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| 1 | Serum proinflammatory cytokines and nutritional status in pediatric chronic liver disease显示文摘AIM: To evaluate the nutritional status and its association with proinflammatory cytokines in children with chronic liver disease.METHODS: We performed a cross-sectional study with 43 children and adolescents, aged 0 to 17 years, diagnosed with chronic liver disease. All patients regularly attended the Pediatric Hepatology Unit and were under nutritional follow up. The exclusion criteria were fever from any etiology at the time of enrollment, inborn errors of the metabolism and any chronic illness. The severity of liver disease was assessed by Child-Pugh, Model for End-stage Liver Disease(MELD) and Pediatric End Stage Liver Disease(PELD) scores. Anthropometric parameters were height/age, body mass index/age and triceps skinfold/age according to World Health Organization standards. The cutoff points for nutritional status were risk of malnutrition(Z-score <-1.00) and malnutrition(Z-score <-2.00). Interleukin-1β(IL-1β), IL-6 and tumor necrosis factor-α levels were assessed by commercial ELISA kits. For multivariate analysis, linear regression was applied to assess the association between cytokine levels, disease severity and nutritional status. RESULTS: The median(25th-75 th centile) age of the study population was 60(17-116)-mo-old, and 53.5% were female. Biliary atresia was the main cause of chronic liver disease(72%). With respect to Child-Pugh score, cirrhotic patients were distributed as follows: 57.1% Child-Pugh A, a mild presentation of the disease, 34.3% Child-Pugh B, a moderate stage of cirrhosis and 8.6% Child-Pugh C, were considered severe cases. PELD and MELD scores were only above the cutoff point in 5 cases. IL-6 values were increased in patients at nutritional risk(34.9%) compared with those who were well-nourished [7.12(0.58-34.23) pg/m L vs 1.63(0.53-3.43) pg/m L; P = 0.02], correlating inversely with triceps skinfold-for-age z-score(rs =-0.61; P < 0.001). IL-6 levels were associated with liver disease severity assessed by Child-Pugh score(P = 0.001). This association remained significant after adjusting for nutritional status in a linear regression model. CONCLUSION: High IL-6 levels were found in children with chronic liver disease at nutritional risk. Inflammatory activity may be related to nutritional status deterioration in these patients. | Daniele Santetti Maria Inês de Albuquerque Wilasco Cristina Toscani Leal Dornelles Isabel Cristina Ribas Werlang Fernanda Urruth Fontella Carlos Oscar Kieling Jorge Luiz dos Santos Sandra Maria Goncalves Vieira Helena Ayako Sueno Goldani | 2015 | World Journal of Gastroenterology2015，21，29： | 2 |
| 2 | The uhrapotassic rocks: Characteristics, classification, and constraints for petrogenetic models显示文摘 | Foley S F Venturelli G Green D H Toscani L | 1987 | Earth Sci Rev1987，24，2： | 1 |
| 3 | A fast, simplified frequency-domain interpolation method for the evaluation of the frequency and amplitude of spectral components 显示文摘 | FERRERO A SALICONE S TOSCANI S | 2011 | IEEE Transactions on Instrumentation and Measurement2011，60，5： | 1 |
| 4 | Thermodynamic study of sulfanilamide polymorphism:(Ⅰ) monotropy of the a-variety显示文摘 | Toscani S Thoren S Agafonov V | 1995 | Pharm Res1995，12，10： | 1 |
| 5 | Influence of abiotic parameters on ochratoxin A production by a Penicillium nordicum strain in dry-cured meat model systems显示文摘 | BATTILANI P FORMENTI S TOSCANI T etal | 2010 | Food Control2010，21，12： | 1 |
| 6 | A fast,simplified frequency-domain interpolation method for the evaluation of the frequency and amplitude of spectral components显示文摘 | Ferrero A Salicone S Toscani S | 2011 | IEEE Transactions on Instrumentation and Measurement2011，60，5： | 1 |
| 7 | A fast, simplified frequency - domain interpolation method for the evaluation of the frequency and amplitude of spectral components显示文摘 | Ferrero A Salicone S Toscani S | 2011 | IEEE Transactions on Instrumentation and Measurement2011，60，5： | 1 |
| 8 | Thermodynamic study of sulfanilamide Polymorphism: (Ⅰ)monotropy of the α-variety显示文摘 | 10,Toscani S Thoren S Agafonov V | 1995 | Pharm Res1995，12，10： | 1 |
| 9 | Thermodynamic study of sulfanilamide polymorphism: ( Ⅰ ) monotropy of the a-variety显示文摘 | TOSCANI S THOREN S AGAFONOV V | 1995 | Pharm Res1995，12，10： | 1 |
| 10 | The ultrapo- tassic rocks: Characteristics, classification, and constraints for petrogenetic models 显示文摘 | Foley S F Venturelli G Green D H Toscani L | 1987 | Earth Sci Rev1987，24，2： | 1 |
| 11 | Nondestructive testing of steel fiber reinforced concrete using a magnetic approaeh显示文摘 | Failer M Ottoboni R Toscani S Ferrara L | 2011 | IEEE Trans Instrum Meas2011，60，5： | 1 |
| 12 | Electronic combinedtransformer for power-quality measurements in high-volt-age 8ystems显示文摘 | Faifer M’Toscani S Ottoboni R | 2011 | IEEE Trans on Instrumentation and Mea-surement2011，60，6： | 1 |
| 13 | Low Frequency Electrical and Magnetic Methods for Non-Destructive Analysis of Fiber Dispersion in Fiber Reinforced Cementitious Composites: An Overview显示文摘 | Faifer M Ferrara L Ottoboni R Toscani S | 2013 | Sensors2013，13，： | 1 |
| 14 | Electronic combined transformer for power-quality measurements in high-voltage systems 显示文摘 | FAIFER M TOSCANI S OTFOBONI R | 2011 | IEEE Transactions on In- strumentation and Measurement2011，60，6： | 1 |
| 15 | The ultrapotassic rocks: characteristics, classification, mid constraints for petrogenetic models显示文摘 | Foley S F Venturelli G Green D H and Toscani L | 1987 | Earth-Science Reviews1987，24，： | 1 |
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