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| 1 | Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma显示文摘Hepatobiliary cystadenomas (HBC) and cystadenocarci- nomas are rare cystic lesions. Most patients with these lesions are asymptomatic, but presentation with ob- structive jaundice may occur. The first patient presented with intermittent colicky pain and recurrent obstructive jaundice. Imaging studies revealed a polypoid lesion in the left hepatic duct. The second patient had recurrent jaundice and cholangitis. Endoscopic retrograde cholan- giopancreatography (ERCP) showed a cystic lesion at the confluence of the hepatic duct. In the third patient with intermittent jaundice and cholangitis, cholangioscopy re- vealed a papillomatous structure protruding into the left bile duct system. In the fourth patient with obstructive jaundice, CT-scan showed slight dilatation of the intrahe- patic bile ducts and dilatation of the common bile duct of 3 cm. ERCP showed filling of a cystic lesion. All patients underwent partial liver resection, revealing HBC in the specimen. In the fifth patient presenting with obstructive jaundice, ultrasound examination showed a hyperecho- genic cystic lesion centrally in the liver. The resection specimen revealed a hepatobiliary cystadenocarcinoma. HBC and cystadenocarcinoma may give rise to obstruc- tive jaundice. Evaluation with cross-sectional imaging techniques is useful. ERCP is a useful tool to differentiate extraductal from intraductal obstruction. | Deha Erdogan Olivier RC Busch Erik AJ Rauws Otto M van Delden Dirk J Gouma Thomas M van Gulik | 2006 | World Journal of Gastroenterology2006，12，35： | 26 |
| 2 | Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease显示文摘AIM: To evaluate the results of the treatment of simple liver cysts (solitary and multiple) and polycystic liver disease (PLD) using percutaneous sclerotherapy and/or surgical procedures in a single tertiary referral centre. METHODS: Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. RESULTS: Simple liver cysts were treated in 41 pts (76/) with a mean size of 12.6 cm. The most common reason for referral was abdominal pain or discomfort (85/). Percutaneous sclerotherapy was performed as initial treatment in 30 pts, showing cyst recurrence in 6 pts (20/). Surgical treatment was initially performed in 11 pts with cyst recurrence in 3 pts (27/). PLD was treated in 13 pts (24/) with a mean size of the dominant cyst of 13 cm. Percutaneous sclerotherapy for PLD was performed in 9 pts with recurrence in 7 pts (77.8/). Surgical treatment for PLD was undertaken in 4 pts (30.8/) with recurrence in all. Eventually, 2 pts with PLD in the presence of polycystic kidney disease underwent liver-and kidney transplantation because of deterioration of liver and kidney function. CONCLUSION: The majority of patients with simple liver cysts and PLD are referred for progressive abdominal pain. As initial treatment, percutaneous sclerotherapy is appropriate. Surgical deroofing is indicated in caseof cyst recurrence after percutaneous sclerotherapy. However, the results of percutaneous sclerotherapy and surgical treatment for PLD are disappointing. Partial liver resection is indicated when there is suspicion of a pre-malignant lesion. | Deha Erdogan Otto M van Delden Erik AJ Rauws Olivier RC Busch Johan S Lameris Dirk J Gouma Thomas M van Gulik | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 3 | Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor显示文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. | Mireen Friedrich-Rust Beate Wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 4 | Depression and vascular disease:what is the relationship显示文摘 | Thomas AJ Kalaria RN O'Brien JT | 2004 | J Affect Disord2004，79，13： | 1 |
| 5 | Stenting and angioplasty of the symptomatic chronically occluded carotid artery显示文摘 | Thomas AJ Gupta R Tayal AH | 2007 | AJNR Am J Neuroradiol2007，28，1： | 1 |
| 6 | Thalidomide-induced severe hepatotoxicity 显示文摘 | HANJE AJ SHAMP JL THOMAS FB | 2006 | Pharmacotherapy2006，26，7： | 1 |
| 7 | Safety, feasibility, and short-term follow-up of drug-eluting stent placement in the intracranial and extracranial circulation 显示文摘 | Gupta R Al-Ali F Thomas AJ | 2006 | Stroke2006，37，10： | 1 |
| 8 | Language hemispheric dominance in patients with congenital lesions of eloquent brain显示文摘 | VIKINGSTAD EM CAO Y THOMAS AJ | 2000 | Neurosurgery2000，47，： | 1 |
| 9 | Effect of aspirin and sodium salicylate on cataract development in diabetic rats 显示文摘 | Shastri GV Thomas M Victoria AJ | 1998 | Indian J Exp Biol1998，36，7： | 1 |
| 10 | Human catechol O-methyltransferase genetic variation:gene resequencing and functional characterization of variant allozymes显示文摘 | Shield AJ Thomae BA Eckloff BW | 2004 | Mol Psychiatry2004，9，2： | 1 |
| 11 | Improvement in motion characteristics and acrosome status in cryopreserved human spermatozoa by swim-up processing before freezing 显示文摘 | Esteves SC Sharma RK Thomas AJ | 2000 | Hum Reprod2000，15，10： | 1 |
| 12 | Improvements in exercise performance with high-intensity interval training coincide with an increase in skeletal muscle mitochondrial content and function 显示文摘 | Robert AJ Daniela F Thomas CB | 2013 | J Appl Physio12013，115，6： | 1 |
| 13 | Effectiveness of crossover transseptal vasoepididymostomy in treating complex obstructive azoospermia显示文摘 | Sabanegh E Thomas AJ Jr | 1995 | Fertil Steril1995，63，： | 1 |
| 14 | Improvement in motion characteristics and acrosome status in cryopreserved human spermatozoa by swim-up processing before freezing显示文摘 | Esteves SC Sharma RK Thomas AJ | 2000 | Hum Reprod2000，15，8： | 1 |
| 15 | The incidence and significance of testicular microlithiasis in a subfertile population显示文摘 | Thomas K Wood SJ Thompson AJ | 2000 | Br J Radiol2000，73，869： | 1 |
| 16 | The incidence and significance of testieular microlithiasis in a subfertile population 显示文摘 | THOMAS K WOOD SJ THOMPSON AJ | 2000 | British Journal of Radiology2000，73，869： | 1 |
| 17 | Transurethral vaporization of the prostate:A promising new technique显示文摘 | Cornaby AJ Hammadeh M | 1997 | Br J Urol1997，79，2： | 1 |
| 18 | Safety,feasibility,and short-term follow-up of drug-eluting stent placement in the intracranial and extracranial circulation显示文摘 | Gupta R Al-Ali F Thomas AJ | 2006 | Stroke2006，37，： | 1 |
| 19 | Long-term incidence of depression and predictors of depressive symptoms in older stroke- survivors显示文摘 | Allan LM Rowan EN Thomas AJ | 2013 | Br J Psychiatry2013，203，6： | 1 |
| 20 | Plasma leptin concentration in fetal sheep during late gestation:ontogeny and effect of glucocorticoids显示文摘 | Thomas L Crabtree J | 2002 | Endocrinology2002，143，4： | 1 |
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