the above-ground maize shoot acquisition of Fe, Mn, Cu and Zn, when averaged over different phosphorus (P) application rates. To our knowledge, this is the first report on the effects of intercropping on micronutrient concentrations in maize grain and on micronutrients acquisition via maize shoots (straw+grain). The maize grain Fe and Cu concentrations, but not Mn and Zn concentrations, were negatively correlated with maize grain yields. The concentrations of Fe, Mn, Cu, and Zn in maize grain were positively correlated with their corresponding harvest indexes. The decreased Fe, Mn, Cu, and Zn concentrations in grain of maize intercropped with legumes were attributed to reduced translocation of Fe, Mn, Cu, and Zn from vegetative tissues to grains. This may also be related to the delayed senescence of maize plants intercropped with legumes. We conclude that turnip/maize intercropping is beneficial to obtain high maize grain yield without decreased concentrations of Fe, Mn, Cu, and Zn in the grain. Further research is required to clarify the mechanisms underlying the changes in micronutrient concentrations in grain of intercropped maize. | XIA HaiYong ZHAO JianHua SUN JianHao XUE YanFang EAGLING Tristan BAO XingGuo ZHANG FuSuo LI Long | 2013 | Science China(Life Sciences)2013，56，9： | 8 |
| 7 | Animal personality and the ecological impacts of freshwater non-native species显示文摘 | Tristan JUETTE | 2014 | Current Zoology2014，60，3： | 7 |
| 8 | 运动教育中体育素养的培养(英文)显示文摘体育教育中体现的'体育素养'认为学生无论具有任何能力都应终身保持体育运动,这一概念的重要性正在不断提高。本文旨在讨论运动教育这一现代教学模式的教学特征如何用于体育教育中以培养'体育素养',以及当前有哪些实证研究可证实这一观点。大量实证研究表明:与体育素养发展相关的属性能通过有效地应用这一模型在体育教育中实现(Whitehead,2000年)。运动教育具有鲜明的教学特色,能对体育素养各方面起积极作用,并可进一步使个人体育素养提高并通过自身在体育教育中得以体现。尽管如此,它仍然有自身的局限性,不能作为发展终身体育的'万能药'。如果这些体育素养的相关属性要将个人的动机和自信转化为其利用自身先天的潜能,并明显提升其生活质量,就必须将运动教育发展成为一门连接性的专门学科。 | Peter A.Hastie Tristan L.Wallhead | 2015 | Journal of Sport and Health Science2015，4，2： | 7 |
| 9 | ESR牙齿珐琅质测年中不同拟合函数对古剂量测定的影响显示文摘本文对单饱和指数(SSE)拟合函数、双饱和指数(DSE)拟合函数、指数加线性(EPL)拟合函数进行了讨论,并对重庆巫山龙骨坡早更新世遗址的8颗哺乳动物牙齿化石的古剂量作了对比研究。结果显示,SSE函数的古剂量拟合结果高于DSE和EPL函数,且拟合残差也较大。与已知参考剂量比较后发现,DSE函数拟合结果的相对偏差最小,SSE函数与参考值的偏差最大。实验说明,对于早期地点的牙齿化石样品采用SSE拟合函数会造成古剂量的高估,DSE的拟合结果更接近样品的真实古剂量。 | 韩非 尹功明 Jean-Jacques Bahain Tristan Garcia 刘春茹 高璐 李建平 | 2011 | 核技术2011，34，2： | 7 |
| 10 | Practical assessment of rock damage due to blasting显示文摘Blasting is the most cost effective methodology to break rock for mining or civil engineering applications.A good production blast will break only the rock that is needed to be removed,leaving the host rock with minimal damage.The control of rock damage due to blasting is very important when it comes to mine or construction design,safety,and cost.Damage to the host rock due to a production blast could result in failures,overbreak and unstable ground.Knowing how far the fractures generated by a production blast will go into the host rock is a valuable tool for engineers to design a safe highwall while keeping the actual excavation close to the design.Currently,there are several methods available to predict damage due to blasting.The accuracy of many of these methods is questionable,and in most cases,the methodologies over predict the results.This often leads to inefficient mines and poor construction works.When the current methodologies are reviewed,each one presents sound approaches,but in many cases they also lack consideration of other variables that,according to the authors,need to be included when predicting blast damage.This paper presents a practical methodology to assess the rock damage from blasting by combining other methodologies.The proposed method allows consideration of more variables when compared to available methods,resulting in a more accurate rock damage assessment.The method uses the estimation of the generated levels of peak particle velocity with the distance from a production blast presented by Persson and Holmberg,the peak particle velocity damage ranges proposed by Forsyth and the relationship between the static compressive strength and dynamic compressive strength of rocks from Liu.The new methodology was validated using the data published in a large-scale study performed in granite by Siskind. | Jhon Silva Tristan Worsey Braden Lusk | 2019 | International Journal of Mining Science and Technology2019，29，3： | 5 |
| 11 | Cell signalling pathways underlying induced pluripotent stem cell reprogramming显示文摘Induced pluripotent stem(i PS) cells, somatic cells reprogrammed to the pluripotent state by forced expression of defined factors, represent a uniquely valuable resource for research and regenerative medicine. However, this methodology remains inefficient due to incomplete mechanistic understanding of the reprogramming process. In recent years, various groups have endeavoured to interrogate the cell signalling that governs the reprogramming process, including LIF/STAT3, BMP, PI3 K, FGF2, Wnt, TGFβ and MAPK pathways, with the aim of increasing our understanding and identifying new mechanisms of improving safety, reproducibility and efficiency. This has led to a unified model of reprogramming that consists of 3 stages: initiation, maturation and stabilisation. Initiation of reprogramming occurs in almost all cells that receive the reprogramming transgenes; most commonly Oct4, Sox2, Klf4 and c Myc, and involves a phenotypic mesenchymal-to-epithelial transition. The initiation stage is also characterised by increased proliferation and a metabolic switch from oxidative phosphorylation to glycolysis. The maturation stage is considered the major bottleneck within the process, resulting in very few 'stabilisation competent' cells progressing to the final stabilisation phase. To reach this stage in both mouse and human cells, pre-i PS cells must activate endogenous expression of the core circuitry of pluripotency, comprising Oct4, Sox2, and Nanog, and thus reach a state of transgene independence. By the stabilisation stage, i PS cells generally use the same signalling networks that govern pluripotency in embryonic stem cells. These pathways differ between mouse and human cells although recent work has demonstrated that this is context dependent. As i PS cell generation technologies move forward, tools are being developed to interrogate the process in more detail, thus allowing a greater understanding of this intriguing biological phenomenon. | Kate Hawkins Shona Joy Tristan Mc Kay | 2014 | World Journal of Stem Cells2014，6，5： | 5 |
| 12 | ACS Nano:新型纳米颗粒运输系统或能克服CRISPR基因编辑障碍显示文摘近日,一项刊登在国际杂志ACSNano上的研究报告中,来自马萨诸塞大学阿默斯特分校的研究人员通过研究利用纳米颗粒设计出了一种新系统能够帮助CRISPR/Cas9系统跨过细胞膜进入到细胞核中,同时还能够避免被细胞器所捕获。研究者Rubul Mout说道,CRISPR由两种组分组成,包括名为Cas9的剪刀样蛋白和名为sgRNA的RNA分子,sgRNA分子能够引导Cas9进入到靶点位置。 | Rubul Mout† Moumita Ray† Gulen Yesilbag Tonga Yi-Wei Lee Tristan Tay Kanae Sasaki Vincent M. Rotello | 2017 | 现代生物医学进展2017，17，14： | 3 |
| 13 | Graph theory approach to determine configurations of multidentate and high coverage adsorbates for heterogeneous catalysis显示文摘Heterogeneous catalysts constitute a crucial component of many industrial processes,and to gain an understanding of the atomicscale features of such catalysts,ab initio density functional theory is widely employed.Recently,growing computational power has permitted the extension of such studies to complex reaction networks involving either high adsorbate coverages or multidentate adsorbates,which bind to the surface through multiple atoms.Describing all possible adsorbate configurations for such systems,however,is often not possible based on chemical intuition alone.To systematically treat such complexities,we present a generalized Python-based graph theory approach to convert atomic scale models into undirected graph representations.These representations,when combined with workflows such as evolutionary algorithms,can systematically generate high coverage adsorbate models and classify unique minimum energy multidentate adsorbate configurations for surfaces of low symmetry,including multi-elemental alloy surfaces,steps,and kinks. | Siddharth Deshpande Tristan Maxson Jeffrey Greeley | 2020 | npj Computational Materials2020，，1： | 3 |
| 14 | Revising how the computer program cervus accommodates genotyping error increases success in paternity assignment显示文摘 | STEVEN T.KALINOWSKI MARK L.TAPER TRISTAN C.MARSHALL | 2007 | Molecular Ecology2007，，5： | 3 |
| 15 | Sam68 is a regulator of Toll-like receptor signaling显示文摘由像使用费的受体(TLR ) 的病原体的识别激活定制装主要有免疫力的回答,发炎,房间幸存和 apoptosis 的基因的多重发信号的串联和表情。尽管小径的导致 TLR 的激活,例如原子因素 kappaB (NF-κ B ) 并且激活 mitogen 的蛋白质 kinases (MAPK ) ,在有免疫力的回答期间控制这些小径的量的规定的很好被学习的、分子的实体仍然保持糟糕定义。我们作为导致 TLR 的 NF-κ 的一个新奇管理者识别了 Sam68; B 和 MAPK 激活。我们发现 TLR2 和 TLR3 完全是依赖的,而 TLR4 部分仅仅依赖于导致 NF-κ 的激活的 Sam68; B c-Rel。Sam68 的缺席极大地减少了导致 TLR2 、导致 TLR3 的 NF-κ B p65 激活,而以一种 Sam68 独立的方式的导致 TLR4 的 p65 激活。相反,因为 Sam68 的缺席提高了细胞外的调整信号的 kinases (英皇家空军之阶级最低之兵) 和 c6 月 N 终端 kinases (JNK ) 的导致 TLR2 的激活, Sam68 看起来是 MAPK 小径的一个否定管理者。有趣地,导致 TLR2 、导致 TLR3 的基因表示显示出 Sam68 的一个微分要求。Sam68 的缺席损害了导致 TLR2 的基因表示,建议 Sam68 有在 myeloid 区别的一个关键角色主要反应基因 88 依赖者 TLR2 发信号。导致 TLR3 的基因表示利用 Toll/ Interleukin-1 receptor-domain-containing 导致改编者的贝它干扰素小径,仅仅部分取决于 Sam68。我们的调查结果建议 Sam68 可以作为平衡 NF-κ 的激活的一个有免疫力的变阻器工作; B p65 和 c-Rel,以及 MAPK,揭示一个潜在的新奇目标操作 TLR 发信号。 | Jeffrey A Tomalka Tristan J de Jesus Parameswaran Ramakrishnan | 2017 | Cellular & Molecular Immunology2017，14，1： | 3 |
| 16 | Manipulating Bloch surface waves in 2D: a platform concept-based flat lens显示文摘At the end of the 1970s,it was confirmed that dielectric multilayers can sustain Bloch surface waves(BSWs).However,BSWs were not widely studied until more recently.Taking advantage of their high-quality factor,sensing applications have focused on BSWs.Thus far,no work has been performed to manipulate and control the natural surface propagations in terms of defined functions with two-dimensional(2D)components,targeting the realization of a 2D system.In this study,we demonstrate that 2D photonic components can be implemented by coating an in-plane shaped ultrathin(l/15)polymer layer on the dielectric multilayer.The presence of the polymer modifies the local effective refractive index,enabling direct manipulation of the BSW.By locally shaping the geometries of the 2D components,the BSW can be deflected,diffracted,focused and coupled with 2D freedom.Enabling BSW manipulation in 2D,the dielectric multilayer can play a new role as a robust platform for 2D optics,which can pave the way for integration in photonic chips.Multiheterodyne near-field measurements are used to study light propagation through micro-and nano-optical components.We demonstrate that a lens-shaped polymer layer can be considered as a 2D component based on the agreement between near-field measurements and theoretical calculations.Both the focal shift and the resolution of a 2D BSW lens are measured for the first time.The proposed platform enables the design of 2D all-optical integrated systems,which have numerous potential applications,including molecular sensing and photonic circuits. | Libo Yu Elsie Barakat Tristan Sfez Lubos Hvozdara Joab Di Francesco Hans Peter Herzig | 2014 | Light(Science & Applications)2014，3，1： | 3 |
| 17 | A Systematic Review on the Efficacy of Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei显示文摘 | Tristan D. Yan BSc (Med) MBBS Deborah Black BSc DipEd MStat PhD Renaldo Savady MD Paul H. Sugarbaker MD | 2007 | Annals of Surgical Oncology2007，，2： | 2 |
| 18 | 视网膜光凝术联合中药治疗糖尿病性视网膜病变(英文)显示文摘目的:探讨口服滋阴凉血散瘀汤联合激光治疗糖尿病性视网膜病变的临床疗效。方法:采用口服滋阴凉血散瘀汤联合视网膜光凝治疗糖尿病性视网膜病变患者,以单纯视网膜光凝为对照组,对比两组患者在治疗后1,6,12mo的视力、视野及新生血管的变化情况。结果:口服滋阴凉血散瘀汤联合光凝治疗组患者12mo时视力提高(62.3%vs43.1%,P=0.037),视野改变(17.0±3.7vs14.9±3.7,P=0.002)及新生血管退缩情况(67.2%vs48.3%,P=0.036)均优于对照组患者。结论:滋阴凉血散瘀汤联合激光治疗糖尿病性视网膜病变较单纯激光治疗更有效。 | 赵宁 万超 邸平会 孙瑞雪 王建仓 Tristan Bice 徐俊杰 | 2011 | 国际眼科杂志2011，11，4： | 2 |
| 19 | Gene expression profiling of Puccinia striiformis f.sp.tritici during development reveals a highly dynamic transcriptome显示文摘Puccinia striiformis f。sp。tritici (Pst ) 原因条纹锈,世界范围的小麦的最重要的疾病之一。cDNA 图书馆从 urediniospores,发芽 urediniospores 和 haustoria 被构造了。然而,很少对与感染过程和病原体的孢子形成有关的基因的表示模式被知道。在这研究,特定的 oligonucleotide microarray 用从 Pst cDNA 图书馆选择的 442 个基因抄本的序列被构造。基因的表示模式被有从在 vitro 和感染 Pst 的小麦的 Pst 的 cDNA 的 microarray 离开的 hybridizing 决定。时间功课学习识别了是在一个兼容相互作用在感染过程期间表示的差别的 55 个抄本。他们被识别有与下列生物进程有关的函数,包括糖类和类脂化合物新陈代谢,精力,发信号的房间,蛋白质合成,房间结构和分割。在一个不兼容的相互作用,病原体的 17 个抄本是在与无毒害的 Pst 赛跑,其十在兼容相互作用有类似的表示模式到那些接种的抵抗小麦叶子表示的差别。相关基因也是的致病力和毒力 / 无毒性的几个候选人识别了。量的即时 PCR 的结果验证了一些选择基因的表示模式。学习证明特定的 oligonucleotide microarray 技术是有用的决定涉及 hostpathogen 相互作用的不同类型和开发的阶段的病原体基因的表示模式。 | Xueling Huang Xianming Chen Tristan Coram Meinan Wang Zhensheng Kang | 2011 | Journal of Genetics and Genomics2011，38，8： | 2 |
| 20 | Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson’s disease显示文摘Parkinson’s disease(PD)is the most common neurodegenerative movement disorder,which is characterized by the progressive loss of dopaminergic neurons in the Substantia Nigra pars compacta concomitant with Lewy body formation in affected brain areas.The detailed pathogenic mechanisms underlying the selective loss of dopaminergic neurons in PD are unclear,and no drugs or treatments have been developed to alleviate progressive dopaminergic neuron degeneration in PD.However,the formation ofα-synuclein-positive protein aggregates in Lewy body has been identified as a common pathological feature of PD,possibly stemming from the consequence of protein misfolding and dysfunctional proteostasis.Proteostasis is the mechanism for maintaining protein homeostasis via modulation of protein translation,enhancement of chaperone capacity and the prompt clearance of misfolded protein by the ubiquitin proteasome system and autophagy.Deregulated protein translation and impaired capacities of chaperone or protein degradation can disturb proteostasis processes,leading to pathological protein aggregation and neurodegeneration in PD.In recent years,multiple molecular targets in the modulation of protein translation vital to proteostasis and dopaminergic neuron degeneration have been identified.The potential pathophysiological and therapeutic significance of these molecular targets to neurodegeneration in PD is highlighted. | Zhi Dong Zhou Thevapriya Selvaratnam Ji Chao Tristan Lee Yin Xia Chao Eng-King Tan | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
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