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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Cardioprotection of sevoflurane postconditioning by activating extracellular signal-regulated kinase 1/2 in isolated rat hearts^1显示文摘瞄准:1/2 免于的细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵) 的激活是化学家灌注损害。ERK1/2 是否调停 sevoflurane 柱子调节的 cardioprotection 是未知的。我们测试了 sevoflurane 柱子调节是否经由 ERK1/2-depen-dent 机制生产 cardioprotection。方法:在协议 1 , 酒Langendorff 的 Sprague Dawley 老鼠心( n=84 , 12 每组)与假冒的组的异常,受到 90 min 灌注跟随的 30 min 局部缺血并且被分到未经治疗(控制)组,由 4 个周期列在后面是化学家帖子调节(各个的 25 s ),3%( v/v ) sevoflurane 帖子调节(为 5 min 和冲刷的 10 min ),并且 PD98059 溶剂 DMSO (<0.2%), ERK1/2 禁止者 PD98059 ( 20 μmol/L ),和 Sevo+PD 管理。在平衡的 30 min 的左室的 hemodynamics 和冠的流动分别地在灌注的 30, 60,和 90 min 被记录。尖锐梗塞尺寸被 triphenyltetrazolium 氯化物染色测量。线粒体的配置被一台电子显微镜观察。西方的污点分析被用来在灌注的结束决定 cytosolic 和 mitochondrial 细胞色素 c 的内容。在协议 2,在灌注的 15 min 以后,总数的表示和 ERK1/2 和它的下游的目标 p70S6K 的 phosphorylated 形式由西方的弄污是坚定的。结果:在基线 hemodynamics 的差别都没在试验性的组(P>0.05 ) 之中被观察。在灌注以后,与控制组相比, sevoflurane 柱子调节并且显著地是化学家柱子调节(P<0.05 ) 改进了功能的恢复并且(P<0.05 ) 大部分减少了心肌的梗塞尺寸(22.9%± 4 .6% 和 21.2%± 3 .8% ,对 39.4%± 5 .7% ,两 P<0.05 ) 。调停 Sevoflurane 的保护被 PD98059 废除。结论:由 sevoflurane 的麻药柱子调节有效地由在 vitro 激活 ERK1/2 免于灌注损坏。 | Hong-tao CHEN Cheng-xiang YANG Heng LI Cheng-jing ZHANG Xian-jie WEN Jun ZHOU You-ling Fan Teng HUANG Yin-ming ZENG | 2008 | Acta Pharmacologica Sinica2008，29，8： | 41 |
| 3 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 4 | Clinical and experimental study on regional administration of phosphorus32 glassmicrospheres in treating hepatic carcinoma显示文摘AIM To study the therapeutical effectiveness, dosage range and toxic adverse effects of domestic phosphorus 32 glass microsphere and evaluate its clinical significance. METHODS Ⅰ. Fifty two BALB/*!c tumor bearing male nude mice were allocated into treatment group( n =38) and control group( n =14). In the former group different doses of 32 P GMS were injected into the tumor mass, while in the latter 31 P GMS or no treatment was given. The experimental animals were sacrificed in batches, and then the tumors and their nearby tissues were examined by light and electron microscopy. Ⅱ. Through selective catheterization of hepatic artery, 32 P GMS was infused to 5 healthy domestic pigs in a dosage equivalent to the therapeutic dose for human being, and 31 P GMS was infused to another 5 healthy domestic pigs. Two pigs infused with contrast medium served as whole course blank controls. One pig from each group was surrendered to euthanasia at week 1, 4, 8 and 16 respectively. The ultrastructural histopath ological changes in liver tissues taken from different sites were evaluated semiquan titatively. Ⅲ. One hundred and twenty seven times of 32 P GMS intrahepatic artery interventional therapies were performed on 93 patients with hepatic carcinoma, including 79 cases of primary hepatic carcinoma and 14 cases of secondary hepatic carcinoma. 32 P GMS ( n =30), and group B, 32 P GMS and half dose of trans hepatic artery embolization (TAE) ( n =49) , and 18 patients with HCC by TAE only as control group C. Fourteen patients with secondary hepatic carcinoma were treated in the same way as group B or C. RESULTS Ⅰ. Comparing with the control group, the treatment group of tumor bearing nude mice attained the tumor inhibition rates of 59 7%-93 7% ( F =579 62, P <0 01) at 14*!d . At an absorbed dose of 7320Gy, the tumor cells were completely destroyed. When the absorbed doses ranged from 1830Gy to 3660Gy, most of the tumor cells showed the evidences of injury or necrosis, but there appeared some well differentiated tumor cells and enhanced effect of the autoimmunocytes. At an absorbed dose of 366Gy or less, some tumor cells still remained active proliferative ability. The definite anticancer effect appeared as early as 3d after intratumoral injection of 32 P GMS. Ⅱ. The cumulative amount of 32 P GMS in the target tissue after trans hepatic artery instillation attained more than 90% of the total dose administrated. Semiquantitative analysis of ultrastructral morphology in the experimental group showed no statistical difference between the nuclear abnormality (N abn ) and mitochondrial variability (M var ) at week 1 or 2, but revealed prominent difference (χ 2=6 70-9 68, P <0 01 , χ 2=65 09-115 09, P <0 001 ) as compared with those in the other groups. In the experimental group the N abn in tissues showed no significant difference between week 8 and week 16. No apparent changes were found in the stomach, spleen, kidney and lung tissues of the experimental pigs. Ⅲ. The therapeutical results of HCC patients in group A were closely approximated to those of group C, no hematological toxic side effects were noted, and the systemic reaction was mild. In some patients 2*!mos - 3*!mos after treatment some secondary foci appeared around the periphery of the primary lesion. In general better effectiveness was obtained in patients with small lesion. After analyzing by RIDIT method, the therapeutic result in group B was significantly better than that in group C, and secondary foci around the original lesion were rarely seen at 3*!mos after treatment. In group C the collateral circulation was reestablished along the periphery of primary foci and the secondary foci appeared more frequently, and required to undergo several courses of treatment. In group B, 4 cases of HCC were treated surgically as their mass decreased in size after 32 P GMS treatment. | LIU Lu, JIANG Zao, TENG Gao Jun, SONG Ji Zhi, ZHANG Dong Sheng, GUO Qing Ming, FANG Wen, HE Shi Cheng and GUO Jin He | 1999 | World Journal of Gastroenterology1999，5，6： | 21 |
| 5 | Isolation and Identification of a Di-(2-Ethylhexyl)Phthalate-Degrading Bacterium and Its Role in the Bioremediation of a Contaminated Soil显示文摘Di-(2-ethylhexyl) phthalate(DEHP) is a high-molecular-weight phthalate ester(PAE) that has been widely used in the manufacture of polyvinylchloride and contributes to environmental pollution.The objectives of the present study were to isolate a DEHP degrader that can utilize DEHP as a carbon source and to investigate its capacity to biodegrade DEHP in both liquid culture and soil.A bacterial strain WJ4 was isolated from an intensively managed vegetable soil,which was contaminated with PAEs.The strain WJ4 was affiliated to the genus Rhodococcus and was able to remove DEHP from soil effectively.A period of only 7 d was required to degrade about 96.4%of DEHP(200 mg L^(-1)) in the liquid culture,and more than 55%of DEHP(1.0 g kg^(-1)) in the artificially contaminated soil was removed within 21 d.Furthermore,Rhodococcus sp.strain WJ4 had a strong ability to degrade DEHP without additional nutrients in liquid minimal medium culture and DEHP-contaminated soil and to degrade the homologue of DEHP in both liquid culture and soil.Strain WJ4 represents a novel tool for removing PAEs from contaminated soils and it may have great potential for application in the remediation of environmental pollution by PAEs. | WANG Jun ZHANG Man-Yun CHEN Ting ZHU Ye TENG Ying LUO Yong-Ming Peter CHRISTIE | 2015 | Pedosphere2015，25，2： | 18 |
| 6 | Transmission of climate change impacts from temperature change to grain harvests, famines and peasant uprisings in the historical China显示文摘Because of the complexity of social responses to climate change,as well as limitations of proxy data concerning interactions between climate change and human responses,the social impacts of past climate change and associated response mechanisms,thus,require further investigation.To shed light on the transmission of climate change impacts within historical Chinese society,we selected 30-year resolution sequences of temperature anomalies in eastern China and 10-year resolution sequences of grain harvest grades,famine indices,and frequencies of peasant uprisings in China over the past 2000 years.Using a food security perspective,we analyzed the impacts of temperature changes historically transmitted through Chinese production,population,and social subsystems,and differences in transmission characteristics between cold and warm units.Our results were as follows.(1)From 210 BC to 1910 AD,temperature changes in China were significantly positively correlated with grain harvest grades(correlation coefficient,0.338),and significantly negatively correlated with famine indices,and frequencies of peasant uprisings(correlation coefficients,-0.301 and-0.277,respectively).The correlation coefficients between famine indices and grain harvest grades or frequencies of peasant uprisings were very low.(2)There was a higher proportion of bumper or normal harvests(86.5%of the total decades),more moderate and mild famines(76%),and a lower proportion of peasant uprisings(33.3%)in the 30-year warm units.Conversely,there was a higher proportion of poor or normal harvests(70.7%),a greater proportion of moderate and severe famines(77.6%),and more peasant uprisings(51.7%)in the 30-year cold units.(3)Of the 23 main transmission pathways extending from temperature change to the social subsystem,13 occurred in cold units,of which 7 had an endpoint of peasant uprisings,and 10 occurred in warm units of which 3 had an endpoint of peasant uprisings.The main transmission pathways that were more likely to be associated with the impacts of temperature change were:Cold→poor harvests→severe famines→more uprisings;cold→poor harvests→moderate famines→more uprisings;warm→bumper harvests→mild famines→no uprisings;warm→bumper harvests→moderate harvests→no uprisings;warm→normal harvests→mild famines→no uprisings;and warm→normal harvests→moderate famines→no uprisings.(4)The transmission of the impacts of temperature change was a complex process.Within this process,famine was most prone to being modulated by human society.In the transmission pathways from the production to the social subsystem,there was a stepwise decrease in the occurrence rate of decades that were probably affected by climate change.In all cold units,10.4%of decades ending in more uprisings were most likely to be associated with the impacts of temperature change.In all warm units,47.9%of decades ending in no uprisings were most likely to be associated with the impacts of temperature change.This research can contribute a better understanding on the past interaction mechanisms and processes within the human-climate-ecosystem complex,as well as a better response to the impacts of the ongoing climate change. | FANG XiuQi SU Yun YIN Jun TENG JingChao | 2015 | Science China Earth Sciences2015，58，8： | 15 |
| 7 | Serial stimulated thyroglobulin measurements are more specific for detecting distant metastatic differentiated thyroid cancer before radioiodine therapy显示文摘Objective: Preablative stimulated thyroglobulin(ps-Tg) has the potential to be used in identifying distant metastatic differentiated thyroid carcinoma(DM-DTC), but its single level can be affected by remnant thyroid tissue and thyrotropin(TSH). The objective of this retrospective study was to evaluate the value of serial ps-Tg measurements in identifying DM-DTC specifically.Methods: A total of 317 DTC patients with serial measurements of ps-Tg, TSH and anti-Tg antibody were divided into M1(n=72) and M0(n=245) according to the presence of distant metastasis(DM) or not. The initial psTg measurement, with a corresponding TSH exceeding 30 μIU/m L, was marked as Tg1, and ps-Tg measured right before radioactive iodine(RAI) therapy was defined as Tg2, with a median interval of 8 days. ΔTg denotes Tg2–Tg1, and ΔTSH denotes TSH2–TSH1. Tg1, Tg2, ΔTg, and ΔTg/ΔTSH were tested for efficacy in identifying DM-DTC using receiver operating characteristic(ROC) curve analysis, and further compared with chest computed tomography(CT) and posttreatment whole-body RAI scan(Rx WBS).Results: Compared with single ps-Tg measurement(Tg1 or Tg2), both ΔTg and ΔTg/ΔTSH were more narrowly distributed around zero in the M0 group, which made their distribution in the M1 group more distinguished in a relatively dispersed way. ΔTg/ΔTSH manifested a higher accuracy(88.64%) and specificity(90.20%) in identifying DM-DTC than Tg1 or Tg2 measurements, with a much higher specificity than chest CT(90.20% vs. 66.00%) and a much higher sensitivity than Rx WBS(83.33% vs. 61.11%).Conclusions: Serial ps-Tg measurements even over as short an interval as 8 days hold incremental value in identifying DM-DTC. ΔTg/ΔTSH is a specific early biochemical marker for DM-DTC. | Teng Zhao Jun Liang Tianjun Li Wen Gao Yansong Lin | 2017 | Chinese Journal of Cancer Research2017，29，3： | 15 |
| 8 | Synthesis and characterization of lower generation broom molecules显示文摘与亢奋的分支被迈克尔增加与 dodecylamine 和甲基压克力在甲醇综合的十二烷基组一起的树枝状的分子作为原料吃了。这新型的树枝状的分子生动地被叫“在这的扫帚分子”报导。扫帚分子的水溶液的表面张力解雇了氨基的组被使用落下卷方法测量。为油 / 水(O/W ) 的扫帚分子的反乳化表演模仿了原油乳状液被检验。试验性的结果揭示了那,作为一表面活化剂新型,扫帚分子解雇了为 O/W 给反乳化看的氨基的组模仿的原油乳状液。 | Jun Wang Cui Qin Li Shu Yan Zhang Fang Sun Teng Jie Ge | 2008 | Chinese Chemical Letters2008，19，1： | 13 |
| 9 | Electroacupuncture inhibits annulus fibrosis cell apoptosis in vivo via TNF-α-TNFR1-caspase-8 and integrin β1/Akt signaling pathways显示文摘OBJECTIVE: To examine whether electroacupuncture(EA) treatment inhibited cell apoptosis of intervertebral annulus fibrosis(AF) via tumor necrosis factor-α(TNF-α)-tumor necrosis factor receptor 1(TNFR1)-caspase-8 and integrin β1/Akt signaling pathways in a rat model of cervical intervertebral disc degeneration caused by unbalanced dynamic and static forces.METHODS: Thirty-two Sprague-Dawley rats were included in this study, of which 24 rats underwent surgery to induce cervical intervertebral disc degeneration, while eight rats received EA treatment at Dazhui(GV 14). Immunohistochemical staining was used to detect TNF-α, TNFR1, and caspase-8Apoptosis of AF cells was examined with terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end labeling(TUNEL) staining. The m RNA and protein expression levels of integrin β1 andAkt were evaluated with real-time polymerase chain reaction and western blot analysis, respectively.RESULTS: Treatment with EA decreased TUNEL-positive AF cells and lowered TNF-α, TNFR1 and caspase-8 positive cells compared with control groups. EA treatment also increased integrin β1and Akt m RNA and protein levels compared with controls.CONCLUSION: Treatment with EA inhibits AF cell apoptosis through suppression of the TNF-α-TNFR1-caspase-8 signal pathway and increases the expression of integrin β1 and Akt. EA may be a good alternative therapy for treating cervical spondylosis. | Jun Liao Le Zhang Jiaxuan Zheng Debiao Yu Meigui Ke Teng Xu | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 12 |
| 10 | Characterization and Fine Mapping of a Novel Rice Albino Mutant low temperature albino 1显示文摘白化体异种是为学习叶绿素生合成和叶绿体开发并且克隆在植物涉及这些过程的基因的有用基因资源。这里,我们报导新奇米饭异种低温度白化体 1 (lta1 ) 当在比 20 楢潮低的温度下面成长时,那显示出的白化体在 4 | Yu Peng Yi Zhang Jun Lv Jianhui Zhang Ping Li Xiaoliang Shi Yufeng Wang Honglei Zhang Zuhua He Sheng Teng | 2012 | Journal of Genetics and Genomics2012，39，8： | 9 |
| 11 | Sequential organ failure assessment score is superior to other prognostic indices in acute pancreatitis显示文摘BACKGROUND Acute pancreatitis(AP)is a common surgical condition,with severe AP(SAP)potentially lethal.Many prognostic indices,including;acute physiology and chronic health evaluation II score(APACHE II),bedside index of severity in acute pancreatitis(BISAP),Glasgow score,harmless acute pancreatitis score(HAPS),Ranson’s score,and sequential organ failure assessment(SOFA)evaluate AP severity and predict mortality.AIM To evaluate these indices'utility in predicting severity,intensive care unit(ICU)admission,and mortality.METHODS A retrospective analysis of 653 patients with AP from July 2009 to September 2016 was performed.The demographic,clinical profile,and patient outcomes were collected.SAP was defined as per the revised Atlanta classification.Values for APACHE II score,BISAP,HAPS,and SOFA within 24 h of admission were retrospectively obtained based on laboratory results and patient evaluation recorded on a secure hospital-based online electronic platform.Data with<10%missing data was imputed via mean substitution.Other patient information such as demographics,disease etiology,and patient outcomes were also derived from electronic medical records.RESULTS The mean age was 58.7±17.5 years,with 58.7%males.Gallstones(n=404,61.9%),alcohol(n=38,5.8%),and hypertriglyceridemia(n=19,2.9%)were more common aetiologies.81(12.4%)patients developed SAP,20(3.1%)required ICU admission,and 12(1.8%)deaths were attributed to SAP.Ranson’s score and APACHE-II demonstrated the highest sensitivity in predicting SAP(92.6%,80.2%respectively),ICU admission(100%),and mortality(100%).While SOFA and BISAP demonstrated lowest sensitivity in predicting SAP(13.6%,24.7%respectively),ICU admission(40.0%,25.0%respectively)and mortality(50.0%,25.5%respectively).However,SOFA demonstrated the highest specificity in predicting SAP(99.7%),ICU admission(99.2%),and mortality(98.9%).SOFA demonstrated the highest positive predictive value,positive likelihood ratio,diagnostic odds ratio,and overall accuracy in predicting SAP,ICU admission,and mortality.SOFA and Ranson’s score demonstrated the highest area under receiver-operator curves at 48 h in predicting SAP(0.966,0.857 respectively),ICU admission(0.943,0.946 respectively),and mortality(0.968,0.917 respectively).CONCLUSION The SOFA and 48-h Ranson’s scores accurately predict severity,ICU admission,and mortality in AP,with more favorable statistics for the SOFA score. | Thomas Zheng Jie Teng Jun Kiat Thaddaeus Tan Samantha Baey Sivaraj K Gunasekaran Sameer P Junnarkar Jee Keem Low Cheong Wei Terence Huey Vishal G Shelat | 2021 | World Journal of Critical Care Medicine2021，10，6： | 9 |
| 12 | A novel phenylpropanoid glycoside from Callicarpa kwangtungensis Chun显示文摘新奇 phenylpropanoid glycoside, Callicarposide A 从 Callicarpa kwangtungensis Chun 的天线部分被孤立。化学结构被阐明根据光谱分析。 | Er Lei Xie Guo Ping Zhou Teng Fei Ji Jun Wu Gui Ping Yuan | 2009 | Chinese Chemical Letters2009，20，7： | 8 |
| 13 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 14 | Effect of Silicon on Growth, Physiology, and Cadmium Translocation of Tobacco (Nicotiana tabacum L.) in Cadmium-Contaminated Soil显示文摘Silicon(Si) offers beneficial effect on plants under cadmium(Cd) stress such as promoting plant growth and increasing resistance to heavy metal toxicity. In this study, a pot experiment was performed to study the role of Si in alleviating Cd toxicity in tobacco(Nicotiana tabacum L.) plants on a yellow soil taken from Guiyang, China. Nine treatments consisting of three concentrations of Cd(0, 1, and 5 mg kg^(-1)) together with three Si levels(0, 1, and 4 g kg^(-1)) were established. Plant growth parameters, Cd concentration,and the malondialdehyde(MDA), chlorophyll, and carotenoid contents were determined 100 d after transplanting of tobacco seedlings.Application of exogenous Si enhanced the growth of tobacco plants under Cd stress. When 5 mg kg^(-1) Cd was added, Si addition at 1 and 4 g kg^(-1) increased root, stem, and leaf biomass by 26.1%–43.3%, 33.7%–43.8%, and 50.8%–69.9%, respectively, compared to Si addition at 0 g kg^(-1). With Si application, the transfer factor of Cd in tobacco from root to shoot under both 1 and 5 mg kg^(-1) Cd treatments decreased by 21%. The MDA contents in the Si-treated tobacco plants declined by 5.5%–17.1% compared to those in the non-Si-treated plants, indicating a higher Cd tolerance. Silicon application also increased the chlorophyll and carotenoid contents by 33.9%–41% and 25.8%–47.3% compared to the Cd only treatments. Therefore, it could be concluded that Si application can alleviate Cd toxicity to tobacco by decreasing Cd partitioning in the shoots and MDA levels and by increasing chlorophyll and carotenoid contents, thereby contributing to lowering the potential health risks of Cd contamination. | LU Yingang MA Jun TENG Ying HE Juny Peter CHRISTIE ZHU Lingjia REN Wenjie ZHANG Manyun Shiping DENG | 2018 | Pedosphere2018，28，4： | 7 |
| 15 | Low-latency deep-reinforcement learning algorithm for ultrafast fiber lasers显示文摘The application of machine learning to the field of ultrafast photonics is becoming more and more extensive.In this paper,for the automatic mode-locked operation in a saturable absorber-based ultrafast fiber laser(UFL),a deep-reinforcement learning algorithm with low latency is proposed and implemented.The algorithm contains two actor neural networks providing strategies to modify the intracavity lasing polarization state and two critic neural networks evaluating the effect of the actor networks.With this algorithm,a stable fundamental modelocked(FML)state of the UFL is demonstrated.To guarantee its effectiveness and robustness,two experiments are put forward.As for effectiveness,one experiment verifies the performance of the trained network model by applying it to recover the mode-locked state with environmental vibrations,which mimics the condition that the UFL loses the mode-locked state quickly.As for robustness,the other experiment,at first,builds a database with UFL at different temperatures.It then trains the model and tests its performance.The results show that the average mode-locked recovery time of the trained network model is 1.948 s.As far as we know,it is 62.8%of the fastest average mode-locked recovery time in the existing work.At different temperatures,the trained network model can also recover the mode-locked state of the UFL in a short time.Remote algorithm training and automatic mode-locked control are proved in this work,laying the foundation for long-distance maintenance and centralized control of UFLs. | QIUQUAN YAN QINGHUI DENG JUN ZHANG YING ZHU KE YIN TENG LI DAN WU TIAN JIANG | 2021 | Photonics Research2021，9，8： | 7 |
| 16 | Two new steroidal glycosides from the root of Cynanchum auriculatum显示文摘二新 steroidal glycosides 把 cyanoauriculoside 称为 A (1 ) 和 B (2 ) ,从 Cynanchum auriculatum Royle 前人类的根被孤立。cyanoauriculoside A (1 ) 的结构决心是 20-O-acetyl-penupogenin-3-O--D-glucopyranosyl-(14 )--D-glucopyranosyl-(14 )--L-cymaropyranosyl-(14 )--D-cymaropyranosyl-(14 )--L-diginopy-ranosyl-(14 )-- D-cymaropyranoside。Cyanoauriculoside B (2 ) 作为 20-O-acetylpenupogenin-3-O--D-glucopyranosyl-(14 ) 被描绘 --L-cymaropyranosyl-(14 )--D-cymaropyranosyl-(14 )--L-diginopyranosyl-(14 )-- D-cymaropyranoside。这些混合物的结构基于化学、分光镜的证据被阐明。 | Hong Li Teng Yu Lu Jun Li Guang Zhong Yang Zhi Nan Mei | 2011 | Chinese Chemical Letters2011，22，1： | 7 |
| 17 | Effect of Spleen Lymphocytes on the Splenomegaly in Hepatocellular Carcinoma-bearing Mice显示文摘Objective To study the effect of spleen lymphocytes on the splenomegaly by hepatocellular carcinoma-bearing mouse model. Methods Cell counts,cell cycle distribution,the percentage of lymphocytes subsets and the levels of IL-2 were measured,and two-dimensional gel electrophoresis(2-DE) was used to investigate the relationship between spleen lymphocytes and splenomegaly in hepatocellular carcinoma-bearing mice. Results Compared with the normal group,the thymus was obviously atrophied and the spleen was significantly enlarged in the tumor-bearing group. Correlation study showed that the number of whole spleen cells was positively correlated with the splenic index. The cell diameter and cell-cycle phase distribution of splenocytes in the tumor-bearing group showed no significant difference compared to the normal group. The percentage of CD3+ T lymphocytes and CD8+ T lymphocytes in spleen and peripheral blood of tumor-bearing mice were substantially higher than that in the normal mice. Meanwhile,the IL-2 level was also higher in the tumor-bearing group than in the normal group. Furthermore,two dysregulated protein,β-actin and S100-A9 were identi?ed in spleen lymphocytes from H22-bearing mice,which were closely related to cellular motility. Conclusion It is suggested that dysregulated β-actin and S100-A9 can result in recirculating T lymphocytes trapped in the spleen,which may explain the underlying cause of splenomegaly in H22-bearing mice. | FANG Jing Jing ZHU Zhen Yuan DONG Hui ZHENG Guo Qiang TENG An Guo LIU An Jun | 2014 | Biomedical and Environmental Sciences2014，27，1： | 6 |
| 18 | Verification of Numerical Modeling in 2-D Wave Propagation in Rock显示文摘Compressional harmonic wave propagation from a cylindrical tunnel or borehole in an intact rock is the basis for investigation of the practical explosion waves in a fractured rock mass. The amplitudes of the radial stress wave obtained from the universal distinct element code (UDEC) were compared with the analytical solutions for two cases with different conditions. Good agreements between the UDEC results and the analytical solutions have been achieved. It indicates that UDEC can model 2-D dynamic problems at a high degree of accuracy. | LEI Wei-dong HEFNY Ashraf TENG Jun ZHAO Jian SONG Hong-wei | 2005 | Journal of China University of Mining and Technology2005，15，4： | 6 |
| 19 | Fiber damage analysis model for RC beam-column based on EEP super-convergent computation显示文摘A new numerical strategy to model nonlinear damage behavior of RC beam-column member based on level of material and superconvergent computation is presented in this paper. A fiber damage analysis model (FDAM) for RC beam-column member is established by analyzing section of fiber beam column element with the uniaxial damage constitutive relations of con-crete. The damage index of RC member through statistical analysis of concrete fibers damage is defined in the extreme section of beam elements, which can describe the nonlinear damage behavior of RC beam-column member under any loadings. The newly proposed element energy projection (EEP) method is applied to the inelastic analysis of FDAM. EEP superconvergent formulas for section forces and deformations of beam-column are established, and general algorithm and numerical strategy adopting EEP super-convergent computation for section deformation increment are proposed in the classical Newton-Raphson process. Both analysis and numerical test show that the EEP method can effectively find out the nonlinear feature of the distribution, and accurately obtain the damage distribution of RC beamcolumn. The proposed numerical scheme in this paper proves to be effective and convenient in its use and can be easily integrated into the present inelastic FEM programs of structure analysis. | TENG Jun LI ZuoHua OU JinPing HE XueFeng | 2011 | Science China(Technological Sciences)2011，54，10： | 6 |
| 20 | Development of uncut crop edge detection system based on laser rangefinder for combine harvesters显示文摘The objective of this research was to develop an uncut crop edge detection system for a combine harvester.A laser rangefinder(LF)was selected as a primary sensor,combined with a pan-tilt unit(PTU)and an inertial measurement unit(IMU).Three-dimensional field information can be obtained when the PTU rotates the laser rangefinder in the vertical plane.A field profile was modeled by analyzing range data.Otsu’s method was used to detect the crop edge position on each scanning profile,and the least squares method was applied to fit the uncut crop edge.Fundamental performance of the system was first evaluated under laboratory conditions.Then,validation experiments were conducted under both static and dynamic conditions in a wheat field during harvesting season.To verify the error of the detection system,the real position of the edge was measured by GPS for accuracy evaluation.The results showed an average lateral error of±12 cm,with a Root-Mean-Square Error(RMSE)of 3.01 cm for the static test,and an average lateral error of±25 cm,with an RMSE of 10.15 cm for the dynamic test.The proposed laser rangefinder-based uncut crop edge detection system exhibited a satisfactory performance for edge detection under different conditions in the field,and can provide reliable information for further study. | Zhao Teng Noboru Noguchi Yang Liangliang Kazunobu Ishii Chen Jun | 2016 | International Journal of Agricultural and Biological Engineering2016，9，2： | 5 |
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