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| 1 | Biliary strictures complicating living donor liver transplantation:Problems,novel insights and solutions显示文摘Biliary stricture complicating living donor liver transplantation(LDLT) is a relatively common complication, occurring in most transplant centres across the world. Cases of biliary strictures are more common in LDLT than in deceased donor liver transplantation. Endoscopic management is the mainstay for biliary strictures complicating LDLT and includes endoscopic retrograde cholangiography, sphincterotomy and stent placement(with or without balloon dilatation). The efficacy and safety profiles as well as outcomes of endoscopic management of biliary strictures complicating LDLT is an area that needs to be viewed in isolation, owing to its unique set of problems and attending complications; as such, it merits a tailored approach, which is yet to be well established. The diagnostic criteria applied to these strictures are not uniform and are over-reliant on imaging studies showing an anastomotic narrowing. It has to be kept in mind that in the setting of LDLT, a subjective anastomotic narrowing is present in most cases due to a mismatch in ductal diameters. However, whether this narrowing results in a functionally significant narrowing is a question that needs further study. In addition, wide variation in the endotherapy protocols practised in most centres makes it difficult to interpret the results and hampers our understanding of this topic. The outcome definition for endotherapy is also heterogenous and needs to be standardised to allow for comparison of data in this regard and establish a clinical practice guideline. There have been multiple studies in this area in the last 2 years, with novel findings that have provided solutions to some of these issues. This review endeavours to incorporate these new findings into the wider understanding of endotherapy for biliary strictures complicating LDLT, with specific emphasis on diagnosis of strictures in the LDLT setting, endotherapy protocols and outcome definitions. An attempt is made to present the best management options currently available as well as directions for future research in the area. | Harshavardhan B Rao Arjun Prakash Surendran Sudhindran Rama P Venu | 2018 | World Journal of Gastroenterology2018，24，19： | 14 |
| 2 | Neuroendocrine carcinoma of the ampulla of Vater:a clinicopathologic evaluation显示文摘BACKGROUND:Only 105 cases of neuroendocrine tumor(NET)of the ampulla of Vater have been described, mostly as single case reports.The incidence of NET is rising.The changes in incidence may result from changes in detection.This study was to determine the relative incidence and clinicopathological characteristics of high- grade neuroendocrine carcinoma(small cell carcinoma and large cell carcinoma)of the ampulla of Vater at a single institution. METHODS:Sections from paraffin blocks of tumors of the ampulla of Vater taken from 45 patients who underwent Whipple's procedure and 6 patients who underwent palliative bypass between September 2003 and January 2007 were subjected to immunohistochemical analysis.The clinical and pathological data from 5 patients diagnosed with NET of the ampulla of Vater were analyzed. RESULTS:The patients were 3 men and 2 women,ranging in age from 39 to 47 years(mean 44 years).Operative procedures included Whipple's procedure in 4 patients and palliative bypass in 1 patient.Histopathological examination revealed large-cell neuroendocrine carcinoma in 2 patients,small cell carcinoma in 2,and carcinoid in 1.Three patients with high-grade neuroendocrine carcinoma who had undergone Whipple's procedure died at postoperatively 7,11,and 13 months.The patient who had undergone palliative triple bypass died 3 months after surgery.CONCLUSIONS:The relative incidence of high-grade neuroendocrine carcinomas of the ampulla of Vater is higher than that generally expected.The tumors behave aggressively and have a dismal prognosis despite aggressive treatment. | Eswaran Selvakumar Shanmugasundaram Rajendran Tirupporur Govindaswamy Balachandar Devy Gounder Kannan Satyanesan Jeswanth Palaniappan Ravichandran Rajagopal Surendran | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 7 |
| 3 | Long-term outcome of gastric access loop in hepaticojejunostomy显示文摘BACKGROUND:The incidence of hepaticojejunostomy stricture is 4%-10% in experienced centres. Many access loops have been designed and used to facilitate endoscopic intervention for this complication of hepaticojejunostomy. In this study, we investigated the effectiveness and safety of gastric access loop. METHODS:A retrospective analysis was conducted on 13 patients who had undergone hepaticojejunostomy with gastric access loop between June 1999 and September 2003. Eleven patients were followed up for a mean period of 51 months (range 20-81 months). Two patients were lost to follow up. RESULTS:On follow-up, 8 patients had patent jejuno- gastrostomy (end to side anastomosis between Roux loop of jejunum and stomach) and hepaticojejunostomy. Three patients developed stricture of jejunogastrostomy at 41 months, 63 months and 81 months of follow-up. Among these 3 patients, one also had hepaticojejunostomy stricture. In the patient with hepaticojejunostomy stricture, dilatation of jejunogastrostomy stricture was attempted but failed. None of the patients had any evidence of bile gastritis/cholangitis. There was no procedure related morbidity/mortality. CONCLUSIONS:Further studies involving large numbers of patients are required before wide application of gastric access loop in hepaticojejunostomy though it is a safer option than percutaneous transhepatic manipulations or revision surgery. | Eswaran Selvakumar Shanmugasundaram Rajendran Tirupporur G. Balachandar Devy Gounder Kannan Satyanesan Jeswanth Palaniappan Ravichandran Rajagopal Surendran | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，2： | 6 |
| 4 | Outcome of severe acute pancreatitis: Is there a role for conservative management of infected pancreatic necrosis?显示文摘BACKGROUND: Infected pancreatic necrosis is associated with high morbidity and mortality and is mandatory for surgical or radiological intervention. A selected group of patients with CT evidence of infected pancreatic necrosis and a comparatively lower APACHE score may be clinically stable throughout the course of their illness. METHODS: Case records of 52 patients with severe acute pancreatitis admitted from October 2000 to September 2005 were retrospectively analysed to assess the feasibility of conservative management of infected pancreatic necrosis. CT evidence of retroperitoneal air pockets, deteriorated clinical condition, sepsis and positive blood culture were used to diagnose infected pancreatic necrosis. RESULTS: In the 52 male patients reviewed, 24 patients had infected pancreatic necrosis. Eighteen patients who had progressively deteriorated clinical conditions required surgical intervention; five patients of whom (27.8%) died. Six patients with transient end organ dysfunction and stable clinical conditions were treated with prolonged administration of antibiotics and ICU support. All these patients recovered and discharged from the hospital, and no symptoms or readmission happened during follow-up of 6-44 months. CONCLUSIONS: Selected patients with infected pancreatic necrosis who are clinically stable with transient end organ dysfunction can be treated conservatively with a favourable outcome. Necrosectomy associated with high morbidityand mortality in these patients can be avoided. The need for intervention should be individualized and based on clinical conditions of the patients. | Amarapathy Sivasankar Devy Gounder Kannan Palaniappan Ravichandran Sathyanesan Jeswanth Tirupporur Govindasamy Balachandar Rajagopal Surendran | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 3 |
| 5 | A sulfur self-doped multifunctional biochar catalyst for overall water splitting and a supercapacitor from Camellia japonica flowers显示文摘A versatile use of a sulfur self-doped biochar derived from Camellia japonica(camellia)flowers is demonstrated as a multifunctional catalyst for overall water splitting and a supercapacitor.The native sulfur content in the camellia flower facilitates in situ self-doping of sulfur,which highly activates the camellia-driven biochar(SA-Came)as a multifunctional catalyst with the enhanced electron-transfer ability and long-term durability.For water splitting,an SA-Came-based electrode is highly stable and shows reaction activities in both hydrogen and oxygen evolution reactions,with overpotentials of 154 and 362 mV at 10 mA cm^(−2),respectively.For supercapacitors,SA-Came achieves a specific capacitance of 125.42 F g^(−1)at 2 A g^(−1)and high cyclic stability in a three-electrode system in a 1 M KOH electrolyte.It demonstrated a high energy density of 34.54 Wh kg^(−1)at a power density of 1600 W kg^(−1)as a symmetric hybrid supercapacitor device with a wide working potential range of 0-1.6 V. | Chengkai Xia Subramani Surendran Seulgi Ji Dohun Kim Yujin Chae Jaekyum Kim Minyeong Je Mi-Kyung Han Woo-Seok Choe Chang Hyuck Choi Heechae Choi Jung Kyu Kim Uk Sim | 2022 | Carbon Energy2022，4，4： | 3 |
| 6 | Gastric sarcoidosis mimicking irritable bowel syndrome-Cause not association?显示文摘肉状瘤是可以在身体影响任何机关的未知原因论的系统病。胃肠道仅仅很少然而在肝外面被影响。症状可能是非特定的。急躁的肠症候群(IBS ) 是普通诊断。IBS 的识别被罗马 II 标准的使用帮助 - 当器质性病不在时。我们与胃的肉状瘤描述一个病人的第一个盒子与 IBS 介绍了症状,但是随后对抑制免疫力的治疗作出回应。 | John Samuel Leeds Mark Edward McAlindon Eleanor Lorenz Asha Kumari Dube David Surendran Sanders | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 7 | Endoscopic therapy for biliary strictures complicating living donor liver transplantation: Factors predicting better outcome显示文摘AIM To identify factors predicting outcome of endoscopic therapy in bile duct strictures(BDS) post living donor liver transplantation(LDLT).METHODS Patients referred with BDS post LDLT, were retrospectively studied. Patient demographics, symptoms(Pruritus, Jaundice, cholangitis), intra-op variables(cold ischemia time, blood transfusions, number of ducts used, etc.), peri-op complications [hepatic artery thrombosis(HAT), bile leak, infections], stricture morphology(length, donor and recipient duct diameters) and relevant laboratory data both pre-and post-endotherapy were studied. Favourable response to endotherapy was defined as symptomatic relief with > 80% reduction in total bilirubin/serum gamma glutamyl transferase. Statistical analysis was performed using SPSS 20.0.RESULTS Forty-one patients were included(age: 8-63 years). All had right lobe LDLT with duct-to-duct anastomosis. Twenty patients(48.7%) had favourable response to endotherapy. Patients with single duct anastomosis, aggressive stent therapy(multiple endoscopic retrogradecholagiography, upsizing of stents, dilatation and longer duration of stents) and an initial favourable response to endotherapy were independent predictors of good outcome(P < 0.05). Older donor age, HAT, multiple ductal anastomosis and persistent bile leak(> 4 wk post LT) were found to be significant predictors of poor response on multivariate analysis(P < 0.05). CONCLUSION Endoscopic therapy with aggressive stent therapy especially in patients with single duct-to-duct anastomosis was associated with a better outcome. Multiple ductal anastomosis, older donor age, shorter duration of stent therapy, early bile leak and HAT were predictors of poor outcome with endotherapy in these patients. | Harshavardhan B Rao Hasim Ahamed Suprabha Panicker Surendran Sudhindran Rama P Venu | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，2： | 3 |
| 8 | Is bactibilia a predictor of poor outcome of pancreaticoduodenectomy?显示文摘BACKGROUND:Although bile infection has been proposed to increase infective complications following pancreaticoduodenectomy,its association with infective complications and non-infective complications like pancreatic fistula is still controversial.METHODS:Seventy-six patients who had undergone pancreaticoduodenectomy between July 2007 and December 2008 were included in a prospective database and their data analyzed.In all patients intraoperative bile from the bile duct was cultured.Preoperative,intra-operative,and post-operative variables were recorded and analyzed.RESULTS:Bile culture showed positive growth in 35 patients and negative growth in 41.Twenty patients in the positive group underwent ERCP and stenting.The patients with a positive bile culture had a higher incidence of infective complications including intra-abdominal abscess (n=8),wound infection (n=27),bacteremia (n=10),and renal insufficiency (n=9).There was no increase in the rate of non-infective complications of pancreaticoduodenectomy including pancreatic fistula (n=7),delayed gastric emptying (n=9),and post-operative hemorrhage (n=3).The hospital stay was significantly prolonged in the patients with a positive bile culture (P=0.0002).CONCLUSIONS:Pre-operative biliary drainage is significantly associated with bile infection,and bile infection increases the overall rates of infective complications and renal insufficiency.Because of the high incidence of complications is associated with infected bile,routine intra-operative bile culture is recommended in patients undergoing pancreaticoduodenectomy.Pre-operative prophylaxis is dependent on sensitivity of cases to perioperative antibiotics and intraoperative bile culture report.Because of its significant association with infected bile,biliary stenting should be used in strictly selected cases. | Sivanpillay Mahadevan Sivaraj Velayutham Vimalraj Palanichamy Saravanaboopathy Shanmugasundaram Rajendran Sathyanesan Jeswanth Palaniappan Ravichandran Rosy Vennilla Rajagopalan Surendran | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 2 |
| 9 | 向光素LOV1-C57S固态Photo-CIDNP效应的磁场依赖性显示文摘利用13C魔角旋转NMR波谱对向光素LOV1-C57S进行固态Photo-CIDNP效应的磁场依赖性研究.在4.7 T(相当于200 MHz1H频率)磁场中,黑暗条件下只检测到较宽的蛋白质信号;但在光照条件下,观测到强烈的固态Photo-CIDNP效应.与在2.3 T(相当于100 MHz1H频率)磁场中得到的全部为发射谱(负)信号的固态Photo-CIDNP图谱(首次在非光合反应系统中观测到的Photo-CIDNP效应)不同,在4.7 T磁场中测得的光诱导13C NMR谱呈现吸收/发射混合峰型,这种峰型与文献报道的LOV2的液态Photo-CIDNP波谱的峰型相似.对比两种磁场中所得谱图发现,向光素LOV1-C57S的固态Photo-CIDNP效应具有强烈的磁场依赖性,而且不同的核对磁场的依赖程度差别很大,这种巨大的差别反映出在被测试的自由基对中的超精细相互作用影响因素发生了很大的改变. | 王孝杰 Smitha Surendran Thamarath 誉宫 | 2013 | 化学学报2013，71，2： | 2 |
| 10 | Expression of calpastatin,minopontin,NIPSNAP 1,rabaptin-5 and neuronatin in the phenylketonuria(PKU) mouse brain:possible role on cognitive defect seen in PKU显示文摘 | Surendran S Trying SK Matalon R | 2005 | Neurochem Int2005，46，8： | 1 |
| 11 | Transabdominal Modified Devascularization Procedure with or without Esophageal Stapler Transection—An Operation Adequate for Effective Control of a Variceal Bleed. Is Esophageal Stapler Transection Necessary?显示文摘 | M. Johnson FRCS S. Rajendran MCh T.G. Balachandar D. Kannan MCh S. Jeswanth MCh P. Ravichandran MCh R. Surendran MCh | 2006 | World Journal of Surgery2006，，8： | 1 |
| 12 | KAI1/CD82 suppresses tumor invasion by MMP9 inactivation via TIMP1 up-regulation in the H1299 human lung carcinoma cell line显示文摘 | Jee BK Park KM Surendran S | 2006 | Biochem Biophys Res Commun2006，342，2： | 1 |
| 13 | A role for Wnt-4 in renal fibrosis显示文摘 | Surendran K McCaul S P Simon T C | 2002 | Am J Physiol Renal Physiol2002，282，3： | 1 |
| 14 | Reduced Notch signaling leads to renal cysts and papillary microadenomas 显示文摘 | Surendran K Selassie M Liapis H | 2010 | J Am See Nephrol2010，21，5： | 1 |
| 15 | Wnt-Dependent {beta}-Catenin Signaling is Activated after Unilateral Ureteral Obstruction,and Recombinant Secreted Frizzled-Related Protein 4 Alters the Progression of Renal Fibrosis显示文摘 | Schiavi S Hruska KA | 2005 | J Am Soc Nephrol2005，16，： | 1 |
| 16 | Tone recognition inMandarin using Focus 显示文摘 | Surendran D Levow G A Xu Y | 2005 | Baseline2005，17，4： | 1 |
| 17 | Wnt - dependentbe- ta- cate -nin signaling is activated after unilater- alureteral obstruction and recombinant secreted frizzled- related protein4 alters the progression of renal fibrosis 显示文摘 | Surendran K Schiavi Hruska K A | 2005 | J Am Soc Nephrol2005，16，8： | 1 |
| 18 | Reduced Notch signa- ling leads to renal cysts and papillary microadenomas 显示文摘 | Surendran K Selassie M Liapis H | 2010 | J Am Soc Nephrol2010，21，5： | 1 |
| 19 | Algorithms to control the moving ship during harbour entry 显示文摘 | LEE G SURENDRAN S KIM Sang-hyun | 2009 | Applied Mathematical Modelling2009，33，5： | 1 |
| 20 | Anthropometry of the medial tibial condyle to design the tibial component for unicondylar knee arthroplasty for the Korean population显示文摘 | Surendran S Kwak DS Lee UY | | 0，，04： | 1 |
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