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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 3 | 平均动脉压、脉压与全因死亡率的纵向变化:来自71629名未经治疗的正常高值血压参与者的数据显示文摘血压通常包括平稳成分[平均动脉压(mean arterial pressure,MAP)]和波动成分,都可独立预测死亡率。目前还没有针对中心脉压(central pulse pressure,cPP)、肱动脉脉压(brachial pulse pressure,bPP)、MAP的纵向变化与死亡率之间关系的调查。方法:对年龄16~95岁未接受高血压治疗的71 629例参与者进行2次常规检查. | Protogerou AD Vlachopoulos C Thomas F Zhang Y Pannier B Blacher J Safar ME 陈云 | 2018 | 中华高血压杂志2018，26，8： | 4 |
| 4 | Morbidity and mortality in compensated cirrhosis type C: A retrospective follow-up study of 384 patients显示文摘 | G Fattovich G Giustina F Degos F Tremolada G Diodati P Almasio F Nevens A Solinas D Mura JT Brouwer H Thomas C Njapoum C Casarin P Bonetti P Fuschi J Basho A Tocco A Bhalla R Galassini F Noventa SW Schalm G Realdi | 1997 | Gastroenterology1997，，2： | 2 |
| 5 | Low band gap donoracceptor conjugated polymers toward organic solar cells applications显示文摘 | Kristof C Sofie F Thomas J C | 2007 | Macromolecules2007，40，： | 1 |
| 6 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 7 | Statin induction of liver fatty acid-binding protein(L-FABP)gene expression is peroxisome proliferator-activated receptor-alpha-dependent显示文摘 | Landrier JF Thomas C Grober J Duez H Percevault F Souidi M | 2004 | J Biol Chem2004，279，45： | 1 |
| 8 | Toxicity criteria of The Radiation Therapy Oncology Group (RTOG) and The European Organization for Research and Treatment of Cancer (EORTC)显示文摘 | James D C Joann S Thomas F P | 1995 | Int J Radiation Ontology Bid Phys1995，31，5： | 1 |
| 9 | Shape Distribution显示文摘 | Robert O Thomas F Bernard C | 2002 | ACM Transactions on Graphics2002，21，4： | 1 |
| 10 | Surgery versus radiation theapy for patients with aggressive fibromatosis or desmoid tumors: a comparative review of 22 articles 显示文摘 | NUYTTENS J J RUST P F THOMAS J R C R | 2000 | Cancer2000，88，： | 1 |
| 11 | Aurantiamine, a diketopiperazine from two varieties of Penicilium aurantiogriseum 显示文摘 | Thomas O L Jens C F Soren R J | 1992 | Phytochemistry1992，31，5： | 1 |
| 12 | Transient electromag- netic interference in substations显示文摘 | Wiggins C M Thomas D E Nickel F S | 1994 | IEEE Transations on Power Delivery1994，9，4： | 1 |
| 13 | Epidemiology of stroke and its subtypes in Chinese vs white populations: a systematic review显示文摘 | Tsai C F Thomas B Sudlow C L M | 2013 | Neurology2013，81，3： | 1 |
| 14 | Experimental investiga- tion of the confluent boundary layer of a high-lift system 显示文摘 | Thomas F O Nelson R C Liu X | 2000 | AIAA Journal2000，38，6： | 1 |
| 15 | 3D collision detection:a survey显示文摘 | Jime Hnez P Thomas F Torras C | 2001 | Computers & Graphics2001，25，： | 1 |
| 16 | Nuclear Magnetic Reso- nance Technology for Medical Studic~ 显示文摘 | Thomas F Budinger Paul C L auterbur | 1954 | Sc/ence1954，226，： | 1 |
| 17 | Randomized Study of for Induction and Recombinant Interleukin-2 for Maintenance in Patients With Acute Myeloid Leukemia Age 50 to 70 Years:Results of the ALFA-9801 Study 显示文摘 | Pautas C Merabet F Thomas Intensified Anthracycline Doses X | 2010 | J Clin Oncol2010，28，5： | 1 |
| 18 | Dissolved organic carbon in the equatorial Atlantic Ocean显示文摘 | THOMAS C CAUWET G MINSTER J F | 1995 | Marine Chemistry1995，49，： | 1 |
| 19 | Un- steady plasma actuator for separation control of low- pressure turbine blades 显示文摘 | HUANG J H CORKE T C THOMAS F O | 2006 | AIAA Journal2006，44，7： | 1 |
| 20 | 3D collision detection: a survey 显示文摘 | Jimenez P Thomas F Torras C | 2001 | Computers & Graphics2001，25，2： | 1 |
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