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| 1 | Sleep disorders in Alzheimer’s disease:the predictive roles and potential mechanisms显示文摘Sleep disorders are common in patients with Alzheimer’s disease,and can even occur in patients with amnestic mild cognitive impairment,which appears before Alzheimer’s disease.Sleep disorders further impair cognitive function and accelerate the accumulation of amyloid-βand tau in patients with Alzheimer’s disease.At present,sleep disorders are considered as a risk factor for,and may be a predictor of,Alzheimer’s disease development.Given that sleep disorders are encountered in other types of dementia and psychiatric conditions,sleep-related biomarkers to predict Alzheimer’s disease need to have high specificity and sensitivity.Here,we summarize the major Alzheimer’s disease-specific sleep changes,including abnormal non-rapid eye movement sleep,sleep fragmentation,and sleep-disordered breathing,and describe their ability to predict the onset of Alzheimer’s disease at its earliest stages.Understanding the mechanisms underlying these sleep changes is also crucial if we are to clarify the role of sleep in Alzheimer’s disease.This paper therefore explores some potential mechanisms that may contribute to sleep disorders,including dysregulation of the orexinergic,glutamatergic,andγ-aminobutyric acid systems and the circadian rhythm,together with amyloid-βaccumulation.This review could provide a theoretical basis for the development of drugs to treat Alzheimer’s disease based on sleep disorders in future work. | Huang Kuang Yu-Ge Zhu Zhi-Feng Zhou Mei-Wen Yang Fen-Fang Hong Shu-Long Yang | 2021 | Neural Regeneration Research2021，16，10： | 4 |
| 2 | 阿尔茨海默病患者睡眠障碍早期诊断与管理进展显示文摘阿尔茨海默病是以进行性认知功能障碍和精神行为异常为特征的神经变性病。睡眠障碍既是阿尔茨海默病的常见临床症状,又是加速疾病进展和认知功能障碍的危险因素,二者存在交互作用。由于目前阿尔茨海默病尚无有效干预靶点,睡眠障碍作为其可控危险因素,早期准确诊断并管理睡眠障碍对延缓阿尔茨海默病进展具有重要作用。本文综述阿尔茨海默病睡眠障碍的临床表现、危险因素、早期筛查及管理,以期从睡眠角度探索阿尔茨海默病治疗的新靶点。 | 唐诗 杜怡峰 | 2021 | 中国现代神经疾病杂志2021，21，12： | 1 |
| 3 | 脂肪酸与阿尔茨海默症关系的研究进展显示文摘由于目前对于阿尔茨海默氏症没有非常有效的治疗方法,因此营养疗法有望成为预防或减缓其进展的一种途径。脂类的作用不仅是作为衰老和中枢神经系统相关变化的生物标志物,而且在这些过程中起着直接的调节作用,饮食中的脂肪酸通过不同的机制在阿尔茨海默症(AD)的病理生理中发挥重要作用。本文对脂肪酸与AD的关系及其作用机制的最新进展进行了综述。 | 饶圣宏 张志敏 | 2020 | 齐齐哈尔医学院学报2020，41，9： | 0 |
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