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| 1 | The FGOALS climate system model as a modeling tool for supporting climate sciences:An overview显示文摘Climate system models are useful tools for understanding the interactions among the components of the climate system and predicting/projecting future climate change. The development of climate models has been a central focus of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences(LASG/IAP) since the establishment of the laboratory in 1985. In China, many pioneering component models and fully coupled models of the climate system have been developed by LASG/IAP. The fully coupled climate system developed in the recent decade is named FGOALS(Flexible Global Ocean-Atmosphere-Land System Model). In this paper, an application-oriented review of the LASG/IAP FGOALS model is presented. The improved model performances are demonstrated in the context of cloud-radiation processes, Asian monsoon, ENSO phenomena, Atlantic Meridional Overturning Circulation(AMOC) and sea ice. The FGOALS model has contributed to both CMIP5(Coupled Model Intercomparison Project-phase 5) and IPCC(Intergovernmental Panel on Climate Change) AR5(the Fifth Assessment Report). The release of FGOALS data has supported the publication of nearly 500 papers around the world. The results of FGOALS are cited ~106 times in the IPCC WG1(Working Group 1) AR5. In addition to the traditional long-term simulations and projections, near-term decadal climate prediction is a new set of CMIP experiment, progress of LAGS/IAP in the development of nearterm decadal prediction system is reviewed. The FGOALS model has supported many Chinese national-level research projects and contributed to the national climate change assessment report. The crucial role of FGOALS as a modeling tool for supporting climate sciences is highlighted by demonstrating the model's performances in the simulation of the evolution of Earth's climate from the past to the future. | TianJun Zhou Bin Wang YongQiang Yu YiMin Liu WeiPeng Zheng LiJuan Li Bo Wu PengFei Lin Zhun Guo WenMin Man Qing Bao AnMin Duan HaiLong Liu XiaoLong Chen Bian He JianDong Li LiWei Zou XiaoCong Wang LiXia Zhang Yong Sun WenXia Zhang | 2018 | Earth and Planetary Physics2018，2，4： | 6 |
| 2 | High levels of circulating GM-CSF^(+) CD4^(+) T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study显示文摘Granulocyte colony-stimulating factor(GM-CSF),produced by CD4^(+)T cells,has recently been implicated in the pathogenesis of inflammatory diseases,such as multiple sclerosis and juvenile arthritis.However,the role of GM-CSF-producing CD4^(+)T cells in sepsis remains unknown.This study reports peripheral changes in GM-CSF-producing CD4^(+)T cells in septic patients and the possible underlying mechanism by which GM-CSF influences the outcome of sepsis.Forty-three septic patients,20 SIRS patients,and 20 healthy controls were enrolled in this study and followed for 28 days to assess mortality.We measured the peripheral frequency of GM-CSF^(+)CD4^(+)T cells and recorded their associated relationship with disease progression.Our data demonstrated that peripheral GM-CSF-producing CD4^(+)T cells were significantly higher in septic patients than in both SIRS patients and healthy controls.These cells exhibit a memory phenotype and impaired IFN-γ-secreting capacity in sepsis patients.Using a receiver operating curve analysis with 8.01%as a cut-off point,the percentage of GM-CSF^(+)CD4^(+)T cells could predict the outcome of septic patients.Combined with the increase in GM-CSF-producing CD4^(+)T cells,inflammatory cytokines IL-1βand IL-6 were also upregulated.Using an in vitro neutrophil model,we found that GM-CSF inhibited C3aR expression,while inducing IL-8 production.Furthermore,this effect was transferrable in plasma from sepsis patients and was attenuated by inhibition of GM-CSF using an anti-GM-CSF antibody.These results indicate that GM-CSF-producing CD4^(+)T cells may serve as a marker of sepsis severity.Thus,targeting GM-CSF overproduction may benefit sepsis patients. | Huihuang Huang Siyu Wang Tianjun Jiang Rong Fan Zheng Zhang Jinsong Mu Ke Li Yonggang Wang Lei Jin Fang Lin Jie Xia Lijian Sun Biao Xu Chengcheng Ji Jing Chen Juan Chang Bo Tu Bing Song Chao Zhang Fu-Sheng Wang Ruonan Xu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 3 | A Robustness Analysis of CMIP5 Models over the East Asia-Western North Pacific Domain显示文摘 | Tianjun Zhou Xiaolong Chen Bo Wu Zhun Guo Yong Sun Liwei Zou Wenmin Man Lixia Zhang Chao He | 2017 | Engineering2017，3，5： | 4 |
| 4 | Observational analysis and numerical simulation of the interannual variability of the boreal winter Hadley circulation over the recent 30 years显示文摘The interannual variability of the boreal winter (DJF) Hadley Cell strength during 1979-2008 is investigated using NCEP/NCAR reanalysis data. The results of AMIP simulation of LASG/IAP AGCM GAMIL2.0 are compared against the reanalysis data. Both the reanalysis data and the simulation show that the interannual variability of the Hadley Cell strength has a non-uniform spatial distribution, as evidenced by the 1st Empirical Orthogonal Function (EOF) mode. The change of Hadley cell strength in the tropics is opposite to that in the subtropical regions. Our analysis indicates that a positive phase of EOF1 is associated with an El Ni o-like warmer equatorial central and eastern Pacific and a warmer southern Indian Ocean. Above features are also seen in the results of GAMIL2.0 simulation, indicating that the interannual variability of the Hadley Cell strength is driven by the tropical ocean variability. Our analysis also demonstrates that the contribution of the warmer central-eastern Pacific to the 1st EOF mode is larger than that of the South Indian Ocean. The SST forcing enhances the local Hadley circulation strength in the central Pacific and Africa (30°S-30°N, 150°E-90°W), while it weakens the local Hadley circulation in other regions (30°S-30°N, 90°-10°W). The western Pacific anticyclone remotely driven by the El Ni o forcing leads to a weakened local Hadley cell in the Northern Hemisphere, while the South Indian Ocean anticyclone driven by the remote El Ni o forcing and the local warmer SST anomalies in the southern Indian Ocean results in a weakened local Hadley Cell in the Southern Hemisphere. The enhancement of the Pacific local Hadley Cell is stronger (weaker) than that of the Atlantic, the western Pacific, and the southern Indian Ocean in the tropical (subtropical) part, thus for the zonal mean condition the strength of the total Hadley Cell is stronger (weaker) in the tropical (subtropical) limb. The amplitude of the Hadley Cell change in the Northern Hemisphere is stronger than that in the Southern Hemisphere. Hence the leading interannual variability mode of boreal winter Hadley Cell exhibits a non-uniform spatial pattern. | SUN Yong ZHOU TianJun ZHANG LiXia | 2013 | Science China Earth Sciences2013，56，4： | 3 |
| 5 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 6 | Coal gasification in steam and air medium under plasma conditions: a preliminary study 显示文摘 | Qiu Jieshan He Xiaojun Sun Tianjun | 2004 | Fuel Processing Technology2004，85，： | 1 |
| 7 | Ultra-thin CoAl layered double hydroxide nanosheets for the construction of highly sensitive and selective QCM humidity sensor显示文摘To achieve real-time monitoring of humidity in various applications,we prepared facile and ultra-thin CoAl layered double hydroxide(CoAl LDH)nanosheets to engineer quartz crystal microbalances(QCM).The characteristics of CoAl LDH were investigated by transmission electron microscopy(TEM),X-ray diffraction(XRD),X-ray photoelectric spectroscopy(XPS),Brunauer–Emmett–Telle(BET),atomic force microscopy(AFM)and zeta potential.Due to their large specific surface area and abundant hydroxyl groups,CoAl LDH nanosheets exhibit good humidity sensing performance.In a range of 11.3%and 97.6%relative humidity(RH),the sensor behaved an ultrahigh sensitivity(127.8 Hz/%RH),fast response(9.1 s)and recovery time(3.1 s),low hysteresis(3.1%RH),good linearity(R^(2)=0.9993),stability and selectivity.Besides,the sensor can recover the initial response frequency after being wetted by deionized water,revealing superior self-recovery ability under high humidity.Based on in-situ Fourier transform infrared spectroscopy(FT-IR),the adsorption mechanism of CoAl LDH toward water molecules was explored.The QCM sensor can distinguish different respiratory states of people and wetting degree of fingers,as well as monitor the humidity in vegetable packaging,suggesting excellent properties and a promising application in humidity sensing. | Yongheng Zhu Xuhua Dong Jinsheng Cheng Lumin Wang Cheng Zhao Yonghui Deng Siqi Xie Yingjie Pan Yong Zhao Gengzhi Sun Tianjun Ni | 2023 | Chinese Chemical Letters2023，34，8： | 1 |
| 8 | Highly enhanced selectivity for the separation of CH 4 over N 2 on two ultra-microporous frameworks with multiple coordination modes 显示文摘 | Ren Xinyu Sun Tianjun Hu Jiangliang | 2014 | Microporous Mesoporous Mater2014，186，1： | 1 |
| 9 | Variability of Atlantic Meridional Overturning Circulation in FGOALS-g2显示文摘The variability of Atlantic Meridional Overturning Circulation(AMOC) in the pre-industrial control experiment of the Flexible Global Ocean–Atmosphere–Land System model, Grid-point Version 2(FGOALS-g2) was investigated using the model outputs with the most stable state in a 512-yr time window from the total 1500-yr period of the experiment. The period of AMOC in FGOALS-g2 is double peaked at 20 and 32 years according to the power spectrum, and 22 years according to an auto-correlation analysis, which shows very obvious decadal variability. Like many other coupled climate models, the decadal variability of AMOC in FGOALS-g2 is closely related to the convection that occurs in the Labrador Sea region. Deep convection in the Labrador Sea in FGOALS-g2 leads the AMOC maximum by 3–4 years. The contributions of thermal and haline effects to the variability of the convection in three different regions [the Labrador, Irminger and Greenland–Iceland– Norwegian(GIN) Seas] were analyzed for FGOALS-g2. The variability of convection in the Labrador and Irminger Seas is thermally dominant, while that in the colder GIN Seas can be mainly attributed to salinity changes due to the lower thermal expansion. By comparing the simulation results from FGOALS-g2 and 11 other models, it was found that AMOC variability can be attributed to salinity changes for longer periods(longer than 35 years) and to temperature changes for shorter periods. | HUANG Wenyu WANG Bin LI Lijuan DONG Li LIN Pengfei YU Yongqiang ZHOU Tianjun LIU Li XU Shiming XIA Kun PU Ye WANG Lu LIU Mimi SHEN Si HU Ning WANG Yong SUN Wenqi DONG Fang | 2014 | Advances in Atmospheric Sciences2014，31，1： | 1 |
| 10 | Coal gasification in steam and air medium under plasma conditions; a preliminary study显示文摘 | Jieshan Qiu Xiaojun He Tianjun Sun | 2004 | Fuel Processing Technology2004，85，： | 1 |
| 11 | Transplantation of microskin autografts with overlaid selectively decellulafized split- thickness porcine skin in the repair of deep bum wounds 显示文摘 | Tianjun Sun Yanfu Han Jiake Chai | 2011 | J Burn Care Res2011，32，： | 1 |
| 12 | Controllable fabrication and photocatalytic activity of ZnO nanobelt arrays显示文摘 | SUN Tianjun QIU Jieshan LIANG Changhai | 2008 | The Journal of Physical Chemistry C2008，112，3： | 1 |
| 13 | Coal Gasification in Steam and Air Med um Under Plasma Conditions:a Preliminary Study显示文摘 | Qiu Jieshan He Xiaojun Sun Tianjun | 2004 | Fuel Processing Technology2004，，86： | 1 |
| 14 | Coal gasification in steam and air medium under plasma conditions:a preliminary study显示文摘 | Jieshan Qiu Xiaojun He Tianjun Sun | 2004 | Fuel Processing Technology2004，，85： | 1 |
| 15 | Highly sensitive WO3 hollow sphere gas sensors显示文摘 | Li Xiaolin Lou Tianjun Sun Xiaoming | 2004 | Inorganic Chemistry2004，43，17： | 1 |
| 16 | Highly sensi- tive WO3 hollow-sphere gas sensors显示文摘 | Li Xiaolin Lou Tianjun Sun Xiaoming | 2004 | Inorg Chern2004，43，17： | 1 |
| 17 | Coal Gasification in Steam and Air Medium Under Plasma Conditions:a Preliminary Study显示文摘 | Qiu Jieshan He Xiaojun Sun Tianjun | 2004 | Fuel Processing Technology2004，，85： | 1 |
| 18 | Coal gasification in steam and air medium under plasma conditions a preliminary study 显示文摘 | QIU JIESHAN HE XIAOJUN SUN TIANJUN | 2004 | Fuel Processing Technology2004，85，： | 1 |
| 19 | Controllable fabri- cation and photocatalytic activity of ZnO nanobelt arrays 显示文摘 | Sun Tianjun Qiu Jieshan Liang Changha | 2008 | The Journal of Physical Chemistry C2008，112，： | 1 |
| 20 | A chromosome-level genome assembly of the blackspotted croaker(Protonibea diacanthus)显示文摘The blackspotted croaker(Protonibea diacanthus)is an endangered coastal marine fish.It is also a valuable species that is cultured on the southeast coast of China.While some genetic studies have been conducted to protect this species,genomic resources are lacking.Here,we report a chromosome-scale assembly of P.diacanthus genome by high-depth genome sequencing,assembly,and annotation.The genome scale was 635.69 Mb with contig and scaffold N50 length of 3.33 Mb and 25.60 Mb,respectively.Hi-C scaffolding of the genome resulted in 24 chromosomes of 94.15%total genome.We predicted 23,971 protein-coding genes.In addition,we constructed a phylogenetic tree using 2755 single-copy gene families and identified 462 unique gene families in P.diacanthus genome compared to three other sciaenids.What’s more,from the analysis of gene families,we found that several gene families related to innate immunity were significantly expanded in the blackspotted croaker genome compared to other teleost genomes.The high-quality genome can improve our understanding of the molecular mechanisms behind economically valuable traits and provide insights into characteristics of the immune system. | Tianjun Xu Ye Li Weiwei Zheng Yuena Sun | 2022 | Aquaculture and Fisheries2022，7，6： | 1 |
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