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| 1 | Chronic obstructive pulmonary disease as a risk factor for lung cancer显示文摘The association between chronic obstructive pulmonary disease(COPD) and lung cancer has long been a subject of intense debate. The high prevalence of COPD in elderly smokers inevitably strengthens their coincidence. In addition to this contingent coincidence, recent studies have revealed a close association between the two diseases that is independent of the smoking history; that is, the existence of COPD is an independent risk factor for the development of lung cancer. Molecular-based evidence has been accumulating as a result of the efforts to explain the underlying mechanisms of this association. These mechanisms may include the following: the retention of airborne carcinogens followed by the activation of oncogenes and the suppression of tumor suppressor genes; the complex molecular mechanism associated with chronic inflammation in the distal airways of patients with COPD; the possible in-volvement of putative distal airway stem cells; and gel netic factors that are common to both COPD and lung cancer. The existence of COPD in patients with lung l cancer may potentially affect the process of diagnosis, surgical resection, radiotherapy, chemotherapy, and end-of-life care. The comprehensive management of COPD is extremely important for the appropriate treatment of lung cancer. Surgical resections with the aid of early interventions for COPD are often possible, even for patients with mild-to-moderate COPD. New challenges, such as lung cancer CT screening for individuals t at high risk, are now in the process of being implemented. Evaluating the risk of lung cancer in patients with COPD may be warranted in community-based lung cancer screening. | Yuichi Takiguchi Ikuo Sekine Shunichiro Iwasawa Ryota Kurimoto Koichiro Tatsumi | 2014 | World Journal of Clinical Oncology2014，5，4： | 21 |
| 2 | Making continental crust:The sanukitoid connection显示文摘The average continental crust possesses intermediate compositions that typify arc magmatism and as a result it is believed to have been created at ancient convergent plate boundaries. One possible mechanism for intermediate continental crust formation is the direct production of andesitic melts in the upper mantle. Sanukitoids, which characterize the Setouchi volcanic belt, SW Japan, include un-usually high-Mg andesites (HMA). They were generated by slab melting and subsequent melt-mantle interactions under unusual tectonic settings such as where warm lithosphere subducts into hot upper mantle. Such conditions would have existed in the Archean. Hydrous HMA magmas are likely to have solidified within the crust to form HMA plutons, which were then remelted to produce differentiated sanukitoids. At present, generation and differentiation of HMA magmas may be taking place in the Izu-Bonin-Mariana arc-trench system (IBM), because (1) HMA magmatism characterizes the initial stages of the IBM evolution and (2) the IBM middle crust exhibits Vp identical to that of the bulk conti-nental crust. Vp estimates for plutonic rocks with HMA compositions support this. However tonalitic composition for middle-crust-forming rocks cannot be ruled out, suggesting an alternative possibility that the continental crust has been created by differentiation of mantle-derived basaltic magmas. | Yoshiyuki TATSUMI | 2008 | Chinese Science Bulletin2008，53，11： | 8 |
| 3 | 陆壳的生成:与赞歧岩类的联系显示文摘陆壳的平均成分为中性,而某些典型岛弧岩浆岩也具中性的化学组成,因而,人们认为陆壳应产生于古老的会聚板块边界.中性陆壳形成的一个可能机制是直接产生于上地幔的安山质熔体.产于日本西南Setouchi火山岩带的赞歧岩类包括高镁安山岩(HMA),是俯冲板片熔融及其后的熔体-地幔相互作用的结果.该岩类形成于特殊构造环境(例如,热的岩石圈俯冲进入异常热的上地幔),这种环境可能在太古代时业已存在.富水的高镁安山岩岩浆很可能在地壳内固结形成高镁安山质岩体,然后这些岩体重熔产生了分异的赞歧岩类.目前,高镁安山岩岩浆的形成和分异可能正发生于Izu-Bonin Mariana(IBM)弧-沟系.这是因为:(1)IBM演化初始阶段以高镁安山岩岩浆作用为特征(2)IBM中地壳的波速VP与总体陆壳的波速一致.对具高镁安山质深成岩的VP估计也支持了这一点,但也不能排除英云闪长质岩在该岛弧中部地壳的存在.因此,陆壳的形成也有可能由幔源玄武质岩浆分异而产生. | Yoshiyuki Tatsumi | 2008 | 科学通报2008，53，9： | 6 |
| 4 | Treatment of bleaching wastewater from pulp paper plants in China using enzymes and coagulants显示文摘The treatment of wastewater from pulp\|paper plants in China by horseradish peroxidase was investigated in this study. The effects of horseradish peroxidase and coagulants were discussed in detail. The results indicated that enzymes might improve the removal of AOX, TOC and colour for pulp\|paper wastewater and modified chitosan is far more effective than Al\-2(SO\-4)\-3 to remove AOX, TOC and colour. | ZHANG Tong\+1, Shinji Wada\+2, Takao Yamagishi\+2, Ichikawa Hiroyasu\+2, Kenji Tatsumi\+ 2* , ZHAO Qing\|xiang\+1 (1. Department of Environmental Engineering, East China University of Science and Technology, Shanghai 200237,China 2. National Institut | 1999 | Journal of Environmental Sciences1999，11，4： | 5 |
| 5 | Effects on coagulation factor production following primary hepatomitogen-induced direct hyperplasia显示文摘AIM:To investigate the molecular mechanisms involved in coagulation factor expression and/or function during direct hyperplasia(DH) -mediated liver regeneration.METHODS:Direct hyperplasia-mediated liver regeneration was induced in female C57BL/6 mice by administering 1,4-bis[2-(3,5-dichloropyridyloxy) ] benzene(TCPOBOP) ,a representative hepatomitogen.Mice were weighed and sacrificed at various time points [Day 0(D0:prior to injection) ,3 h,D1,D2,D3,and D10] after TCPOBOP administration to obtain liver and blood samples.Using the RNA samples extracted from the liver,a comprehensive analysis was performed on the hepatic gene expression profiling of coagulation-related factors by real-time RT-PCR(fibrinogen,prothrombin,factors Ⅴ,Ⅶ,Ⅷ,Ⅸ,Ⅹ,Ⅺ,Ⅻ,XⅢβ,plasminogen,antithrombin,protein C,protein S,ADAMTS13,and VWF) .The corresponding plasma levels of coagulation factors(fibrinogen,prothrombin,factors Ⅴ,Ⅶ,Ⅷ,Ⅸ,Ⅹ,Ⅺ,Ⅻ,XⅢ,and VWF) were also analyzed and compared with their mRNA levels.RESULTS:Gavage administration of TCPOBOP(3 mg/kg body weight) resulted in a marked and gradual increase in the weight of the mouse livers relative to the total body weight to 220% by D10 relative to the D0(control) ratios.At the peak of liver regeneration(D1 and D2) ,the gene expression levels for most of the coagulationrelated factors(fibrinogen,prothrombin,factors Ⅴ,Ⅶ,Ⅷ,Ⅸ,Ⅺ,Ⅻ,XⅢβ,plasminogen,antithrombin,protein C,ADAMTS13,VWF) were found to be downregulated in a time-dependent manner,and gradually recovered by D10 to the basal levels.Only mRNA levels of factor Ⅹ and protein S failed to show any decrease during the regenerative phase.As for the plasma levels,5 clotting factors(prothrombin,factors Ⅷ,Ⅸ,Ⅺ,and Ⅻ) demonstrated a significant decrease(P < 0.05) during the regeneration phase compared with D0.Among these 5 factors,factor Ⅸ and factor Ⅺ showed the most dramatic decline in their activities by about 50% at D2 compared to the basal levels,and these reductions in plasma activity for both factors were consistent with our RT-PCR findings.In contrast,the plasma activities of the other coagulation factors(fibrinogen,factors Ⅴ,Ⅶ,XⅢ,and VWF) were not significantly reduced,despite the reduction in the liver mRNA levels.Unlike the other factors,FX showed a temporal increase in its plasma activity,with significant increases(P < 0.05) detected at D1.CONCLUSION:Investigating the coagulation cascade protein profiles during liver regeneration by DH may help to better understand the basic biology of the liver under normal and pathological conditions. | Kohei Tatsumi Kazuo Ohashi Sanae Taminishi Soichi Takagi Rie Utoh Akira Yoshioka Midori Shima Teruo Okano | 2009 | World Journal of Gastroenterology2009，15，42： | 5 |
| 6 | 利用钐掺杂氧化铈提高燃料电池阳极活性显示文摘用浸渍法制备并采用交流阻抗、极化等技术考察了不同组成的Ni-Sm^(3+)掺杂的CeO_2(SDC)复合镍阳极的电化学性能及相应电池的功率输出性能.结果表明,SDC掺入镍阳极后,阳极极化过电位及电池的欧姆电阻显著减小.其中阳极过电位的减小与SDC掺入镍电极引起的三相界扩展有关,但SDC的掺入同时引起了电极反应活化能的增加,造成低温下Ni-SDC的极化过电位大于纯Ni电极.高温下,Ni-SDC阳极的阻抗谱由两个半圆组成,其中高频半圆随着SDC掺入量的增加而减小,而低频环与SDC的掺入量基本无关.低温下只观察到一个高频环.高频环可能对应三相界反应,而低频环可能对应氢的解离吸附及扩散.75%(w)Ni-25%(w)SDC/La_(0.9)Sr_(0.1)Ga_(0.8)Mg_(0.2)O_3(LSGM)/Sm_(0.5)Sr_(0.5)CoO_3(SSC)在所研究的电池中具有最大功率输出密度,其值在1073、973、873 K下分别达到1.1、0.43、0.14 W·cm^(-2). | 王世忠 Ishihara Tatsumi | 2003 | 物理化学学报2003，19，9： | 4 |
| 7 | 900~2800K多晶石墨电阻率与温度的关系显示文摘1.前言石墨,在惰性气氛下有3300K以上的耐热性,加之它在导电、耐粒子等方面也显示优异的特性,因此作为超高温炉的发热体、宇航材料、原子反应堆用材料等被广泛利用。然而,测定1800K以上的物性,在设备和技术方面是困难的。目前超高温用石墨材料的设计是采用从低温区域得到的石墨数据外推值,再参考经验积累的推断值进行的。因此,开发能够高精度测量炭,石墨材料的电气、机械、高温特性的设备,进而确立可靠性高的评价技术就显得很迫切。有关3300K温度范围内的电导率,虽然美国,苏联已有报告发表,但测试设备和测试条件没有详细说明,并且测试的试样也只局限于特定的石墨种类。 | Masakazu Adachi Hiroshi Shioyama Masaki Narisawa Shigeru Ikeda kuniaki Tatsumi Isao Souma Hideo Isozaki kazunori Egawa Hirofumi Kyutoku Takesi Tanamura 刘培桐 | 1991 | 炭素技术1991，10，4： | 4 |
| 8 | Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection显示文摘 | Mika Kurokawa Naoki Hiramatsu Tsugiko Oze Takayuki Yakushijin Masanori Miyazaki Atsushi Hosui Takuya Miyagi Yuichi Yoshida Hisashi Ishida Tomohide Tatsumi Shinichi Kiso Tatsuya Kanto Akinori Kasahara Sadaharu Iio Yoshinori Doi Akira Yamada Masahide Oshita | 2012 | Journal of Gastroenterology2012，，5： | 4 |
| 9 | 二甲醚的电催化氧化反应显示文摘考察了负载于镓酸镧基电解质上的镍电极与镍 钐掺杂氧化铈复合电极电催化二甲醚氧化反应的特性 .结果表明 ,反应的主要产物均为CO ,H2 和CH4,同时生成少量完全氧化的产物H2 O和CO2 .在开路电位下二甲醚发生裂解反应 ,生成的CO ,H2 和CH4三种主要产物的比例接近于 1.在有电泵氧存在下 ,二甲醚的电催化氧化反应强烈地依赖于阳极及电解质材料的组成 .Ni/La0 9Sr0 1Ga0 8Mg0 2 O3 界面上发生的主反应是二甲醚的部分氧化 ,且存在有严重的积碳现象 .电极中掺入SDC( 15 %Sm3 + 掺杂的CeO2 )后 ,二甲醚完全氧化性能明显增强 ;随着电流的增大 ,氢的生成速率显著减小 ,并生成大量的H2 O .采用掺钴镓酸镧基电解质后 ,Ni SDC主要表现为催化二甲醚部分氧化反应 ,且显著抑制了积碳的发生 .Ni SDC/La0 8Sr0 2Ga0 8 Mg0 11Co0 0 9O3 上二甲醚电催化氧化反应的主要产物为 1∶1的CO和H2 .掺钴电解质引起Ni SDC具有特殊的催化性能 ,可能与电解质中 | 王世忠 Tatsumi ISHIHARA | 2003 | 催化学报2003，24，9： | 4 |
| 10 | Clear cell adenocarcinoma of the colon:A case report and review of literature显示文摘A primary clear cell adenocarcinoma of the colon is a rare oncologic entity. We herein report a case of such a tumor of the sigmoid colon in a 71-year-old woman who was successfully treated by an endoscopic polypectomy in our hospital. We also reviewed the published reports regarding cases of primary clear cell tumors in the colon. | Koichi Soga Hideyuki Konishi Natsuko Tatsumi Chika Konishi Keimei Nakano Naoki Wakabayashi Shoji Mitsufuji Keisho Kataoka Takeshi Okanoue Ken-Ichi Mukaisho Takanori Hattori | 2008 | World Journal of Gastroenterology2008，14，7： | 4 |
| 11 | 利用钐掺杂的氧化铈夹层提高燃料电池阳极的活性显示文摘考察了Ni-钐掺杂的氧化铈(Ni-SDC)复合阳极与La_(0.9)Sr_(0.1)Ga_(0.8)Mg_(0.2)O_3(LSGM)电解质中间加入的SDC中间层对阳极及整个电池性能的影响.结果表明,SDC中间层的加入显著减小了阳极极化过电位,但同时引入了欧姆降,降低了电池的功率输出密度.氢在Ni-SDC电极的氧化主要由两个过程控制,分别对应于交流阻抗谱的两个阻抗半圆,高频环随着SDC中间层的加入显著减小,可能对应于H_2在Ni-SDC/SDC/H_2三相界的电化学氧化或氧从LSGM向SDC的传输,低频环与SDC中间层无关,可能对应于氢在电极表面的解离吸附及吸附物种的扩散过程.使用Ni-SDC/SDC夹层阳极可以明显地提高电池的稳定性. | 王世忠 Ishihara Tatsumi | 2003 | 物理化学学报2003，19，9： | 3 |
| 12 | Paradoxical reduction of cerebral blood flow after acetazolamide loading:a hemodynamic and metabolic study with ^(15)O PET显示文摘Paradoxical reduction of cerebral blood flow(CBF)after administration of the vasodilator acetazolamide is the most severe stage of cerebrovascular reactivity failure and is often associated with an increased oxygen extraction fraction(OEF).In this study,we aimed to reveal the mechanism underlying this phenomenon by focusing on the ratio of CBF to cerebral blood volume(CBV)as a marker of regional cerebral perfusion pressure(CPP).In 37patients with unilateral internal carotid or middle cerebral arterial(MCA)steno-occlusive disease and8 normal controls,the baseline CBF(CBF_b),CBV,OEF,cerebral oxygen metabolic rate(CMRO_2),and CBF after acetazolamide loading in the anterior and posterior MCA territories were measured by^(15)O positron emission tomography.Paradoxical CBF_b reduction was found in 28 of 74 regions(18of 37 patients)in the ipsilateral hemisphere.High CBF_b(>47.6 mL/100 mL/min,n=7)was associated with normal CBF_b/CBV,increased CBV,decreased OEF,and normal CMRO_2.Low CBF_b(<31.8 mL/100mL/min,n=9)was associated with decreased CBF_b/CBV,increased CBV,increased OEF,and decreased CMRO_2.These findings demonstrated that paradoxical CBF reduction is not always associated with reduction of CPP,but partly includes highCBF_b regions with normal CPP,which has not been described in previous studies. | Tadashi Watabe Eku Shimosegawa Hiroki Kato Kayako Isohashi Mana Ishibashi Mitsuaki Tatsumi Kazuo Kitagawa Toshiyuki Fujinaka Toshiki Yoshimine Jun Hatazawa | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 13 | Elimination of aflatoxin B 1 in peanuts by acidic electrolyzed oxidizing water显示文摘 | Qian Zhang Ke Xiong Eizo Tatsumi Li-te Li Hai-jie Liu | 2012 | Food Control2012，，1： | 2 |
| 14 | Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice显示文摘 | Fumitake Usui Hiroaki Kimura Taichi Ohshiro Kazuki Tatsumi Akira Kawashima Akiyo Nishiyama Yo-ichiro Iwakura Shun Ishibashi Masafumi Takahashi | 2012 | Biochemical and Biophysical Research Communications2012，，1： | 2 |
| 15 | An Intravoxel Incoherent Motion Diffusion-Weighted Imaging Study of Prostate Cancer显示文摘 | Hiroshi Shinmoto Chiharu Tamura Shigeyoshi Soga Eisuke Shiomi Nobuyuki Yoshihara Tatsumi Kaji Robert V. Mulkern | 2012 | American Journal of Roentgenology2012，，： | 2 |
| 16 | Kinematic evaluation of the adjacent segments after lumbar instrumented surgery: a comparison between rigid fusion and dynamic non-fusion stabilization显示文摘 | Yuichiro Morishita Hideki Ohta Masatoshi Naito Yoshiyuki Matsumoto George Huang Masato Tatsumi Yoshiharu Takemitsu Hirotaka Kida | 2011 | European Spine Journal2011，，9： | 2 |
| 17 | The effect of phosphatidylserine administration on memory and symptoms of attention‐deficit hyperactivity disorder: a randomised, double‐blind, placebo‐controlled clinical trial显示文摘 | S. Hirayama K. Terasawa R. Rabeler T. Hirayama T. Inoue Y. Tatsumi M. Purpura R. J?ger | 2014 | J Hum Nutr Diet2014，，： | 2 |
| 18 | Effect of selective thermal denaturation of seybean proteins on soymilk viscosity and tofu's physical properties显示文摘 | Liu Z S Chang S K C Li L T Tatsumi E | 2004 | Food Research International2004，37，： | 1 |
| 19 | Chemical characteristics of fluid phase from a subducted lithosphere and origin of arc magmas: Evidence from high-pressure experiments and natural rocks 显示文摘 | Tatsumi Y Hamilton D L Nesbitt R W | 1986 | Journal of Velcanology and Geothermal Research1986，29，： | 1 |
| 20 | Investigation of the structure of cellulose in LiCl/DMAc solution and its gelation behavior by small-angle X-ray scattering measurements显示文摘 | DAISUKE Ishii DAISUKE Tatsumi TAKAYOSHI Matsumoto | 2006 | Macromolecular Bioscience2006，6，： | 1 |
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