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| 1 | Effects of octreotide on acute necrotizing pancreatitis in rabbits显示文摘AIM: To assess the role of oxygen-derived free radicals and cytokines in the pathogenesis of taurocholic acid-induced acute pancreatitis, and to evaluate the preventive effects of octreotide towards the development of acute pancreatitis. METHODS: Acute pancreatitis was induced in male New Zealand white rabbits by retrograde injection of 0.8 mL/kg·b·m, of 50 g/L sodium taurocholate(NaTC) in the pancreatic duct. Sham-operated animals served as control. Octreotide 1 mglkg·b.m.was administered subcutaneously before the induction of pancreatitis. Blood was taken from the jugular vein before and at 1, 3, 6, 12 and 24 h after pancreatitis induction.Serum activities of amylase, IL-6 and TNF-α and levels of malonyl dialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), catalase and superoxide dismutase (Mn-,Cu-,and Zn-SOD) in pancreatic tissue were measured.RESULTS: Serum TNF-α and IL-6 levels increased significantly 3 h after the onset of pancreatitis, and then returned to control level. The tissue concentration of MDA was significantly elevated at 24 h, while the GSH level and GP-x, catalase, Mn-SOD, Cu-, Zn-SOD activities were all significantly decreased in animals with pancreatitis as compared to the control. Octreotide pretreatment significantly reversed the changes in cytokines and reactive oxygen metabolites. Octreotide treatment did not alter the serum amylase activity and did not have any beneficial effects on the development of histopathological changes.CONCLUSION: Oxygen-derived free radicals and proinflammatory cytokines are generated at an early stage of NaTc-induced acute pancreatitis in rabbits. Prophylac ticoctreotide treatment can prevent release of cytokines and generation of reactive oxygen metabolites, but does not have any beneficial effects on the development of necrotizing pancreatitis. | Lászl6Czakó PéterHegyi TamásTakács CsabaGóg AndrásFarkas YvetteMándy Ilona Sz.Varga LászlóTiszlavicz JánosLonovics | 2004 | World Journal of Gastroenterology2004，10，14： | 21 |
| 2 | L-arginine-induced experimental pancreatitis显示文摘Despite medical treatment, the lethality of severe acute pancreatitis is still high (20-30%). Therefore, it is very important to find good animal models to characterise the events of this severe disease. In 1984, Mizunuma et. al. developed a new type of experimental necrotizing pancreatitis by intraperitoneal administration of a high dose of L-arginine in rats. This non-invasive model is highly reproducible and produces selective, dose-dependent acinar cell necrosis.Not only is this a good model to study the pathomechanisne of acute necrotizing pancreatitis, but it is also excellent to observe and influence the time course changes of the disease. By writing this review we iluminate some new aspects of cell physiology and pathology of acute necrotizing pancreatitis. Unfortunately, the reviews about acute experimental pancreatitis usually did not discuss this model.Therefore, the aim of this manuscript was to summarise the observations and address some challenges for the future in L-arginine-induced pancreatitis. | PéterHegyi ZoltánRakonczayJr RékaSári CsabaGóg JánosLonovics TamásTakács LászlóCzakó | 2004 | World Journal of Gastroenterology2004，10，14： | 7 |
| 3 | 神经连接蛋白-3缺乏可阻止高分级神经胶质瘤生长显示文摘在一项新的研究中,来自美国国家卫生研究院、斯坦福大学、达纳法伯癌症研究所和哈佛医学院的研究人员发现某些侵袭性脑瘤的生长能够通过切断它们获取大脑中神经细胞产生的一种信号分子加以阻止.这些研究人员发现当这种被称作神经连接蛋白-3(neuroligin-3,NLGN3)的信号分子缺乏时,或者当利用药物干扰这种信号分子时,人高分级神经胶质瘤不能够在小鼠大脑中扩散. | Venkatesh H S Tam L T Woo P J | 2017 | 临床误诊误治2017，30，11： | 3 |
| 4 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 5 | Accumulation of miR-155 and BIC RNA in human B cell lyrephomas 显示文摘 | Eis P S Tam W Sun L | 2005 | Proc Nail Acad Sci USA2005，102，10： | 1 |
| 6 | Effects of Matrine on proliferation and differentiation in K-562 cells显示文摘 | ZHANG L P JIANG J K TAM J W | 2001 | Leuk Res2001，25，9： | 1 |
| 7 | Antimicrobial dendrimeric peptides 显示文摘 | Tam J P Lu Y A Yang J L | 2002 | Eur J Biochem2002，269，3： | 1 |
| 8 | Accumulation of miR-155 and BIC RNA in human B cell lymphomas显示文摘 | Eis P S Tam W Sun L | 2005 | Proc Natl Acad Sci U S A2005，102，10： | 1 |
| 9 | X-chromosome activity of the mouse primordial germ cells revealed by the expression of an X-linked lacZ transgene显示文摘 | Zhou S X Tan S S | 1994 | Development1994，120，： | 1 |
| 10 | Gustatory perception alterations in obesity: An fMRI study显示文摘 | Csaba Szalay Mihály Aradi Attila Schwarcz Gergely Orsi Gábor Perlaki Lívia Németh Sophia Hanna Gábor Takács István Szabó László Bajnok András Vereczkei Tamás Dóczi József Janszky Sámuel Komoly Péter ?rs Horváth László Lénárd Zoltán Karadi | 2012 | Brain Research2012，，： | 1 |
| 11 | Accumulation of miR-155 and BIC RNA in human B cell lymphomas显示文摘 | Eis P S Tam W Sun L | 2005 | Proc Natl Acad Sci USA2005，102，： | 1 |
| 12 | Proliferation and migration of primordial germ cells during compensatory growth in mouse embryos 显示文摘 | TAM P L SNOW M L | 1981 | J Embryol Exp Morph1981，64，2： | 1 |
| 13 | Late-life body mass index and waist circumference in amnestic mild cognitive impairment and Alzheimer's disease显示文摘 | Chu L W Tam S Lee P W et a1 | 2009 | J Alzheimer''s Dis2009，17，1： | 1 |
| 14 | Accumulation of miR-155 and BIC RNA in human B cell lymphomas显示文摘 | Eis P S Tam W Sun L | 2005 | Proc Natl Acad Sci USA2005，102，10： | 1 |
| 15 | Synthesis and applications of unprotected cyclic peptides as building blocks for peptide dendrimers显示文摘 | Zhang L Tam J P | 1997 | J Am Chem Soc1997，119，： | 1 |
| 16 | Accumulation of miR-155 and BIC RNA in human B cell lymphomas显示文摘 | EIS P S TAM W SUN L | 2005 | Proc Natl Acad Sci U S A2005，102，10： | 1 |
| 17 | Recovery voice and satisfaction after service failure: an experimental investiga- tion of mediating and moderating factors 显示文摘 | KARANDE K MAGNINI V P TAM L | 2007 | Journal of Service Research2007，10，3： | 1 |
| 18 | Structural,mechanical,and tribological studies of Cr-Ti-AI-N coating with different chemical compositions显示文摘 | Tam P L Zhou Z F Shum P W | | 0，，16： | 1 |
| 19 | High temperature oxi- dation of CrTiAIN hard coatings prepared by unbalanced magnetron sputtering 显示文摘 | Zhou Z F Tam P L Shum P W | 2009 | Thin Solid Films2009，517，17： | 1 |
| 20 | Uniqueness and regularity of proper harmonic maps显示文摘 | LI P TAM L F | 1993 | Ann of Math1993，，137： | 1 |
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