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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 3 | 广谱抗生素在成人肺结核诊断中的应用显示文摘抗生素试验广泛用于菌阴肺结核的诊断已有30多年,尤其是在低资源国家。估计每年至少有2650万疗程的抗生素处方是出于这种做法,这可能增加抗生素的暴露及耐药的发生。为评估抗生素试验的诊断效能,研究人员对相关文献进行了系统综述和荟萃分析。通过检索Medline、Embase和Global Health数据库截至2019年3月15日关于成人疑似结核患者抗生素试验诊断效能的文献,使用QUADAS-2工具评估偏倚风险,使用双变量随机效应模型估算抗生素试验的合并敏感性和特异性,使用I2统计量进行异质性分析。 | Divala TH Fielding KL Kandulu C 刘盛盛(编译) | 2020 | 中华医学杂志2020，100，26： | 2 |
| 4 | Terrestrial xenology 显示文摘 | Staudacher Th Allegre C J | 1982 | Earth Planet Sci Lett1982，60，： | 2 |
| 5 | Advanced glycosylation end products induce inducible nitric oxide synthase (iNOS) expression via a p38 MAPK - dependent pathway 显示文摘 | Chang PC Chen TH Chang C J | 2004 | Kidney Int2004，65，5： | 1 |
| 6 | MUC16 (CA125) regulates epithelial ovarian cancer cell growth,tumorigenesis and metastasis显示文摘 | Thériault C Pinard M Comamala M | 2011 | Gynecol Oncol2011，121，3： | 1 |
| 7 | Clinical Outcomes after acute osteopor- otic vertebral fractures:a 2-year non-ran- domised trial comparing percutaneous vertebroplasty with conservative therapy显示文摘 | Diamond TH Bryant C Browne L | 2006 | Med J Aust2006，184，3： | 1 |
| 8 | Application of pressurized liquid extraction technology to pharmaceutical solid dosage from analysis显示文摘 | Hoang TH Farkas R Wells C | 2002 | Journal of Chromatography A2002，968，： | 1 |
| 9 | Anastomotie leakage following low anterior resection : results of a standardized diagnostic and therapeutic approach显示文摘 | Eekmann C Kujath P Schiedeck TH | 2004 | Int J Clorectal Dis2004，19，2： | 1 |
| 10 | Novel fuzzy feedback linearization strategy for control via differential geometry approach 显示文摘 | Li TH Huang C J Chen CC | 2010 | ISA Transactions2010，3，49： | 1 |
| 11 | Complete Characterization of a Broadband High - Finesse Cavity using an Optical Frequency Comb显示文摘 | Schliesser g Gohle C Udem Th | | 0，，： | 1 |
| 12 | Catastrophic debris flows on 13 August 2010 in the Qingping area, southwestern China: The combined effects of a strong earthquake and subsequent rainstorms显示文摘 | Tang C Van Asch Th W J Chang M | 2012 | Geomorphology2012，，： | 1 |
| 13 | Anastomotic leakage following low anterior resection:results of a standardized diagnostic and therapeutic approach显示文摘 | Eckmamn C Kujath P Schiedeck TH | 2004 | Int Colorectal Dis2004，19，2： | 1 |
| 14 | Increased P-wave dispersion predicts recurrent atrial fibrillation after cardioversion 显示文摘 | Perzanowski C Andrew TH Jacobson AK | 2005 | J Electrocardio12005，38，1： | 1 |
| 15 | Clinical out comes after acuteosteoporotic vertebral fractures: a 2 year non-randomised trial compa-ring percutaneous ver- tebroplasty with conservative therapy显示文摘 | Diamond TH Bryant C Browne L | 2006 | Med J Aust2006，184，： | 1 |
| 16 | Farfield impact of water injection dredging in the Crouch River 显示文摘 | Winterwerp J C Wang Z B Kester J A Th M van | 2002 | Water & maritime engineering2002，，4： | 1 |
| 17 | Anastomotic leak- age follow low anterior resection results of a standard ized di- agnostic and the rap eutic approach显示文摘 | Eckm ann C Kujath P Sch iedeck TH | 2004 | Int J ColorectalD is2004，19，2： | 1 |
| 18 | Clinical and radiographicpresentions of pulmonary cryptococcosis in immunocompetentpatients显示文摘 | Yang C J Hwang JJ Wang TH | 2006 | Scand J Infect Dis2006，38，9： | 1 |
| 19 | Effects of furfural on the respiratory melabolism of Saccharomyces cerevisiae in glucose-limited chemostats显示文摘 | Horva' th I S Franzen C J Taherzadeh M J er al | 2008 | Applied and Environmental Microbiology2008，69，： | 1 |
| 20 | Diagnostic and prognostic value of procalcitonin in patients with septic shock显示文摘 | Clec'th C Ferriere F Karoubi P | | 0，，05： | 1 |
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