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| 1 | 慢性阻塞性肺疾病加重期间肠道和肺部微生物的动态变化显示文摘肠道-肺微生态系统紊乱和调节障碍在慢性阻塞性肺疾病(COPD)恶化过程中发挥关键性作用然而,COPD急性加重期肠道-肺菌群的动态变化及其在疾病病因学中的潜在作用仍知之甚少。研究者为了解慢性阻塞性肺疾病急性加重期(AECOPD)肠道和肺部微生物的动态变化,在15例AECOPD患者急性发作第1、7天和第4天纵向收集90份标本(痰液和粪便标本各45份)。 | Sun Z Zhu QL Shen Y 曾雪涛(编译) | 2020 | 中华医学杂志2020，100，40： | 23 |
| 2 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 3 | Isolated olistoliths from the Lower Triassic Xikou Formation in southwestern Fujian and its geological significance显示文摘ISOLATED olistoliths refer to massive blocks of rock occurring out of place, but with sedimentary contact relationship, within unrelated sediments. They were transported as single masses into the basins in which they occurred. In this note we will first report examples found from the Lower Triassic Xikou Formation in southwestern Fujian and discuss its geological significance. | Li, PJ Hou, QL Li, JL Sun, S | 1997 | Chinese Science Bulletin1997，42，2： | 2 |
| 4 | A study of mifepris tone/IFN-~'-indueed apoptosis of human cholangiocarcino ma cell line FRH 0201 in vitro显示文摘 | Sun QL Zhang XG Xing QT | 2012 | Onco Targets Ther2012，5，4： | 1 |
| 5 | Rapamycin suppresses TLR4-triggered IL-6 and PGE2 production of colon cancer cells by inhibiting TLR4 expression and NF-kappaB acti- vation显示文摘 | Sun QL Liu QY Zheng YY | 2008 | Mol Immunol2008，45，10： | 1 |
| 6 | Combined approaches for fixation of Schatzker type II tibial plateau fractures involving the posterolateral column:a prospective observational cohort study 显示文摘 | Sun H Zhai QL Xu YF | 2015 | Arch Orthop Trauma Surg2015，135，2： | 1 |
| 7 | Intragenomic heterogeneity of 16S rRNA genes causes overestimation of prokaryotic diversity显示文摘 | Sun DL Jiang X Wu QL | 2013 | Applied and Environmental Microbiology2013，79，19： | 1 |
| 8 | Intragenomicheterogeneity of 16S rRNA genes causes overestimation ofprokaryotic diversity显示文摘 | Sun DL Jiang X Wu QL | 2013 | Applied and EnvironmentalMicrobiology2013，79，19： | 1 |
| 9 | Intragenomic heterogeneity of 16S rRNA genes causes overestimation of prokaryotic diversity显示文摘 | Sun DL Jiang X Wu QL | 2013 | Applied and Environmental Microbiology2013，79，19： | 1 |
| 10 | Myeloid-derived suppressor cells are associated with viral persistence and downregulation of TCR chain expression on CD8 + T cells in chronic hepatitis C patients 显示文摘 | Zeng QL Yang B Sun HQ | 2014 | Mol Cells2014，37，1： | 1 |
| 11 | Cloning and high level nonfusion expression of recombinant human fibroblast growth factor in Eschrichia coli 显示文摘 | Chen XJ Sun FY Xie QL | 2002 | Acta Pharmcol Sin2002，23，9： | 1 |
| 12 | Endogenous Hormone in Response to Molybdenum in Winter Wheat Roots under Low Temperature Stress显示文摘 | Sun XC Hu CX Tan QL | 2010 | Journal of Food Agriculture & Environment2010，8，3： | 1 |
| 13 | Intragenomic hterogenity in 16S rRNA causes overestimation of prokaryotic diversity显示文摘 | Sun DL Jiang X Wu QL | 2013 | Applied Environmental Microbiology2013，79，： | 1 |
| 14 | Intragenomic heterogeneity of 16S rRNA genes causes over estimation of prokaryotic diversity显示文摘 | Sun DL Jiang X Wu QL | 2013 | Applied and Environmental Microbiology2013，79，19： | 1 |
| 15 | Transgenic rice homozygous lines expressing GNA showed enhanced resistance to rice brown planthopper显示文摘Mature seed-derived callo from two elite Chinese japonica rice (Oryza saliva L.) cultivars Eyi 105 and Ewan 5 were co-transformed with two plasmids, pWRG1515 and pRSSGNAl, containing the selectable marker hygromy-cin phosphotransferase gene (hpt), the reporter β-glu-curonidase gene (gusA) and the snowdrop (Galanthus nivalis) lectin gene (gna) via particle bombardment. 61 independent transgenic rice plants were regenerated from 329 bombarded calli. 79% transgenic plants contained all the three genes, revealed by PCR/Southern blot analysis. Western blot analysis revealed that 36 out of 48 gna-containing transgenic plants expressed GNA (75%) at various levels with the highest expression being approximately 0.5% of total soluble protein. Genetic analysis confirmed Mendelian segregation of transgenes in progeny. From the R2 generations whose R1 parent plants showing 3:1 Mendelian segregation patterns, we identified five independent homozygous lines containing and expressing all the three transgenes. Insect | SUN Xiaofen TANG Kexuan WAN Bingliang Ql Huaxiong LU Xinggui | 2001 | Chinese Science Bulletin2001，46，20： | 1 |
| 16 | Intragenomic hterogenityin 16S rRNA causes overestimation of prokaryoticdiversity 显示文摘 | Sun DL Jiang X Wu QL | 2013 | Applied Environmental Microbiology2013，79，： | 1 |
| 17 | Combined approaches for fixation of Schatzker type II tibial plateau fractures involving the postero- lateral column: a prospective observational cohort study显示文摘 | Sun H Zhai QL Xu YF | 2015 | Arch Orthop Trauma Surg2015，135，2： | 1 |
| 18 | Flavonoids and volatiles in Chrysanthemum morifolium Ramat flower from Tongxiang County in China显示文摘 | Sun QL Hua S Ye JH | | 0，，25： | 1 |
| 19 | Mesenchymal stem cells derived from human induced pluripotent stem cells modulate T-cellphenotypes in al ergic rhinitis显示文摘 | Fu QL Chow YY Sun SJ | | 0，，10： | 1 |
| 20 | Intragenomic heterogeneity in 16S rRNA genes causes overestimation of prokaryotic diversity显示文摘 | Sun DL Jiang X Wu QL | 2013 | Applied and Environmental Microbiology2013，79，19： | 1 |
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