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| 1 | Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis显示文摘AIM To investigate the temporal clinical, proteomic, histological and cellular immune profiles of dextran sulfate sodium(DSS)-induced acute colitis.METHODS Acute colitis was induced in C57 BL/6 female mice by administration of 1%, 2% or 3% DSS in drinking water for 7 d. Animals were monitored daily for weight loss, stool consistency and blood in the stool, while spleens and colons were harvested on day 8. A time course analysis was performed in mice ingesting 3% DSS, which included colon proteomics through multiplex assay, colon histological scoring by a blinded investigator, and immune response through flow cytometry or immunohistochemistry of the spleen, mesenteric lymph node and colon.RESULTS Progressive worsening of clinical colitis was observed with increasing DSS from 1% to 3%. In mice ingesting 3% DSS, colon shortening and increase in proinflammatory factors starting at day 3 was observed, with increased spleen weights at day 6 and day 8. This coincided with cellular infiltration in the colon from day 2 to day 8, with progressive accumulation of macrophages F4/80^+, T helper CD4^+(Th), T cytotoxic CD8^+(Tcyt) and T regulatory CD25^+(Treg) cells, and progressive changes in colonic pathology including destruction of crypts, loss of goblet cells and depletion of the epithelial barrier. Starting on day 4, mesenteric lymph node and/or spleen presented with lower levels of Treg, Th and Tcyt cells, suggesting an immune cell tropism to the gut. CONCLUSION These results demonstrate that the severity of experimental colitis is dependent on DSS concentration, correlated with clinical, proteomic, histological and cellular immune response on 3% DSS. | Natalia Schneider Nunes Saejeong Kim Maggie Sundby Parwathy Chandran Scott Robert Burks Ana Helena Paz Joseph Alan Frank | 2018 | World Journal of Gastroenterology2018，24，38： | 5 |
| 2 | The phosphorus cycle in coastal marine sediments 显示文摘 | Sundby B Gobeil C Silberberg N | 1992 | Limnology and Oceanography1992，37，6： | 2 |
| 3 | The phosphorus cycle in coastal marine sediments显示文摘 | SUNDBY B GOBEIL C SILBERBERG N | 1992 | Limnol Oceanogr1992，37，： | 1 |
| 4 | The phosphorus cycle in coastal marine sediments 显示文摘 | SUNDBY B GOBEIL C SILVERBERG N | 1992 | Limnol Oceanogr1992，37，： | 1 |
| 5 | Behaviour of minor and major elements in suspended matter in the Rhine and Meuse rivers and estuary显示文摘 | Nolting R F Sundby B Duinker J C | 1990 | Sci Total Environ1990，9798，： | 1 |
| 6 | Dietary carbohydrateutilization in cod ( Gadus morhua ) : metabolicresponses to feeding and fasting显示文摘 | Hemre G I Lie 0 Sundby A | 1993 | Fish Physiologyand Biochemistry1993，10，6： | 1 |
| 7 | Midodrine prevents orthostatic intolerance associated with simulated spaceflight 显示文摘 | Ramsdell CD Mullen TJ Sundby GH | 2001 | J Appl Physiol2001，90，6： | 1 |
| 8 | The effect of vertical and horizontal distribution on retention of sar- dine (Sardinops sagax) larvae in the Northern Benguela - observations and modeling 显示文摘 | Stenevik E K Skogen M Sundby S | 2003 | Fisheries Oceanography2003，12，： | 1 |
| 9 | One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: arandomized trial显示文摘 | Joensuu H Eriksson M Sundby Hall K | 2012 | JAMA2012，307，12： | 1 |
| 10 | One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial显示文摘 | Joensuu H Eriksson M Sundby Hall K | 2012 | JAMA2012，307，： | 1 |
| 11 | Simultaneous measurement of O2, Mn, Fe, I^-, and S (-II) in marine pore waters with a solid-state voltammetric microelectrode 显示文摘 | Luther G W III Brendel P J Lewis B L Sundby B Lefranqois L Silverberg N Nuzzio D B | 1998 | Limnol Oceanogr1998，43，2： | 1 |
| 12 | miR-17-92 cooperates with RB pathway mutations to promote retino- blastoma 显示文摘 | CONKRITEI K SUNDBY M MUKAI S | 2011 | Genes Dev2011，25，16： | 1 |
| 13 | Plasma levels of insulin, glucagon and glucagon-like peptide in salmonids of different weights显示文摘 | Sundby A Eliassen K Refstie T | 1991 | Fish Physiology and Biochemistry1991，9，3： | 1 |
| 14 | The phosphorus cycle in coastal marine sediments 显示文摘 | Sundby B Gobeil C Silverberg N | 1992 | Limnology and Oceanography1992，37，6： | 1 |
| 15 | Temperature-dependent changes in the antenna size of photosystem Ⅱ :Reversible conversion of photosystem Ⅱα to photo-system 11β 显示文摘 | Sundby C Melis A Maenpaa P | 1986 | Biochimica et Biophysica Acta (BBA)- Bioenergetics1986，，851： | 1 |
| 16 | The phosphorus cycle in coastal marine sediments显示文摘 | SUNDBY B GOBEIL C SILBERBERG N | 1992 | Limnology and Ocea- nography1992，37，6： | 1 |
| 17 | Photoferrotrophs thrive in an Archean Ocean analogue显示文摘 | Crowe S A Jones C Katsev S Magen C O'Neill A H Sturm A Canfield D E Haffner G D Mucci A Sundby B and Fowle D A | | 0，，： | 1 |
| 18 | Eddies of vestfjorden, norway显示文摘 | Gay Mitchelson-Jacoba Svein Sundby | 2001 | Continental Shelf Research2001，，21： | 1 |
| 19 | Gravity core shortening and pore water chemical gradients显示文摘 | LEBEL J SILVERBERG N SUNDBY B | 1982 | Deep-Ssa Res1982，29，： | 1 |
| 20 | The phosphorus cycle in coastal marine sediments 显示文摘 | Sundby B Gobeil C Silverberg N | 1992 | Limnol Oceanogr1992，37，6： | 1 |
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