|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of herbal medicine Juzentaihoto on hepatic and intestinal heat shock gene expression requires intestinal microflora in mouse显示文摘AIM: To evaluate the role of intestinal microflora in the effects of multi-herbal medicine on gene expression in the gut and liver. METHODS: The multi-herbal medicine Juzentaihoto (JTX) was administered to five germ-free mice and regular mice for 2 wk. Among the results of the comprehensive gene chip analysis of the intestine and liver, we featured heat shock proteins (HSPs) 70 and 105 because their gene expression changed only in the presence of microflora. Real-time RT-PCR was performed to confirm the expression levels of these HSP genes. To determine whether JTX acts directly on the HSP genes, sodium arsenite (SA) was used to induce the heat shock proteins directly. To examine the change of the intestinal microflora with administration of JTX, the terminal restriction fragment polymorphism (T-RFLP) method was used. To identify the changed bacteria, DNA sequencing was performed. RESULTS: Heat shock protein gene expression,documented by gene chip and real-time RT-PCR, changed with the administration of JTX in the regular mice but not in the germ-free mice. JTX did not suppress the direct induction of the HSPs by SA. T-RFLP suggested that JTX decreased unculturable bacteria and increased Lactobacillus johnsoni. These data suggested that JTX changed the intestinal microflora which, in turn, changed HSP gene expression. CONCLUSION: Intestinal microflora affects multi-herbal product JTX on the gene expression in the gut and liver. | Miho Kato Atsushi Ishige Naoko Anjiki Masahiro Yamamoto Yoshifumi Irie Mitsue Taniyama Ryoko Kibe Junichiro Oka Yoshimi Benno Kenji Watanabe | 2007 | World Journal of Gastroenterology2007，13，16： | 5 |
| 2 | Periostin as a Novel Factor Responsible for Ventricular Dilation显示文摘 | Naruto Katsuragi Ryuichi Morishita Noriko Nakamura Tayehito Ochiai Yoshiaki Taniyama Yasuhiro Hasegawa Kayoko Kawashima Yasufumi Kaneda Toshio Ogihara Keijiro Sugimura | 2004 | Circulation2004，，13： | 2 |
| 3 | Combined thoracoscopic and endoscopic surgery for a large esophageal schwannoma显示文摘A 47-year-old woman presented to our hospital with complaints of dysphagia. Esophagogastroduodenoscopy identified a submucosal tumor in the left wall of the esophagus that was diagnosed as a benign schwannoma on biopsy. Computed tomography revealed a tumor of length 60 mm in the thoracic esophagus, with its cranial edge at the level of the aortic arch. On endoscopy, a submucosal tunnel was created 40 mm proximal to the cranial edge of the tumor, and its oral end was dissected from the mucosal and muscular layers. This was followed by the resection of the entire tumor by left-sided thoracoscopy. The esophageal defect was closed in layer by continuous suture from the thoracic side. Endoscopic closure was achieved by using clips. No postoperative complications were observed. Oral diet was resumed from postoperative day 7 and the patient was discharged on postoperative day 9. This combined approach has not been described for similar tumors. Our experience demonstrated that large esophageal tumors can be safely excised with minimally invasive surgery by using a combination of thoracoscopy and endoscopy. | Yu Onodera Toru Nakano Daisuke Takeyama Shota Maruyama Yusuke Taniyama Tadashi Sakurai Takahiro Heishi Chiaki Sato Takuro Kumagai Takashi Kamei | 2017 | World Journal of Gastroenterology2017，23，46： | 2 |
| 4 | Local delivery of plasmid DNA into rat carotid artery using ultrasound 显示文摘 | Taniyama Y Tachibana K Hiraoka K | 2002 | Circulation2002，105，10： | 2 |
| 5 | Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle显示文摘 | Taniyama Y Tachibana K Hiraoka K | 2002 | Gene Ther2002，9，6： | 2 |
| 6 | Changes in intensity of wind erosion at different stages of degradation development in grasslands of Inner Mongolia, China显示文摘 | F.-R. Li L.-F. Kang H. Zhang L.-Y. Zhao Y. Shirato I. Taniyama | 2005 | Journal of Arid Environments2005，，4： | 2 |
| 7 | Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction显示文摘 | Hiroshi Ito Yoshiaki Taniyama Katsuomi Iwakura Nagahiro Nishikawa Tohru Masuyama Tsunehiko Kuzuya Masatsugu Hori Yorihiko Higashino Kenshi Fujii Takazo Minamino | 1999 | Journal of the American College of Cardiology1999，，3： | 2 |
| 8 | Cancer immunotherapy for pancreatic cancer utilizing α-gal epitope/natural anti-Gal antibody reaction显示文摘Pancreatic ductal adenocarcinoma(PDAC) has the poorest prognosis of all malignancies and is largely resistant to standard therapy. Novel treatments against PDAC are desperately needed. Anti-Gal is the most abundant natural antibody in humans,comprising about 1% of immunoglobulins and is also naturally produced in apes and Old World monkeys. The anti-Gal ligand is a carbohydrate antigen called 'α-gal epitopes' with the structure Galα1-3Galβ1-4Glc NAc-R. These epitopes are expressed as major carbohydrate antigens in non-primate mammals,prosimians,and New World monkeys. Anti-Gal is exploited in cancer vaccines to increase the immunogenicity of antigen-presenting cells(APCs). Cancer cells or PDAC tumor lysates are processed to express α-gal epitopes. Vaccination with these components results in in vivo opsonization by anti-Gal Ig G in PDAC patients. The Fc portion of the vaccine-bound anti-Gal interacts with Fcγ receptors of APCs,inducing uptake of the vaccine components,transport of the vaccine tumor membranes to draining lymph nodes,and processing and presentation of tumor-associated antigens(TAAs). Cancer vaccines expressing α-gal epitopes elicit strong antibody production against multiple TAAs contained in PDAC cells and induce activation of multiple tumor-specific T cells. Here,we review new areas of clinical importance related to the α-gal epitope/anti-Gal antibody reaction and the advantages in immunotherapy against PDAC. | Masahiro Tanemura Eiji Miyoshi Hiroaki Nagano Hidetoshi Eguchi Katsuyoshi Matsunami Kiyomi Taniyama Nobutaka Hatanaka Hiroki Akamatsu Masaki Mori Yuichiro Doki | 2015 | World Journal of Gastroenterology2015，21，40： | 2 |
| 9 | Reactive oxygen species in the vasculature molecular and cellular mechanisms 显示文摘 | Taniyama Y Griendling KK | 2003 | Hypertension2003，42，6： | 1 |
| 10 | Adjuvant and antitumor activities of Nocardia cell-wall skeletons 显示文摘 | Azuma I Taniyama T Yamawaki M | 1976 | Gann1976，67，： | 1 |
| 11 | Carcinosarcoma of the esophagus显示文摘 | Taniyama K Sasaki N Mukaai T | 1995 | PatholInt1995，45，4： | 1 |
| 12 | Local delivery of plasmid DNA into a rat carotid artery using ultrasound显示文摘 | Taniyama Y Tachibana K Hiraoka K | 2002 | Circulation2002，105，： | 1 |
| 13 | A surgical case of cerebral hem- orrhage in a patient with factor XI deficiency显示文摘 | Goto Y Taniyama I Ebisu T | 2012 | Blood Coagul Fi- brinolysis2012，4，： | 1 |
| 14 | Recombinant BCG Tokyo (Ag85A) protects cynomolgus mon- keys (Macaca fascicularis) infected with H37Rv Mycobacterium tuberculosis 显示文摘 | Sugawara I Li Z Sun L Udagawa T Taniyama T | 2007 | Tuberculosis (Edinb)2007，87，6： | 1 |
| 15 | Hepatocyte growth factor inhibits lipopolysaccharide -induced oxida-tive stress via epithelial growth factor receptor degradation显示文摘 | Shimizu K Taniyama Y Sanada F | 2012 | Arterioscler Thromb Vasc Biol2012，32，11： | 1 |
| 16 | Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor- induced smooth muscle cell migration显示文摘 | Weber DS Taniyama Y Rodc P | 2004 | Circ Res2004，94，9： | 1 |
| 17 | A pneumopeficardium caused by gastric ulcer perforation显示文摘 | Taniyama D Miyamoto K Mashimo S | 2013 | Intern Med2013，52，： | 1 |
| 18 | Reactive oxygen species in the vasculature:molecular and cellular machanisms显示文摘 | Taniyama Y Gtiendling KK | 2003 | Hypertension2003，42，6： | 1 |
| 19 | Alterationin the coronary blood flow velocity pattern in patients with no reflow and reperfusedacute myocardial infarction显示文摘 | Iwakura K Ito H Takiuchi S Taniyama Y Nakatsuchi Y Negoro S | 1996 | Circulation1996，94，： | 1 |
| 20 | The codon 620 single nucleotide polymorphism of the protein tyrosine phosphatase-22 gene does not contribute to autoimmune thyroid disease susceptibility in the Japanese显示文摘 | Ban Y Tozaki T Taniyama M | 2005 | Thyroid2005，15，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员