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| 1 | Matrix metalloproteinase-9 contributes to parenchymal hemorrhage and necrosis in the remnant liver after extended hepatectomy in mice显示文摘AIM:To investigate the effect of matrix metalloproteinase-9(MMP-9) on the remnant liver after massive hepatectomy in the mouse.METHODS:Age-matched,C57BL/6 wild-type(WT),MMP-9(-/-),and tissue inhibitors of metalloproteinases(TIMP)-1(-/-) mice were used.The mice received 80%-partial hepatectomy(PH).Samples were obtained at 6 h after 80%-PH,and we used histology,immunohistochemical staining,western blotting analysis and zymography to investigate the effect of PH on MMP-9.The role of MMP-9 after PH was investigated using a monoclonal antibody and MMP inhibitor.RESULTS:We examined the remnant liver 6 h after 80%-PH and found that MMP-9 deficiency attenuated the formation of hemorrhage and necrosis.There were significantly fewer and smaller hemorrhagic and necrotic lesions in MMP-9(-/-) remnant livers compared with WT and TIMP-1(-/-) livers(P < 0.01),with no difference between WT and TIMP-1(-/-) mice.Serum alanine aminotransaminase levels were significantly lower in MMP-9(-/-) mice compared with those in TIMP-1(-/-) mice(WT:476 ± 83 IU/L,MMP-9(-/-):392 ± 30 IU/L,TIMP-1(-/-):673 ± 73 IU/L,P < 0.01).Western blotting and gelatin zymography demonstrated a lack of MMP-9 expression and activity in MMP-9(-/-) mice,which was in contrast to WT and TIMP-1(-/-) mice.No change in MMP-2 expression was observed in any of the study groups.Similar to MMP-9(-/-) mice,when WT mice were treated with MMP-9 monoclonal antibody or the synthetic inhibitor GM6001,hemorrhagic and necrotic lesions were significantly smaller and fewer than in control mice(P < 0.05).These results suggest that MMP-9 plays an important role in the development of parenchymal hemorrhage and necrosis in the small remnant liver.CONCLUSION:Successful MMP-9 inhibition attenuates the formation of hemorrhage and necrosis and might be a potential therapy to ameliorate liver injury after massive hepatectomy. | Norifumi Ohashi Tomohide Hori Florence Chen Sura Jermanus Christopher B Eckman Akimasa Nakao Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，19： | 3 |
| 2 | Dysphagia in the elderly: management and nutritional considerations显示文摘 | Michael Crary Giselle Carnaby-Mann Aarthi Madhavan Livia Sura | 2012 | Clinical Interventions in Aging (default)2012，，： | 2 |
| 3 | Isolation of Boswelliains A-E,Cembrane-Type Diterpenoids from Boswellia papyifera,and an Evaluation of Their Wound Healing Properties显示文摘Boswelliai ns A-E(1-5),five new cembra ne-type diterpenoids,were isolated from the resin of Boswellia papyifera.Their structures,determined by using spectroscopic,computational and chemical methods,demonstrate that 2-5 are novel 4,5-seco-,4,5-seco-,9,10-seco-,and 6,7-seco-cembrane diterpenoids,and that 1,4 and 5 bear aldehyde moieties.An evaluation of the wound healing properties of these natural products along with a derivative of 2 shows that compounds 2 and 3 significantly stimulate proliferation,mobility and tuber formation of human umbilical vein endothelial cells(HUVECs)at the concentration of 20μmol/L. | Qi-Hua Yu Madhu Babu Sura Dai-Wei Wang Danling Huang Yong-Ming Yan Ya-Bin Jiao Qing Lu Yong-Xian Cheng | 2021 | Chinese Journal of Chemistry2021，39，9： | 2 |
| 4 | PCN6 economical evaluation of raltitrexed versus fluorouraeil plus leucovorin (5-fu + Iv) for treatment of ad- vanced colorectal cancer显示文摘 | Vorobyov P Sura M Avxentieva M | 2002 | Value in Health2002，5，6： | 1 |
| 5 | Wear mechanism maps for the belt finishing of steel and cast iron显示文摘 | Mezghani S Mansori M Sura E | 2009 | Wear2009，267，： | 1 |
| 6 | Controlling acute inflammation with fast releasing dexamethasone-PLGA microsphere/PVA hydrogel composites for implantable devices 显示文摘 | Bhardwaj U Sura R Papadimitrakopoulos F | 2007 | Diab Sci Technol2007，1，1： | 1 |
| 7 | IFN-gamma primes macrophages for enhanced TNF-alpha expression in response to stimulatory and non-stimulatory amounts of microparticulate beta-glucan显示文摘 | Berner MD Sura ME Alves BN | 2005 | Immunol Lett2005，98，1： | 1 |
| 8 | Plasma homocysteine and ischemic stroke patients in Thailand显示文摘 | Sura T Moleerergpoom W | 2007 | J Med Assoc Thai2007，90，6： | 1 |
| 9 | Association between serum homocysteine,folate and B12 concentration with coronary artery disease in Thai patients显示文摘 | Moleerergpoom W Sura T Sritara P | 2004 | J Med Assoc Thai2004，87，6： | 1 |
| 10 | Biodegradation of mono-al- kyl phthalate esters in natural sediments 显示文摘 | OTI'ON S V SURA S BLAI J | 2008 | Chemosphere2008，71，： | 1 |
| 11 | Hemoglobin H disease induced by the common SEA deletion and the rarehemoglobin Quong Sze in a Thai female:longitudinal clinical course,molecular characterization,and developmentof a PCR/RFLP-based detection method显示文摘 | Sura T Trachoo O Viprakasit V | 2007 | Ann Hematol2007，86，9： | 1 |
| 12 | Involved-field radiation therapy for inoperable non small-cell lung cancer显示文摘 | Rosenzweig KE Sura S Jackson A | | 0，，： | 1 |
| 13 | Multiple contiguous isolated spinous process fracture(Clay-Shoveler's fracture)of the cervicodorsal spine显示文摘 | Umredkar A Sura S Mohindra S | 2011 | Neurol India2011，59，5： | 1 |
| 14 | Matrix metalloproteinase-9 in the initial injury after hepatectomy in mice显示文摘AIM:To investigate the role of matrix metalloproteinase(MMP)-9 in the pathogenesis of postoperative liver failure(PLF) after extended hepatectomy(EH).METHODS:An insufficient volume of the remnant liver(RL) results in higher morbidity and mortality,and a murine model with 80%-hepatectomy was used.All investigations were performed 6 h after EH.Mice were first divided into two groups based on the postoperative course(i.e.,the PLF caused or did not),and MMP-9 expression was measured by Western blotting.The source of MMP-9 was then determined by immunohistological stainings.Tissue inhibitor of metalloproteinase(TIMP)-1 is the endogenous inhibitor of MMP-9,and MMP-9 behavior was assessed by the experiments in wild-type,MMP-9(-/-) and TIMP-1(-/-) mice by Western blotting and gelatin zymography.The behavior of neutrophils was also assessed by immunohistological stainings.An anti-MMP-9 monoclonal antibody and a broadspectrum MMP inhibitor were used to examine the role of MMP-9.RESULTS:Symptomatic mice showed more severe PLF(histopathological assessments:2.97 ± 0.92 vs 0.11 ± 0.08,P < 0.05) and a higher expression of MMP-9(71085 ± 18274 vs 192856 ± 22263,P < 0.01).Nonnative leukocytes appeared to be the main source of MMP-9,because MMP-9 expression corresponding with CD11b positive-cell was observed in the findings of immunohistological stainings.In the histopathological findings,the PLF was improved in MMP-9(-/-) mice(1.65% ± 0.23% vs 0.65% ± 0.19%,P < 0.01) and it was worse in TIMP-1(-/-) mice(1.65% ± 0.23% vs 1.78% ± 0.31%,P < 0.01).Moreover,neutrophil migration was disturbed in MMP-9(-/-) mice in the immunohistological stainings.Two methods of MMP-9 inhibition revealed reduced PLF,and neutrophil migration was strongly disturbed in MMP-9-blocked mice in the histopathological assessments(9.6 ± 1.9 vs 4.2 ± 1.2,P < 0.05,and 9.9 ± 1.5 vs 5.7 ± 1.1,P < 0.05).CONCLUSION:MMP-9 is important for the process of PLF.The initial injury is associated with MMP-9 derived from neutrophils,and MMP-9 blockade reduces PLF.MMP-9 may be a potential target to prevent PLF after EH and to overcome an insufficient RL. | Norifumi Ohashi Tomohide Hori Florence Chen Sura Jermanus Akimasa Nakao Shinji Uemoto Justin H Nguyen | 2013 | World Journal of Gastroenterology2013，19，20： | 1 |
| 15 | Association between Serum Homoeysteine, Folate and B12 Concentration with Coronary Artery Disease in Thai Patients显示文摘 | Worachat Moleerergpoom MD Thunyaehai Sura MD Piyamitr Sritara MD | 2004 | J Med Assoc Thai2004，87，6： | 1 |
| 16 | A genomewide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians显示文摘 | Kamatani Y Wattanapokayakit S Ochi H Kawaguchi T Takahashi A Hosono N Kubo M Tsunoda T Kamatani N Kumada H Puseenam A Sura T Daigo Y Chayama K Chantratita W Nakamura Y Matsuda K | 2009 | Nat Genet2009，41，5： | 1 |
| 17 | High-dose radiotherapy for the treatment of inoperable non-small cell lung cancer显示文摘 | Sura S Yorke E Jackson A | 2007 | Cancer J2007，13，4： | 1 |
| 18 | Plasma homocysteine and ischemic stroke patients in Thailand显示文摘 | Tantirittisak T Sura T Moleerergpoom W | 2007 | J Med Assoc Thai2007，90，6： | 1 |
| 19 | Wear Mechanism Maps for the Belt Finishing of Steel and Cast Iron显示文摘 | Mezghani S Mansori M Sura E | 2009 | Wear2009，267，： | 1 |
| 20 | A framework for predicting surface areas in microporous coordination polymers 显示文摘 | Schnobrich J K Koh K Sura K N | 2010 | Langmuir2010，26，： | 1 |
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