|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice显示文摘AIM To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil(5-FU)-induced diarrhea.METHODS Diarrhea was induced in wild-type(WT), Fn14 knockout(KO), and IL-13 receptor(IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. Histological analysis, cytokine analysis, and flow cytometry was performed on ileal tissues and cells. Murine colon carcinomabearing mice were co-treated with an anti-TWEAK antibody and 5-FU. Embryonic fibroblast response to cytokines was also analyzed.RESULTS5-FU induced high Fn14 expression in epithelial cells. The severity of 5-FU-induced diarrhea was lower in Fn14 KO mice compared with WT mice. Administration of anti-TWEAK antibody reduced 5-FU-induced diarrhea without affecting the antitumor effects of 5-FU in vivo. 5-FU-induced expression of IL-13, IL-17 A, TNF-α, and IFN-γ in the ileum was Fn14 dependent. The severity of 5-FU-induced diarrhea was lower in IL-13Rα1 KO mice, indicating major role for IL-13 signaling via IL-13Rα1 in pathogenesis. We found that IL-13Rα2, an IL-13 neutralizing/cell protective receptor, was strongly induced by IL-33 in vitro and in vivo. IL-13Rα2 was upregulated in the ileum of 5-FU-treated Fn14 KO mice. Thus, the deletion of Fn14 upregulated IL-13Rα2 expression, which reduced IL-13 expression and activity. CONCLUSION Disruption of the TWEAK/Fn14 pathway affects several interconnected pathways, including those associated with IL-13, IL-33, and IL-13Rα2, to attenuate 5-FUinduced intestinal side effects. | Takuhito Sezaki Yuki Hirata Teruki Hagiwara Yuki I Kawamura Tadashi Okamura Rieko Takanashi Kenta Nakano Miwa Tamura-Nakano Linda C Burkly Taeko Dohi | 2017 | World Journal of Gastroenterology2017，23，13： | 3 |
| 2 | The therapeutic effect of Lipo PGE1 on diabetic neuropathy-changes in endothelin and various angiopathic factors 显示文摘 | Yasutoshi I Tadashi Y | 2001 | Prostaglandins & other Lipid Mediators2001，66，： | 1 |
| 3 | Molecular magnetism: present and future 显示文摘 | Tadashi S Akira I | 1997 | Molecular Crystals and Liquid Crystals Science and Technology1997，，305： | 1 |
| 4 | Anti -allergic effect of a combination of Citrus unshiu unripe fruits extract and prednisolone on picryl chloride- induced contact dermatitis in mice 显示文摘 | I TADASHI F TAKEHUMI S MEGUMI M | 2008 | Natural Medicines2008，62，2： | 1 |
| 5 | Real time monitoring of biphasic glutamate release asing dialg sis electrode in rat acute brain is ehemia 显示文摘 | Satoshi A Yuji I Tadashi K | 1996 | Neuroerport1996，30，7： | 1 |
| 6 | Contribution of the net charge to the regulatory effects of amino acids and epsilon–poly(L–lysine)on the gelatinization behavior of potato starch granules显示文摘 | Azusa I Makoto H Tadashi Y | 2006 | Bioscience Biotechnology and Biochemistry2006，70，16： | 1 |
| 7 | Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine-7 ( 5-HT7 ) and 5-HTIA receptor activity 显示文摘 | Tadashi I Tomoko H Kumiko T | 2010 | JPET2010，334，1： | 1 |
| 8 | The surface and morphology and structure of carbon-carbon composites in high-energy sliding contact显示文摘 | Yen B K Tadashi I | 1994 | Wear1994，174，： | 1 |
| 9 | Effect of proteolytic squid protein hydrosate on the state of water and denaturation of lizardfish myofibrillar protein during freezing显示文摘 | Md A H Abu A Tadashi I | 2004 | Innov Food Sci Emrg Technol2004，5，： | 1 |
| 10 | Low temperature operation ofthin-film limiting-current type oxygen sensor using graded- composition layer electrodes 显示文摘 | TADASHI I KEIICHI S | 2008 | Sens Actuators B-Chem2008，129，2： | 1 |
| 11 | Influence of daylight and noise current on cloud and aerosol observations by space borne elastic scattering lidar显示文摘 | Tadashi I Osamu U | 1999 | Applied Optics1999，38，： | 1 |
| 12 | Direct measurement of interactions between stimulation-responsive drug delivery vehicles and artifieial muein layers by colloid probe atomic force mieroseopy 显示文摘 | Motoyuki I Motoyasu Y Tadashi T | 2008 | Langmuir2008，24，8： | 1 |
| 13 | Bronchioloalveolar carcinoma arising in a bronchogenic cyst显示文摘 | Chiaki E Tadashi I Hideyuki N | 2000 | Ann Thorac Surg2000，69，： | 1 |
| 14 | Copper Partition Between Na2S Bearing Fluxes and Carbon Saturated Iron Melts 显示文摘 | Tadashi I Nobuo S | 1988 | Transactions ISIJ1988，28，： | 1 |
| 15 | Vascular cell-like potential ofundifferentiated ligament fibroblasts to construct vascular cell-specificmarker-positive blood vessel structures in a PI3Kactivation-dependentmanne显示文摘 | Naoto O Akira I Tadashi I | 2010 | J Vasc Resz2010，47，5： | 1 |
| 16 | Effects of sodium sulfate and sodium bicarbonateon the growth, gas exchange and mineral composition of lettuce显示文摘 | Bie Z L Tadashi I Yutaka S | 2004 | Horticultural Science2004，99，： | 1 |
| 17 | C-type natriuretic peptide induces redifferentiation of vascular smooth muscle cells with accelerated reendothelialization显示文摘 | Kentaro D Tadashi I Hiroshi I | 2001 | Arterioscler Thromb Vasc Biol2001，21，6： | 1 |
| 18 | Bronchioloalveolar carcinoma arising in a bronchogenic cysts显示文摘 | Chiaki E Tadashi I Hideyuki N | 2000 | Ann Thorac Surg2000，69，3： | 1 |
| 19 | Calculation of ion flow fields of HVDC transmission lines by the finite element method显示文摘 | Takuma T Tsutomu I Tadashi K | 1981 | IEEE Transactions on Power Apparatus and Systems1981，100，12： | 1 |
| 20 | Proteus Mirabilis Clinical Isolate Harbouring a New Variant of Salmonella Genomic Island 1 Containing the Multiple Antibiotic Resistance Region显示文摘 | ASHRAF M A AMJAD I A TADASHI S | | 0，，02： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员