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| 1 | Amino Acid Catabolism in Plants显示文摘氨基酸在植物有各种各样的突出的功能。除他们的用法以外在蛋白质生合成期间,他们也为几条另外的生合成小径代表积木并且在表明过程期间以及在植物压力反应起枢轴的作用。一般来说, 20 氨基酸的水池尺寸强烈不同并且动态地变化取决于植物房间的发展、生理的状态。除氨基酸生合成,它已经详细地被调查了以外,氨基酸的分解代谢具有为调整他们的水池尺寸的中央重要性,但是到目前为止画了少得多注意。氨基酸的降级能也在某些生理的条件下面实质地作出贡献到植物房间的精力状态,例如碳饥饿。在这评论,我们讨论氨基酸分解代谢的生物角色并且在植物房间生理学的上下文在氨基酸降级小径和他们的规定上总结当前的知识。 | Tatjana M. Hildebrandt Adriano Nunes Nesi Wagner L. Araujo Hans-Peter Braun | 2015 | Molecular Plant2015，8，11： | 28 |
| 2 | Epidemiology of hepatitis B virus infection in Albania显示文摘AIM:To assess the prevalence and socio-demographic distribution of hepatitis B virus(HBV) infection in Albania.METHODS:Blood samples from 410 unselected schoolboys,666 students,500 military personnel,1286 casual blood donors,378 voluntary blood donors and 640 pregnant women(total 3880 non-vaccinated residents of rural and metropolitan areas from all over Albania;2354(60.7%) male and 1526(39.3%) female;mean age of 26.3 years) were tested during 2004-2006 for hepatitis B surface antigen(HBsAg) and antibodies to hepatitis B virus(anti-HBs) by ELISA.RESULTS:The HBsAg and anti-HBs prevalence were 9.5% and 28.7%,respectively.The highest HBsAg prevalence was evident in the younger age group,such as in schoolchildren(11.8%) and the military(10.6%).Consequently,the anti-HBs prevalence increased with age,from 21.2% in schoolchildren(mean age:15.7 years),to 36.3% in pregnant women(mean age:26.3 years) and 29.7% in voluntary blood donors(mean age:40.1 years).There were no significant differences between males and females.CONCLUSION:Despite the estimated two-fold reduction of HBsAg prevalence in the general population from about 18%-19% to 9.5%,Albania remains a highly endemic country(i.e.over 8% of HBsAg prevalence rate). | Bashkim Resuli Skerdi Prifti Bledar Kraja Tatjana Nurka Mimoza Basho Edita Sadiku | 2009 | World Journal of Gastroenterology2009，15，7： | 9 |
| 3 | 红外光谱法研究古代彩绘蛋白胶料光老化的二级结构变化显示文摘动物胶和蛋清是古代重要彩绘文物蛋白胶结材料,对其光老化蛋白质结构变化的研究与探索彩绘文物病变机理和选择科学保护材料、修复方法密切相关。以维也纳艺术历史博物馆的动物胶(骨胶、兔皮胶、鲟鱼胶)和蛋清为研究对象,利用红外光谱技术,结合酰胺Ⅰ带去卷积和高斯拟合法研究光老化过程中蛋白质二级结构的改变。结果表明,四种胶光老化后仍然具备蛋白质红外光谱的典型吸收特征。但红外吸收峰出现了不同程度的位移,其中蛋清糖苷键明显蓝移。酰胺Ⅰ带去卷积和高斯拟合结果显示,蛋白胶的二级结构占比发生了改变。其中,骨胶α-螺旋结构占比降低22.24%,逐渐解螺旋,无规则卷曲结构占比明显增高(9.76%);兔皮胶和鲟鱼胶α-螺旋结构占比分别降低5.31%,4.15%,前者无规则卷曲增幅最低(6.96%),后者反而减少,推测两者的光老化稳定性高。蛋清α-螺旋占比降低程度最高(44.45%),无规则卷曲占比增幅极大(27.49%),光老化稳定性最差。证实利用红外光谱技术,结合酰胺Ⅰ带去卷积和高斯拟合法研究文物蛋白胶料二级结构变化的方法是可行的,但其转化机理还需后期进一步探讨。 | 马珍珍 王丽琴 Gabriela Krist Tatjana Bayerova 杨璐 | 2017 | 光谱学与光谱分析2017，37，9： | 9 |
| 4 | Clinical outcome in patients with hilar malignant strictures type Ⅱ Bismuth-Corlette treated by minimally invasive unilateral versus bilateral endoscopic biliary drainage显示文摘BACKGROUND:Stenting of malignant hilar strictures remains a standard endoscopic treatment in patients with unresectable tumors.The aim of this two-center prospective study was to compare unilateral versus bilateral drainage in hilar malignant stenosis Bismuth-Corlette type II.METHODS:During a 3-year period,a total of 49 patients with hilar tumors(Bismuth-Corlette type II) were referred for endoscopic treatment,following the criteria of unresectability.Ultrasound,computed tomography scan and magnetic resonance cholangiopancreatography(MRCP) were previously performed in all patients in order to facilitate endoscopic retrograde cholangiopancreatography(ERCP).The stricture was first passed by the hydrophilic guide-wire and then contrast medium was injected.Mechanical bile duct dilation was performed,followed by plastic stent placement only in the liver lobe which was previously opacified.The procedures were performed under conscious sedation.The patients were followed up for the next 12 months with a stent exchange every 3 months.Primary outcome was assessed by patient survival in the first 12 months after the procedure.RESULTS:All 49 patients were treated with ERCP while 39(79.59%) had successful stent placement.Among these,32 had hilar cholangiocarcinoma(82%) and 7(18%) had gallbladder cancer.Two groups of patients had Bismuth II strictures:A,21 patients(54%) with unilateral contrast injection and drainage,and B,18(46%) with bilateral contrast injection and drainage.A total of 57 plastic stents were used(10 Fr,89%;11.5 Fr,11%).Group B showed a lower bilirubin level 7 days after the procedure(P=0.008).Early complications were cholangitis(3 patients,2 in group A and 1 in group B) and acute pancreatitis(2 patients,1 each in A and B) with no statistical difference between the groups.Late complications were stent migration(5 patients,1 in A and 4 in B) and stent clogging(6 patients,2 in A and 4 in B) showing a significant difference between the groups(P<0.01).The first stent replacement after 3 months was successful in 87% of patients(four died due to disease progression and one due to cardiopulmonary insufficiency) showing no statistical difference between the groups.At 6 months follow-up,72% patients survived,with no statistical difference between the groups.A final follow-up(12 months) showed the survival rate of 18%(4 patients from group A and 3 from group B)(P>0.05).CONCLUSIONS:A minimally invasive approach,based on the criterion that every bile duct being opacified needs to be drained,is associated with a lower incidence of early complications.Considering that the clinical outcome measured by bilirubin level was lower in patients with bilateral drainage 7 days after the procedure,we assumed that drainage of 50% or more of the liver volume leads to sufficient drainage effectiveness. | Milutin Bulajic Nikola Panic Miodrag Radunovic Radisav Scepanovic Radoslav Perunovic Predrag Stevanovic Tatjana Ille Maurizio Zilli Mirko Bulajic | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 8 |
| 5 | Trans-arterial chemoperfusion for the treatment of liver metastases of breast cancer and colorectal cancer: Clinical results in palliative care patients显示文摘AIM To evaluate the clinical value and efficiency of transarterial chemoperfusion(TACP) in patients with liver metastases from breast cancer(BC) and colorectal cancer(CRC).METHODS We treated 36 patients with liver metastases of BC(n = 19, 19 females) and CRC(n = 17; 8 females, 9 males) with repeated TACP. The treatment interval was 4 wk. TACP was performed with gemcitabine(1000 mg/m2) and mitomycin(10 mg/m2), administered within 1 h after positioning the catheter tip in the hepatic artery. Before treatment, the size, location, tumour volume, vascularization and number of liver tumours were evaluated using magnetic resonance imaging(MRI). Tumour response was evaluated according to the Response Evaluation Criteria in Solid Tumors guidelines.RESULTS TACP using gemcitabine and mitomycin for metastases from CRC and BC was performed without any serious side effects. The follow-up MRI showed a therapeutic response in 84.2% of the BC patients-stable disease 47.4% and partial response 36.8%. A progression was seen in 15.8%.CRC patients showed a therapeutic response in 52.9% of cases. A progression of the disease was documented in 47.1% of the patients with CRC. These data show that TACP in patients with liver metastases of BC leads to a significantly better therapeutic response compared with CRC patients(P = 0.042). The median survival time was 13.2 mo for the BC patients, which is significantly longer than for CRC patients at 9.3 mo(P = 0.001).CONCLUSION TACP for liver metastases of BC appears to be a safe and effective palliative treatment with improved outcomes in comparison to patients with CRC. | Tatjana Gruber-Rouh Marcel Langenbach Nagy NN Naguib Nour-Eldin M Nour-Eldin Thomas J Vogl Stephan Zangos Martin Beeres | 2017 | World Journal of Clinical Oncology2017，8，4： | 7 |
| 6 | pregnane X receptor and constitutive androstane receptor modulate differently CYp3A-mediated metabolism in earlyand late-stage cholestasis显示文摘AIM To ascertain whether cholestasis affects the expression of two CYP3 A isoforms(CYP3 A1 and CYP3 A2) and of pregnane X receptor(PXR) and constitutive androstane receptor(CAR).METHODS Cholestasis was induced by bile duct ligation in 16 male Wistar rats; whereas 8 sham-operated rats were used as controls. Severity of cholestasis was assessed on histological examination of liver sections, and serum concentrations of albumin, AST, ALT, GGT, ALPK and bilirubin. Gene and protein expressions of PXR, CAR, CYP3 A1 and CYP3 A2 were assessed by means of q RT-PCR and Western blot, respectively. Alterations in CYP3 A activity were measured by calculating the kinetic parameters of 4-OH and 1'-OH-midazolam hydroxylation, marker reactions for CYP3 A enzymes.RESULTS The m RNA and protein expression of CYP3 A1 increased significantly in mild cholestasis(P < 0.01). At variance, m RNA and protein expression of CYP3 A2 didn't change in mild cholestasis, whereas the expression and activity of both CYP3 A1 and CYP3 A2 decreased dramatically when cholestasis became severe. Consistently with these observations, the nuclear expression of both PXR and CAR, which was measured because they both translocate into the cell nucleus after their activation, virtually disappeared in the late stage of cholestatic injury, after an initial increase. These results indicate that early-and late-stage cholestasis affects CYP3 Amediated drug metabolism differently, probably as consequence of the different activation of PXR and CAR.CONCLUSION Early-and late-stage cholestasis affects CYP3 Amediated drug metabolism differently. PXR and CAR might be targeted therapeutically to promote CYP3 Amediated liver detoxification. | Daniela Gabbia Arianna Dalla Pozza Laura Albertoni Roberta Lazzari Giorgia Zigiotto Maria Carrara Vincenzo Baldo Tatjana Baldovin Annarosa Floreani Sara De Martin | 2017 | World Journal of Gastroenterology2017，23，42： | 5 |
| 7 | Effects of food quality on trade-offs among growth, immunity and survival in the greater wax moth Galleria mellonella显示文摘对在任何给定的环境的一个个人可得到的资源是有限的,并且特点反映的生活历史上的变化到竞争生活的这些资源的微分分配工作食物的营养的质量具有在在这研究的这些生活历史决定的特别重要性,我们在生长之中测试了交易,在幼虫在我们发现生长快速的高、平均的营养的质量的节食喂了的3组更大的蜡蛾(街郎 mellonella )的免疫和弱免疫(是由封装反应测量了)在高精力的食物组的幼虫,它更长拿了在食物上发展平均营养不管多么的质量,封装反应在这是更强壮的幼虫在低精力的食物组更长种了,并且有的组我们观察了的最强壮的封装反应在低精力的食物的幼虫的最高的幸存率组织,当最高的死亡率在高精力的食物组被观察时,在身体质量和封装反应的力量之间的重要否定关联仅仅在仅仅在这研究的结果帮助建立关系的最高的增长率揭示在生长和免疫之间的重要竞争的高精力的食物组被发现在食物,它的营养的价值和G. mellonella 幼虫的生活历史特点的类型之间。 | Indrikis Krams Sanita Kecko Katariina Kangassalo Fhionna R. Moore Eriks Jankevics Inna Inashkina Tatjana Krama Vilnis Lietuvietis Laila Meija Markus J. Rantala | 2015 | Insect Science2015，22，3： | 5 |
| 8 | SESAR:The Past,Present,and Future of European Air Traffic Management Research显示文摘The Single European Sky Air Traffic management(ATM)Research(SESAR)project is the technological pillar of the European Commission’s Single European Sky Initiative to modernize ATM.Here,we describe the process of establishing SESAR and the main parts of the project:the research and development(R&D)part,which is led by the SESAR Joint Undertaking;the deployment part,which is managed by the SESAR Deployment Manager;and the European ATM Master Plan,which collects and lays out both the R&D and deployment needs.The latest European ATM Master Plan was adopted just prior to the current pandemic.The huge loss in air traffic due to the pandemic,and the speed of the recovery of the aviation industry will require reprioritization,but the main elements that have been established-particularly those in support of the environment-remain valid. | Tatjana Bolic Paul Ravenhill | 2021 | Engineering2021，7，4： | 4 |
| 9 | Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients显示文摘AIM:To investigate whether the evaluation of tumor budding can complement K-RAS analysis to improve the individualized prediction of response to anti-epidermal growth factor receptor based therapies in metastatic colorectal cancer (mCRC) patients. METHODS:Forty-three patients with mCRC treated with cetuximab or panitumumab were entered into this study. According to the Response Evaluation Criteria in Solid Tumors criteria, 30 patients had stable or progressive disease (non-responsive), while 13 patients had a partial response. Tumor buds were evaluated from whole tissue sections stained for pan-cytokeratin, evaluated in the densest region using a 40 × objective and 'high-grade' tumor budding was defi ned as 15 buds/high-power f ield.RESULTS: Tumor buds and K-RAS mutation both correctly classif ied 68% of patients. All patients with K-RAS mutation (n=7) or high-grade tumor budding (n=11) were non-responsive, of which 4 patients had both features. All 13 partial responders were K-RAS wild-type with low-grade tumor budding. Combined, the predictive value of K-RAS and tumor budding was 80%. Additionally, high-grade tumor budding was significantly related to worse progression-free survival [HR (95% CI): 2.8 (1.3-6.0, P=0.008)].CONCLUSION: If confirmed in larger cohorts, the addition of tumor budding to K-RAS analysis may represent an effective approach for individualized patient management in the metastatic setting. | Inti Zlobec Francesca Molinari Vittoria Martin Luca Mazzucchelli Piercarlo Saletti Rosangela Trezzi Sara De Dosso Tatjana Vlajnic Milo Frattini Alessandro Lugli | 2010 | World Journal of Gastroenterology2010，16，38： | 4 |
| 10 | Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease显示文摘AIM: To investigate autonomic nervous function in patients with a diagnosis of gastroesophageal reflux disease(GERD).METHODS: The investigation was performed on 29patients(14 men), aged 18-80 years(51.14 ± 18.34),who were referred to our Neurocardiology Laboratory at the Clinical and Hospital Center 'Bezanijska Kosa'with a diagnosis of GERD. One hundred sixteen healthy volunteers matched in age and sex with the examinees served as the control group. The study protocol included the evaluation of autonomic function and hemodynamic status, short-term heart rate variability(HRV) analysis, 24 h ambulatory ECG monitoring with long-term HRV analysis and 24 h ambulatory blood pressure monitoring.RESULTS: Pathologic results of cardiovascular reflex test were more common among patients with reflux compared to the control group. Severe autonomic dysfunction was detected in 44.4% of patients and in7.9% of controls(P < 0.001). Parameters of short-term analysis of RR variability, which are the indicators ofvagal activity, had lower values in patients with GERD than in the control group. Long-term HRV analysis of time-domain parameters indicated lower values in patients with reflux disease when compared to the control group. Power spectral analysis of long-term HRV revealed lower low- and high-frequency values.Detailed 24 h ambulatory blood pressure analysis showed significantly higher values of systolic blood pressure and pulse pressure in the reflux group than in the control group.CONCLUSION: Patients with GERD have distortion of sympathetic and parasympathetic components of the autonomic nervous system, but impaired parasympathetic function appears more congruent to GERD. | Branislav Milovanovic Branka Filipovic Slavica Mutavdzin Marija Zdravkovic Tatjana Gligorijevic Jovana Paunovic Marina Arsic | 2015 | World Journal of Gastroenterology2015，21，22： | 4 |
| 11 | Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes显示文摘 | Burkhard Kloesch Tatjana Becker Elisabeth Dietersdorfer Hans Kiener Guenter Steiner | 2013 | International Immunopharmacology2013，，2： | 3 |
| 12 | Annular pancreas associated with duodenal carcinoma显示文摘Annular pancreas (AP) is a rare congenital anomaly. Coexisting malignancy has been reported only in a few cases. We report what is, to the best of our knowledge, the first case in the English literature of duodenal adenocarcinoma in a patient with AP. In a 55-year old woman with duodenal outlet stenosis magnetic resonance cholangiopancreatography showed an aberrant pancreatic duct encircling the duodenum. Duodenojejunostomy was performed. Eight weeks later she presented with painless jaundice. Duodenopancreatectomy revealed a duodenal adenocarcinoma, surrounded by an incomplete AP. Thus, co-existent malignancy with AP can be present without obstructive jaundice and without being visible through preoperative diagnostics. | Enrico Bronnimann Silke Potthast Tatjana Vlajnic Daniel Oertli Oleg Heizmann | 2010 | World Journal of Gastroenterology2010，16，25： | 3 |
| 13 | Co-expression of the proteinase inhibitors oryzacystatin I and oryzacystatin II in transgenic potato alters Colorado potato beetle larval development显示文摘科罗拉多土豆甲壳虫(CPB;Leptinotarsa decemlineata 说,翘目:Chrysomelidae ) 显示出显著适应性到许多控制措施。尽管 oryzacystatin 我和 II (OCI 和 OCII ) 在控制为食物消化使用半胱氨酸朊酶的害虫有潜力,在土豆的单个 OC 基因的表示展出了一最小或 CPB 健康特点上的没有效果。这研究的目的是在土豆(茄属 tuberosum L.) 检验 coexpressed OCI 和 OCII 的效果 CPB 幼虫上的栽培变种 Desiree, Dragaevka 和 Jelica。CPB 幼虫的朊酶的生长参数,消费率和食物利用,以及活动是 assayed。第二和第三个中间形态幼虫在更高相对的生长和消费比在 nontransformed 叶子喂的幼虫评估的更早、有的转变叶子 molted 上喂了,当食物利用的效率是未受影响的时。相反,消费的叶子的第四中间形态最大值重量获得和数量是大约 20% 为在转基因的土豆上喂的幼虫更低。第三个中间形态幼虫的全部的朊酶活动的分析在 azocasein 水解作用测量的全面解朊的活动揭示了减小,在土豆的摄取离开以后,与半胱氨酸朊酶活动 24 h 的抑制伴随了表示 OCI 和 OCII。然而,在在转变叶子的长期的喂以后,幼虫的解朊的活动变得类似于控制。尽管在 OCI/OCII 叶子喂没影响幼虫的幸存, OC 基因的 coexpression 减少了发展时间并且显著地因此减少了 CPB 幼虫引起的植物损坏。 | Aleksandar Cingel Jelena Savic Jelica Lazarevic Tatjana Cosic Martin Raspor Ann Smigocki Slavica Ninkovic | 2017 | Insect Science2017，24，5： | 3 |
| 14 | Telmisartan induces melanoma cell apoptosis and synergizes with vemurafenib in vitro by altering cell bioenergetics显示文摘Objective: Despite recent advancements in targeted therapy and immunotherapies, prognosis for metastatic melanoma patients remains extremely poor. Development of resistance to previously effective treatments presents a serious challenge and new approaches for melanoma treatment are urgently needed. The objective of this study was to examine the effects of telmisartan, an AGTR1 inhibitor and a partial agonist of PPARγ, on melanoma cells as a potential agent for repurposing in melanoma treatment.Methods: Expression of AGTR1 and PPARγ m RNA in melanoma patient tumor samples was examined in publicly available datasets and confirmed in melanoma cell lines by qRT-PCR. A panel of melanoma cell lines was tested in viability, apoptosis and metabolic assays in presence of telmisartan by flow cytometry and immunocytochemistry. A cytotoxic effect of combinations of telmisartan and targeted therapy vemurafenib was examined using the Chou-Talalay combination index method.Results: Both AGTR1 and PPARγ mRNA were expressed in melanoma patient tumor samples and decreased compared to the expression in the healthy skin. In vitro, we found that telmisartan decreased melanoma cell viability by inducing cell apoptosis.Increased glucose uptake, but not utilization, in the presence of telmisartan caused the fission of mitochondria and release of reactive oxygen species. Telmisartan altered the cell bioenergetics, thereby synergizing with vemurafenib in vitro, and even sensitized vemurafenib-resistant cells to the treatment.Conclusions: Given that the effective doses of telmisartan examined in our study can be administered to patients and that telmisartan is a widely used and safe antihypertensive drug, our findings provide the scientific rationale for testing its efficacy in treatment of melanoma progression. | Jelena Grahovac Tatjana Srdic-Rajic Juan Francisco Santibanez Marijana Pavlovic Milena Cavic Sinisa Radulovic1 | 2019 | Cancer Biology & Medicine2019，16，2： | 3 |
| 15 | Geographical Distribution and Morphological Variability of the Rapid Racerunner,Eremias velox (Pallas,1771)(Reptilia,Lacertidae) in the Eastern Periphery of Its Range显示文摘Phenotypic traits are usually correlated with the environment where organism occurs. In this study, the distribution of Eremias velox in the eastern periphery of its range was specified, and its morphological variation was analyzed. Linear dimensions, pholidosis, coloration and pattern features were compared among 135 specimens from nine populations inhabiting the Balkhash, Ili and Alakol basins, Junggar and Turpan depressions in the territory of Southeast Kazakhstan and Xinjiang, Northwest China. The populations from the Junggar Depression(Kuytun, Shihezi and Urumqi) were characterized by higher mean values of linear characters, the number of scales across the middle of the body and gular, and were similar in the dominant coloration patterns. Small size, dark coloration and almost complete dominance of the striped-type coloration pattern among the specimens from the Alakol Lake islands seem to have an adaptive significance associated with the isolation of the population and type of their habitats. The subspecies Eremias velox roborowskii(endemic to the Turpan Depression) is elevated to species level, as supported by morphological divergence congruent with molecular and geographical data, including its peculiar type of coloration pattern, significantly lower amount of femoral pores and a higher percentage of specimens with one enlarged preanal scale(72.7%). These results together confirm a high degree of variability in morphology for E.veloх in the eastern periphery of its range, reflecting a complex orography and the existence of multiple geographical barriers in this territory. | Marina A.CHIRIKOVA Tatjana N.DUJSEBAYEVA Jinlong LIU Xianguang GUO | 2019 | Asian Herpetological Research2019，10，4： | 3 |
| 16 | Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study显示文摘 | Irina A. Kirpich Natalia V. Solovieva Svetlana N. Leikhter Natalia A. Shidakova Oxsana V. Lebedeva Pavel I. Sidorov Tatjana A. Bazhukova Andrej G. Soloviev Shirish S. Barve Craig J. McClain Matt Cave | 2008 | Alcohol2008，，8： | 2 |
| 17 | Epidemiology of hepatitis C in Croatia in the European context显示文摘We analyzed prevalence, risk factors and hepatitis C virus(HCV) genotype distribution in different population groups in Croatia in the context of HCV epidemiology in Europe, with the aim to gather all existing information on HCV infection in Croatia which will be used to advise upon preventive measures. It is estimated that 35000-45000 of the Croatian population is chronically infected with HCV. Like in other European countries, there have been changes in the HCV epidemiology in Croatia over the past few decades. In some risk groups(polytransfused and hemodialysis patients), a significant decrease in the HCV prevalence was observed after the introduction of routine HCV screening of blood/blood products in 1992. Injecting drug users(IDUs) still represent a group with the highest risk for HCV infection with prevalence ranging from 29% to 65%. Compared to the prevalence in theCroatian general population(0.9%), higher prevalence rates were found in prison populations(8.3%-44%), human immunodeficiency virus-infected patients(15%), persons with high-risk sexual behavior(4.6%) and alcohol abusers(2.4%). Low/very low prevalence was reported in children and adolescents(0.3%) as well as in blood donors(0%-0.009%). In addition, distribution of HCV genotypes has changed due to different routes of transmission. In the general population, genotypes 1 and 3 are most widely distributed(60.4%-79.8% and 12.9%-47.9%, respectively). The similar genotype distribution is found in groups with high-risk sexual behavior. Genotype 3 is predominant in Croatian IDUs(60.5%-83.9%) while in the prison population genotypes 3 and 1 are equally distributed(52.4% and 47.6%). Data on HCV prevalence and risk factors for transmission are useful for implementation of preventive measures and HCV screening. | Tatjana Vilibic-Cavlek Jasmina Kucinar Bernard Kaic Maja Vilibic Nenad Pandak Ljubo Barbic Vladimir Stevanovic Jasmina Vranes | 2015 | World Journal of Gastroenterology2015，21，32： | 2 |
| 18 | Understanding the multifaceted etiopathogenesis of foot complications in individuals with diabetes显示文摘Diabetes mellitus,a chronic disease of metabolism,is characterized by a disordered production or cellular utilization of insulin.Diabetic foot disease,which comprises the spectrum of infection,ulceration,and gangrene,is one of the most severe complications of diabetes and is the most common cause of hospitalization in diabetic patients.The aim of this study is to provide an evidence-based overview of diabetic foot complications.Due to neuropathy,diabetic foot infections can occur in the form of ulcers and minor skin lesions.In patients with diabetic foot ulcers,ischemia and infection are the main causes of non-healing ulcers and amputations.Hyperglycemia compromises the immune system of individuals with diabetes,leading to persistent inflammation and delayed wound healing.In addition,the treatment of diabetic foot infections is challenging due to difficulty in accurate identification of pathogenic microorganisms and the widespread issue of antimicrobial resistance.As a further complicating factor,the warning signs and symptoms of diabetic foot problems can easily be overlooked.Issues associated with diabetic foot complications include peripheral arterial disease and osteomyelitis;accordingly,the risk of these complications in people with diabetes should be assessed annually.Although antimicrobial agents represent the mainstay of treatment for diabetic foot infections,if peripheral arterial disease is present,revascularization should be considered to prevent limb amputation.A multidisciplinary approach to the prevention,diagnosis,and treatment of diabetic patients,including those with foot ulcers,is of the utmost importance to reduce the cost of treatment and avoid major adverse consequences such as amputation. | Tatjana Matijević Jasminka Talapko Tomislav Meštrović Marijan Matijević Suzana Erić Ivan Erić IvanaŠkrlec | 2023 | World Journal of Clinical Cases2023，11，8： | 2 |
| 19 | The DNA-binding factor Ctcf critically controls gene expression in macrophages显示文摘巨噬细胞在免疫和动态平衡起一个重要作用。在经由特定的受体的病原体识别之上,他们很快导致煽动性的回答。这个过程紧在 transcriptional 水平被控制。DNA 有约束力的锌手指蛋白质 CCCTC 有约束力的因素(Ctcf ) 是远程的染色质相互作用的一个关键管理者并且协调在抄写因素和基因表达式进程之间的特定的通讯。在这研究, Ctcf 基因被使用转基因的 Cre-LoxP 系统明确地在 myeloid 房间删除。在 myeloid 房间的 Ctcf 基因的有条件的删除在 vivo 导致了温和显型。显著地展出的 Ctcf 缺乏的老鼠减少了主要 histocompatibility 的表示在肝的建筑群(MHC ) 班 II。Ctcf 缺乏的巨噬细胞表明了正常表面显型和吞噬作用能力。在像使用费的受体(TLR ) 之上刺激,他们生产了支持 inflammatory cytokines IL-12 和 IL-6 的正常层次,但是表明了一个强烈损害的能力生产肿瘤坏死因素(TNF ) 和 IL-10,以及表示 IL-10 家庭成员 IL-19, IL-20 和 IL-24。一起拿,我们的数据表明涉及巨噬细胞功能调整的 Ctcf 的一个角色。 | Tatjana Nikolic Dowty Movita Margaretha EH Lambers Claudia Ribeiro de Almeida] Paula Biesta Kim Kreefft Marjolein JW de Bruijn Ingrid Bergen Niels Galjart Andre Boonstra Rudi Hendriks | 2014 | Cellular & Molecular Immunology2014，11，1： | 2 |
| 20 | Weight gain in long-term survivors of kidney or liver transplantation—Another paradigm of sarcopenic obesity?显示文摘 | Tatjana Schütz Heike Hudjetz Anne-Eve Roske Cornelia Katzorke Georg Kreymann Klemens Budde Lutz Fritsche Hans-Hellmut Neumayer Herbert Lochs Mathias Plauth | 2012 | Nutrition2012，，4： | 2 |
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