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| 1 | Golgi protein-73:A biomarker for assessing cirrhosis and prognosis of liver disease patients显示文摘BACKGROUND Reliable biomarkers of cirrhosis,hepatocellular carcinoma(HCC),or progression of chronic liver diseases are missing.In this context,Golgi protein-73(GP73)also called Golgi phosphoprotein-2,was originally defined as a resident Golgi type II transmembrane protein expressed in epithelial cells.As a result,GP73 expression was found primarily in biliary epithelial cells,with only slight detection in hepatocytes.However,in patients with acute or chronic liver diseases and especially in HCC,the expression of GP73 is significantly up-regulated in hepatocytes.So far,few studies have assessed GP73 as a diagnostic or prognostic marker of liver fibrosis and disease progression.AIM To assess serum GP73 efficacy as a diagnostic marker of cirrhosis and/or HCC or as predictor of liver disease progression.METHODS GP73 serum levels were retrospectively determined by a novel GP73 ELISA(QUANTA Lite®GP73,Inova Diagnostics,Inc.,Research Use Only)in a large cohort of 632 consecutive patients with chronic viral and non-viral liver diseases collected from two tertiary Academic centers in Larissa,Greece(n=366)and Debrecen,Hungary(n=266).Aspartate aminotransferase(AST)/Platelets(PLT)ratio index(APRI)was also calculated at the relevant time points in all patients.Two hundred and three patients had chronic hepatitis B,183 chronic hepatitis C,198 alcoholic liver disease,28 autoimmune cholestatic liver diseases,15 autoimmune hepatitis,and 5 with other liver-related disorders.The duration of follow-up was 50(57)mo[median(interquartile range)].The development of cirrhosis,liver decompensation and/or HCC during follow-up were assessed according to internationally accepted guidelines.In particular,the surveillance for the development of HCC was performed regularly with ultrasound imaging and alpha-fetoprotein(AFP)determination every 6 mo in cirrhotic and every 12 mo in non-cirrhotic patients.RESULTS Increased serum levels of GP73(>20 units)were detected at initial evaluation in 277 out of 632 patients(43.8%).GP73-seropositivity correlated at baseline with the presence of cirrhosis(96.4%vs 51.5%,P<0.001),decompensation of cirrhosis(60.3%vs 35.5%,P<0.001),presence of HCC(18.4%vs 7.9%,P<0.001)and advanced HCC stage(52.9%vs 14.8%,P=0.002).GP73 had higher diagnostic accuracy for the presence of cirrhosis compared to APRI score[Area under the curve(AUC)(95%CI):0.909(0.885-0.934)vs 0.849(0.813-0.886),P=0.003].Combination of GP73 with APRI improved further the accuracy(AUC:0.925)compared to GP73(AUC:0.909,P=0.005)or APRI alone(AUC:0.849,P<0.001).GP73 levels were significantly higher in HCC patients compared to non-HCC[22.5(29.2)vs 16(20.3)units,P<0.001)and positively associated with BCLC stage[stage 0:13.9(10.8);stage A:17.1(16.8);stage B:19.6(22.3);stage C:32.2(30.8);stage D:45.3(86.6)units,P<0.001]and tumor dimensions[very early:13.9(10.8);intermediate:19.6(18.4);advanced:29.1(33.6)units,P=0.004].However,the discriminative ability for HCC diagnosis was relatively low[AUC(95%CI):0.623(0.570-0.675)].Kaplan-Meier analysis showed that the detection of GP73 in patients with compensated cirrhosis at baseline,was prognostic of higher rates of decompensation(P=0.036),HCC development(P=0.08),and liver-related deaths(P<0.001)during follow-up.CONCLUSION GP73 alone appears efficient for detecting cirrhosis and superior to APRI determination.In combination with APRI,its diagnostic performance can be further improved.Most importantly,the simple GP73 measurement proved promising for predicting a worse outcome of patients with both viral and nonviral chronic liver diseases. | Nikolaos K Gatselis Tamás Tornai Zakera Shums Kalliopi Zachou Asterios Saitis Stella Gabeta Roger Albesa Gary L Norman Mária Papp George N Dalekos | 2020 | World Journal of Gastroenterology2020，26，34： | 21 |
| 2 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 3 | Non-structural Fuzzy Decision Support System for Evaluation of Construction Safety Management System显示文摘 | Tam C M Tong Thomas K L Chiu Gerald C W Fung Ivan W H | 2002 | International Journal of Project Management2002，，20： | 1 |
| 4 | Exact analytical bit error rates for multiple access Chaos-based communication systems显示文摘 | TAM W M FRANCIS C M L CHI K | 2004 | IEEE Trans Circuit Syst Ⅱ2004，51，： | 1 |
| 5 | An optimization model for wayfinding problems in terminal building显示文摘 | TAM M L | 2011 | Journal of Air Transport Manage- ment2011，17，2： | 1 |
| 6 | A reliability- based stochastic traffic assignment model for net- work with multiple user classes under uncertainty in demand显示文摘 | SHAO H LAM W H K TAM M L | 2006 | Network and Spatial Economics2006，，6： | 1 |
| 7 | Microleakage of posterior composite restorations lined with self-adhesive resin cements显示文摘 | Al-Saleh M El-Mowafy O Tam L | 2013 | Oper Dent2013，35，5： | 1 |
| 8 | A reliability-based stochastic traffic assignment model for network with multiple user classes under uncertainty in demand 显示文摘 | Shao H Lam W H K Tam M L | 2006 | Networks and Spatial Economics2006，6，3： | 1 |
| 9 | Estimation of glomerular filtration rate in patients with systemic lupus erythematosus 显示文摘 | Leung Y Y Lo K M Tam L S | 2006 | Lupus2006，15，5： | 1 |
| 10 | Capsaicin-sensitive local sensory innervation is involved in pacing-induced preconditioning in rat hearts: role of nitric oxide and CGRP?显示文摘 | P. Ferdinandy Tamás Csont Csaba Csonka Marianna T?r?k Mária Dux József Németh László I. Horváth László Dux Zoltán Szilvássy Gábor Jancsó | 1997 | Naunyn - Schmiedeberg’s Archives of Pharmacology1997，，3： | 1 |
| 11 | Effect of light energy on peroxide tooth bleaching显示文摘 | Luk K Tam L Hubert M | 2004 | J Am Dent Assoc2004，135，2： | 1 |
| 12 | MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRHI显示文摘 | TAY Y M TAM W L ANG Y S | 2008 | Stem Ceils2008，26，1： | 1 |
| 13 | Demand Driven traffic assignment problem based on travel time reliability显示文摘 | Shao H Lam W H K Tam M L | 2006 | Transportation Research Record2006，1985，： | 1 |
| 14 | Comparison of two non-parametric models for daily traffic forecasting in Hong Kong 显示文摘 | LAM W H K TANG Y F TAM M L | 2006 | Journal of Forecasting2006，25，3： | 1 |
| 15 | A reliability-based stochastic traffic assignment model for network with multiple user classes under uncertain in demand 显示文摘 | Shao H Lain W H K Tam M L | 2006 | Network and Spatial Economics2006，6，34： | 1 |
| 16 | A reliability-based stochastic traffic assignment model for network with multiple user classes under uncertainty in demand显示文摘 | Shao H Lam W H K Tam M L | | 0，，3： | 1 |
| 17 | Non-structural fuzzy decision support system for evaluation of construction safety management system 显示文摘 | TAM C M TONG T K L CHIU G C V | 2002 | International Journal of Project Manage- ment2002，20，4： | 1 |
| 18 | Using automatic vehicle identification data for travel time estimation in Hong Kong 显示文摘 | TAM M L LAM W H K | 2008 | Transportmetrica2008，4，3： | 1 |
| 19 | Proliferation and migration of primordial germ cells during compensatory growth in mouse embryos 显示文摘 | TAM P L SNOW M L | 1981 | J Embryol Exp Morph1981，64，2： | 1 |
| 20 | De- termination of user acceptance of digital libraries: an em- pirical examination of individual difference and system characteristic显示文摘 | HONG W THONG J Y L WONG W M TAM K Y | 2002 | Journal of Management Information Sys- tem2002，，3： | 1 |
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