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| 1 | Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis显示文摘AIM To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis(PSC) patients.METHODS Sera of 67 PSC patients [median age(range): 32(5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin(AAA Ig A/Ig G) and gliadin(AGA Ig A/Ig G)] and for serum level of intestinal fatty acid-binding protein(I-FABP) by ELISA. Markers of lipopolysaccharide(LPS) exposure [LPS binding protein(LBP)] and various antimicrobial antibodies [anti-OMP Plus Ig A and endotoxin core Ig A antibody(Endo CAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99(14-106) mo]. One hundred and fifty-three healthy subjects(HCONT) and 172 ulcerative colitis(UC) patients were the controls. RESULTS A total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA Ig A, AAA Ig G, AGA Ig A and AGA Ig G, respectively. Frequencies of AAA Ig A and AAA Ig G(P < 0.001, for both) and AGA Ig G(P = 0.01, for both) but not AGA Ig A were significantly higher compared to both of the HCONT and the UC groups. In survival analysis, AAA Ig A-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15(1.27-20.86), P = 0.022 or for the Mayo risk score(HR = 4.24(0.99-18.21), P = 0.052]. AAA Ig A-positivity was significantly associated with higher frequency of antimicrobial antibodies(P < 0.001 for Endo Cab Ig A and P = 0.012 for anti-OMP Plus Ig A) and higher level of the enterocyte damage marker(median I-FABP_(AAA Ig A pos vs neg): 365 vs 166 pg/m L, P = 0.011), but not with serum LBP level. CONCLUSION Presence of Ig A type AAA identified PSC patients with progressive disease. Moreover, it is associated with enhanced mucosal immune response to various microbial antigens and enterocyte damage further highlighting the importance of the gut-liver interaction in PSC. | Tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas Gary L Norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos Maria Papp | 2017 | World Journal of Gastroenterology2017，23，29： | 5 |
| 2 | Role of reactive oxygen species generating enzymes and hydrogen peroxide during cadmium mercury and osmotic stresses in barley root tip 显示文摘 | Tamas L Mistrik I Huttova J | 2010 | Planta2010，231，2： | 1 |
| 3 | The impact of heavy metals on the activity of some enzymes along the barley root 显示文摘 | TAMAS L DUD KOV J UR EKOV K | 2008 | Environmental and Experimental Botany2008，62，1： | 1 |
| 4 | Safety and immunogenicity of a 2009 pandemic influenza A H1N1 vaccine when administered alone or simultaneously with the seasonal influenza vaccine for the 2009-10 influenza season:a multicentre,randomised controlled trial显示文摘 | Vajo Z Tamas F Sinka L | 2010 | Lancet2010，375，9708： | 1 |
| 5 | Trainable blotch detection on high resolution archive films minimizing the human interaction显示文摘 | Attila L Tamas S Laszlo D | 2010 | Machine Vision and Applications2010，21，5： | 1 |
| 6 | Inhibition of Al-induced root elongation and enhancement of Al-induced peroxidase in Al-sensitive and Al-resistant barley cultivars are positively correlated 显示文摘 | Tamas L Huttova J Mistrik I | 2003 | Plant Soil2003，250，： | 1 |
| 7 | Effect of cadmium and temperature on the lipoxygenase activity in barley root tip显示文摘 | TAMAS L DUDIKOVA J DUCREKOVA K | 2009 | Protoplasma2009，235，： | 1 |
| 8 | Effect of plant growth substances on the growth of axillary buds in cultured stem segments of Phaseolus vulgaris L显示文摘 | Tamas I A Schlossberg-Jacobs J L Lim R | 1998 | Plant Growth Regul1998，8，： | 1 |
| 9 | Alumimtm-indueed cell death of barley-root border cells is correlated with peroxidase and oxalate oxidase-mediated hydrogen peroxide production显示文摘 | TAMAS L BUDIKOVA S HUTYOVA J | 2005 | Plant Cell Report2005，24，： | 1 |
| 10 | Comparison of GC-MS and TLC techniques for asarone isomers determination显示文摘 | Oprean R Tamas M Roman L | 1998 | J PharmBiomed Anal1998，18，12： | 1 |
| 11 | Identification and partial characterization of β-1,3-glucanase from virus-infected cucumber cotyledons 显示文摘 | Repka V Tamas L Fischerova I | 1997 | Acta Virol1997，41，1： | 1 |
| 12 | Alterations of the gene expression,lipid peroxidation,proline and thiol content along the barley root exposed to cadmium显示文摘 | TAMAS L DUDIKOVA J DURCEKOVA K | 2008 | Journal of Plant Physiology2008，165，： | 1 |
| 13 | Safety and immunngenicity of a 2009 pandemic influenza A H1N1 vaccine when administered alone or simultaneously with the seasonal influenza vaccine for the 2009-10 influenza season:a multicentre,randomised controlled trial显示文摘 | Vajo Z Tamas F Sinka L | 2010 | Lancet2010，375，9708： | 1 |
| 14 | Heterologous expression and protein engineering of wheat gluten proteins显示文摘 | TAMAS L SHEWRY P R | 2006 | Journal of Cereal Science2006，43，： | 1 |
| 15 | Aluminum-induced cell death of barley-root border cells is correlated with peroxidase- and oxalate oxidase-mediated hydrogen peroxide production 显示文摘 | Tamas L Budikova S Huttova J | 2005 | Plant Cell Rep2005，24，： | 1 |
| 16 | Direct evidence that the number and location of cysteine residues affect glutenin polymer structure显示文摘 | LINDSAY M P TAMAS L APPELS R | 2000 | Journal of Cereal Science2000，31，3： | 1 |
| 17 | Determination of the analgesic dose–response relationship for epidural fentanyl and sufentanil with bupivacaine 0.125% in laboring patients显示文摘 | Norman L Herman Kevin L Sheu Tama K Van Decar Joyce D Rubin Farida Gadalla Howard D Koff John E Reynolds | 1998 | Journal of Clinical Anesthesia1998，，8： | 1 |
| 18 | Inhibition of Al-induced root elongation and enhancement of Al-induced peroxidase activity in Al-sensitive and Al-resistance barley cultivars are positively correlated显示文摘 | TamAs L Huttov J Mistrik I | 2003 | Plant & Soil2003，250，： | 1 |
| 19 | The impact of heavy metals on the activity of some enzymes along the barley root显示文摘 | TAMAS L DUDAKOV)t J DURCEKOVA K | 2008 | Environmental and Experimental Botany2008，62，1： | 1 |
| 20 | The proteasome inhibitor MG132 protects against acute pancreatitis 显示文摘 | Tama's L Csaba S Tama's T | 2005 | Free Radic Biol Med2005，39，9： | 1 |
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