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| 1 | 初级保健中原发性醛固酮增多症的患病率和临床表现显示文摘原发性醛固酮增多症(primaryaldosteronism,PA)是一种异质性疾病,以高血压和相对自主于肾素血管紧张素系统产生过量醛固酮为特征。与心血管病风险相似的原发性高血压患者相比,PA患者发生心脑血管并发症的风险以及代谢综合征患病率增加,提示正确诊断PA的重要性。 | Monticone S Burrello J Tizzani D Bertello C Viola A Buffolo F Gabetti L Mengozzi G Williams TA Rabbia F Veglio F Mulatero P 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 58 |
| 2 | 三级高血压单位5100例患者低血钾症与原发性醛固酮增多症的发病率显示文摘常伴有低血钾症的原发性醛固酮增多症(原醛)被认为是一个少见病。广泛筛查高血压患者发现正常血钾的原醛发生率增加。许多研究报道原醛低血钾症的发生率,相反,低血钾症患者中原醛的发生率并不明确。在该回顾性观察研究,研究者探讨了高血压患者中低钾的发生率以及低血钾症合并高血压患者中原醛的发生率。 | 赵狄(译) 刘莉(审校) Burrello J Monticone S Losano I Cavaglià G Buffolo F Tetti M Covella M Rabbia F Veglio F Pasini B Williams TA Mulatero P | 2020 | 中华高血压杂志2020，28，3： | 7 |
| 3 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 4 | 出生到17岁儿童肥胖和血压的关系显示文摘儿童期肥胖易导致成年高血压和糖尿病。研究者已发现儿童期肥胖与青春期早期胰岛素抵抗增加相关。该研究旨在探讨这些肥胖轨迹与儿童期血压发展的关系。方法:在西澳大利亚怀孕队列后代从0到14岁时,采用系列人体测量,通过半参数混合模型描绘出7种肥胖轨迹。Logistic回归分析17岁时这些肥胖轨迹与高血压、正常高值血压发病率的相关性。 | Huang RC Burrows S Mori TA Oddy WH Beilin LJ 练桂丽 | 2015 | 中华高血压杂志2015，23，12： | 3 |
| 5 | 乙琥胺、丙戊酸和拉莫三嗪治疗儿童失神癫痫的临床试验显示文摘背景:儿童失神癫痫(CAE)是最常见的儿童癫痫综合征,一般常用乙琥胺、丙戊酸或拉莫三嗪治疗,但最有效和耐受性好的首选治疗尚未确定。方法:该研究是美国多中心、随机、双盲、对照临床试验,旨在比较乙琥胺、丙戊酸和拉莫三嗪治疗新诊断CAE儿童的疗效、耐受性和对神经心理的影响。 | Glauser TA Cnaan A Shinnar S 李新 王纪佐 | 2011 | 中华神经科杂志2011，44，8： | 3 |
| 6 | Biomechanical characteristics of the human anterior lens capsule in relation to age 显示文摘 | Krag S Olsen T Andreassent TA | 1997 | Invest Ophthalmol Vis Sci1997，38，： | 2 |
| 7 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 8 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 9 | Combined angiotensin II receptor antagonism and angiotensin-converting enzyme inhibition further attenuates postinf arction left ventricular remodeling显示文摘 | Mankad S d'Amato TA Reichek N | 2001 | Circulation2001，103，23： | 2 |
| 10 | Human disease in Europe caused by a granulocytic Ehrlichia species显示文摘 | Petrovec M Lotric Furlan S Zupanc TA | 1997 | J Clin Microbiol1997，35，6： | 1 |
| 11 | Anti-allergic effects of Sanguisorba officinalis on animal models of allergic reactions显示文摘 | SHIN T Y LEE K B KIM S H TA Y | 2002 | Immunopharmacology & Immunotoxicology2002，24，3： | 1 |
| 12 | Pancreatic somatostatin inhibits insulin secretion via SSTR 5 in the isolated perfused mouse pancreas model 显示文摘 | Tirone TA Norman MA Moldovan S | 2003 | Pancreas2003，26，3： | 1 |
| 13 | Multiple fates of L1 retrotransposition intermediates in cultured human cells 显示文摘 | Gilbert N Lutz S Morrish TA | 2005 | Mol Cell Biol2005，25，17： | 1 |
| 14 | Treatment of pruritic diseases with topical calcineurin inhibitors显示文摘 | Stander S Schurmeyer-Horst F Luger TA | 2006 | Ther Clin Risk Manag2006，2，： | 1 |
| 15 | Proteomic analysis of glial fibrillary acidic protein in Alzheimer's disease and aging brain 显示文摘 | Korolainen MA Auriola S Nyman TA | 2005 | Neurobiol Dis2005，20，3： | 1 |
| 16 | Argonaute2 cleaves the anti - guide strand of siRNA during RISC activation 显示文摘 | Rand TA Petersen S Du F | 2005 | Cell2005，123，4： | 1 |
| 17 | Ribotyping in the detec- tion of Clostridium diffieile outbreaks in a single university hospital显示文摘 | Patel TA Smith R Hopkins S | 2012 | J Hosp Infect2012，83，1： | 1 |
| 18 | A phase Ⅱ multicenter study of lenalidomide in relapsed or refractory classical Hodgkin lymphoma显示文摘 | Fehniger TA Larson S Trinkaus K | 2009 | Blood2009，114，： | 1 |
| 19 | Heterogeneity in the muscle satellite cell population显示文摘 | Biressi S Rando TA | 2010 | Semin Cell Dev Biol2010，21，8： | 1 |
| 20 | Robot-assisted gait training for patients with hemiparesis due to stroke 显示文摘 | Fisher S Lucas L Thrasher TA | 2011 | Top Stroke Reeabil2011，18，3： | 1 |
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