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| 1 | Roles of unphosphorylated STATs in signaling显示文摘信号变换器的七个成员和抄写(STAT ) 的使活跃之物抄写因素的家庭被特定的酷氨酸残余的磷酸化响应许多不同 cytokines 和生长因素激活。STAT1 和 STAT3 基因是激活的 STAT 的特定的目标 1 和 3 分别地,响应干扰素(STAT1 ) 或 ligands 导致这些 unphosphorylated STAT (U-STATs ) 的层次的大增加那活跃 gp130,例如 IL-6 (STAT3 ) 。由从那些不同的新奇机制的 U-STATs 开车基因表示由 phosphorylated STAT (P-STAT ) 使用了暗淡 ers。在这评论,我们在基因表示的抄写和规定讨论 U-STATs 的角色。 | Jinbo Yang George R Stark | 2008 | Cell Research2008，18，4： | 12 |
| 2 | Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes显示文摘Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings.Genetically-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution.We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo.We describe the design,fabrication,and assembly of low-noise,multisite/multicolor optoelectrodes.Each shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design requirements.To better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μW.We implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW illumination.We highlight the potential use of this technology for functional dissection of neural circuits. | Komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon | 2018 | Microsystems & Nanoengineering2018，4，1： | 8 |
| 3 | Lysine methylation of promoter-bound transcription factors and relevance to cancer显示文摘p53, NF 魏 B, STAT3,和几个另外的抄写因素是 reversibly 由也修改 histones 的酶的离氨酸残余上的 methylated。NF 魏 B 和 STAT3 的 methylations 当他们倡导者一定时,发生,建议到 DNA 的可诱导的抄写因素的绑定在帮助到成员染色质修正机械的一个更一般的模型,它然后可以修改不仅 histones 而且界限抄写因素。某 histone 离氨酸 methyltransferases 和 demethylases 的变化被连接到癌症,并且这些变化可以改变不仅 histones 而且抄写因素的 methylation,并且可以因此是通过超过一机制的 tumorigenic。 | George R Stark Yuxin Wang Tao Lu | 2011 | Cell Research2011，21，3： | 3 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Evolution of endovascular mechanical thrombectomy for acute ischemic stroke显示文摘Acute ischemic stroke(AIS) is a common medical problem associated with significant morbidity and mortality worldwide. A small proportion of AIS patients meet eligibility criteria for intravenous thrombolysis(IVT) with recombinant tissue plasminogen activator, and its efficacy for large vessel occlusion is poor. Therefore, an increasing number of patients with AIS are being treated with endovascular mechanical thrombectomy when IVT is ineffective or contraindicated. Rapid advancement in catheter-based and endovascular device technology has led to significant improvements in rates of cerebral reperfusion with these devices. Stentrievers and modern aspiration catheters have now surpassed earlier generation devices in the degree and rapidity of revascularization. This progress has been achieved with no concurrent increase in risk of major complications or mortality, both when used alone or in combination with IVT. The initial randomized controlled trials comparing endovascular therapy to IVT for AIS failed to show superior outcomes with endovascular treatment, butkey limitations of each trial may limit the significance of these results to current practice. While endovascular devices and operator experience continue to evolve, we are optimistic that this will be accompanied by improvements in patient outcomes. This review highlights the major endovascular devices used in current practice and the trials which have investigated their efficacy. | Colin J Przybylowski Dale Ding Robert M Starke Christopher R Durst R Webster Crowley Kenneth C Liu | 2014 | World Journal of Clinical Cases2014，2，11： | 2 |
| 6 | Changes in efficiency and resource utilization after increasing experience with double balloon enteroscopy显示文摘AIM:To investigate changes in efficiency and resource utilization as a single endoscopist's experience increased with each subsequent 100 double balloon enteroscopy(DBE) procedures.METHODS:We reviewed consecutive DBE procedures performed by a single endoscopist at our center over 4 years.DBE was employed when the clinician deemed the procedure was needed for disease management.The approach(oral,anal or both) was chosen based on suspected location of the target lesion.All DBE was performed in a standard endoscopy room with a portable fluoroscopy unit.Fluoroscopy was used to aid in shortening the small intestine and reducing bowel loops.For oral DBE,measurements were taken from the incisors.For anal DBE,measurements were taken from the anal verge.Enteroscopy continued until the target lesion was reached,until the entire small intestine was examined,or until no further progress was deemed possible.The length of small intestine examined(cm),procedure duration(min),and fluoroscopy time(s) were analyzed for sequential groups of 100 DBE.Sub-groups of diagnostic and therapeutic procedures were analyzed using multivariable linear regression.RESULTS:802 consecutive DBE procedures were analyzed.For oral DBE,median [interquartile range(IQR)] length of small bowel examined was 230.8 cm(range:210-248 cm) and for anal DBE was 143.5 cm(range:100-180 cm).No significant increase in length examined was noted for either the oral or anal approach with advancing position in series.In terms of duration of procedure,the median(IQR) for oral DBE was 86 min(range:71-105 min) and for anal DBE was 81.3 min(range:67-105 min).When comparing by the position in series,there was a significant(P value < 0.001) decrease in procedure duration for both upper and lower procedures with increasing experience.Median(IQR) time of exposure to fluoroscopy for oral DBE was 190 s(114-275) compared to anal DBE which was 196.4 s(312-128).This represented a significant(P value < 0.001) decrease in the amount of fluoroscopy used with increasing position in series.For both oral and anal DBE,fluoroscopy time was reduced by greater than 50% over the course of 802 total procedures performed.Sub-group analysis was conducted on therapeutic and diagnostic groups.Out of 802 procedures,a total of 434 were considered therapeutic.Argon plasma coagulation was by far the most common therapeutic intervention performed.There was no evidence of a difference in length examined or fluoroscopy exposure among oral DBE for diagnostic and therapeutic procedures,P = 0.91 and P = 0.32 respectively.The median(IQR) for length was 235 cm(range:178-280 cm) for diagnostic vs 230 cm(range:180-275 cm) for therapeutic procedures;additionally,fluoroscopy time median(IQR) was 180 s(range:110-295 s) and 162 s(range:102-263 s) for no intervention and intervention.However,there was a significant difference in procedure duration among oral DBE(P < 0.001).The median(IQR) was 80 min(range:60-97 min) and 94 min(range:77-110 min) for diagnostic and therapeutic interventions respectively.CONCLUSION:For a single endoscopist,increased DBE experience with number of performed procedures is associated with increased efficiency and decreased resource utilization. | Neal C Patel William C Palmer Kanwar R Gill David Cangemi Nancy Diehl Mark E Stark | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 2 |
| 7 | Plant responses of ultra narrow row cotton to nitrogen fertilization显示文摘 | MCCONNEL J S Francis P B Stark C R | 2008 | Journal of Plant Nutrition2008，31，： | 1 |
| 8 | C4A deficiency and nonresponse to hepatitis B vaccination显示文摘 | Hohler T Stradmann-Bellinghausen B Starke R | 2002 | J Hepatol2002，37，3： | 1 |
| 9 | Novel algorithmsfor remote estimation of vegetation fraction显示文摘 | Gitelson A A Kaufman Y J Stark R | 2002 | Remote Sens-ing of Environment2002，80，： | 1 |
| 10 | Structural proteins of hog cholera virus expressed by vaccinia virus: Further characterization and induction of protective immunity显示文摘 | Rumenapf T Stark R Meyers G | 1991 | J Virol1991，65，2： | 1 |
| 11 | Feature-based reverse engineering of mechanical parts显示文摘 | Thompson W B Owen J C Stark S R | 1999 | IEEE Transactions on Robotics and Automation1999，15，1： | 1 |
| 12 | Rnase of Classical swine fever virus; biochemical characterization and inhibition by virus neutralizing monoclonal antibodies显示文摘 | Windisch J M Schneider R Stark R | 1996 | J Virol1996，70，1： | 1 |
| 13 | Relative sensitive of spring wheat grain yield and quality parameters to moisture deficit 显示文摘 | Guttieri M J Ahmad R Stark J C | 2001 | Crop Science2001，41，： | 1 |
| 14 | State-space model of freely vi- brating and surface-coupled cantilever dynamics in atomic force mi- croscopy显示文摘 | Stark R W Schitter G Stark M etc | 2004 | Physical Review B (Condensed Matter and Materials Physics)2004，69，8： | 1 |
| 15 | Managing irrigation and nitrogen fertility of hard spring wheats for optimum bread and noodle quality 显示文摘 | Guttieri M J McLean R Stark J C Souza E | 2005 | Crop Science2005，45，： | 1 |
| 16 | Ribonuclease P: an enzyme with an essential RNA component 显示文摘 | STARK B C KOLE R BOWMAN E J | 1978 | Proc Natl Acad Sci USA1978，75，8： | 1 |
| 17 | Bioelectrics new applications for pulsed power technology显示文摘 | Schoenbach K Katsuki S Stark R | | 0，，01： | 1 |
| 18 | On the capacity of channels withblock memory显示文摘 | Stark W and McEliece R J | 1988 | IEEE Transactions on Information Theory1988，34，2： | 1 |
| 19 | Coordinate actions of BMPs,Wnts,Shh and noggin mediate patterning of the dorsal somite显示文摘 | MARCELLE C STARK M R BRONNER-FRASER M | 1997 | Development1997，124，： | 1 |
| 20 | Bioeleclrics-new appli- cations for pulsed power technology显示文摘 | Schoenbach K H Katsuki S Stark R H | 2002 | IEEE Transactions on Plasma Science2002，30，1： | 1 |
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