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| 1 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 2 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
| 3 | Penetration simulation for uncontained engine debris impact on fuselage-likepanels using LS-DYNA显示文摘 | Knight N F Jaunky N Lawson R E | 2000 | Finite Elements in Analysis and Design2000，，36： | 1 |
| 4 | Uptake of cadmium and zinc by the alga Chlorella vulgaris (II):Multi-ion situation显示文摘 | TING Y P PRINCE I G LAWSON F | 1991 | Biotechnol Bioeng1991，37，： | 1 |
| 5 | An electrochemical study of the effect of chloride ions on the dissolution of chalcopyrite in acidic solutions 显示文摘 | Lu Z Y Jeffery M I Lawson F | 2000 | Hydrometallurgy2000，56，2： | 1 |
| 6 | Simplified design of composit beams with large Web Openings to Eureeode 4 显示文摘 | Chung K F Lawson R M | 2001 | Journal of Construction Steel Research2001，57，： | 1 |
| 7 | Development and application of molecular marker linkage maps in woody fruit crops显示文摘 | N F Weeden M Hemmatt D M Lawson M Lodhi R L Bell A G Manganaris B I Reischs S K Brown G N Ye | 1994 | Euphytica1994，77，12： | 1 |
| 8 | Simplified design of composite beams with large web openings to Eurocode 4显示文摘 | Chung K F Lawson R M | 2001 | Journal of Constructional Steel Research2001，114，3： | 1 |
| 9 | Hydrolysis of 2-hydroxy-4-(methyhhio)- butanoic acid dimmer in two model systems 显示文摘 | Lawson C Q Ivey F J | 1986 | Poultry Sci1986，65，： | 1 |
| 10 | Transverse infrahyoid approach to bilateral glottic tumors显示文摘 | REINO A J LAWSON W BILLER H F | 1999 | Ann Otol Rhinol Laryngol1999，108，： | 1 |
| 11 | Using the Input-Output Diagram to Determine the Spatial and Temporal Extents of a Queue Upstream of a bottleneck显示文摘 | Lawson T W Lovell D J Daganzo C F | 1997 | Transportation Research Record1997，1572，： | 1 |
| 12 | Tourism and recreational development显示文摘 | Lawson F M Baud-Bovy | 1977 | 1977，，： | 1 |
| 13 | Primary biliary carcinoma :CT evaluation显示文摘 | Thorsen MK Quiroz F Lawson TL | 1984 | Radiology1984，152，4： | 1 |
| 14 | Using the input-output diagram to determine the spatial and temporal extents of a queue upstream of a bottleneck显示文摘 | Lawson T W Lovell D J Daganzo C F | | 0，，11： | 1 |
| 15 | Automatic extraction of citations from the text of english language pa- tents-an example of template mining显示文摘 | LAWSON M KEMP N LYNCH M F | 1996 | Journal of In- formation Science1996，22，6： | 1 |
| 16 | Report of the committee on the nomenclature of faults 显示文摘 | Reid H F Davis W M Lawson A C | 1914 | Geologische Rundsehau1914，5，4： | 1 |
| 17 | Calcium Carbonate Precipitation by Ureolytic Subsurface Bacleria显示文摘 | Fujita Y Ferris F G Lawson R D | 2000 | Geomicrobiology Journal2000，17，4： | 1 |
| 18 | Kinetics of Heterogeneous reduction of arsenic (V) to arsenic (III) with sulphur dioxide 显示文摘 | LI N LAWSON F | 1989 | Hydrometallurgy1989，22，： | 1 |
| 19 | Induction of gamma-glutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells 显示文摘 | Rahman I Smith C A Lawson M F | 1996 | FEBS Lett1996，396，1： | 1 |
| 20 | Homocysteine and atherothrombosis显示文摘 | Lawson M F | 1998 | N Engl J Med1998，339，7： | 1 |
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