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| 1 | Estrogen upregulates MICA/B expression in human non-small cell lung cancer through the regulation of ADAM17显示文摘雌激素涉及支持肺癌症房间分割和转移。云母和 MICB 为 NKG2D 作为 ligands 工作,在生来的杀手(NK ) 上表示的重要 immunoreceptor 房间。然而,雌激素是否调整 MICA/B 表示并且影响肿瘤免疫者逃跑,仍然保持未知。在这研究,我们测量了非小的房间肺癌症(NSCLC ) 房间线与雌激素对待的云母, MICB 和 ADAM17in 的 mRNA 层次。LTEP-a2 和 A549 上的 MICA/B 的表面表示用流动 cytometry 被检测。我们证明 mRNA 和在肺腺癌房间线的 MICA/B 的能分泌的蛋白质层次是由 estradiol 的 upregulated。Estradiol 提高了 ADAM17 的表示,它与 MICA/B 的分泌物被联系。MICA/B downregulated 的这分泌物 NK92 房间的表面上的 NKG2D 受体并且损害了 NK 房间的细胞毒素的活动。Estradiol 提高了 ADAM17 的表示,它与 MICA/B 的分泌物被联系。而且,在 estradiol 和云母的表示的集中之间的重要关联在 NSCLC 病人的肿瘤纸巾被发现。因此,我们断定雌激素能通过 ADAM17 调整 MICA/B 的表示和分泌物,它帮助肺癌症房间逃离调停 NKG2D 的有免疫力的监视。 | Jing Ren Yunzhong Nie Mingming Lv Sunan Shen Ruijing Tang Yujun Xu Yayi Hou Shuli Zhao Tingting Wang | 2015 | Cellular & Molecular Immunology2015，12，6： | 6 |
| 2 | Evaluation of Bacillus sp. MZS10 for decolorizing Azure B dye and its decolorization mechanism显示文摘To evaluate decolorization and detoxification of Azure B dye by a newly isolated Bacillus sp. MZS10 strain, the cultivation medium and decolorization mechanism of the isolate were investigated. The decolorization was discovered to be dependent on cell density of the isolate and reached 93.55%(0.04 g/L) after 14 hr of cultivation in a 5 L stirred-tank fermenter at 2.0 g/L yeast extract and 6.0 g/L soluble starch and a small amount of mineral salts. The decolorization metabolites were identified with ultra performance liquid chromatography-tandem mass spectroscopy(UPLC-MS). A mechanism for decolorization of Azure B was proposed as follows: the C=N in Azure B was initially reduced to –NH by nicotinamide adenine dinucleotide phosphate(NADPH)-dependent quinone dehydrogenase, and then the –NH further combined with –OH derived from glucose to form a stable and colorless compound through a dehydration reaction. The phytotoxicity was evaluated for both Azure B and its related derivatives produced by Bacillus sp. MZS10 decolorization, indicating that the decolorization metabolites were less toxic than original dye. The decolorization efficiency and mechanism shown by Bacillus sp. MZS10 provided insight on its potential application for the bioremediation of the dye Azure B. | Huixing Li Ruijing Zhang Lei Tang Jianhua Zhang Zhonggui Mao | 2014 | Journal of Environmental Sciences2014，26，5： | 1 |
| 3 | Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells显示文摘全身的豺狼座 erythematosus (SLE ) 的一个特点是由汽车反应的 B 房间的各种各样的自身抗体的一致生产。Interferon-α(IFN-α) 发信号高度在 SLE B 房间被激活并且由 B 房间在抗体反应起一个重要作用。以前的研究证明了 CD180 否定的 B 房间,戏剧性地在 SLE 病人被增加,为自身抗体的生产负责。然而,在 CD180 和 IFN-α 之间的协会;未知的发信号的遗体。在现在的学习,我们在调整 IFN-α 的激活上探索了 CD180 的效果;在 B 房间发信号。我们发现 CD180 否定的 B 房间的数字在 MRL/Mp-Fas (lpr/lpr ) 被增加豺狼座容易的老鼠与野类型的老鼠相比。Phenotypic 分析证明 CD180 否定的 B 房间包括了 CD138 + plasmablast/plasma 房间和 GL-7 + 幼芽的中心(GC ) B 房间。尤其是, CD180 的结扎显著地禁止了 IFN-α信号变换器的导致的 phosphorylation 和抄写 2 的使活跃之物(STAT-2 ) 和以在 vitro 的一种 Lyn-PI3K-BTK-dependent 方式的刺激 IFN 的基因(ISG ) 的表示。而且, CD180 的结扎能也禁止 IFN-α在在 vivo 的 B 房间的导致的 ISG 表示。而且,像使用费的受体 7 并且像使用费的受体 9 发信号小径能显著地 downregulate CD180 表示并且调制在 IFN-α 的激活上发信号的 CD180 的禁止的效果;发信号。一起,我们的结果加亮在 CD180 否定的 B 房间的增加的比例和 IFN-α 的激活之间的靠近的协会;在 SLE 发信号。我们的数据提供分子的卓见进 IFN-α 的机制;在为 SLE 处理的 SLE B 房间和一条潜在的治疗学的途径的发信号的激活。 | Ming You Guanjun Dong Fanlin Li Feiya Ma Jing Ren Yujun Xu Huimin Yue Ruijing Tang Deshan Ren Yayi Hou | 2017 | Cellular & Molecular Immunology2017，14，2： | 0 |
| 4 | Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor显示文摘The adoptive transfer of chimeric antigen receptor-T(CAR-T)cells has shown remarkable clinical responses in hematologic malignancies.However,unsatisfactory curative results and side effects for tumor treatment are still unsolved problems.Herein we develop a click CAR-T cell engineering strategy via cell glycometabolic labeling for robustly boosting their antitumor effects and safety in vivo.Briefly,paired chemical groups(N3/BCN)are separately incorporated into CAR-T cell and tumor via nondestructive intrinsic glycometabolism of exogenous Ac4GalNAz and Ac4ManNBCN,serving as an artificial ligand-receptor.Functional groups anchored on cell surface strengthen the interaction of CAR-T cell and tumor via bioorthogonal click chemistry,further enhancing specific recognition,migration and selective antitumor effects of CAR-T cells.In vivo,click CAR-T cell completely removes lymphoma cells and minimizes off-target toxicity via selective and efficient bioorthogonal targeting in blood cancer.Surprisingly,compared to unlabeled cells,artificial bioorthogonal targeting significantly promotes the accumulation,deep penetration and homing of CAR-T cells into tumor tissues,ultimately improving its curative effect for solid tumor.Click CAR-T cell engineering robustly boosts selective recognition and antitumor capabilities of CAR T cells in vitro and in vivo,thereby holding a great potential for effective clinical cell immunotherapy with avoiding adverse events in patients. | Hong Pan Wenjun Li Ze Chen Yingmei Luo Wei He Mengmeng Wang Xiaofan Tang Huamei He Lanlan Liu Mingbin Zheng Xin Jiang Ting Yin Ruijing Liang Yifan Ma Lintao Cai | 2021 | Bioactive Materials2021，6，4： | 0 |
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