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| 1 | Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage显示文摘AIM: This study investigated the mechanisms of protection afforded by the proton pump inhibitor lansoprazole against gastric injury induced by different non-steroidal antiinflammatory drugs (NSAIDs) in rats.METHODS: Male Sprague-Dawley rats were orally treated with indomethacin (100 μmol/kg), diclofenac (60 μmol/kg),piroxicam (150 μmol/kg) or ketoprofen (150 μmol/kg).Thirty minutes before NSAIDs, animals were orally treated with lansoprazole 18 or 90 μmol/kg. Four hours after the end of treatments, the following parameters were assessed: gastric mucosal PGE2, malondialdehyde (MDA), myeloperoxidase (MPO) or non-proteic sulfhydryl compounds (GSH) levels; reverse transcription-polymerase chain reaction (RT-PCR) of mucosal COX-2 mRNA; gastric acid secretion in pylorus-ligated animals; in vitro effects of lansoprazole (1-300 μmol/L) on the oxidation of low density lipoproteins (LDLs) induced by copper sulphate.RESULTS: All NSAIDs elicited mucosal necrotic lesions which were associated with neutrophil infiltration and reduction of PGE2 levels. Increments of MPO and MDA contents, as well as a decrease in GSH levels were detected in the gastric mucosa of indomethacin- or piroxicam-treated animals. Indomethacin enhanced mucosal cyclooxygenase-2 expression, while not affecting cyclooxygenase-1. At the oral dose of 18 μmol/kg lansoprazole partly counteracted diclofenac-induced mucosal damage, whereas at 90 μmol/kg it markedly prevented injuries evoked by all test NSAIDs. Lansoprazole at 90 μmol/kg reversed also the effects of NSAIDs on MPO, MDA and GSH mucosal contents, without interfering with the decrease in PGE2 levels or indomethacin-induced cyclooxygenase-2 expression. However, both lansoprazole doses markedly inhibited acid secretion in pylorus-ligated rats. Lansoprazole concentration-dependently reduced the oxidation of LDLs in vitro.CONCLUSION: These results suggest that, besides the inhibition of acid secretion, lansoprazole protection against NSAID-induced gastric damage depends on a reduction in mucosal oxidative injury, which is also responsible for an increment of sulfhydryl radical bioavailability. It is also suggested that lansoprazole does not influence the downregulation of gastric prostaglandin production associated with NSAID treatment. | Corrado Blandizzi Matteo Fornai Rocchina Colucci Gianfranco Natale Valter Lubrano Cristina Vassalle Luca Antonioli Gloria Lazzeri Mario Del Tacca | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 2 | Prospects for personalized immunosuppression:pharmacologic tools显示文摘 | Del Tacca M | 2004 | Transplant Proc2004，36，3： | 1 |
| 3 | Changes in and prognostic value of hormone receptor status in a series of operable breast cancer patients treated with neoadjuvant chemotherapy显示文摘 | TACCA O PENAULT L F ABRIAL C | 2007 | Oncologist2007，12，： | 1 |
| 4 | Cooperative and reliable ARQ protocols for energy harvesting wireless sensor nodes显示文摘 | TACCA M MONTI P FUMAGALLI A | | 0，，07： | 1 |
| 5 | Free-space orbital angular momentum division multiplexing with Bessel beams显示文摘 | Gatto A Tacca M Martelli P | 2011 | Journal of Optics2011，13，06： | 1 |
| 6 | Prostaglandins from tumors of human large bowel显示文摘 | BENNETT A TACCA M D STAMFORD I F | 1977 | Br J Surg1977，35，6： | 1 |
| 7 | CAD tools in optical network design 显示文摘 | Isabella Cerutti Luca Valcarenghi | 2000 | Optical Networks Magazing2000，1，2： | 1 |
| 8 | Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti-inflammatory therapy显示文摘 | Corrado Blandizzi Marco Tuccori Rocchina Colucci Matteo Fornai Luca Antonioli Narcisa Ghisu Mario Del Tacca | 2008 | Pharmacological Research2008，，2： | 1 |
| 9 | Differentiated reliability in optical networks:theoretical and practical results显示文摘 | Tacca M Fumagalli A Paradisi A | 2003 | Journal of Lightwave Technology2003，21，11： | 1 |
| 10 | Survivable networks based on optimal routing and WDM self-healing rings 显示文摘 | Andrea Fumagalli Isabella Cerutti Marco Tacca | 1999 | ICC1999，，8： | 1 |
| 11 | Pharmacogenetics of anticancer drugs in non-hodgkin's lymphomas显示文摘 | Loni L Del Tacca M Danesi R | 2001 | Br J Cancer2001，85，10： | 1 |
| 12 | Preclinical pharmacology and clinical uses of topotecan显示文摘 | Del Tacca M Di Paolo A Danesi R | 1999 | Tumori1999，85，61： | 1 |
| 13 | Emerging role of cyclooxygenase isoforms in the control of gastrointestinal neuromuscular functions显示文摘 | Matteo Fornai Luca Antonioli Rocchina Colucci Nunzia Bernardini Narcisa Ghisu Marco Tuccori Roberto De Giorgio Mario Del Tacca Corrado Blandizzi | 2009 | Pharmacology and Therapeutics2009，，1： | 1 |
| 14 | Thumb metacarpal vascularized bone graft in long-standing scaphoid nonunion-a useful graft via dorsal or palmar approach:a cohort study of24patients显示文摘 | Bertelli JA Tacca CP Rost JR | 2004 | J Hand Surg Am2004，29，6： | 1 |
| 15 | Changes in and prognostic value of hormone receptor status in a series of operable breast cancer patients treated with neoadjuvant chemotherapy显示文摘 | TACCA O PENAULT-LIORCA F ABRIAL C | 2007 | Oncologist2007，12，6： | 1 |
| 16 | Changes in and prognostic value of hormone receptor status in a series of operable breast cancer patients treated with neoadjuvant chemotherapy 显示文摘 | Tacca O Penauh-Llorca F Abrial C | 2007 | The Oncologist2007，12，6： | 1 |
| 17 | Effects of morphine on gastric ulceration, barrier mucus, and acid secretion in pylorus - ligated rats 显示文摘 | Del Tacca M Bemardini C Corsano E | 1987 | Pharmacology1987，35，3： | 1 |
| 18 | Vascular endothelial growth factor pharmacogenetics: a new perspective for anti-angiogenic therapy 显示文摘 | PASQUALETTI G DANESI R DEL TACCA M | 2007 | Pharmacogenomices2007，8，1： | 1 |
| 19 | Irinotecan in combination with thalidomide in patients with advanced solid tumors: a clinical study with pharmacodynamic and pharmacokinetic evaluation显示文摘 | Giacomo Allegrini Antonello Paolo Elisa Cerri Samanta Cupini Federica Amatori Gianluca Masi Romano Danesi Lorenzo Marcucci Guido Bocci Mario Tacca Alfredo Falcone | 2006 | Cancer Chemotherapy and Pharmacology2006，，5： | 1 |
| 20 | Vascular endothelial growth factor pharmacogenetics: a new perspective for anti - angiogenic therapy显示文摘 | PASQUALETFI G DANESI R DEL TACCA M | 2007 | Pharmacogenomics2007，8，1： | 1 |
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