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| 1 | Autoantibodies against G-Protein-Coupled Receptors Modulate Heart Mast Cells显示文摘Mast cells are believed to be involved in myocardial tissue remodelling under pathophysiological conditions. We examined the effects of autoantibodies against G-protein-coupled receptors in sera of patients with heart diseases on myocardial mast cells in the cultured neonatal Sprague-Dawley rat heart cells. Cells collected at day 3 and 10 of the culture were preincubated with autoantibodies against α1-adrenoceptor and angiotensin II AT1-receptor, agonist phenylephrine and angiotensin II, and control IgG. The pretreated cultured cells were stained for selected mast cell markers tryptase, chymase and TNF-α. The cultured cells were also processed for observation with electron microscopy. The autoantibodies-treatment of the 3-day cultured cells caused both increased intensity of immunofluorescence (p < 0.05) and their enlarged diameters of the mast cells when compared to age-matched ones. In contrast, the fluorescence of preincubated 10-day-old mast cells was decreased compared with controls (p < 0.01). In control samples, the fluorescence of 10-day-old mast cells was significantly higher than that of 3-day-old ones (p < 0.001). Results of electron microscopy examination demonstrated there was an increased granulation of treated 3-day-old mast cells, while a degranulation of mast cells at day 10 of application. The results suggest the modulation effect of the autoantibodies against G-protein-coupled receptors on mast cells, indicating a potential functional link between the autoantibodies against G-protein-coupled receptors and the mast cells in progression of heart disease. | Ludmila Okruhlicova Rosemarie Morwinski Wolfgang Schulze Sabine Bartel Peter Weismann Narcisa Tribulova Gerd Wallukat | 2007 | Cellular & Molecular Immunology2007，4，2： | 6 |
| 2 | Biofunctionalization of textile materials by antimicrobial treatments : A crit- ical overview 显示文摘 | Diana C Simona O Narcisa V | 2010 | Rom Biotech Lett2010，15，1： | 1 |
| 3 | Selection of quinolone resistance in Streptococcus pneumonia exposed in vitro to subinhibitory drug concentrations 显示文摘 | LAETITIA A MORK G NARCISA M | 2007 | J Antimicro Chemother2007，60，5： | 1 |
| 4 | Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti-inflammatory therapy显示文摘 | Corrado Blandizzi Marco Tuccori Rocchina Colucci Matteo Fornai Luca Antonioli Narcisa Ghisu Mario Del Tacca | 2008 | Pharmacological Research2008，，2： | 1 |
| 5 | A combined phenotypic and genotypie method for the detection of Mex efflux pumps in Pseudomonas aeruginosa显示文摘 | Narcisa M Youri G Laetitia A | 2007 | Journal of Antimicrobial Chemotherapy2007，59，1： | 1 |
| 6 | Emerging role of cyclooxygenase isoforms in the control of gastrointestinal neuromuscular functions显示文摘 | Matteo Fornai Luca Antonioli Rocchina Colucci Nunzia Bernardini Narcisa Ghisu Marco Tuccori Roberto De Giorgio Mario Del Tacca Corrado Blandizzi | 2009 | Pharmacology and Therapeutics2009，，1： | 1 |
| 7 | Physiological and bio chemical effects of conjugated linoleic acid and its use in aquacul ture显示文摘 | Rosa R Andrade A M Narcisa M | 2010 | Reviews in Aquaculture2010，2，： | 1 |
| 8 | Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti-inflammatory therapy显示文摘 | Corrado Blandizzi Marco Tuccori Rocchina Colucci Matteo Fornai Luca Antonioli Narcisa Ghisu Mario Del Tacca | 2008 | Pharmacological Research2008，，2： | 1 |
| 9 | All Trypanosoma cruzi developmental forms present lysosome-related organelles显示文摘 | Celso Sant’Anna Fabiola Parussini Daniela Louren?o Wanderley Souza Juan Jose Cazzulo Narcisa Leal Cunha-e-Silva | 2008 | Histochemistry and Cell Biology2008，，： | 1 |
| 10 | Reservosomes: multipurpose organelles?显示文摘 | Narcisa Cunha-e-Silva Celso Sant’Anna Miria Gomes Pereira Isabel Porto-Carreiro André Luiz Jeovanio Wanderley Souza | 2006 | Parasitology Research2006，，： | 1 |
| 11 | Influence of thiamphenicol on the primary functions of human polymorphonuclear leucocytes against Streptococcus pyogenes 显示文摘 | Vivian T Annamaria C Narcisa M | 2004 | Intemational Journal of Anti- microbial Agents2004，24，4： | 1 |
| 12 | Methods for Obtaining and Determination of Squalene from Natural Sources显示文摘 | Ovidiu Popa Narcisa Elena B?beanu Ioana Popa Sultana Ni?? Cristina Elena Dinu-Parvu Giuseppe Valacchi | 2015 | BioMed Research International2015，，： | 1 |
| 13 | Case of acute hepatitis E with concomitant signs of autoimmunity显示文摘Sporadic cases of acute viral hepatitis E have been described in developed countries, despite the more common occurrence in endemic areas and developing countries. We present the case of a 58 years old Portuguese female, with no epidemiological relevant factors, admitted with acute hepatitis with positive anti-nuclear antibodies, anti-smooth muscle antibody and high serum gamma globulin (> 1.5 fold increase). Serologies for hepatitis A virus, hepatitis B virus, hepatitis C virus, Epstein-Barr virus, cytomegalovirus, hereditary sensory neuropathy and varicella zoster virus were negative. Liver biopsy histology revealed changes compatible with autoimmune hepatitis. Prednisolone and azathioprine was started. She tested positive for immunoglobulin M anti hepatitis E virus (HEV) with detectable viremia by reverse transcription polymerase chain reaction (RT-PCR) technique. HEV-RNA was confirmed throughRT-PCR in a liver specimen, establishing the diagnosis of acute hepatitis E. Immunosuppression was stopped. She clinically improved, with resolution of laboratory abnormalities. Therefore, we confirmed acute hepatitis E as the diagnosis. We review the literature to elucidate about HEV infection and its autoimmune effects. | Catarina Lima Vieira Cilénia Baldaia Narcisa Fatela Fernando Ramalho Carlos Cardoso | 2013 | World Journal of Hepatology2013，5，3： | 0 |
| 14 | The Influence of Financial Markets on Countries' Economic Life显示文摘 | Narcisa Roxana Mosteanu | 2017 | Economics World2017，5，3： | 0 |
| 15 | Chronic cardiotoxicity of doxorubicin involves activation of myocardial and circulating matrix metalloproteinases in rats显示文摘瞄准: 在对延长 doxorubicin (纪录影片) 的老鼠的回答调查矩阵 metalloproteinases (MMP ) 的角色治疗。 | Monika IVANOVA Ima DOVINOVA Ludmila OKRUHLICOVA Narcisa TRIBULOVA Petra SIMONCIKOVA Monika BARTE-KOVA Jana VLKOVICOVA Miroslav BARANACIK | 2012 | Acta Pharmacologica Sinica2012，33，4： | 0 |
| 16 | European Tax Models显示文摘 | Narcisa Roxana Mosteanu Mihaela Mitroi | 2015 | Economics World2015，3，1： | 0 |
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