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| 1 | BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair显示文摘Calvarial bones are connected by fibrous sutures. These sutures provide a niche environment that includes mesenchymal stem cells(MSCs), osteoblasts, and osteoclasts, which help maintain calvarial bone homeostasis and repair. Abnormal function of osteogenic cells or diminished MSCs within the cranial suture can lead to skull defects, such as craniosynostosis. Despite the important function of each of these cell types within the cranial suture, we have limited knowledge about the role that crosstalk between them may play in regulating calvarial bone homeostasis and injury repair. Here we show that suture MSCs give rise to osteoprogenitors that show active bone morphogenetic protein(BMP) signalling and depend on BMP-mediated Indian hedgehog(IHH) signalling to balance osteogenesis and osteoclastogenesis activity. IHH signalling and receptor activator of nuclear factor kappa-Β ligand(RANKL) may function synergistically to promote the differentiation and resorption activity of osteoclasts. Loss of Bmpr1a in MSCs leads to downregulation of hedgehog(Hh) signalling and diminished cranial sutures. Significantly, activation of Hh signalling partially restores suture morphology in Bmpr1a mutant mice, suggesting the functional importance of BMP-mediated Hh signalling in regulating suture tissue homeostasis. Furthermore, there is an increased number of CD200+ cells in Bmpr1a mutant mice, which may also contribute to the inhibited osteoclast activity in the sutures of mutant mice. Finally, suture MSCs require BMPmediated Hh signalling during the repair of calvarial bone defects after injury. Collectively, our studies reveal the molecular and cellular mechanisms governing cell–cell interactions within the cranial suture that regulate calvarial bone homeostasis and repair. | Yuxing Guo Yuan Yuan Ling Wu Thach-Vu Ho Junjun Jing Hideki Sugii Jingyuan Li Xia Han Jifan Feng Chuanbin Guo Yang Chai | 2018 | Bone Research2018，6，4： | 12 |
| 2 | Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal显示文摘 | Kazuichi Okazaki Shigeyuki Kawa Terumi Kamisawa Satoru Naruse Shigeki Tanaka Isao Nishimori Hirotaka Ohara Tetsuhide Ito Seiki Kiriyama Kazuro Inui Tooru Shimosegawa Masaru Koizumi Koichi Suda Keiko Shiratori Koji Yamaguchi Taketo Yamaguchi Masanori Sugiy | 2006 | Journal of Gastroenterology2006，，7： | 3 |
| 3 | Impact of shallow source/drain on the short-channel characteristics of pMOSFETs 显示文摘 | KURATA H SUGII T | 1999 | IEEE EDL1999，20，2： | 1 |
| 4 | PPARgammaactivation in adipocytes is suficient for systemic insu lin sensitization显示文摘 | SUGII S OLSON P SEARS D D | 2009 | Proc Nat! Acad Sci U S A2009，106，22： | 1 |
| 5 | Dynamic threshold pass transistor logic for improved delay at lower power supply voltages显示文摘 | LINDERT N SUGII T TANG S | 1999 | IEEE Sol Sta Circ1999，34，1： | 1 |
| 6 | A benzoxadiazole-thiourea conjugate as a fluorescent chemodosimeter for Hg( II ) in aqueous media显示文摘 | Sumiya S Sugii T Shiraishi Y etal | 2011 | Journal of Photochemistry and Photobiology A : Chemistry2011，，219： | 1 |
| 7 | Transformation of Dendrobium orchid using particle bombardment of protocorms显示文摘 | Adelheid R. Kuehnle Nellie Sugii | 1992 | Plant Cell Reports1992，，9： | 1 |
| 8 | Epigenetic codes of PPAR gamma in metabolic disease显示文摘 | Sugii S Evans RM | 2011 | FEBS Lett2011，585，： | 1 |
| 9 | Velocity measurement of both red blood cells and plasma of in vitro blood flow using high-speed micro PIV technique 显示文摘 | YASUHIKO Sugii REMI Okuda KOJI Okamoto | 2005 | Meas Sci Technol2005，16，： | 1 |
| 10 | Epigenetic codes of PPARgamma in metabolic disease显示文摘 | Sugii S Evans R M | 2011 | FEBS Lett2011，585，13： | 1 |
| 11 | Performance enhancement of strained-Si MOSFETs fabricated on a chemical-mechanical-polished SiGe substrate显示文摘 | SUGII N HISAMOTO D WASHIO K | 2002 | IEEE Trans Elec Dev2002，49，12： | 1 |
| 12 | Evaluation of methane oxidation in rice plant-soil system显示文摘 | Kazuyuki Inubushi Hotaka Sugii Iwao Watanabe Reiner Wassmann | 2002 | Nutrient Cycling in Agroecosystems (-)2002，，1： | 1 |
| 13 | Callus induction and plantlet regeneration in tissue cultures of Hawaiian anthuriums显示文摘 | Kuehnle A R Sugii N | 1991 | Hort Science1991，26，7： | 1 |
| 14 | In vivo PIV measurement of red blood cell velocity field in microvessels considering mesentery motion 显示文摘 | SUGII Y NISHIO S OKAMOTO K | 2002 | Physiological Measurement2002，23，： | 1 |
| 15 | A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain显示文摘 | Reid PC Sekashita N Sugii S | 2004 | J Lipid Res2004，45，3： | 1 |
| 16 | Identification of the porcine cytomegalovirus major capsid protein gene显示文摘 | RUPASINGHE V IWATSUKI-HORIMOTO K SUGII S | 2001 | J Vet Med Sci2001，63，6： | 1 |
| 17 | Characterization of carbona-ceous gel beads prepared in presence of polymer using water inoil emulsion显示文摘 | Sugii H Esumi K Honda H | 1995 | Carbon1995，33，： | 1 |
| 18 | Anthurium roots for micropropagation and Agrobacterium tumefacins-mediated gene transfer显示文摘 | CHEN F C KUEHNLE A R SUGII N | 1997 | Plant Cell Tissue and Organ Culture1997，49，： | 1 |
| 19 | Identification of the porcine cytomegalovirus major capsid protein gene显示文摘 | RUPASINGHE V IWATSUKI-HORIMOTO K SUGII S | 2001 | J Vet Med Sci2001，63，60： | 1 |
| 20 | Transformation of Dendrobium orchid using particle bombardment of protocorms显示文摘 | KUEHNLE A R SUGII N | 1992 | Plant Cell Rep1992，，11： | 1 |
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