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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 3 | A model for strong attenuation and dispersion of seismic P-waves in a partially saturated fractured reservoir显示文摘In this work we interpret the data showing unusually strong velocity dispersion of P-waves (up to 30%) and attenuation in a relatively narrow frequency range. The cross-hole and VSP data were measured in a reservoir, which is in the porous zone of the Silurian Kankakee Limestone Formation formed by vertical fractures within a porous matrix saturated by oil, and gas patches. Such a medium exhibits significant attenuation due to wave-induced fluid flow across the interfaces between different types of inclusions (fractures, fluid patches) and background. Other models of intrinsic attenuation (in particular squirt flow models) cannot explain the amount of observed dispersion when using realistic rock properties. In order to interpret data in a satisfactory way we develop a superposition model for fractured porous rocks accounting also for the patchy saturation effect. | BRAJANOVSKI Miroslav MüLLER Tobias M PARRA Jorge O | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，8： | 4 |
| 4 | Assessment of stricturing Crohn's disease:Current clinicalpractice and future avenues显示文摘Crohn's disease(CD) is a chronic remittent idiopathic disease. Although the early phase of the disease is commonly characterized by inflammation-driven symptoms, such as diarrhea, the frequency of fibrostenotic complications in patients with CD increases over the long-term course of the disease. This review presents the current diagnostic options for assessing CD-associated strictures. In addition to the endoscopic evaluation of CD strictures, this review summarizes the currently available imaging modalities, including ultrasound and cross-sectional imaging techniques. In addition to stricture detection, differentiating between the primarily inflammatory strictures and the predominantly fibrotic ones is essential for selecting the appropriate treatment strategy(anti-inflammatory medical treatment vs endoscopical or surgical approaches). Therefore, recent imaging advances, such as contrast-enhanced ultrasound and ultrasound elastography, contribute to the development of noninvasive non-radiating imaging of CD-associated strictures. Finally, novel magnetic resonance imaging techniques, such as diffusion-weighted, motility and magnetization transfer imaging, as well as 18F-FDG PET/CT, molecular imaging approaches and biomarkers, are critically reviewed with regard to their potential role in assessing stricturing CD. | Dominik Bettenworth Tobias M Nowacki Friederike Cordes Boris Buerke Frank Lenze | 2016 | World Journal of Gastroenterology2016，22，3： | 4 |
| 5 | Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound显示文摘AIM To study mucosal addressin cellular adhesion molecule-1(MAd CAM-1) and vascular endothelial growth factor(VEGF)-targeted contrast enhanced ultrasound(CEUS) for the assessment of murine colitis and carcinogenesis. METHODS C57BL/6 mice were challenged with 3% dextran sodium-sulfate(DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAd CAM-1-targeted contrast agent was used to detect and quantify MAd CAM-1 expression. Inflammatory driven colorectal azoxymethane(AOM)/DSS-induced carcinogenesis was examined on day 42 and 84 using VEGF-targeted contrast agent. Highly specific tissue echogenicity was quantified using specialized software. Sonographic findings were correlated to tissue staining, western blot analysis and immunohistochemistry to quantify the degree of inflammation and stage of carcinogenesis. RESULTS Native ultrasound detected increased general bowel wall thickening that correlated with more progressed and more severe DSS-colitis(healthy mice: 0.3 mm ± 0.03 vs six days DSS: 0.5 mm ± 0.2 vs nine days DSS: 0.6 mm ± 0.2, P < 0.05). Moreover, these sonographic findings correlated well with clinical parameters such as weight loss(r2 = 0.74) and histological damage(r2 = 0.86)(P < 0.01). In acute DSS-induced murine colitis, CEUS targeted against MAd CAM-1 detected and differentiated stages of mild, moderate and severe colitis via calculation of mean pixel contrast intensity in decibel(9.6 d B ± 1.6 vs 12.9 d B ± 1.4 vs 18 d B ± 3.33, P < 0.05). Employing the AOM/DSSinduced carcinogenesis model, tumor development was monitored by CEUS targeted against VEGF and detected a significantly increased echogenicity in tumors as compared to adjacent healthy mucosa(healthy mucosa, 1.6 d B ± 1.4 vs 42 d, 18.2 d B ± 3.3 vs 84 d, 18.6 d B ± 4.9, P < 0.01). Tissue echogenicity strongly correlated with histological analysis and immunohistochemistry findings(VEGF-positive cells in 10 high power fields of healthy mucosa: 1 ± 1.2 vs 42 d after DSS start: 2.4 ± 1.6 vs 84 d after DSS start: 3.5 ± 1.3, P < 0.01). CONCLUSION Molecularly targeted CEUS is a highly specific and noninvasive imaging modality, which characterizes murine intestinal inflammation and carcinogenesis in vivo. | Markus Brückner Jan Heidemann Tobias M Nowacki Friederike Cordes Jorg Stypmann Philipp Lenz Faekah Gohar Andreas Lügering Dominik Bettenworth | 2017 | World Journal of Gastroenterology2017，23，16： | 4 |
| 6 | 增压器:高性能发动机的关键技术显示文摘通过增加增压系统可以提高内燃机性能。增压器可以压缩空气以使更多氧气能够流入燃烧室,这样可以燃烧更充分,从而提高发动机输出功率。增压器由废气驱动,这就使得涡轮增压柴油机非常高效。MTU公司为自主研制高性能发动机而不断开发这一关键技术。 | Johannes Kech Ronald Hegner Tobias Mnnle 杨名 | 2016 | 国外铁道机车与动车2016，，3： | 2 |
| 7 | Hepatitis B virus subgenotype F3 reactivation with vaccine escape mutations:A case report and review of the literature显示文摘Hepatitis B represents a global health threat because its chronic course and sequelae contribute to a high morbidity and mortality. Hepatitis B virus(HBV) infection can be controlled by vaccines, antiviral treatment, and by interrupting transmission. Rare vaccine escape mutants are serious because they eliminate vaccine protection. Here, we present a 74-year-old vaccinated patient with HBV reactivation 11 years after kidney transplantation. The patient was HBV-positive but HBs Ag-negative prior to vaccination 6 years before transplantation. The reactivated virus was HBV genotype F3 with vaccine escape mutations G145 R, P120 Q, and Q129 P. The patient was successfully treated with entecavir. The epidemiological reasons for this subgenotype, which is extremely rare in Western Europe, were unclear. This case illustrates that second-generation vaccines are not always effective in a specific group of patients. | Stefan Schlabe Kathrin van Bremen Souhaib Aldabbagh Dieter Glebe Corinna M Bremer Tobias Marsen Walter Mellin Veronica Di Cristanziano Anna M Eis-Hübinger Ulrich Spengler | 2018 | World Journal of Hepatology2018，10，7： | 2 |
| 8 | Measurement of bound states in the continuum by a detector embedded in a photonic crystal显示文摘We directly measure optical bound states in the continuum(BICs)by embedding a photodetector into a photonic crystal slab.The BICs observed in our experiment are the result of accidental phase matching between incident,reflected and in-plane waves at seemingly random wave vectors in the photonic band structure.Our measurements were confirmed through a rigorously coupled-wave analysis simulation in conjunction with temporal coupled mode theory.Polarization mixing between photonic crystal slab modes was observed and described using a plane wave expansion simulation.The ability to probe the field intensity inside the photonic crystal and thereby to directly measure BICs represents a milestone in the development of integrated opto-electronic devices based on BICs. | Roman Gansch Stefan Kalchmair Patrice Genevet Tobias Zederbauer Hermann Detz Aaron M Andrews Werner Schrenk Federico Capasso Marko Lončar Gottfried Strasser | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 9 | Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection显示文摘 | Eckart Schott Heiko Witt Holger Hinrichsen Konrad Neumann Viola Weich Alexandra Bergk Juliane Halangk Tobias Müller Sebastian Tinjala Gero Puhl Peter Neuhaus Bertram Wiedenmann Thomas Berg | 2006 | Journal of Hepatology2006，，3： | 2 |
| 10 | Delayed transplantation of fibroblasts genetically modified to secrete BDNF and NT -3 into a spinal cord injury site is associated with limited recovery of Function 显示文摘 | Shumsky JS Tobias CA Tumolo M | 2003 | Experimental Neurology2003，184，1： | 1 |
| 11 | Effects of habitat and landscape fragmentation on humans and hiodiversity in densely populated landscapes显示文摘 | Giulio M D Holderegger R Tobias S | 2009 | Journal o( Environmental Mmagement2009，90，10： | 1 |
| 12 | Probability hypothesis density-based multitarget tracking with bistatic range and doppler observations显示文摘 | Tobias M and Lanterman A D | 2005 | IET Radar Sonar and Navigation2005，152，3： | 1 |
| 13 | SELaKT-social network analysis as a method for expert localization and sustainable knowledge transfer显示文摘 | TOBIAS M PROTHMANN I | 2004 | Journal of Universal Computer Science2004，10，6： | 1 |
| 14 | The APN'sguide to pediatric constipation management 显示文摘 | Mason D Tobias N Lutkenhoff M | 2004 | Nurse Pract2004，29，7： | 1 |
| 15 | The APN's guide to ped- iatric constipation management显示文摘 | Mason D Tobias N Lutkenhoff M et a l | 2004 | The Nurse Practitioner2004，29，7： | 1 |
| 16 | Investigating the five facet mindfulness questionnaire (FFMQ):construction of a short form and evidence of a two-factor higher order structure of mindfulness显示文摘 | ULRICH S TRAN TOBIAS M GLUCK INGO W NADER | 2013 | Journal of Clinical Psychology2013，69，9： | 1 |
| 17 | Procalcitonin and interleukin 6 for predicting blood culture positivity in sepsis显示文摘 | Naffaa M Makhoul BF Tobia A | 2014 | Am J Emerg Med2014，32，5： | 1 |
| 18 | Influence of the temperature on the release of inorganic species during high-temperature gasification of hardcoal显示文摘 | Marc B Tobias M Michael M | 2010 | Energy Fuels2010，24，： | 1 |
| 19 | The role of dietary zinc in modifying the onset and severity of spontaneous diabetes in the BB Wister rat显示文摘 | Tobia M H Zdanowicz M M Wingertzahn M A | 1998 | Mol Genet Metab1998，63，3： | 1 |
| 20 | Dexmedetomidine for the treatment of postanesthesia shivering in children显示文摘 | BLAINE EASLEY R BRADY K M TOBIAS J D | 2007 | Paediatr Anaesth2007，17，4： | 1 |
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