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| 1 | Comparative study of the net exchange of CO_(2) in 3 types of vegetation ecosystems on the Qinghai-Tibetan Plateau显示文摘Using the eddy covariance method,from 1 July2003 to 30 June 2004, we conducted the observation andanalysis of ecosystem CO2 flux in 3 types of alpine meadowvegetation (Kobresia humilis, Potentilla fruticosa shrub andKobresia tibetica swamp meadows) on the Qinghai-TibetanPlateau. The results show that the Kobresia humilis meadow,the shrub meadow and the swamp meadow’s highest CO2uptake rates are 16.78, 10.42 and 16.57 μmol·m?2·s?1respectively, while their highest CO2 release rates are 8.22,7.73 and 18.67 μmol·m?2·s?1 respectively. The Kobresiahumilis meadow and shrub meadow’s annual atmosphericuptakes are 282 g CO2/m2 and 53 g CO2/m2, respectively,while swamp meadow’s annual atmospheric release is 478 gCO2/m2. This proves that the Kobresia humilis meadow andthe shrub meadow on the Qinghai-Tibetan Plateau haverelatively low potential for CO2 uptake and release comparedto C4 grasslands, a number of lowland grasslands, andforests. Moreover, swamp meadow has relatively high releasepotential. This, in turn, reveals clear differences in carbonsource/sink between different types of vegetation in theQinghai-Tibetan Plateau alpine meadow ecosystem. Thesedifferences are mainly brought by differences in thevegetations’ photosynthetic capacity and soil respiration. | ZHAO Liang LI Yingnian ZHAO Xinquan XU Shixiao TANG Yanhong YU Guirui GU Song DU Mingyuan WANG Qinxue | 2005 | Chinese Science Bulletin2005，50，16： | 34 |
| 2 | Characterizing the dynamics of soil organic carbon in grasslands on the Qinghai-Tibetan Plateau显示文摘Carbon dynamics of grasslands on the Qinghai-Tibetan Plateau may play an important role in regional and global carbon cycles. The CENTURY model (Version 4.5) is used to examine temporal and spatial variations of soil organic carbon (SOC) in grasslands on the Plateau for the period from 1960 to 2002. The model successfully simulates the dynamics of aboveground carbon and soil surface SOC at the soil depth of 0-20 cm and the simulated results agree well to the measurements. Examination of SOC for eight typical grasslands shows different patterns of temporal variation in different ecosystems in 1960-2002. The extent of temporal variation increases with the increase of SOC of ecosystem. SOC increases first and decreases quickly then during the period from 1990 to 2000. Spatially, SOC density obtained for the equilibrium condition declines gradually from the southeast to the northwest on the plateau and showed a high heterogeneity in the eastern plateau. The results suggest that (i) SOC den-sity in the alpine grasslands shows remarkable response to climate change during the 42 years, and (ii) the net carbon exchange rate between the alpine grassland ecosystems and the atmosphere increases from 1990 to 2000 as compared with that before 1990. | ZHANG YongQiang TANG YanHong JIANG Jie YANG YongHui | 2007 | Science China Earth Sciences2007，50，1： | 25 |
| 3 | BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders显示文摘Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey embryos. These monkeys showed higher nocturnal locomotion and reduced sleep, which was further exacerbated by a constant light regimen. Physiological circadian disruption was reflected by the markedly dampened and arrhythmic blood hormonal levels. Furthermore, BMAL1-deficient monkeys exhibited anxiety and depression, consistent with their stably elevated blood cortisol, and defective sensory processing in auditory oddball tests found in schizophrenia patients. Ablation of BMAL1 up-regulated transcriptional programs toward inflammatory and stress responses, with transcription networks associated with human sleep deprivation, major depressive disorders, and aging. Thus, BMAL1 knockout monkeys are potentially useful for studying the physiological consequences of circadian disturbance, and for developing therapies for circadian and psychiatric disorders. | Peiyuan Qiu Jian Jiang Zhen Liu Yijun Cai Tao Huang Yan Wang Qiming Liu Yanhong Nie Fang Liu Jiumu Cheng Qing Li Yun-Chi Tang Mu-ming Poo Qiang Sun Hung-Chun Chang | 2019 | National Science Review2019，6，1： | 21 |
| 4 | Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis显示文摘 | Wenling Zhang Zhaoyang Zeng Yanhong Zhou Wei Xiong Songqing Fan Lan Xiao Donghai Huang Zheng Li Dan Li Minghua Wu Xiaoling Li Shourong Shen Rong Wang Li Cao Ke Tang Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 11 |
| 5 | Foreword to the special issue:looking into the impacts of global warming from the roof of the world显示文摘To most people,the Qinghai-Tibetan Plateau is a place full of mystery.It is also mysterious to many ecologists.The vast central Asian plateau lies at an average elevation>4000 m and covers about 370 million km2.Spanning the highest range of elevations of any ecosystem in the world makes the plateau unique even among alpine ecosystems due to the presence of extreme abiotic environments:the lowest atmospheric pressure and thus,the lowest partial pressures of CO_(2) and O_(2),low temperatures and high levels of radiation,including high ultraviolet radiation. | Yanhong Tang Shiqiang Wan Jinsheng He Xinquan Zhao | 2009 | Journal of Plant Ecology2009，2，4： | 11 |
| 6 | Estimation of aboveground biomass using in situ hyperspectral measurements in five major grassland ecosystems on the Tibetan Plateau显示文摘Aims There are numerous grassland ecosystem types on the Tibetan Plateau.These include the alpine meadow and steppe and degraded alpine meadow and steppe.This study aimed at developing a method to estimate aboveground biomass(AGB)for these grasslands from hyperspectral data and to explore the feasibility of applying air/satellite-borne remote sensing techniques to AGB estimation at larger scales.Methods We carried out a field survey to collect hyperspectral reflectance and AGB for five major grassland ecosystems on the Tibetan Plateau and calculated seven narrow-band vegetation indices and the vegetation index based on universal pattern decomposition(VIUPD)from the spectra to estimate AGB.First,we investigated correlations between AGB and each of these vegetation indices to identify the best estimator of AGB for each ecosystem type.Next,we estimated AGB for the five pooled ecosystem types by developing models containing dummy variables.At last,we compared the predictions of simple regression models and the models containing dummy variables to seek an ecosystem type-independent model to improve prediction of AGB for these various grassland ecosystems from hyperspectral measurements.Important findings When we considered each ecosystem type separately,all eight vegetation indices provided good estimates of AGB,with the best predictor of AGB varying among different ecosystems.When AGB of all the five ecosystems was estimated together using a simple linear model,VIUPD showed the lowest prediction error among the eight vegetation indices.The regression models containing dummy variables predicted AGB with higher accuracy than the simple models,which could be attributed to the dummy variables accounting for the effects of ecosystem type on the relationship between AGB and vegetation index(VI).These results suggest that VIUPD is the best predictor of AGB among simple regression models.Moreover,both VIUPD and the soil-adjusted VI could provide accurate estimates of AGB with dummy variables integrated in regression models.Therefore,ground-based hyperspectral measurements are useful for estimating AGB,which indicates the potential of applying satellite/airborne remote sensing techniques to AGB estimation of these grasslands on the Tibetan Plateau. | Miaogen Shen Yanhong Tang Julia Klein Pengcheng Zhang Song Gu Ayako Shimono Jin Chen | 2008 | Journal of Plant Ecology2008，1，4： | 10 |
| 7 | Patterns of plant diversity at high altitudes on the Qinghai-Tibetan Plateau显示文摘To describe the biodiversity patterns of plants along an altitudinal gradient on the Qinghai-Tibetan Plateau and to clarify the bias in plant specimen records at high altitude.Methods We conducted a large-scale investigation of vegetation at a wide range of altitudes,focusing on a high-altitudinal range(3200-5200 m)at different locations on the Qinghai-Tibetan Plateau.We then compared the altitudinal distribution of plant species obtained from our field investigation with that in plant specimen records from published sources and an online database.Important Findings Our data provide evidence that altitude plays a large role in regulating species composition on the Qinghai-Tibetan Plateau.We could not,however,detect a clear relationship between altitude and species richness,although a weak monotonically increasing trend of richness was detected with increasing altitude.According to specimen records,most species have been sampled at a wide range of altitudes,and the average range of 145 species is>2000 m.Despite this wide range,more than half of the species we observed were at higher altitudes than the specimen records indicate.High-altitude areas have probably been so poorly sampled that only a small fraction of the resident species has been recorded.This study clearly shows the regional bias of specimen records in the Qinghai-Tibetan Plateau. | Ayako Shimono Huakun Zhou Haihua Shen Mitsuru Hirota Toshiyuki Ohtsuka Yanhong Tang | 2010 | Journal of Plant Ecology2010，3，1： | 6 |
| 8 | Altitudinal variation of ecosystem CO_(2) fluxes in an alpine grassland from 3600 to 4200 m显示文摘Aims Recent studies have recognized the alpine grasslands on the Qinghai-Tibetan plateau as a significant sink for atmospheric CO_(2).The carbon-sink strength may differ among grassland ecosystems at various altitudes because of contrasting biotic and physical environments.This study aims(i)to clarify the altitudinal pattern of ecosystem CO_(2) fluxes,including gross primary production(GPP),daytime ecosystem respiration(Redaytime)and net ecosystem production(NEP),during the period with peak above-ground biomass;and(ii)to elucidate the effects of biotic and abiotic factors on the altitudinal variation of ecosystem CO_(2) fluxes.Methods Ecosystem CO_(2) fluxes and abiotic and biotic environmental factors were measured in an alpine grassland at four altitudes from 3600 to 4200 m along a slope of the Qilian Mountains on the northwestern Qinghai-Tibetan Plateau during the growing season of 2007.We used a closed-chamber method combined with shade screens and an opaque cloth to measure several carbon fluxes,GPP,Redaytime and NEP,and factors,light-response curve for GPP and temperature sensitivity of Redaytime.Above-and below-ground biomasses and soil C and N contents at each measurement point were also measured.Important Findings(i)Altitudinal pattern of ecosystem CO_(2) fluxes:The maximum net ecosystem CO_(2) flux(NEPmax),i.e.the potential ecosystem CO_(2) sink strength,was markedly different among the four altitudes.NEPmax was higher at the highest and lowest sites,ap proximately7.460.9 and6.760.6 lmol CO_(2) m^(-2)s^(-1)(mean 6 standard error),respectively,but smaller at the intermediate altitude sites(3800 and 4000 m).The altitudinal pattern of maximum gross primary production was similar to that of NEPmax.The Redaytime,however,was significantly higher at the lowest altitude(3.460.3 lmol CO_(2) m^(-2)s^(-1))than at the other three altitudes.(ii)Altitudinal variation of vegetation biomass:The aboveground biomass was higher at the highest altitude(154627 g DW m2)than at the other altitudes,which we attribute mainly to the large biomass in cushion plants at the highest altitude.The small above-ground biomass at the lower altitudes was probably due to heavy grazing during the growing season.(iii)Features of ecosystem CO_(2) fluxes:Redaytime and GPP were positively correlated with above-ground biomass.The low ratio of Redaytime to GPP at either the measurement point or the site level suggests that CO_(2) uptake efficiency tends to be higher at higher altitudes,which indicates a high potential sink strength for atmospheric CO_(2) despite the low temperature at high altitudes.The results suggest that the effect of grazing intensity on ecosystem carbon dynamics,partly by decreasing vegetation biomass,should be clarified further. | Mitsuru Hirota Pengcheng Zhang Song Gu Mingyuan Du Ayako Shimono Haihua Shen Yingnian Li Yanhong Tang | 2009 | Journal of Plant Ecology2009，2，4： | 6 |
| 9 | Grazing alters warming effects on leaf photosynthesis and respiration in Gentiana straminea,an alpine forb species显示文摘Aims Vast grasslands on the Tibetan Plateau are almost all under livestock grazing.It is unclear,however,what is the role that the grazing will play in carbon cycle of the grassland under future climate warming.We found in our previous study that experimental warming can shift the optimum temperature of saturated photosynthetic rate into higher temperature in alpine plants.In this study,we proposed and tested the hypothesis that livestock grazing would alter the warming effect on photosynthetic and respiration through changing physical environments of grassland plants.Methods Experimental warming was carried by using an infrared heating system to increase the air temperature by 1.2 and 1.7℃ during the day and night,respectively.The warming and ambient temperature treatments were crossed over to the two grazing treatments,grazing and un-grazed treatments,respectively.To assess the effects of grazing and warming,we examined photosynthesis,dark respiration,maximum rates of the photosynthetic electron transport(J_(max)),RuBP carboxylation(V_(cmax))and temperature sensitivity of respiration Q_(10) in Gentiana straminea,an alpine species widely distributed on the Tibetan grassland.Leaf morphological and chemical properties were also examined to understand the physiological responses.Important findings 1)Light-saturated photosynthetic rate(A_(max))of G.straminea showed similar temperature optimum at around 16℃ in plants from all experimental conditions.Experimental warming increased A_(max) at all measuring temperatures from 10 to 25℃,but the positive effect of the warming occurred only in plants grown under the un-grazed conditions.Under the same measuring temperature,A_(max) was significantly higher in plants from the grazed than the un-grazed condition.2)There was significant crossing effect of warming and grazing on the temperature sensitivity(Q_(10))of leaf dark respiration.Under the un-grazed condition,plants from the warming treatment showed lower respiration rate but similar Q_(10) in comparison with plants from the ambient temperature treatment.However,under the grazed condition Q_(10) was significantly lower in plants from the warming than the ambient treatment.3)The results indicate that livestock grazing can alter the warming effects on leaf photosynthesis and temperature sensitivity of leaf dark respiration through changing physical environment of the grassland plants.The study suggests for the first time that grazing effects should be taken into account in predicting global warming effects on photosynthesis and respiration of plants in those grasslands with livestock grazing. | Haihua Shen Shiping Wang Yanhong Tang | 2013 | Journal of Plant Ecology2013，6，5： | 5 |
| 10 | Leaf photosynthesis and simulated carbon budget of Gentiana straminea from a decade-long warming experiment显示文摘Aims Alpine ecosystems may experience larger temperature increases due to global warming as compared with lowland ecosystems.Information on physiological adjustment of alpine plants to temperature changes can provide insights into our understanding how these plants are responding to current and future warming.We tested the hypothesis that alpine plants would exhibit acclimation in photosynthesis and respiration under long-term elevated temperature,and the acclimation may relatively increase leaf carbon gain under warming conditions.Methods Open-top chambers(OTCs)were set up for a period of 11 years to artificially increase the temperature in an alpine meadow ecosystem.We measured leaf photosynthesis and dark respiration under different light,temperature and ambient CO_(2)concentrations for Gentiana straminea,a species widely distributed on the Tibetan Plateau.Maximum rates of the photosynthetic electron transport(J_(max)),RuBP carboxylation(V_(cmax))and temperature sensitivity of respiration Q10 were obtained from the measurements.We further estimated the leaf carbon budget of G.straminea using the physiological parameters and environmental variables obtained in the study.Important findings 1)The OTCs consistently elevated the daily mean air temperature by;1.6℃and soil temperature by;0.5℃during the growing season.2)Despite the small difference in the temperature environment,there was strong tendency in the temperature acclimation of photosynthesis.The estimated temperature optimum of light-saturated photosynthetic CO_(2)uptake(A_(max))shifted;1℃higher from the plants under the ambient regime to those under the OTCs warming regime,and the Amax was significantly lower in the warming-acclimated leaves than the leaves outside the OTCs.3)Temperature acclimation of respiration was large and significant:the dark respiration rates of leaves developed in the warming regime were significantly lower than leaves from the ambient environments.4)The simulated net leaf carbon gain was significantly lower in the in situ leaves under the OTCs warming regime than under the ambient open regime.However,in comparison with the assumed non-acclimation leaves,the in situ warmingacclimated leaves exhibited significantly higher net leaf carbon gain.5)The results suggest that there was a strong and significant temperature acclimation in physiology of G.straminea in response to long-term warming,and the physiological acclimation can reduce the decrease of leaf carbon gain,i.e.increase relatively leaf carbon gain under the warming condition in the alpine species. | Haihua Shen Julia AKlein Xinquan Zhao Yanhong Tang | 2009 | Journal of Plant Ecology2009，2，4： | 5 |
| 11 | Characterization of CO_(2) flux in three Kobresia meadows differing in dominant species显示文摘Aims Kobresia meadows,the dominant species of which differ in different habitats,cover a large area of alpine grassland on the QinghaiTibetan Plateau and act as potential CO_(2) sinks.Kobresia meadows with different dominant species may differ in carbon sink strength.We aimed to test the hypothesis and to clarify the differences in CO_(2) sink strength among three major Kobresia meadows on the plateau and the mechanisms underlying these differences.Methods We measured the net ecosystem exchange flux(NEE),ecosystem respiration flux(ER),aboveground biomass(AGB)and environmental variables in three Kobresia meadows,dominated by K.pygmaea,K.humilis,or K.tibetica,respectively,in Haibei,Qinghai.NEE and ER were measured by a closed-chamber method.Environmental variables,including photosynthetic photon flux density(PPFD),air and soil temperature and air and soil moisture,were monitored during the above flux measurements.Important findings The measured peak AGB increased with soil water content and was 365,402 and 434 g dry weight m2 for K.pygmaea,K.humilis and K.tibetica meadow,respectively.From the maximum ecosystem photosynthetic rate in relation to PPFD measured during the growing season,we estimated gross ecosystem photosynthetic potential(GEPmax)as 22.2,29.9 and 37.8 lmol CO_(2) m2 s1 for K.pygmaea,K.humilis and K.tibetica meadow,respectively.We estimated the respective gross primary production(GPP)values as 799,1063 and 1158 g C m^(-2) year^(-1) and ER as 722,914 and 1011 g C m^(-2) year^(-1).Average net ecosystem production(NEP)was estimated to be 76.9,149.4 and 147.6 g C m^(-2) year^(-1) in K.pygmaea,K.humilis and K.tibetica meadows,respectively.The results indicate that(i)the three meadows were CO_(2) sinks during the study period and(ii)Kobresia meadows dominated by different species can differ considerably in carbon sink strength even under the same climatic conditions,which suggests the importance of characterizing spatial heterogeneity of carbon dynamics in the future. | Pengcheng Zhang Mitsuru Hirota Haihua Shen Akinori Yamamoto Shigeru Mariko Yanhong Tang | 2009 | Journal of Plant Ecology2009，2，4： | 4 |
| 12 | Visualization of aging-associated chromatin alterations with an engineered TALE system显示文摘在实时房间的特定的 genomic loci 的可视化在多样的生物过程期间是为在染色质建筑学的动态变化的调查的一个前提,例如细胞的老化。然而,当前的精确 genomic 成像方法被缺乏妨碍荧光灯有高特性和 signal-to-noise 的探针形成对照。我们发现那常规抄写像使活跃之物的受动器(故事) 趋于形成蛋白质总数,从而在成像应用程序损害他们的性能。通过屏蔽,我们发现有故事的那熔化 thioredoxin 阻止了总数形成,开基于故事的 genomic 成像的完整的力量。用熔化 thioredoxin 的故事(TTALE ) ,我们在各种各样的 genomic loci 完成了高质量的成像并且观察联系老化(epi ) 在在人和老鼠早衰模型的 telomeres 和着丝点的 genomic 改变。重要地,我们鉴别 ribosomal DNA 的摩擦为人的老化作为一个分子的标记重复。我们的学习为精确在 vitro 并且在 vivo 监视染色质动力学建立一个简单、柔韧的成像方法。 | Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu | 2017 | Cell Research2017，27，4： | 4 |
| 13 | Ethylene Production and 1-Aminocyclopropane-l-Carboxylate (ACC) Synthase Gene Expression in Tomato ( L ycopsicon esculentum Mill.) Leaves Under Enhanced UV-B Radiation显示文摘西红柿(Lycopsicon esculentum 米尔) 在一个温室种的植物与 UV-B 的二个不同层次被照耀,也就是 8.82 (T1 ) 并且 12.6 kJ/m2 每天(T2 ) 。乙烯生产, 1-aminocyclopropane-1-carboxylate (ACC ) 内容, 1-(malonylamino ) cyclopvopane-1-carboxylic 酸(MACC ) 内容, ACC synthase (EC 4.4.1.14 ) 的基因表示,和在西红柿叶子的 ACC oxidase 活动是坚定的。结果显示了那个 ACC 内容, ACC synthase 的活动和 ACC oxidase,并且乙烯生产在 UV-B 放射的低剂量下面连续地增加了,而在放射的高剂量这些参数在开始的 12 d 期间增加了然后开始减少。MACC 内容在 UV-B 照耀的两剂量下面在 18 d 上连续地增加了。在 ACC 内容, ACC synthase 活动, ACC oxidase 活动, ACC synthase 基因的 transcriptional 水平,和乙烯生产的变化与对方一致,建议 ACC synthase 在在 UV-B 放射下面的西红柿叶纸巾是在乙烯生合成和那乙烯生产的关键酶能被 ACC synthase 基因的表示调整。结果也显示在乙烯新陈代谢的变化可以是到提高的 UV-B 放射的适应机制。 | Lizhe An Xiaofeng Xu Hongguan Tang Manxiao Zhang Zongdong HOU Yanhong Liu Zhiguang Zhao Huyuan Feng Shijian Xu Xunling Wang | 2006 | Journal of Integrative Plant Biology2006，48，10： | 2 |
| 14 | Efficacy and safety of chemotherapy combined with bevacizumab in Chinese patients with metastatic colorectal cancer:A prospective,multicenter,observational,non-interventional phaseⅣtrial显示文摘Objective:Bevacizumab has an important and evolving role in improving outcomes in patients with metastatic colorectal cancer(mCRC)worldwide and was approved in China in 2010.However,there are limited real-world data on the efficacy and safety of chemotherapy regimens combined with bevacizumab in Chinese patients with mCRC.This observational,phase IV trial study aimed to obtain more experience on the efficacy and safety of bevacizumab combined with chemotherapy in Chinese mCRC patients.Methods:Between September 2013 and November 2016,patients with histologically confirmed mCRC were enrolled in a prospective,multicenter,observational,non-interventional phase IV trial at 26 centers across China.Eligible patients received different chemotherapeutic regimens combined with bevacizumab.The efficacy and safety data in the intention-to-treat study population were analyzed.Results:A total of 611 patients were included in the efficacy analysis.The median overall survival and median progression-free survival was 18.00 and 10.05 months,respectively.The objective response rate was 21.00%and disease control rate was 89.40%.In subgroup analyses,the survival differences were observed according to metastatic status,duration of treatment and elevation in blood pressure.A total of 613 patients were evaluable for safety assessments.And 569(92.82%)patients reported at least one adverse event(AE),and 151(24.63%)experienced grade 3 or higher AEs.The incidence of bevacizumab-associated AEs of special interest was reported in 31(5.06%)patients with hypertension(n=12),abscesses and fistulae(n=7),bleeding(n=6),proteinuria(n=3),gastrointestinal perforation(n=2)and venous thrombotic events(n=1).Conclusions:This observational phase IV trial broadens our experience and knowledge of bevacizumab in the Chinese population and provides a good indication of its overall efficacy and safety.Bevacizumab in combination with chemotherapy offers clinical benefits to Chinese patients with mCRC and has an acceptable and manageable safety profile. | Fenghua Wang Guanghai Dai Yanhong Deng Yong Tang Wei Wang Zuoxing Niu Feng Bi Liangjun Zhu Zengqing Guo Jin Yan Bing Hu Min Tao Shujun Yang Suzhan Zhang Lu Wen Ruihua Xu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 2 |
| 15 | Phylogeography of Potentilla fruticosa,an alpine shrub on the Qinghai-Tibetan Plateau显示文摘Aims Our objectives were(i)to elucidate the phylogeography of chloroplast DNA(cpDNA)in Potentilla fruticosa in relation to Quaternary climate change and postglacial colonization,(ii)to infer historical population range expansion using mismatch distribution analyses and(iii)to locate the refugia of this alpine species on the Qinghai-Tibetan plateau during glacial-interglacial periods.Methods Potentilla fruticosa is a widespread species distributed on the Qinghai-Tibetan Plateau.We sampled leaves of P.fruticosa from 10 locations along a route of;1300 km from the northeastern plateau(Haibei,Qinghai)to the southern plateau(Dangxiong,Tibet).We examined the cpDNA of 15 haplotypes for 87 individuals from the 10 populations based on the sequence data from;1000 base pairs of the trnS-trnG and rpl20-rps12.Phylogenetic relationship of haplotypes was analyzed using the Phylip software package and the program TCS.The diversity of populations indices was obtained using the program ARLEQUIN.Important Findings With the limited samples,we found that(i)higher nucleotide diversity often occurs in high-altitude populations,(ii)the ancestral haplotypes distribute in the populations with higher nucleotide diversity than recent haplotypes,(iii)the expansion time of population in the high altitudes was estimated to be approximately at 52-25 ka BP(1000 years Before Present,where'Present'is AD 1950)and that in the low altitudes to be;5.1-2.5 ka BPand(iv)the source location of P.fruticosa is at the high altitudes,which might provide refugia for the species during the interglacial warm periods.The species expanded from the high-elevated locations on the Tanggula Mountains during the Holocene. | Cui Li Ayako Shimono Haihua Shen Yanhong Tang | 2010 | Journal of Plant Ecology2010，3，1： | 2 |
| 16 | Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development显示文摘Objective:Hepatocellular carcinoma(HCC)is a severely lethal cancer that usually originates from chronic liver injury and inflammation.Although progress on diagnosis and treatment is obvious,the cause of HCC remains unclear.In this study,we sought to determine key genes in HCC development.Methods:To identify key regulators during HCC progression,we performed transcriptome sequencing to obtain time series gene expression data from a mouse model with diethylnitrosamine-induced liver tumors and further verified gene expression and function in vitro and in vivo.Results:Among the differentially expressed genes,Cyp2c29 was continuously downregulated during HCC progression.Overexpression of Cyp2c29 suppressed N F-kB activation and proinflammatory cytokine production by increasing the production o f 14,15-epoxyeicosatrienoic acid in vitro.Furthermore,overexpression of Cyp2c29 in vivo protected against liver inflammation in mouse models of liver injury induced by both acetaminophen and CC14.Two human homologs of mouse Cyp2c29,CYP2C8 and CYP2C9,were found to be downregulated in human HCC progression,and their expression was positively correlated with overall survival in patients with HCC(significance:P=0.046 and 0.0097,respectively).Conclusions:Collectively,through systematic analysis and verification,we determined that C yp2c29 is a novel gene involved in liver injury and inflammation,which may be a potential biomarker for HCC prevention and prognosis determination. | Qi Wang Qin Tang Lijun Zhao Qiong Zhang Yuxin Wu Hui Hu Lanlan Liu Xiang Liu Yanhong Zhu Anyuan Guo Xiangliang Yang | 2020 | Cancer Biology & Medicine2020，17，2： | 2 |
| 17 | Causes for the unimodal pattern of biomass and productivity in alpine grasslands along a large altitudinal gradient in semi‐arid regions显示文摘 | Zhong Wang Tianxiang Luo Ruicheng Li Yanhong Tang Mingyuan Du | 2012 | J Veg Sci2012，，1： | 1 |
| 18 | Energy exchange between the atmosphere and a meadowecosystem on the Qinghai-Tibetan Plateau显示文摘 | Song Gu Yanhong Tang Xiaoyong Cui | 2005 | Agricultural and Forest Meteorology2005，129，： | 1 |
| 19 | Analysis of bread dielectric properties using mixture equations显示文摘 | Liu Yanhong Tang Juming Mao Zhihuai | 2009 | Journal of Food Engineering2009，93，1： | 1 |
| 20 | The latent causal chain of industrial water pollution in China显示文摘 | Miao Xin Tang Yanhong Wong Christina W Y | 2015 | Environmental Pollution2015，196，： | 1 |
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