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| 1 | Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis显示文摘Sphingolipids 被建议了在植物房间为一连串的细胞的发信号活动充当第二个送信人,包括压力回答并且规划了房间死亡(PCD ) 。然而,这些过程不是的机制 underpinning 很好理解。这里,我们报导那 Arabidopsis 异种, fumonisin B1 抵抗 11-1 ( fbr 11-1 )没能产生反应的氧中介( ROI ),不能当异种被 fumonisin B ( 1 )( FB ( 1 ))质问时,开始 PCD , ceramide synthase 的一个特定的禁止者。显示的分子的分析 FBR11 编码一个长链的底 1 (LCB1 ) 丝氨酸 palmitoyltransferase (SPT ) 的子单元,它催化 de novo sphingolipid 的第一限制率的步合成。sphingolipid 集中的集体度谱的分析表明而 fbr 11-1 变化没影响 sphingoid 底的基础层次,异种响应 FB (1 ) 显示出 sphingoid 底的稀释形成。由一个直接的喂实验,我们证明免费 sphingoid 底 dihydrosphingosine, phytosphingosine 和鞘氨醇高效地导致产生由房间死亡跟随了的 ROI。相反地, dihydrosphingosine 导致的 ROI 产生和房间死亡被它的 phosphorylated 形式 dihydrosphingosine-1-phosphate 明确地以一种剂量依赖者方式堵住,建议在一个免费 sphingoid 底和它的 phosphorylated 衍生物之间的动态平衡的维护对决定房间命运批评。因为 sphingolipid 水平的改变发生在 ROI 生产以前,我们建议免费 sphingoid 库在 Arabidopsis 涉及 PCD 的控制,大概在收到不同发展或环境的暗示之上通过 ROI 的规定铺平。 | Lihua Shi Jacek Bielawski Jinye Mu Haili Dong Chong Teng Jian Zhang Xiaohui Yang Nario Tomishige Kentaro Hanada Yusuf A Hannun Jianru Zuo | 2007 | Cell Research2007，17，12： | 12 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | A new rotavirus VP6-based foreign epitope presenting vector and immunoreactivity of VP4 epitope chimeric proteins 显示文摘 | Teng Y Zhao B Pan X et a/ | 2014 | Viral Immunol2014，27，3： | 1 |
| 4 | Rest chest pain, negative treadmill exercise electrocardiogram and reverse redistribution in dipyridamole myocardial perfusion imaging might be the features of coronary artery spasm显示文摘 | XIANG D C YIN J L TENG A P | 2007 | Clin Cardiol2007，30，10： | 1 |
| 5 | Absorption,distribution,metabolism,and excretion of ticagrelor in healthy subjects显示文摘 | TENG R OLIVER S HAYES M A | 2010 | Drug Metab Dispos2010，38，： | 1 |
| 6 | Critical mechanical conditions around neovessels in carotid atherosclerotic plaque may promote intraplaque hemorrhage 显示文摘 | Teng Z He J Degnan A | 2012 | Atherosclerosis2012，223，： | 1 |
| 7 | The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan显示文摘 | HSU L A TENG M S KO Y L | 2009 | Clin Chem Lab Med2009，47，2： | 1 |
| 8 | Degenerative disorders of the lumbar and cervical spine显示文摘 | ROH J S TENG A L YOO J U | 2005 | Orthop Clin North Am2005，36，3： | 1 |
| 9 | Outage probability at arbitrary SNR with cooperative diversity显示文摘 | ZHAO Y RAVIRAJ A TENG J L | 2005 | IEEE Communications Letters2005，9，8： | 1 |
| 10 | Further characterization of the epagene cluster and Epapolysaccharides of Enterococcus fae-calis显示文摘 | Teng F Singh KV Bourgogne A | 2009 | Infect Immun2009，77，9： | 1 |
| 11 | Improvement of alum andPAC1 coagulation by plolyacrylamides for the treatment of pulp and papermill wastewater显示文摘 | AHM AD A L WONG S S TENG T T | 2007 | Chemical Engineering Joumal2007，5279，8： | 1 |
| 12 | Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects显示文摘 | TENG R OLIVER S HAYES M A | 2010 | Drug Metab Dispos2010，38，9： | 1 |
| 13 | Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2显示文摘 | LI B RH(E)AUME C TENG A | 2007 | Genesis2007，45，5： | 1 |
| 14 | Dynamic analysis of an SIR epidemic model with state dependent pulse vaccination显示文摘 | Nie L Teng Z Torres A | 2012 | Nonlinear Analysis: Real World Applications2012，13，4： | 1 |
| 15 | Beamforming with limited feedback in amplify-and-forward cooperative networks 显示文摘 | Zhao Y Raviraj A Teng L | 2008 | IEEE Transactions on Wireless Communications2008，7，12： | 1 |
| 16 | MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction显示文摘 | Teng J Takei Y | 2002 | J Cell Biol2002，158，3： | 1 |
| 17 | Interfacial slippage of a unidirectional fiber composite under longitudinal shear 显示文摘 | Agah-Tehrami A | 1992 | J Appl Mech1992，59，3： | 1 |
| 18 | Soy protein and isoflavones: their effects on blood lipids and bone density in posmaenopansal women 显示文摘 | POTTER S M BAUM J A TENG H | 1998 | Am J Clin Nutr1998，68，： | 1 |
| 19 | Analytic expression of the diffraction of a circular aperture 显示文摘 | Teng S Y Liu L R Liu D A | 2005 | Optik2005，116，12： | 1 |
| 20 | Potential impact of nutritional intervention on end-stage renal disease hospitalization, death, and treatment costs 显示文摘 | Lacson E Ikizler A Lazarus M Teng M Hakim R | 2007 | J Ren Nutr2007，17，6： | 1 |
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