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| 1 | Micro RNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling显示文摘Liver fibrosis is a repair process in response to damage in the liver; however, severe and chronic injury promotes the accumulation of fibrous matrix, destroying the normal functions and architecture of liver. Hepatic stellate cells(HSCs) are quiescent in normal livers, but in damaged livers, they transdifferentiate into myofibroblastic HSCs, which produce extracellular matrix proteins. Hedgehog(Hh) signaling orchestrates tissue reconstruction in damaged livers and contributes to liver fibrogenesis by regulating HSC activation. Micro RNAs(mi RNAs), endogenous small non-coding RNAs interfering with RNA post-transcriptionally, regulate various cellular processes in healthy organisms. The dysregulation of mi RNAs is closely associated with diseases, including liver diseases. Thus, mi RNAs are good targets in the diagnosis and treatment of various diseases, including liver fibrosis; however, the regulatory mechanisms of mi RNAs that interact with Hh signaling in liver fibrosis remain unclear. We review growing evidence showing the association of mi RNAs with Hh signaling. Recent studies suggest that Hh-regulating mi RNAs induce inactivation of HSCs, leading to decreased hepatic fibrosis. Although mi RNAdelivery systems and further knowledge of interacting mi RNAs with Hh signaling need to be improved for the clinical usage of mi RNAs, recent findings indicate that the mi RNAs regulating Hh signaling are promising therapeutic agents for treating liver fibrosis. | Jeongeun Hyun Youngmi Jung | 2016 | World Journal of Gastroenterology2016，22，29： | 8 |
| 2 | 肝星状细胞在肝脏发育和再生中作用的研究进展显示文摘肝星状细胞(HSCs)是位于肝窦内皮细胞与肝上皮细胞之间的一种多能细胞。HSCs激活后转化为肌成纤维样细胞,增殖并上调部分促炎和促纤维化基因表达,从而促进肝纤维化。既往对HSCs的研究主要集中在其与肝纤维化的关系方面,近年研究发现在肝脏发育和再生过程中,HSCs对肝脏细胞的增殖、分化和成熟亦至关重要。本文系统总结了HSCs的来源、发育调控和功能,着重阐述近年关于HSCs在肝脏发育和再生中作用的研究进展,以期为肝脏疾病的治疗提供新思路。 | 姚荔嘉 邓星 王维 谢渭芬 | 2016 | 胃肠病学2016，21，3： | 0 |
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