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| 1 | 平均动脉压、脉压与全因死亡率的纵向变化:来自71629名未经治疗的正常高值血压参与者的数据显示文摘血压通常包括平稳成分[平均动脉压(mean arterial pressure,MAP)]和波动成分,都可独立预测死亡率。目前还没有针对中心脉压(central pulse pressure,cPP)、肱动脉脉压(brachial pulse pressure,bPP)、MAP的纵向变化与死亡率之间关系的调查。方法:对年龄16~95岁未接受高血压治疗的71 629例参与者进行2次常规检查. | Protogerou AD Vlachopoulos C Thomas F Zhang Y Pannier B Blacher J Safar ME 陈云 | 2018 | 中华高血压杂志2018，26，8： | 4 |
| 2 | Neutralizing antibodies in hepatitis C virus infection显示文摘Hepatitis C virus (HCV) is a major cause of hepatitis world-wide. The majority of infected individuals develop chronic hepatitis which can then progress to liver cirrhosis and hepatocellular carcinoma. Spontaneous viral clearance occurs in about 20%-30% of acutely infected individuals and results in resolution of infection without sequaelae. Both viral and host factors appear to play an important role for resolution of acute infection. A large body of evidence suggests that a strong, multispecific and long-lasting cellular immune response appears to be important for control of viral infection in acute hepatitis C. Due too the lack of convenient neutralization assays, the impact of neutralizing responses for control of viral infection had been less defined. In recent years, the development of robust tissue culture model systems for HCV entry and infection has finally allowed study of antibody-mediated neutralization and to gain further insights into viral targets of host neutralizing responses. In addition, detailed analysis of antibody-mediated neutralization in individual patients as well as cohorts with well defined viral isolates has enabled the study of neutralizing responses in the course of HCV infection and characterization of the impact of neutralizing antibodiesfor control of viral infection. This review will summarize recent progress in the understanding of the molecular mechanisms of antibody-mediated neutralization and its impact for HCV pathogenesis. | Mirjam B Zeisel Samira Fafi-Kremer Isabel Fofana Heidi Barth Franoise Stoll-Keller Michel Doffo■l Thomas F Baumert | 2007 | World Journal of Gastroenterology2007，13，36： | 3 |
| 3 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 4 | Modeling superheat removal during continuous casting of steel slabs显示文摘 | Huang X Thomas B G Najjar F M | 1992 | Metall Trans B1992，23，： | 2 |
| 5 | Mechanisms of formation damage and permeability impairment associated with the drilling,completion and production of low API gravity oil reservoirs显示文摘 | Thomas F B Bennion D W | 1996 | SPE 303201996，，： | 1 |
| 6 | computer analysis of the tonic,phasic,and kinesthetic activity of pallidal discharges in parkinson patients显示文摘 | Jacques F Jamal M Thomas B | 1999 | Surg Neurol1999，51，： | 1 |
| 7 | Regulation of epidermal apoptosis and DNA repair by E2F1 in response to ultraviolet B radiation显示文摘 | THOMAS R B DAVID L M GUO R F | 2005 | Oncogene2005，24，15： | 1 |
| 8 | Sampling errors in the estimation of empirical orthogonal functions显示文摘 | North G B Thomas L B Cahalan R F | 1982 | Men Wen Bey1982，110，： | 1 |
| 9 | Primary geometric perforce indices for analysis and synthesis of a fruit harvesting robot arm显示文摘 | SIVARAMAN B THOMAS F B | 2006 | Trans ASAE2006，49，5： | 1 |
| 10 | Application of heat treatment to enhance permeability in tight gas reservoirs显示文摘 | Jamaluddin A K M Bennion D B Thomas F B | 2000 | JCPT2000，39，11： | 1 |
| 11 | Reductions in the productivity of oil and low permeability gas reservoirs due to aque- ous phase trapping 显示文摘 | Bennion D B Bietz R F Thomas F B | 1994 | Journal of Crgstallization Process and Tech- nology1994，33，8： | 1 |
| 12 | Numerical study of steady turbulent flow through bifurcated nozzles in continu- ous casting显示文摘 | Najjar F Thomas B Hershey D | 1995 | Metall Mater Trans B1995，26，4： | 1 |
| 13 | Epidemiology of stroke and its subtypes in Chinese vs white populations: a systematic review显示文摘 | Tsai C F Thomas B Sudlow C L M | 2013 | Neurology2013，81，3： | 1 |
| 14 | cDNA cloning of cyto- plasmic ribosomal protein S7 of winter rye(Secale cereale) and its expression in low-temperature-treated leaves显示文摘 | THOMAS B MICHAEL U JU'RGEN F | 2000 | Biochim Biophys Acta2000，1492，1： | 1 |
| 15 | Collapsing glomerulopathy associ ated with inherited mitochondriai injury显示文摘 | Barisoni L Diomedi-Camassei F Santorelli F M Caridi G Thomas D B Emma F | 2008 | Kidney Int2008，74，： | 1 |
| 16 | Manganese(Ⅲ)acetate mediated radical reactions in the presence of an ionic liquid显示文摘 | BAR G PARSONS A F THOMAS C B | 2001 | ChemCommun2001，15，： | 1 |
| 17 | Remediation of water and hydrocarbon phase trapping problems in low permeability gas reservoirs显示文摘 | BENNION D B THOMAS F B BIETZ R F | | 0，，8： | 1 |
| 18 | Colloid and heavy metal transport at landfill sites in direct contact with groundwater显示文摘 | Thomas B Peter F Thorsten K | 2006 | Water Research2006，40，14： | 1 |
| 19 | Fuel options for the fuel cell vehicle:hydrogen,methanol or gasoline显示文摘 | Thomas C E James B D Lomax F D | 2000 | Hydrogen Energy2000，25，： | 1 |
| 20 | 查看详情显示文摘 | Van de Vyver S Thomas J Geboers J Keyzer S Smet M Dehaen W Jacobs P A Sels B F | | 0，，09： | 1 |
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