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| 1 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 2 | Morphological and molecular discrimination of green macroalgae Chaetomorpha aerea and C. linum显示文摘Green macroalgae Chaetomorpha aerea and C. linum are taxonomically confused. In this paper, we tried morphological and molecular analyses to separate these two species. C. aerea and C. linum can be distinguished from morphological characteritics, such as frond dimension, cells size and shape, their mean length/width ratios(LWR), and cell walls constriction. Thalli of C. aerea attenuate basipetally, with diameter 270–500 μm at upper portion, 160–360 μm at middle portion, 100–160 μm at basal portion. For the upper part, the length of cells is less than their diameter. Cell walls usually constrict at the dissepiments, which are pellucid or colorless and give the filament beaded appearance. In contrast, thalli of C. linum often have a constant diameter of 90–300 μm within the same individual, cell walls usually do not constrict and cells are cylindrical or barrel shaped. The LWR is larger than that of C. aerea. Results show that the pairwise distance between two species is 3.6%–3.7% for 18 S r RNA gene and 53.5%–54.3% for ITS region. In phylogeny, they distribute at distant clades, which confirms a genetic divergence at molecular level. In addition, morphological data indicates that filament diameter of C. linum samples is highly variable, ranging from 90 μm to 300 μm. Then these two species can be considered as separate species. | HUANG Bingxin TENG Linhong DING Lanping | 2016 | Acta Oceanologica Sinica2016，35，4： | 1 |
| 3 | Microscopic Observation of Pyrenoids in Order Ulvales(Chlorophyta) Collected from Qingdao Coast显示文摘Pyrenoids found in green algae Order Ulvales have taxonomical significance.Their morphology,microstructure,and the location and number in the cells have been widely used as identification criteria. As these traits can be affected by environmental conditions,it is necessary to look for other different characteristics.Here pyrenoids in several algae species collected along the Qingdao coast were studied for such purpose. The morphology and distribution of pyrenoids in the cells,as well as their change in different parts of the frond and at different times were studied with light microscope.The results are as follows.Pyrenoids appeared to be spherical or oval in observed Ulvales'algae cells.They were embedded in chloroplasts with the number of 1-3 per cell on average.The number of pyrenoids for Ulva pertusa could change drastically with continuing culture and could reach up to 10-20 per cell in late-growth stages.Generally, the pyrenoids in the marginal part were more observable than those in the central part for Ulva pertusa. In addition, the basal part of frond had more distinct pyrenoids with an average diameter of 2.42 μm for Enteromorpha linza. For some species the pyrenoids were difficult to be observed while dark treatment made them more distinguishable.The apoptosis rate of pyrenoids in different species varied under continuing dark treatment, which could be used to identify different species. Pyrenoids disappeared faster in E. linza than those in E.intestinalis. | TENG Linhong DING Lanping LU Qinqin | 2011 | Journal of Ocean University of China2011，10，3： | 1 |
| 4 | Triphenylamine-based highly active two-photon absorbing chromophores with push-pull systems显示文摘Two triphenylamine-based star-type push-pull chromophores(T1, T2) were designed and synthesized.Triphenylamine serves as the central core and acts as an electron-donating group surrounded by electronwithdrawing pentafluorobenzene or N,N-dimethyl substituted tetrafluorobenzene, which are connected by ethylene bridges. Single-crystal X-ray diffraction confirmed the structures and molecular arrangement of two chromophores. The systematic photophysical research of T1 and T2 absorption characteristics was carried out to gain a better understanding of how structure-property relationships affect the observed nonlinear optical absorption phenomenon. Complementary calculations based on density functional theory(DFT) further confirmed the experimental results. Both chromophores exhibited excellent two-photon absorption(TPA) properties in CH_(2)Cl_(2). Notably, T2 has more remarkable nonlinear optical absorption effects with the TPA cross-section up to 4.24 × 10~7GM. By adjusting the electronic structures of the chromophores through introducing pentafluorobenzene or N,N-dimethyl as functional groups with different electron-donating or withdrawing behaviors, the TPA performance of the small organic molecule could be greatly enhanced. These molecular structures with push-pull systems were excellent candidates for different two-photon applications. | Yanqi Ban Linhong Hao Zhenbo Peng Lishui Sun Lihua Teng Yingjie Zhao | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 5 | Phenotypic plasticity and taxonomy of Cladophora gracilis(Griffiths)Kützing(Cladophorales,Chlorophyta)in the western Yellow Sea with the implication of its DNA barcode显示文摘Due to extensive morphological plasticity,the taxonomy of Cladophora species remains unclear.As one of the widely distributed species,C.gracilis was reported to hold many varieties,which make it difficult to identify the species.This study explored the morphology diversity of nine C.gracilis samples collected along the coast of western Yellow Sea.Some samples showed extremely varied characteristics,by which one cannot classify them correctly.Hence,18S rDNA and nuclear ribosomal DNA internal transcribed spacer regions(ITS)sequences were employed to delimit species.For 18S rDNA,sequence similarity ranged from 99.6%to 100%.For ITS region,the similarity ranged from 98.7%to 100%.Molecular data strongly suggested that the morphologically heterogeneous samples were actually the same species.Characteristics comparison of the samples revealed that the taxonomy criteria including branching pattern and density,thallus color,height and texture varied widely,influenced by environmental conditions and age of alga.Besides,cell dimensions,as the relatively stable criterion,also exhibited intraspecific variance.Successful application of 18S rDNA and ITS sequences indicated that molecular method can be a powerful assistant as DNA barcodes to traditional morphology taxonomy. | Bingxin Huang Linhong Teng Jingjing Jiang Lanping Ding | 2020 | Acta Oceanologica Sinica2020，39，10： | 0 |
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