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| 1 | Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk显示文摘AIM: To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplémentation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected controls (n = 100). Conditional logistic regression models were used to investigate the associations between pre-diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory potential of the models. RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend = 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement = 0.01, RIDI = 26.5%). CONCLUSION: These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies. | Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela Sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow | 2012 | World Journal of Gastroenterology2012，18，22： | 15 |
| 2 | Potentialfor reduction of odorous compounds in seine manure through diet modification 显示文摘 | A L K B Kephart M W A Verstegen | 1998 | J Anim Sci (Submitted)1998，，： | 1 |
| 3 | Potential for reduction of odorous compounds in swine manure through diet modification显示文摘 | Sutton A L Kephart K B Verstegen M W A | 1999 | Journal of Animal Science1999，77，： | 1 |
| 4 | Fulbfield repersentation of discretely smapled surface deformational for displacement and strain analysis 显示文摘 | Sutton M A Turner J L Burck H A | 1991 | Experimental Meehnaies1991，31，2： | 1 |
| 5 | Impact of Field Release of Genetically Modified Pseudomonas Fluoreseens on Indigenous Microbial Populations of Wheat显示文摘 | DE L F SUTTON E J WHIPPS J M | 1995 | Appl Environ Micrnbiol1995，61，： | 1 |
| 6 | The growth performance,carcass characteristics,and meat quality of halothane carrier and negative pigs显示文摘 | Leach L M Ellis M Sutton D S | 1996 | Journal of Animal Science1996，74，： | 1 |
| 7 | Two pleiotropic classes of daf-2 mutation affect larval arrest,adult behavior,reproduction and longevity in Caenorhabditis elegans显示文摘 | GEMS D SUTTON A J SUNDERMEYER M L | 1998 | Genetics1998，150，1： | 1 |
| 8 | Employee posi- tive emotion and favorable outcomes at the work-place显示文摘 | Staw B M Sutton R I Pelled L H | 1994 | Organization Science1994，5，1： | 1 |
| 9 | Effects of in vivo and in vitro environment on the metabolism of the cumulus-oocyte complex and its influence on oo- cyte developmental capacity显示文摘 | Sutton M L Gilchrist R B Thompson J G | 2003 | Human Reproduction Update2003，9，1： | 1 |
| 10 | Evi- dence for extreme partitioning of copper into a magmatic va- por phase显示文摘 | Lowenstern J B Mahood G A Rivers M L Sutton S R | 1991 | Nature1991，252，5011： | 1 |
| 11 | Cardio vascular death and left ventricular remodeling two years after myocardial infarction:baseline predictors and impact of long-term use of captopril:information from the survival and ventricular enlargement trial显示文摘 | St John Sutton M Preffer MA Moye L | 1997 | Circulation1997，96，： | 1 |
| 12 | Assembling millions of short DNA sequences using SSAKE显示文摘 | WARREN R L SUTTON G G JONES S J M | 2007 | Bioinformatics2007，23，4： | 1 |
| 13 | Autologous hematopoietic stemcell transplantation in chronic lymphocytic leukemia : results of Europe-an intergroup randomized trial comparing autografting versus observa-tion显示文摘 | Michallet M Dreger P Sutton L | 2011 | Blood2011，117，5： | 1 |
| 14 | Evidence for extreme partitioning of copper into a magmatic vaporphase显示文摘 | Lowenstern J B Mahood G A Rivers M L Sutton S R | 1991 | Scicence1991，252，5011： | 1 |
| 15 | Preoperative CA19-9 levels and lymph node ratio are independent predictors of survival in patients with resected pancreatic ductal adenocarcinoma显示文摘 | Smith R A Bosonnet L Ghaneh P Raraty M Sutton R Campbell F | 2008 | Dig Surg2008，25，： | 1 |
| 16 | Effects of in vivo and in vitro environments on the metabolism of the cumulus-oocyte complex and its influence on oocyte developmental capacity显示文摘 | Sutton M L Gilchrist R B Thompson J G | 2003 | Hum Reprod Update2003，9，1： | 1 |
| 17 | Synchrotron XRF evidence for thesources and distribution of metals in porphyry copper deposits显示文摘 | Bodnar R J Mavrogenes J A Anderson A J Bajt S Sutton S R and Rivers M L | | 0，，： | 1 |
| 18 | Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies显示文摘 | Haigwood N L Montefiori D C Sutton W F McClure J Watson A J Voss G Hirsch V M Richardson | | 0，，11： | 1 |
| 19 | The structure of amorphous iron at high pressures to 67 GPa measured in a diamond anvil cell显示文摘 | SHEN G RIVERS M L SUTTON S R | 2004 | Phys Earth Planet Inter2004，，： | 1 |
| 20 | Cardiovascular death and left ventricular remodeling two years after myocardial infarction; baseline predictors and impact of long-term use of captopril; information from the Survival and Ventricular Enlargement (SAVE) trial显示文摘 | St John Sutton M Pfeffer MA Moye L | 1997 | Circulation1997，96，： | 1 |
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