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| 1 | Role of PRMTs in cancer: Could minor isoforms be leaving a mark?显示文摘Protein arginine methyltransferases(PRMTs) catalyze the methylation of a variety of protein substrates, many of which have been linked to the development, progression and aggressiveness of different types of cancer. Moreover, aberrant expression of PRMTs has been observed in several cancer types. While the link between PRMTs and cancer is a relatively new area of interest, the functional implications documented thus far warrant further investigations into its therapeutic potential. However, the expression of these enzymes and the regulation of their activity in cancer are still significantly understudied. Currently there are nine main members of the PRMT family. Further, the existence of alternatively spliced isoforms for several of these family members provides an additional layer of complexity. Specifically, PRMT1, PRMT2, CARM1 and PRMT7 have been shown to have alternative isoforms and others may be currently unrealized. Our knowledge with respect to the relative expression and the specific functions of these isoforms is largely lacking and needs attention. Here we present a review of the current knowledge of theknown alternative PRMT isoforms and provide a rationale for how they may impact on cancer and represent potentially useful targets for the development of novel therapeutic strategies. | R Mitchell Baldwin Alan Morettin Jocelyn C té | 2014 | World Journal of Biological Chemistry2014，5，2： | 14 |
| 2 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 3 | 选择性雄激素受体调节剂治疗迟发性男性性腺功能低下症显示文摘几种睾酮制剂用于治疗老年男性性腺功能减退。这些疗法在其便利性、灵活性、区域供应和费用等方面有区别,但有共同的药代动力学基础,同时缺乏长期安全性数据。简洁和成本较低的基于药代动力学的注册临床试验使得开发改善性的治疗迟发性性腺功能减退的新疗法的商业动机减少了。在前列腺、头发、皮肤受雄激素缺乏影响的患者中,选择性雄激素受体调节剂已被证明可以提供合成代谢的好处。(目前,选择性雄激素受体调节剂的临床进展集中在有限定身体功能的临床终点的急性肌肉萎缩和低体重)。在具有有益的药理、理想的药代动力学的选择性雄激素受体调节剂应用于治疗迟发性男性性腺功能低下症前,其在男性性腺功能低下治疗中关于临床缺陷的更清晰的监管是必须的。 | Christopher C Coss Amanda Jones Michael L Hancock Mitchell S Steiner James T Dalton | 2014 | Asian Journal of Andrology2014，16，2： | 3 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 6 | Text classification from labeled and unlabeled documents using EM显示文摘 | K Nigam A McCallum S Thrun T Mitchell | 2000 | Machine Learning2000，39，： | 1 |
| 7 | Seed and Seedling Bank Dynamics in Secondary Forests Following Hurrican Georges in Puerto Rico显示文摘 | Lomascolo T Mitchell T | 2001 | Caribean Journal of Science2001，37，： | 1 |
| 8 | A second gene for cenllean cataracls maps to Ihe hera crysiallin region on chromosome 22显示文摘 | Kramer P Yount J Mitchell T et el | 1996 | Genomics1996，35，3： | 1 |
| 9 | Purification,bioactivity,and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF)显示文摘 | Bernhagen J Mitchell R A Calandra T | 1994 | Biochemistry1994，33，14： | 1 |
| 10 | MIF is a pituitary derived cytokine that potentiates lethal endotoxemia显示文摘 | Bernhagen J Calandra T Mitchell RA | 1993 | Nature1993，365，： | 1 |
| 11 | MR cholangiopancreatography:evaluation of common pancreatic diseases显示文摘 | Fayad L M Kowalski T Mitchell D G | 2003 | Radiol Clin North Am2003，41，： | 1 |
| 12 | Cyclocryotherapy in neovascular glaucoma显示文摘 | Krupin T Mitchell KB Becker B | 1978 | Am J Ophthalmol1978，86，： | 1 |
| 13 | Facilitating integrated resource and environmental management: Australian and Canadian perspectives 显示文摘 | Hooper B P McDonald G T Mitchell B | 1999 | J Environ Plann Manage1999，42，5： | 1 |
| 14 | Design for mass customization显示文摘 | MITCHELL T M JIAO Jianxin | 1996 | Annals of the CIRP1996，45，1： | 1 |
| 15 | ADC measurement of abdominal organs and lesions using parallel imaging technique 显示文摘 | Yoshikawa T Kawamitsu H Mitchell DG | 2006 | A JR Am J Roentgenol2006，187，6： | 1 |
| 16 | Rock re lationships in the Mogok metamorphic belt,Tatkon to Manda lay,central Myanmar显示文摘 | MITCHELL A H G HTAY M T HTUN K M | 2007 | Journal of Asian Earth Sciences2007，29，： | 1 |
| 17 | Design and analysis of computer experiments (with discussion)显示文摘 | Sacks J Welch W J Mitchell T J | 1989 | Statistical Science1989，4，4： | 1 |
| 18 | Design and analysis of computer experiments 显示文摘 | SACKS J WELCH W J MITCHEL T J WYNN H P | 1989 | Statistical Science1989，4，4： | 1 |
| 19 | Photosynthesis and nutrient- use efficiency of barley in response to low arbuscular mycorrhlzal colonization and addition of phosphorus 显示文摘 | Fay P Mitchell D T Osborne B A | 1996 | New Phytologist1996，132，： | 1 |
| 20 | Recent progress and understanding of the molecular mechanisms of the rice-Magnaporthe oryzae interaction显示文摘 | Liu J Wang X Mitchell T | 2010 | Mol Plant Pathol2010，11，3： | 1 |
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