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218篇 您的检索式：作者名="TOMLINSON E"

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	题名	作者	年代	出处	被引量
1	The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients.	Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens	2016	Bone Research2016，4，2：	6
2	The role of causal attribution di-mensions in trust repair显示文摘	TOMLINSON E C MAYER R C	2009	Academy of Management Review2009，34，1：	1
3	Controllable gene therapy Pharmaceutics of non-viral gene delivery systems显示文摘	TOMLINSON E ROLLAND A P	1996	J Controlled Release1996，39，：	1
4	The role of causal attribution dimensions in trust repair显示文摘	Tomlinson E C and Mayer R C	2009	Academy of Management Review2009，34，1：	1
5	Sucrose-metabolizing enzymes in transport tissue as determinants of sucrose concentration in developing citrus fruit显示文摘	LOWELL C A TOMLINSON P T KOCH K E	1989	Plant Physiol1989，90，4：	1
6	Sucrose-metabolizing enzymes in transport tissue and adjacent sink structures in de- veloping citrus fruit 显示文摘	Lowell C A Tomlinson P T Koch K E	1989	Plant Physiol1989，90，：	1
7	The role of causal attributiondimensions in trust repair显示文摘	Tomlinson E C Meyer R C	2009	Academy of Management Re-view2009，34，1：	1
8	Neuritin mediates nerve growth factor-induced axonal regeneration and is deficient in experimental diabetic neuropathy显示文摘	Karamoysoyli E Burnand RC Tomlinson DR	2008	Diabetes2008，57，1：	1
9	Ne- uritin mediates nerve growth factor-induced axonal re- generation and is deficient in experimental diabetic nan- ropathy显示文摘	Karamoysoyli E Burnand RC Tomlinson DR	2008	Diabetes2008，57，1：	1
10	Including the urban heat island in spatial heat health risk assessment strategies: a case study for Birmingham, UK显示文摘	TOMLINSON C J CHAPMAN L THORNES J E	2011	International Journal of Health Geographies2011，10，1：	1
11	Measuring stress intensity factors during fatigue crack growth using thermoelasticity显示文摘	Diaz F A Patterson E A Tomlinson R A	2004	Fatigue&Fracture of Engineering Materials&Structures2004，27，7：	1
12	Sucrose-metabolizing enzymes in transport tissue and adjacent sink structures in developing citrus fruit 显示文摘	Lowell C A Tomlinson P T Koch K E	1989	Plant Physiol1989，90，：	1
13	Sucrose-metabolizing enzymes in transport tissue and adjacent sink structures in developing citrus fruit 显示文摘	Lowell C A Tomlinson P T Koch K E	1989	Plant Physiol1989，90，：	1
14	Transgenic mice expressing human fibroblast growth factor - 19 display increased and decreased adiposity显示文摘	Tomlinson E Fu L John L	2002	Endocrinology2002，143，5：	1
15	Impacts of dystoeia on health and survival of dairy calves 显示文摘	Lombard J E Garry F B Tomlinson S M et ol	2007	J Dairy Sei2007，90，4：	1
16	cDNA se- quence of human apolipoprotein (a) is homologous to plas- minogen显示文摘	McLean J W Tomlinson J E Kuang W J	1987	Nature1987，，330：	1
17	Sucrose Metabolizing Enzymes in Transport Tissue and Adjacent Sink Structures in Developing Citrus Fruit 显示文摘	LOWELL C A TOMLINSON P T KOCH K E	1989	Plant physiol1989，90，4：	1
18	Im- pacts of dystocia on health and survival of dairy calves 显示文摘	LOMBARD E GARRY F B TOMLINSON S M	2007	Journal of Dairy Science2007，90，4：	1
19	Including the urban heat island in spatial heat health risk assessment strategies: A case study for birmingham, UK显示文摘	Tomlinson C J Chapman L Thomes J E	2011	Int J Health Geogr2011，10，：	1
20	Neuritin mediates nerve growth factor - induced axonal regeneration and is efficient in experimental diabetic neuropathy 显示文摘	Karamoysoyli E Bumand RC Tomlinson DR	2008	Diabetes2008，57，1：	1

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