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| 1 | 抗癌活性植物精油的主要功效成分及作用机制研究进展显示文摘癌症是严重威胁人类健康的顽疾,致死率高。现代医学中常用的治疗癌症的放化疗方法毒副作用大,而抗癌植物精油具有多靶点、多效应、不良反应低、不易产生耐药性及提高机体免疫力等优势,在癌症治疗中得到高度重视。对植物精油的主要活性成分及其抗癌机制进行综述。已有研究报道中有抗癌活性的精油主要包括柠檬香茅、鼠尾草、泽兰蒿、薰衣草、野芹菜、橘皮、杨梅叶等19种植物精油,其中柠檬烯、β-榄香烯、薄荷醇、广藿香醇、百里酚、丁香酚、柠檬醛、β-石竹烯及其氧化物等成分可能是抗癌精油主要功效成分。 | 朱丽云 张春苗 高永生 宋林珍 陈玮 泮莞坤 Wang Sunan 李素芳 | 2017 | 中草药2017，48，6： | 32 |
| 2 | Estrogen upregulates MICA/B expression in human non-small cell lung cancer through the regulation of ADAM17显示文摘雌激素涉及支持肺癌症房间分割和转移。云母和 MICB 为 NKG2D 作为 ligands 工作,在生来的杀手(NK ) 上表示的重要 immunoreceptor 房间。然而,雌激素是否调整 MICA/B 表示并且影响肿瘤免疫者逃跑,仍然保持未知。在这研究,我们测量了非小的房间肺癌症(NSCLC ) 房间线与雌激素对待的云母, MICB 和 ADAM17in 的 mRNA 层次。LTEP-a2 和 A549 上的 MICA/B 的表面表示用流动 cytometry 被检测。我们证明 mRNA 和在肺腺癌房间线的 MICA/B 的能分泌的蛋白质层次是由 estradiol 的 upregulated。Estradiol 提高了 ADAM17 的表示,它与 MICA/B 的分泌物被联系。MICA/B downregulated 的这分泌物 NK92 房间的表面上的 NKG2D 受体并且损害了 NK 房间的细胞毒素的活动。Estradiol 提高了 ADAM17 的表示,它与 MICA/B 的分泌物被联系。而且,在 estradiol 和云母的表示的集中之间的重要关联在 NSCLC 病人的肿瘤纸巾被发现。因此,我们断定雌激素能通过 ADAM17 调整 MICA/B 的表示和分泌物,它帮助肺癌症房间逃离调停 NKG2D 的有免疫力的监视。 | Jing Ren Yunzhong Nie Mingming Lv Sunan Shen Ruijing Tang Yujun Xu Yayi Hou Shuli Zhao Tingting Wang | 2015 | Cellular & Molecular Immunology2015，12，6： | 6 |
| 3 | Development and utilization of a new chemically-induced soybean library with a high mutation density显示文摘Mutagenized populations have provided important materials for introducing variation and identifying gene function in plants. In this study, an ethyl methanesulfonate(EMS)-induced soybean(Glycine max) population,consisting of 21,600 independent M_2 lines, was developed.Over 1,000 M_(4(5))families, with diverse abnormal phenotypes for seed composition, seed shape, plant morphology and maturity that are stably expressed across different environments and generations were identified. Phenotypic analysis of the population led to the identification of a yellow pigmentation mutant, gyl, that displayed significantly decreased chlorophyll(Chl) content and abnormal chloroplast development. Sequence analysis showed that gyl is allelic to Minn Gold, where a different single nucleotide polymorphism variation in the Mg-chelatase subunit gene(ChlI1a) results in golden yellow leaves. A cleaved amplified polymorphic sequence marker was developed and may be applied to marker-assisted selection for the golden yellow phenotype in soybean breeding. We show that the newly developed soybean EMS mutant population has potential for functional genomics research and genetic improvement in soybean. | Zhongfeng Li Lingxue Jiang Yansong Ma Zhongyan Wei Huilong Hong Zhangxiong Liu Jinhui Lei Ying Liu Rongxia Guan Yong Guo Longguo Jin Lijuan Zhang Yinghui Li Yulong Ren Wei He Ming Liu Nang Myint Phyu Sin Htwe Lin Liu Bingfu Guo Jian Song Bing Tan Guifeng Liu Maiquan Li Xianli Zhang Bo Liu Xuehui Shi Sining Han Sunan Hua Fulai Zhou Lili Yu Yanfei Li Shuang Wang Jun Wang Ruzhen Chang Lijuan Qiu | 2017 | Journal of Integrative Plant Biology2017，59，1： | 6 |
| 4 | Effect of pH,temperature and heating time on the formation of furan in sugar–glycine model systems显示文摘Furan(C4H4O)has been classified as a possible animal and human carcinogen by many international agencies.The formation of furan in three sugar–glycine models using glucose,fructose,and sucrose was investigated using headspace gas chromatography mass spectrometry method(HSGC–MS)with various dual combinations of three important heat processing conditions,i.e.pH,temperature,and heating time.Results indicated that furan levels from sugar–glycine model systems during the thermal processing can be attributed to selective sugar types,pH,temperature,and heating time.In glucose–glycine and fructose–glycine system,the lowest furan level was detected in acid condition but in sucrose–glycine system furan formed significantly lower(P<0.05)in acidic conditions the lowest furan level was found in alkaline conditions.The furan levels were observed to increase with heating time in all three model systems.Furthermore,less furan was generated in non-reducing sugar system(sucrose)than in reducing sugar system(glucose and fructose).Therefore,they demonstrate the possibility of limiting the formation of furan in heat processed foods by both the careful selection of carbohydrates(i.e.non-reducing sugars and reducing sugars)ingredients and appropriate processing conditions.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Shaoping Nie Jungen Huang Jielun Hu Yanan Zhang Sunan Wang Chang Li Massimo Marcone Mingyong Xie | 2013 | Food Science and Human Wellness2013，2，2： | 4 |
| 5 | Interference-Driven Designs of Nonlinear-Phase FIR Filter with Application in FBMC System显示文摘In the forthcoming 5G systems, new technologies, such as amorphous networks and non-orthogonal filter bank multicarriers(FBMC), provide an effective way to accommodate high-rate transmissions. Meanwhile, the prototype filter affects the adjacent channel interference, and therefore is important for FBMC systems. Besides, once the amorphous network is taken into account, the requirement for interference controlmust be much stricter. Accordingly, this paper focuses on the design of prototype filter with better ability of interference controlling, where we exploit the nonlinear phase FIR filter(NLPFF) instead of traditional linear phase FIR filter(LPFF) to achieve more optimization spaces under a small sacrifice of linear phase. In ourdesigns, both the amplitude and phase responsesare handled independently to approach the stopband performance enhancements, in while the nearly perfect reconstruction(NPR) conditionsare relaxed by pre-specified thresholds. Computer simulations confirm the effectiveness of the NLPFF designs, and demonstrate the advantages of the proposed NLPFF in FBMC applications. | Jiangang Wen Jingyu Hua Sunan Li Kai Zhou Dongming Wang | 2016 | China Communications2016，13，12： | 4 |
| 6 | Identification of a novel seed size associated locus SW9-1 in soybean显示文摘Seed size is one of the vital traits determining seed appearance, quality, and yield. Untangling the genetic mechanisms regulating soybean 100-seed weight (100-SW), seed length and seed width across environments may provide a theoretical basis for improving seed yield. However, there are few reports related to QTL mapping of 100-SW across multiple ecological regions. In this study, 21 loci associated with seed size traits were identified using a genome-wide association of 5361 single nucleotide polymorphisms (SNPs) across three ecoregions in China, which could explain 8.12%–14.25% of the phenotypic variance respectively. A new locus, named as SW9-1 on chromosome 9 that explained 10.05%–10.93% of the seed weight variance was found significantly related to seed size traits, and was not previously reported. The selection effect analysis showed that SW9-1 locus has a relatively high phenotypic effect (13.67) on 100-SW, with a greater contribution by the accessions with bigger seeds (3.69) than the accessions with small seeds (1.66). Increases in seed weight were accompanied by increases in the frequency of SW9-1T allele, with >90% of the bred varieties with a 100-SW >30 g carrying SW9-1T. Analysis of SW9-1 allelic variation in additional soybean accessions showed that SW9-1T allele accounting for 13.83% of the wild accessions, while in 46.55% and 51.57% of the landraces and bred accessions, respectively, this results indicating that the SW9-1 locus has been subjected to artificial selection during the early stages of soybean breeding, especially the utilization of SW9-1T in edamame for big seed. These results suggest that SW9-1 is a novel and reliable locus associated with seed size traits, and might have an important implication for increasing soybean seed weight in molecular design breeding. Cloning this locus in future may provide new insights into the genetic mechanisms underlying soybean seed size traits. | Jiajia Li Jinghui Zhao Yinghui Li Yali Gao Sunan Hua Muhammad Nadeem Genlou Sun Wenming Zhang Jinfeng Hou Xiaobo Wang Lijuan Qiu | 2019 | The Crop Journal2019，7，4： | 4 |
| 7 | Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies显示文摘Chronic inflammation caused by persistent infections and metabolic disorders is thought to contribute to the increased cancer risk and the accelerated cancer progression.Oppositely,acute inflammation induced by bacteria-based vaccines or that is occurring after cancer selectively inhibits cancer progression and metastasis.However,the interaction between inflammation and cancer may be more complex than the current explanations for the relationship between chronic and acute inflammation and cancer.In this review,we described the impact of inflammation on cancer on the basis of three perspectives,including inflammation with different durations(chronic and acute inflammation),different scopes(systemic and local inflammation)and different occurrence sequences(inflammation occurring after and before cancer).In addition,we also introduced bacteria/virus-based cancer immunotherapies.We perceive that inflammation may be a double-edged sword with cancer-promoting and cancer-suppressing functions in certain cases.We expect to further improve the understanding of the relationship between inflammation and cancer and provide a theoretical basis for further research on their complex interaction. | Xinghan Liu Lijie Yin Sunan Shen Yayi Hou | 2023 | Genes & Diseases2023，10，1： | 2 |
| 8 | Comparative population genomics dissects the genetic basis of seven domestication traits in jujube显示文摘Jujube(Ziziphus jujuba Mill.)is an important perennial fruit tree with a range of interesting horticultural traits.It was domesticated from wild jujube(Ziziphus acidojujuba),but the genomic variation dynamics and genetic changes underlying its horticultural traits during domestication are poorly understood.Here,we report a comprehensive genome variation map based on the resequencing of 350 accessions,including wild,semi-wild and cultivated jujube plants,at a>15×depth.Using the combination of a genome-wide association study(GWAS)and selective sweep analysis,we identified several candidate genes potentially involved in regulating seven domestication traits in jujube.For fruit shape and kernel shape,we integrated the GWAS approach with transcriptome profiling data,expression analysis and the transgenic validation of a candidate gene to identify a causal gene,ZjFS3,which encodes an ethyleneresponsive transcription factor.Similarly,we identified a candidate gene for bearing-shoot length and the number of leaves per bearing shoot and two candidate genes for the seed-setting rate using GWAS.In the selective sweep analysis,we also discovered several putative genes for the presence of prickles on bearing shoots and the postharvest shelf life of fleshy fruits.This study outlines the genetic basis of jujube domestication and evolution and provides a rich genomic resource for mining other horticulturally important genes in jujube. | Mingxin Guo Zhongren Zhang Yanwei Cheng Sunan Li Peiyin Shao Qiang Yu Junjie Wang Gan Xu Xiaotian Zhang Jiajia Liu Linlin Hou Hanxiao Liu Xusheng Zhao | 2020 | Horticulture Research2020，7，1： | 2 |
| 9 | Optimization of a reversible hood for protecting a pedestrian: head during car collisions显示文摘 | Huang Sunan Yang Jikuang | 2010 | Accident Analysis and Prevention2010，，42： | 1 |
| 10 | The biochemistry and biological properties of the world ' s most expensive under- ground ediblee mushroom:Truffles显示文摘 | Sunan Wang Massimo F Marcone | 2011 | Food Research In- ternational2011，44，： | 1 |
| 11 | Remote plasma-enhanced atomic layer deposition of gallium oxide thin films with NH_3 plasma pretreatment显示文摘High quality gallium oxide(Ga_2O_3) thin films are deposited by remote plasma-enhanced atomic layer deposition(RPEALD) with trimethylgallium(TMG) and oxygen plasma as precursors. By introducing in-situ NH3 plasma pretreatment on the substrates, the deposition rate of Ga_2O_3 films on Si and GaN are remarkably enhanced, reached to 0.53 and 0.46 ?/cycle at 250 °C,respectively. The increasing of deposition rate is attributed to more hydroxyls(–OH) generated on the substrate surfaces after NH3 pretreatment, which has no effect on the stoichiometry and surface morphology of the oxide films, but only modifies the surface states of substrates by enhancing reactive site density. Ga_2O_3 film deposited on GaN wafer is crystallized at 250 °C, with an epitaxial interface between Ga_2O_3 and GaN clearly observed. This is potentially very important for reducing the interface state density through high quality passivation. | Hui Hao Xiao Chen Zhengcheng Li Yang Shen Hu Wang Yanfei Zhao Rong Huang Tong Liu Jian Liang Yuxin An Qing Peng Sunan Ding | 2019 | Journal of Semiconductors2019，40，1： | 1 |
| 12 | De- centralized adaptive controller design of large-scale un- certain robotic systems显示文摘 | Tan Kok Kiong Huang Sunan Lee Tong Heng | 2009 | Automatica2009，45，2： | 1 |
| 13 | Antioxidant capacities and phenolic compounds of the husk, bran and endosperm of the rice显示文摘 | SUNAN B SIRITHON S | 2010 | Food Chemis- try2010，119，2： | 1 |
| 14 | Brain edema in meningomasis associated with increased vascular endothelial growth factor expression显示文摘 | Goldman K Sunan B Palmer A | 1997 | Neurosurgery1997，40，6： | 1 |
| 15 | Adaptive friction compensation with a dynamical friction model 显示文摘 | Tong Heng Lee Kok K T Sunan Huang | 2011 | IEEE2011，16，1： | 1 |
| 16 | Can phytochemical antioxidant rich foods act as anti-cancer agents?显示文摘 | Sunan Wang Kelly A. Meckling Massimo F. Marcone Yukio Kakuda Rong Tsao | 2011 | Food Research International2011，，9： | 1 |
| 17 | Antioxidant capacities and phenolic compounds of the husk,bran and endosperm of Thai rice显示文摘 | Sunan B Sirithon S | 2010 | Food Chemistry2010，119，2： | 1 |
| 18 | Adaptive Friction Compensation with a Dynamical Friction Model 显示文摘 | LEE Tong Heng TAN Kok Kiong HUANG Sunan | 2011 | IEEE/ASME Transactions on Mechatronics2011，16，1： | 1 |
| 19 | Using financial statement data to identify factors associated with fraudulent financial repotring显示文摘 | Persons Obeua S Lanunie Sunaner | 1995 | Journal of Applied Busineas Research1995，11，3： | 1 |
| 20 | Intelligent friction modeling and compensation using neural network approximations 显示文摘 | HUANG Sunan TAN Kok Kiong | 2012 | IEEE Transactions on Industrial Electronics2012，59，8： | 1 |
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