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| 1 | Stepwise Fabrication of Co-Embedded Porous Multichannel Carbon Nanofibers for High-Efficiency Oxygen Reduction显示文摘A novel nonprecious metal material consisting of Coembedded porous interconnected multichannel carbon nanofibers(Co/IMCCNFs) was rationally designed for oxygen reduction reaction(ORR)electrocatalysis.In the synthesis,ZnCo2O4 was employed to form interconnected mesoporous channels and provide highly active Co3O4/Co core–shell nanoparticle-based sites for the ORR.The IMC structure with a large synergistic effect of the N and Co active sites provided fast ORR electrocatalysis kinetics.The Co/IMCCNFs exhibited a high half-wave potential of 0.82 V(vs.reversible hydrogen electrode) and excellent stability with a current retention up to 88% after 12,000 cycles in a current–time test,which is only 55% for 30 wt% Pt/C. | Zeming Tang Yingxuan Zhao Qingxue Lai Jia Zhong Yanyu Liang | 2019 | Nano-Micro Letters2019，11，2： | 3 |
| 2 | Ultra-high -speed combined machining of electrical dischargemachining and arc machining显示文摘 | WANG Fei’LIU Yonghong TANG Zeming | 2013 | Proceedings of the Insti-tution of Mechanical Engineers Part B:Journal of Engi-neering Manufacture2013，228，5： | 1 |
| 3 | The Green Emission and Local Structure of the Scintillator PbWO4显示文摘 | Qi Zeming Shi Chaoshu Zhou Dongfang Tang Honggao Liu Tao Hu Taidou | 2001 | Physica B2001，307，： | 1 |
| 4 | Convenient and efficient access to tri-and tetra-substituted 4-fluoropyridines via a[3+2]/[2+1]cyclization reaction显示文摘A[3+2]/[2+1]cycloaddition reaction of gem–difluorocyclopropenes is presented,offering a mild and efficient approach to accessing tri-and tetra-substituted 4-fluoropyridines in moderate to good yields with excellent regioselectivity.Multiple synthetic applications,including process-scale reactions,modification of bioactive molecules,derivatization reactions and synthesis of the analogue of the PKM2 modulator,are subsequently described. | Xuejiao Tang Kun Liu Zeming Qu Junyan Zhan Rukui Zhu Fan Teng Lili Meng Yanmin Huang Chusheng Huang Yimiao He Qiang Zhu | 2022 | Chinese Chemical Letters2022，33，6： | 1 |
| 5 | Embedding Pd-Cu Alloy Nanoparticles in Shell of Surface-Porous N-Doped Carbon Nanosphere for Selective Hydrogenation of p-Chloronitrobenzene显示文摘Main observation and conclusion A catalyst PdxCuy/NC in which Pd-Cu alloy nanoparticles are superficially embeded in shell of surface-porous N-doped carbon nanosphere was successfully devised for p-chloronitrobenzene(p-CNB)selective hydrogenation.Bimetal ions were loaded in shell of a m-phenylenediamine derived core-shell polymer sphere and the catalyst was obtained after calcination under reducing atmosphere.The as synthesized catalyst exhibited high selectivity in hydrogenation of p-CNB to p-chloroaniline(p-CAN)(up to 98.8%)under full conversion and the performance was basically remained after 6 cyclic experiments.The reasons for the high selectivity were discussed based on the characterization results of catalyst.The interaction between N-doped support and metal atoms affected the electron distribution in alloy,electron-deficient Pd and electron-rich Cu,and thus improved hydrogenation selectivity.In addition,the alloy nanoparticles were distributed only in the porous shell of support,which benefits to prevent side reactions.This work described a scheme for tactfully designing catalyst for selective hydrogenation,which can provide experience and inspiration for relevant works and fields. | Yingcen Liu Wanyue Ye Hua Lin Caicheng Song Zeming Rong Rongwen Lu Hao Zhang He Huang Zhicheng Tang Shufen Zhang | 2021 | Chinese Journal of Chemistry2021，39，10： | 0 |
| 6 | DNA repair-and nucleotide metabolism-related genes exhibit differential CHG methylation patterns in natural and synthetic polyploids (Brassica napus L.)显示文摘Polyploidization plays a crucial role in the evolution of angiosperm species.Almost all newly formed polyploids encounter genetic or epigenetic instabilities.However,the molecular mechanisms contributing to genomic instability in synthetic polyploids have not been clearly elucidated.Here,we performed a comprehensive transcriptomic and methylomic analysis of natural and synthetic polyploid rapeseeds(Brassica napus).Our results showed that the CHG methylation levels of synthetic rapeseed in different genomic contexts(genes,transposon regions,and repeat regions)were signi fi cantly lower than those of natural rapeseed.The total number and length of CHG-DMRs between natural and synthetic polyploids were much greater than those of CG-DMRs and CHH-DMRs,and the genes overlapping with these CHG-DMRs were signi fi cantly enriched in DNA damage repair and nucleotide metabolism pathways.These results indicated that CHG methylation may be more sensitive than CG and CHH methylation in regulating the stability of the polyploid genome of B.napus.In addition,many genes involved in DNA damage repair,nucleotide metabolism,and cell cycle control were significantly differentially expressed between natural and synthetic rapeseeds.Our results highlight that the genes related to DNA repair and nucleotide metabolism display differential CHG methylation patterns between natural and synthetic polyploids and reveal the potential connection between the genomic instability of polyploid plants with DNA methylation defects and dysregulation of the DNA repair system.In addition,it was found that the maintenance of CHG methylation in B.napus might be partially regulated by MET1.Our study provides novel insights into the establishment and evolution of polyploid plants and offers a potentialidea for improving the genomic stability of newly formed Brassica polyploids. | Liqin Yin Zhendong Zhu Liangjun Huang Xuan Luo Yun Li Chaowen Xiao Jin Yang Jisheng Wang Qiong Zou Lanrong Tao Zeming Kang Rong Tang Maolin Wang Shaohong Fu | 2021 | Horticulture Research2021，8，1： | 0 |
| 7 | Graphene Quantum Dot‑Mediated Atom‑Layer Semiconductor Electrocatalyst for Hydrogen Evolution显示文摘The hydrogen evolution reaction performance of semiconducting 2H-phase molybdenum disulfide(2H-MoS_(2))presents a significant hurdle in realizing its full potential applications.Here,we utilize theoretical calculations to predict possible functionalized graphene quantum dots(GQDs),which can enhance HER activity of bulk MoS_(2).Subsequently,we design a functionalized GQD-induced in-situ bottom-up strategy to fabricate near atom-layer 2H-MoS_(2) nanosheets mediated with GQDs(ALQD)by modulating the concentration of electron withdrawing/donating functional groups.Experimental results reveal that the introduction of a series of functionalized GQDs during the synthesis of ALQD plays a crucial role.Notably,the higher the concentration and strength of electron-withdrawing functional groups on GQDs,the thinner and more active the resulting ALQD are.Remarkably,the synthesized near atom-layer ALQD-SO_(3)demonstrate significantly improved HER performance.Our GQD-induced strategy provides a simple and efficient approach for expanding the catalytic application of MoS_(2).Furthermore,it holds substantial potential for developing nanosheets in other transition-metal dichalcogenide materials. | Bingjie Hu Kai Huang Bijun Tang Zhendong Lei Zeming Wang Huazhang Guo Cheng Lian Zheng Liu Liang Wang | 2023 | Nano-Micro Letters2023，15，12： | 0 |
| 8 | A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis显示文摘Pleural and peritoneal metastasis accompanied by malignant pleural effusion(MPE)or malignant ascites(MA)is frequent in patients with advanced solid tumors that originate from the lung,breast,gastrointestinal tract and ovary.Regional delivery of CAR-T cells represents a new strategy to control tumor dissemination in serous cavities.However,malignant effusions constitute an immune-suppressive environment that potentially induces CAR-T cell dysfunction.Here,we demonstrated that the anti-tumor cytotoxicity of conventional 2nd-generation CAR-T cells was significantly inhibited by both the cellular and non-cellular components of MPE/MA,which was primarily attributed to impaired CAR-T cell proliferation and cytokine production in MPE/MA environment.Interestingly,we found that PD-L1 was widely expressed on freshly-isolated MPE/MA cells.Based on this feature,a novel PD-L1-targeting chimeric switch receptor(PD-L1.BB CSR)was designed,which can bind to PD-L1,switching the inhibitory signal into an additional 4-1BB signal.When co-expressed with a 2nd-generation CAR,PD-L1.BB CSR-modified CAR-T cells displayed superior fitness and enhanced functions in both culture medium and MPE/MA environment,causing rapid and durable eradication of pleural and peritoneal metastatic tumors in xenograft models.Further investigations revealed elevated expressions of T-cell activation,proliferation,and cytotoxicity-related genes,and we confirmed that PD-L1 scFv and 4-1BB intracellular domain,the two important components of PD-L1.BB CSR,were both necessary for the functional improvements of CAR-T cells.Overall,our study shed light on the clinical application of PD-L1.BB CSR-modified dual-targeting CAR-T cells.Based on this study,a phase I clinical trial was initiated in patients with pleural or peritoneal metastasis(NCT04684459). | Qizhi Ma Xia He Benxia Zhang Fuchun Guo Xuejin Ou Qiyu Yang Pei Shu Yue Chen Kai Li Ge Gao Yajuan Zhu Diyuan Qin Jie Tang Xiaoyu Li Meng Jing Jian Zhao Zeming Mo Ning Liu Yao Zeng Kexun Zhou Mingyang Feng Weiting Liao Wanting Lei Qiu Li Dan Li Yongsheng Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 0 |
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