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| 1 | Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia显示文摘 | Wang HK Fung HC Hsu WC Wu YR Lin JC Ro LS Chang KH Hwu FJ Hsu Y Huang SY Lee-Chen GJ Chen CM | 2006 | 中国生物学文摘2006，20，8： | 8 |
| 2 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 3 | The identification of a phospholipase B precursor in human neutrophils显示文摘 | Xu SY Zhao LS Venge P | 2009 | FEBS2009，276，1： | 1 |
| 4 | Decidual relaxins:gene and protein up-regulation in preterm premature rupture of membranes by complementary DNA arrays and quantitative immunocytochemistry显示文摘 | Tashima LS Yamamoto SY Yasuda M | 2002 | Am J Obstet Gynecol2002，187，3： | 1 |
| 5 | Health-related quality of life among urban,rural,and island community elderly in Taiwan显示文摘 | Tsai SY Chi LY Lee LS | 2004 | J Formos Med Assoc2004，103，3： | 1 |
| 6 | Congenild urethroculaneous fistulas显示文摘 | Tennenhaum SY Palmer LS | 1994 | Urology1994，43，： | 1 |
| 7 | Anatomical localisa-tion of beta1 integrin-like immunoreactivity in rat brain显示文摘 | Grooms SY Terracio L Jones LS | 1993 | Exp Neurol1993，122，2： | 1 |
| 8 | Detection of sodium channel toxins:directed cytotoxicity assays of purified ciguatoxins, brevetoxins, saxitoxins and seafood extracts 显示文摘 | Manger RL Leja LS Lee SY | 1995 | AOAC lnt1995，78，： | 1 |
| 9 | Metabolic syndrome in Chinese patients with systemic lupus erythematosus: no association with plasma cortisol level显示文摘 | Liu SY Han LS GuoJY | 2013 | Lupus2013，22，5： | 1 |
| 10 | Electrical stimulation and swimming in the acute phase of axonotmesis: their influence on nerve regeneration and functional recovery显示文摘 | Oliveira LS Sobral LL Takeda SY | 2008 | Rev Neurol2008，47，1： | 1 |
| 11 | Effects of dietary alkylglycerols in lac-tating rats on immune responses in pups 显示文摘 | Oh SY Jadhav LS | 1994 | Pediatr Res1994，36，3： | 1 |
| 12 | Health-related quality of life among urban, rural, and island community elderly in Taiwan显示文摘 | Tsai SY Chi LY Lee LS | 2004 | Journal of the Formosan Medical Association2004，103，3： | 1 |
| 13 | Chemical-protein interactome and its application in off-target identification显示文摘 | Yang L Wang KJ Wang LS Jegga AG Qin SY He G | | 0，，01： | 1 |
| 14 | Safety of a tetanus - diphtheria - acellular pertussis vaccine when used off - label in an elderly popula- tion 显示文摘 | Tseng HF Sy LS Qian L | 2013 | Clinic Infect Dis2013，56，3： | 1 |
| 15 | Impact of MMRV combi- nation vaccine on childhood vaccination compliance 显示文摘 | Ackerson BK Sy LS Yao JF | 2012 | Am J Manag Care2012，18，12： | 1 |
| 16 | Primary adrenal lymphoma with choroidal metastases显示文摘 | Schocket LS Syed NA Fine SL | 2002 | Am J Ophthalmol2002，134，5： | 1 |
| 17 | En bloc resection of lamina and os-sified ligamentum flavum in the treatment of thoracic ossification ofthe ligamentum flavum显示文摘 | Jia LS Chen XS Zhou SY | 2010 | Neurosurgery2010，6，： | 1 |
| 18 | Electrical stimulation and swimming in the acute phase of axonotmesis:their in fluence on nerve regeneration and functional recovery显示文摘 | Oliveira LS Sobral LL Takeda SY | | 0，，01： | 1 |
| 19 | Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene显示文摘 | Hsiao DJ Wu LS Huang SY | 2009 | Pharmacogenet Genomics2009，19，9： | 1 |
| 20 | The identification of a phospholipase B precursor in human neutrophils 显示文摘 | Xu SY Zhao LS Venge P | 2009 | FEBS2009，276，1： | 1 |
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