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| 1 | m^6A mRNA methylation sustains Treg suppressive functions显示文摘 | Jiyu Tong Guangchao Cao Ting Zhang Esen Sefik Maria Carolina Amezcua Vesely James P Broughton Shu Zhu Huabin Li Bin Li Lei Chen Howard Y Chang Bing Su Richard A Flavell Hua-Bing Li | 2018 | Cell Research2018，28，2： | 30 |
| 2 | Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation显示文摘通过 ubiquitination 小径的 p53 蛋白质周转是在它的 transcriptional 活动的规定的重要机制;然而,很少通过 proteasome 独立的小径对 p53 周转被知道。消化机关扩大因素(Def ) 蛋白质为消化机关的发展是必要的。在 zebrafish, def 的功能的损失有选择地 upregulates p53 反应基因的表示,它提出至于是在 Def 和 p53 之间的关系的一个问题。我们这里报导 Def 是核仁的蛋白质并且 def 的功能的损失导致 p53 蛋白质的 upregulation,它令人惊讶地在 nucleoli 积累。我们的广泛的研究证明了 Def 能调停这个过程是的 p53 蛋白质和那的降级在 Calpain3 的活动独立于 proteasome 小径,却依赖,半胱氨酸朊酶。我们的调查结果定义调整 p53 的周转功能的一条新奇核仁的小径,它将在 organogenesis 和 tumorigenesis 推进我们 p53 的角色的理解。 | Ting Tao Hui Shi Yihong Guan Delai Huang Ye Chen David P Lane Jun Chen Jinrong Peng | 2013 | Cell Research2013，23，5： | 8 |
| 3 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 4 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 5 | Inventory replenishment policy for deteriorating items with a linear trend in demand considering shortages显示文摘 | Ting P S Chung K J | 1994 | International Journal of Operations and Production Management1994，，14： | 1 |
| 6 | Sorption of lead, copper, cadmium, zinc, and nickel by marine algal biomass: characterization of biosorptive capacity and investigation of mechanisms 显示文摘 | Sheng P Ting Y Chen J | 2004 | J Colloid Interface Sci2004，275，： | 1 |
| 7 | A DNA biosensor based on the detection of doxorubicin-conjugated Ag nanoparticle labels using solid-state voltammetry显示文摘 | Ting B P Zhang J Gao Z | 2009 | Biosensors and Bioelectronics2009，25，2： | 1 |
| 8 | The impact of renal insufficiency on clinical outcomes in patients undergoing percutaneous coronary inter-ventions显示文摘 | Best P J Lennon R Ting H H | 2002 | Am Coll Cardiol2002，39，： | 1 |
| 9 | Miniaturized Micros-Trip Low Pass Filter with Wide Stop-Band Using Double Equilateral U- Shaped Defected Ground Structure 显示文摘 | Ting S W Tam K W Martins R P | 2006 | IEEE Microwave and Wireless Components Letters2006，16，5： | 1 |
| 10 | Uptake of cadmium and zinc by the alga Chlorella vulgaris (II):Multi-ion situation显示文摘 | TING Y P PRINCE I G LAWSON F | 1991 | Biotechnol Bioeng1991，37，： | 1 |
| 11 | The addition of hydrogen to a gasoline-fuelled SI engine显示文摘 | HENSHAW P F TING D S K | 2004 | International Journal of Hydrogen Energy2004，，29： | 1 |
| 12 | Schedule coordination in a multiple hub transit network显示文摘 | Ting C J Schonfeld P | | 0，，02： | 1 |
| 13 | Miniaturized microstrip lowpass filter with wide stopband using double equilateral U-shaped defected ground structure显示文摘 | Ting S-W Tam K-W Martins R P | 2006 | IEEE Microwave and Wireless Component Letters2006，16，5： | 1 |
| 14 | Electrospun ZnO Nanowires as Gas Sensors for Ethanol Detection 显示文摘 | W Y Wu 3 M Ting P 3 Huang | 2009 | Nanoscale Res Lett2009，4，： | 1 |
| 15 | Theeffect of modification on structure and dynamic mechan-ical behavior during the processing of acrylic fiber tostabilized fiber显示文摘 | KO T H CHIRANAIRADUL P TING H Y | 1989 | Applied polymer science1989，37，1： | 1 |
| 16 | Genetic control of MHC class Ⅱ expression显示文摘 | TING J P TROWSDALE J | 2002 | Cell2002，109，： | 1 |
| 17 | Sorption of lead, copper, cadmium, zinc and nickel by marine algal biomass : Characterization of biosorptive capacity and investigation of mechanisms显示文摘 | Sheng P X Ting Y P Chen J P | 2004 | Journal of Colloid Interface Science2004，275，1： | 1 |
| 18 | Understanding Microblog Us-ers for Social Recommendation Based on Social Networks Analy- sis 显示文摘 | Ting I H Chang P S Wang S L | 2012 | The Journal of Universal Computer Science2012，18，4： | 1 |
| 19 | Papulonecrotic tuberculid:a rare form of cutaneous tuberculosis显示文摘 | Freiman A Ting P Miller M | | 0，，06： | 1 |
| 20 | An inventory model with non-instantaneous re- ceipt and exponentially deteriorating items for an in- tegrated three layer supply chain system under two levels of trade credit显示文摘 | CHUNG K J CdRDENAS-BARRSN L E TING P S | 2014 | International Journal of Production Economics2014，155，9： | 1 |
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