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| 1 | Neoadjuvant therapy for pancreas cancer: Past lessons and future therapies显示文摘Pancreatic adenocarcinoma remains a most deadly malignancy, with an overall 5-year survival of 5%. A subset of patients will be diagnosed with potentially resectable disease, and while complete surgical resection provides the only chance at cure, data from trials of postoperative chemoradiation and/or chemotherapy demonstrate a modest survival advantage over those patients who undergo resection alone. As such, most practitioners believe that completion of multimodality therapy is the optimal treatment. However, the sequence of surgery, chemotherapy and radiation therapy is frequently debated, as patients may benefit from a neoadjuvant approach by initiating chemotherapy and/or chemoradiation prior to resection. Here we review the rationale for neoadjuvant therapy, which includes a higher rate of completion of multimodality therapy, minimizing the risk of unnecessary surgical resection for patients who develop early metastatic disease, improved surgical outcomes and the potential for longer overall survival. However, there are no prospective, randomized studies of the neoadjuvant approach compared to a surgeryfirst strategy; the established and ongoing investigations of neoadjuvant therapy for pancreatic cancer are discussed in detail. Lastly, as the future of therapeutic regimens is likely to entail patient-specific genetic and molecular analyses, and the treatment that is best applied based on those data, a review of clinically relevant biomarkers in pancreatic cancer is also presented. | Jeffrey M Sutton Daniel E Abbott | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 2 | A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death显示文摘 | Sutton VR Estella E Li C | 2006 | Transplantation2006，81，2： | 1 |
| 3 | Escherichia coli heat-labile enterotoxin promotes protective Thl7 responses against infection by driving innate IL-1 and IL-23 production显示文摘 | Brereton C F Sutton C E Ross P J | 2011 | J Immunol2011，186，10： | 1 |
| 4 | Metadata Principles and Practicalities显示文摘 | DUVAL E HODGINS W SUTTON S | 2002 | D-Lib Magazine2002，8，4： | 1 |
| 5 | Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135显示文摘 | LIU C ERISTE E SUTTON S | 2003 | J Biol Chem2003，278，50： | 1 |
| 6 | preliminary studies on the incidence of needle endophytes on the some European confiers显示文摘 | Muller E Sutton B C | 1997 | Sydowia1997，29，： | 1 |
| 7 | Etiology of apple sooty blotch disease in North Carolina显示文摘 | Johnson E M Sutton T B Hodges C S | 1997 | Phytopathology1997，87，： | 1 |
| 8 | 查看详情显示文摘 | Haynam C A Wegner P J Auerbach J M Bowers M W Dixit S N Erbert G V Heestand G M Henesian M A Hermann M R Jancaitis K S Manes K R Marshall C D Mehta N C Menapace J Moses E Murray J R Nostrand M C Orth C D Patterson R SacksR A Shaw M J Spaeth M Sutton S B W | | 0，，： | 1 |
| 9 | Emotional regulation goals and strategies of teachers 显示文摘 | Sutton R E | 2004 | Social Psychology of Education2004，7，4： | 1 |
| 10 | Impact of Field Release of Genetically Modified Pseudomonas Fluoreseens on Indigenous Microbial Populations of Wheat显示文摘 | DE L F SUTTON E J WHIPPS J M | 1995 | Appl Environ Micrnbiol1995，61，： | 1 |
| 11 | The Tei index a role in the diagnosis of heart failure 显示文摘 | ST JOHN SUTTON U WIEGER S E | 2000 | Eur Heart J2000，21，22： | 1 |
| 12 | Peltaster fructicola:A new species in the complex of fungi causing apple sooty blotch显示文摘 | Johnson E M Sutton T B Hodges C S | 1996 | Mycologia1996，88，： | 1 |
| 13 | Production infection by driving innate IL-1 and IL-23 promotes protective Thl7 responses against heat-labile entero- toxin Escherichia coli 显示文摘 | Brereton C F Sutton C E Ross P J | 2011 | J Immunol2011，186，10： | 1 |
| 14 | 查看详情显示文摘 | Sutton D Nasongkla N Blanco E Gao J.M | | 0，，： | 1 |
| 15 | The relationship of dys- pnoea to function and quality of life in systemic sclerosis显示文摘 | Baron M Sutton E Hudson M | 2008 | Ann Rheum Dis2008，67，5： | 1 |
| 16 | Functionalized micellar systems for cancer targeted drug delivery显示文摘 | Sutton D Nasongkla N Blanco E | 2007 | Pharma ceutical Research2007，24，6： | 1 |
| 17 | Higher physical workload risks with NOTES versus laparoscopy: a quantitative ergonomic assessment显示文摘 | Lee G Sutton E Clanton T | 2011 | Surgical Endoscopy and Other Interventional Techniques2011，25，5： | 1 |
| 18 | High-average-power diode-pumped Yb: YAG lasers 显示文摘 | BEACH R J HONEA E C SUTTON S B | 2000 | SPIE2000，3889，： | 1 |
| 19 | Development changes in the concentration and composition of flavonoids in skin of a red and a green apple eultivar显示文摘 | LISTER C E LANCASTER J E SUTTON K H | 1994 | Sci Food Agric1994，64，： | 1 |
| 20 | Instant cirrhosis, an improved methold for producing cirrhosis in rats by simultaneous administration of carbon tetrachloride and phenobarbitone 显示文摘 | Mclean E Mclean AEM Sutton PM | 1996 | Br J Exp Pathol1996，50，3： | 1 |
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